ROBERTO RIZZI

PERSONAL INFORMATION Roberto Rizzi, Ph.D.

roberto.rizzi@uniroma1.it

rbt.rizzi@pec.it

Orcid ID: 0000-0001-6084-7199

Sex Male | | Nationality Italian

RESEARCH INTERESTS

Development of innovative biotechnologies for regenerative medicine and modelling
Personalized organs generation in vitro
Stem Cell and Bio Additive-based therapies for cardiac and skeletal muscles regeneration
Biomaterials for tissue engineering and organoids 2.0 generation
Strategic consulting for 3D Bio-fabricated disease modelling

Roberto Rizzi is a distinguished expert in regenerative medicine, recognized for his leadership and innovation in the development of advanced 3D physiological models and human tissue engineering. His research focuses on introducing and integrating cutting-edge technologies that have significantly advanced the high-profile modeling of human physiology. Rizzi’s laboratory has become a hub for pioneering efforts in creating patient-specific 3D organs, including sophisticated organ-on-chip systems, microfluidic devices, organoids, and mini-organ models. These innovations are instrumental in the translational investigation of new therapeutic strategies, particularly in oncology and regenerative medicine. Roberto Rizzi's contributions have highlighted the essential roles of biophysical, biochemical, and environmental factors in the development of advanced in vitro methods, enhancing the precision and effectiveness of these models. His recent work emphasizes the creation of patient-specific dynamic bioenvironments using induced pluripotent stem cells (iPSCs), immunocompetent organoids, and customized biological sensors integrated with Machine Learning (ML) technologies. With his expertise in extrusion-based 3D bioprinting, Roberto Rizzi has successfully replicated the hierarchical structures of natural human organs, pushing the boundaries of personalized medicine. His leadership has not only propelled his team to the forefront of biomedical research but has also positioned them as key contributors to the future of healthcare and therapeutic innovation.

WORK EXPERIENCE
2025 to date Associate Professor MEDS 26A (06-N1)
Interdisciplinary Department of Well-being, Health and Environmental Sustainability (BeSSA)
Faculty of Dentistry and Medicine
“Sapienza” University of Rome
Rieti, Italy
Regenerative Medicine

2022 – 2025 Assistant Professor MEDS 26A (06-N1)
Department of Medical Surgical Sciences and Biotechnologies
Faculty of Pharmacy and Medicine
“Sapienza” University of Rome
P.le Aldo Moro 5 – Roma, Italy
Regenerative Medicine

2021 – 2024 Head of Bioprinting and Biofabrication Unit
Organoids Center -Invernizzi Foundation c/o INGM
Via Francesco Sforza, 35 – 20122 Milan, Italy
https://ingm.org/en/organoid-center/
Hi-fidelity modelling for Immunology

2019 – 2024 Principal Investigator-PI/HEAD
National Institute of Molecular Genetics Foundation (INGM)
Head of Rigenerative Medicine Unit
Via Francesco Sforza, 35 – 20122 Milan, Italy
https://ingm.org/en/rizzi_lab_eng/
Development of innovative biotechnologies for regenerative medicine

2008 - 2022 Permanent Researcher. (leave)
National Research Council (CNR) of Italy
Institute of Biomedical Technologies (ITB): 10/2019 – 05/2022
Institute of Cell Biology and Neurobiology (IBCN): 10/2008 – 09/2019
7 Aldo Moro Square – Rome, Italy
https://www.itb.cnr.it/laboratori/ingegneria-tissutale/
Stem cells supported by innovative biomaterials in regenerative medicine

2009 - 2015 Consultant: Researcher- Group Leader
IRCCS MultiMedica
16/15 Fantoli Street – Milan, Italy
Generation of induced pluripotent stem cells for personalized medicine approaches
Business or sector Health and life science
2007 - 2008 Post-Doc
Harvard Medical School
Brigham and Women's Hospital
75 Francis Street – Boston, Massachusetts, USA
Characterization of calcium channels in cardiac differentiation

2006 – 2007 Post-Doc
New York Medical College
40 Sunshine Cottage Road – Valhalla, New York, USA
Identification of a population of cardiac progenitors residing in the human heart

2005 – 2006 Post-Doc
Istituto Dermopatico dell'Immacolata (IDI)
Via dei Monti di Creta 104 - Rome, Italy
Regeneration of muscle tissues

2004 Post-Doc
University of Rome "Tor Vergata"
Via O. Raimondo, 8 Loc. La Romanina - Rome, Italy
Biological effects of peptides VGF-derived

EDUCATION, TRAINING, MEMBERSHIP

2025

2024

2024

2023 MEMBER of the PhD Committee in Morphogenesis and Tissue Engineering
“Sapienza” University of Rome
S.I.R.T.E.P.S. FULL Member (Societa' Italiana Ricerca Traslazionale E Professioni Sanitarie)
SAPIexcellence, MEMBER OF BOARD PANEL

ASN- National Scientific Qualification
CALL D.D. 553/2021 Eligibility Full Professor -Sector _MEDS26A
2018 ASN- National Scientific Qualification
CALL D.D. 1532/2016 Eligibility Associate Professor -Sector _MEDS26A
Science of health professions and applied medical technologies
2005 Specialty: Consultant in Clinical Sexology
Clinical Sexology Institute - Rome, Italy
2003 Ph.D. in Psychobiology and Psychopharmacology
Psychobiology and Psychopharmacology Institute, University of Rome "La Sapienza"
Piazza Aldo Moro, 5 - Rome, Italy
1999 Master’s degree in Clinical Psychology
University of Rome "La Sapienza"
Piazza Aldo Moro, 5 - Rome, Italy

2009 “EUGENEheart Mouse phenotyping-Catheter-based in vivo hemodynamics of murine hearts”, under the supervision of Mylene Pezet, PhD, Consulting Engineer, Bichat Hospital, Paris.
2009

2002 “EUGENEheart Mouse phenotyping- small rodens echocardiography,” under the supervision of Dr. Brigitte Escoubet, cardiologist, MD, PhD, Bichat Hospital, Paris.
“Physiology of pain” under the supervision of Prof. Giancarlo Carli, Nuovi Istituti Biologici, University of Siena.

TEACHING ACTIVITIES

PHARMACEUTICAL CHEMISTRY AND TECHNOLOGY LM-13 (CTF)
General and Molecular Pathology with Medical Terminology
(10611094)

MEDICAL BIOTECHNOLOGIES LM-9
Cellular, Tissue, and Organ Bioengineering
(10600243)

NURSING (QUALIFICATION FOR THE PROFESSION OF NURSE) L/SNT1
General Pathology and Pathophysiology
(10589388)
Seminar Activities
(AAF1405)

BIOMEDICAL LABORATORY TECHNIQUES (QUALIFICATION FOR THE PROFESSION OF BIOMEDICAL LABORATORY TECHNICIAN) L/SNT3
Pathophysiology
(1036417)
Molecular Diagnostic Methodology
(1035176)
Professional Laboratories
(AAF1404)

H-INDEX
30 (scopus) https://www.scopus.com/authid/detail.uri?authorId=57192337212

RIZZI’S LAB FUNDED PROJECTS

2023-2025 MINISTRY OF HEALTH- ISS "ITALIAN NETWORK FOR VIROLOGICAL SURVEILLANCE, IMMUNOLOGICAL MONITORING, TRAINING AND RESEARCH IN PREPARATION FOR THE MANAGEMENT OF INFECTIOUS EMERGENCIES - R.I.Pr.E.I.". Multifocal dynamic bioengineered 3D cardiac models to unveil the epigenetic remodeling of SARS-CoV-2 infection. RIPREI2023_2ad9f6598b09 Euro 400.000
2023-2024 "Progetti di Ricerca - Progetti Grandi" SAPIENZA UNIVERSITY OF ROME, 2023 Artificial Protein Coronas: A Pathway to Enhance Liposomal Transport Across Endothelial Vessels. Numero protocollo: RG1231889FD00B1F. Euro 29.000
2022-2023 "Progetti di Ricerca - Progetti Medi" SAPIENZA UNIVERSITY OF ROME, 2022 Magnetically guided CD8+ T cells to boost the immune response and therapeutic effects in triple negative cancer organoids of female patients. - n. protocollo RM122181677BE4B7. Euro 10.000.
2022-2023, PROGETTI DI RICERCA@CNR -call. 2021, Dipartimento Scienze Biomediche “Human 3D myocardium-integrated competent coronary vessel to unveil epigenetics dynamics of Sars-CoV-2 infection on heart” (197/2021 del 21/12/2021). Euro 209.000.
2020-2023, MINISTRY OF DEFENCE “GRENADE – “Generazione di tessuti individuo-specifici per il riparo di organi danneggiati” – prot. M_D GCOM REG2020 0009780 23-06-2020 Euro 597.000.
2020-2023, FONDAZIONE REGIONALE per la RICERCA BIOMEDICA, Bando Giovani “Early Career Award”: “Chondroitin sulfate proteoglycan‐4, secreted by a binding imbalance between SP1 and NF‐kB on CHST11 gene, triggers sympathetic cardiac denervation in Duchenne Muscular Dystrophy” – ID 1731651. Euro 600.000.
2020-2023, CARIPLO FOUNDATION “The role of microRNA-34 in regulating autoimmune T cell response in the depressive syndrome”– prot. 2019-3392. Euro 300.000.
2020-2023, Ricerca Finalizzata Giovani, Ministero della Salute: “Engineered T cells (CAR-T) for the treatment of cardiac fibrosis in Duchenne Muscular Dystrophy” – ID SG-2019-12368961. Euro 140.000.
2018-2021, Roche: “Caratterizzazione degli effetti dell’HDACi Givinostat nel ripristino della funzionalità della sinapsi neurocardiacadel topo mdx, attraverso la modulazione dell’espressione di NGF nei fibroblasti interstiziali cardiaci” - ID CNR 0004002. Euro 50.000.
2018-2020, LAZIOINNOVA SATISFY “Generazione di tessuti umani individuo-specifici per test di efficacia di nuovi farmaci” – prot. 85-2017-15095. Euro 150.000.
2017-2020, PARENT PROJECT, “Role of the HDAC inhibitor givinostat in cardiac remodelling in mdx mice. Euro 60.000.
2017-2018, ITALFARMACO, “ACE and HDAC inhibitors effects after myocardial infarction”. Euro 45.000.
2014-2017, Cluster ALISEI IRMI Project, ITALIAN MINISTRY OF EDUCATION, UNIVERSITY AND RESEARCH, “Creation of a multiregional infrastructure for the development of advanced therapies for organ and tissue regeneration” – prot. CTN01 00177 888744. Euro 100.000.
2013-2015, Lombardy Region, Framework agreement, RSPPTech “Research and development of products and technological platforms for the competitiveness of the lombard industry” – prot. 18095. Euro 250.000.
2011-2014, Lombardy Region, Superpig 2010, “Technological platform for using the pig model in biomedical (organ and tissue transplantation) and biotechnological (animal model) fields” – prot. 14388. Euro 599.000.
2008-2012, EC | FP7 | SP1 | NMP, “Angiogenesis-inducing Bioactive and Bioresponsive Scaffolds in Tissue Engineering”. ID: 214402. Euro 500.000

SCIENTIFIC PUBBLICATIONS
• MAIULLARI S, MELE G, CALANDRA P, DI BLASIO G, VALENTINI S, TORCINARO A, MANNI I, TEVERONI E, MANCINO F, PROIETTI L, MAIULLARI F, PESAVENTO M, GIORGINI L, PUTTI S, RIZZI R, BORTOLANI S, SCAVIZZI F, RASPA M, RICCI E, PIAGGIO G, GARGIOLI C, PONTECORVI A, LUVISETTO S, MAZZONE M, DEIDDA G, MORETTI F. Estrogen rescues muscle regeneration impaired by DUX4 in a humanized xenograft mouse model. Cell Death Dis. 2025 Jul 9;16(1):508. doi: 10.1038/s41419-025-07827-2. PMID: 40634301.
• CERAOLO, M. G., MILAN, M., FRATINI, N., VIGANÒ, R., BOUSSELMI, S., SOLURI, A., PESCE, E., MAURI, P. L., CIUFFREDA, G., LANDONI, E., BRAMBILLA, F., DOTTI, G., DI SILVESTRE, D., MAIULLARI, F., BEARZI, C., & RIZZI, R. (2025). CSPG4.CAR-T Cells Modulate Extracellular Matrix Remodeling in DMD Cardiomyopathy. International Journal of Molecular Sciences, 26(14), 6590. https://doi.org/10.3390/ijms26146590
• FABIO MAIULLARI, MARIA GRAZIA CERAOLO, DARIO PRESUTTI, NICOLE FRATINI, MATTEO GALBIATI, ALESSANDRA FASCIANI, KONRAD GIŻYŃSKI, SALMA BOUSSELMI, FRANCESCA MEGIORNI, CINZIA MARCHESE, PIOTR KASPRZYCKI, KAROL KARNOWSKI, ALESSANDRO TALONE, GASPARE VARVARO, DAVIDE PEDDIS, MARCO COSTANTINI, CLAUDIA BEARZI, ROBERTO RIZZI. “Modeling breast cancer dynamics through modulable small Vessel Environment Bioreactor (sVEB)”. Biomaterials, Volume 323, 2025, 123441, ISSN 0142-9612, https://doi.org/10.1016/j.biomaterials.
• MAILA CHIRIVÌ, FABIO MAIULLARI, MARIKA MILAN, MARIA GRAZIA CERAOLO, ALESSANDRA FASCIANI, MICHAEL STIRM, FRANCESCA SCALERA, FRANCESCA GERVASO, MICHELA VILLA, PAOLA CONFORTI, RAFFAELLO VIGANÒ, FRANCESCA BRAMBILLA, PIERLUIGI MAURI, DARIO DI SILVESTRE, MARCO COSTANTINI, ELENA CATTANEO, ECKHARD WOLF, CLAUDIA BEARZI, ROBERTO RIZZI*. “Mimicking the Dystrophic Cardiac Extracellular Environment through DystroGel”. Adv Healthc Mater. 2025 Apr;14(9):e2404251. doi: 10.1002/adhm.202404251.
• MATTEO GALBIATI, FABIO MAIULLARI, MARIA GRAZIA CERAOLO, SALMA BOUSSELMI, NICOLE FRATINI, KLAJDI GEGA, SANDRO RECCHIA, ANNA MARIA FERRETTI, GIOVANNI SCALA, MARCO COSTANTINI, TOMMASO SCIARRA, ROBERTO RIZZI,* AND CLAUDIA BEARZI,*. Bioactive Hydrogel Supplemented with Stromal Cell-Derived Extracellular Vesicles Enhance Wound Healing. Pharmaceutics 2025, 17, 162. https://doi.org/10.3390/ pharmaceutics17020162
• MILAN M, MAIULLARI F, CHIRIVÌ M, CERAOLO MG, ZIGIOTTO R, SOLURI A, MAIULLARI S, LANDONI E, SILVESTRE DD, BRAMBILLA F, MAURI P, DE PAOLIS V, FRATINI N, CROSTI MC, CORDIGLIERI C, PARISI C, CALOGERO A, SELIKTAR D, TORRENTE Y, LANZUOLO C, DOTTI G, TOCCAFONDI M, BOMBACI M, DE FALCO E, BEARZI C, RIZZI R. Macrophages producing chondroitin sulfate proteoglycan-4 induce neuro-cardiac junction impairment in Duchenne muscular dystrophy. J Pathol. 2024 Nov 11. doi: 10.1002/path.6362. Epub ahead of print. PMID: 39523812.
• FABIO MAIULLARI, MARIKA MILAN, MAILA CHIRIVÌ, MARIA GRAZIA CERAOLO, SALMA BOUSSELMI, NICOLE FRATINI, MATTEO GALBIATI, ORAZIO FORTUNATO, MARCO COSTANTINI, FRANCESCA BRAMBILLA, PIERLUIGI MAURI, DARIO DI SILVESTRE, ANTONELLA CALOGERO, TOMMASO SCIARRA, ROBERTO RIZZI* AND CLAUDIA BEARZI*. Enhancing neovascularization post-myocardial infarction through injectable hydrogel functionalized with endothelial-derived EVs. Biofabrication (2024), 7/2024, DOI 10.1088/1758-5090/ad6190
• NEHAR CELIKKIN, DARIO PRESUTTI, FABIO MAIULLARI, MARINA VOLPI, YURII PROMOVYCH, KONRAD GIZYNSKI, JOANNA DOLINSKA, AGNIESZKA WI ́SNIEWSKA, MARCIN OPAŁŁO, ALESSIA PARADISO, CHIARA RINOLDI, CLAUDIA FUOCO, WOJCIECH SWIESZKOWSKI, CLAUDIA BEARZI, ROBERTO RIZZI, CESARE GARGIOLI AND MARCO COSTANTINI. Combining rotary wet-spinning biofabrication and electro-mechanical stimulation for the in vitro production of functional myo-substitutes. Biofabrication 15 (2023) 045012. 10.1088/1758-5090/ace934
• TRIPODI F, MOTTA Z, MURTAS G, RABATTONI V, NONNIS S, GRASSI SCALVINI F, RINALDI AM, RIZZI R, BEARZI C, BADONE B, SACCHI S, TEDESCHI G, MAFFIOLI E, COCCETTI P, POLLEGIONI L. Serine metabolism during differentiation of human iPSC-derived astrocytes. FEBS J. 2023 May 11. doi: 10.1111/febs.16816. Epub ahead of print. PMID: 37166453.
• BELLINI, D.; MILAN, M.; BORDIN, A.; RIZZI, R.; RENGO, M.; VICINI, S.; ONORI, A.; CARBONE, I.; DE FALCO, E. A Focus on the Synergy of Radiomics and RNA Sequencing in Breast Cancer. Int. J. Mol. Sci. 2023, 24, 7214. https://doi.org/10.3390/ijms24087214
• DARIO DI SILVESTRE, FRANCESCA BRAMBILLA, FRANCESCA LAVATELLI, MAILA CHIRIVÌ, DIANA CANETTI, CLAUDIA BEARZI, ROBERTO RIZZI, JOHAN BIJZET, BOUKE P. C. HAZENBERG, VITTORIO BELLOTTI, JULIAN D. GILLMORE AND PIERLUIGI MAURI. The Protein Network in Subcutaneous Fat Biopsies from Patients with AL Amyloidosis: More Than Diagnosis? Cells 2023, 12(5),699.
• PIANCA N, SACCHI F, UMANSKY KB, CHIRIVÌ M, IOMMARINI L, DA PRA S, PAPA V, BONGIOVANNI C, MIANO C, PONTIS F, BRAGA L, TASSINARI R, PANTANO E, PATNALA RS, MAZZESCHI M, CENACCHI G, PORCELLI AM, LAURIOLA M, VENTURA C, GIACCA M, RIZZI R, TZAHOR E, D’UVA G. Glucocorticoid receptor antagonization propels endogenous cardiomyocyte proliferation and cardiac regeneration. Nat Cardiovasc Res. 2022 1, pages 617–633 (2022). https://doi.org/10.1038/s44161-022-00090-0
• SPINELLI S, GUIDA L, VIGLIAROLO T, PASSALACQUA M, BEGANI G, MAGNONE M, STURLA L, BENZI A, AMERI P, LAZZARINI E, BEARZI C, RIZZI R, ZOCCHI E. The ABA-LANCL1/2 Hormone-Receptors System Protects H9c2 Cardiomyocytes from Hypoxia-Induced Mitochondrial Injury via an AMPK- and NO-Mediated Mechanism. Cells. 2022 Sep 15;11(18):2888. doi: 10.3390/cells11182888.
• MAILA CHIRIVÌ, CLAUDIA BEARZI, PAOLO ROSA, SELENIA MIGLIETTA, FRANCESCA PETRONELLA, ELENA DE FALCO, ANTONELLA CALOGERO, ROBERTO PANI, VINCENZO PETROZZA, GIOVANNI PEROTTO, ROBERTO RIZZI AND LUCIANO DE SIO. Biomimetic Keratin-Coated Gold Nanoparticles for Photo-Thermal Therapy in a 3D Bioprinted Glioblastoma Tumor Model. Int. J. Mol. Sci. 2022, 23, 9528.
• VERONICA DE PAOLIS, FABIO MAIULLARI, MAILA CHIRIVÌ, MARIKA MILAN, CHIARA CORDIGLIERI, FRANCESCA PAGANO, ALESSANDRA RITA LA MANNA, ELENA DE FALCO, CLAUDIA BEARZI, ROBERTO RIZZI*,† AND CHIARA PARISI*,†. Unusual Association of NF-κB Components in Tumor-Associated Macrophages (TAMs) Promotes HSPG2-Mediated Immune-Escaping Mechanism in Breast Cancer. Int. J. Mol. Sci. 2022, 23, 7902. https://doi.org/10.3390/ijms23147902.
• ANTONELLA BORDIN, MAILA CHIRIVÌ, FRANCESCA PAGANO, MARIKA MILAN, MARCO IULIANO, ELEONORA SCACCIA, ORAZIO FORTUNATO, GIORGIO MANGINO, XHULIO DHORI, ELISABETTA DE MARINIS, ALESSANDRA D’AMICO, SELENIA MIGLIETTA, VITTORIO PICCHIO, ROBERTO RIZZI, GIOVANNA ROMEO, FABIO PULCINELLI, ISOTTA CHIMENTI, GIACOMO FRATI, ELENA DE FALCO. Human platelet lysate derived extracellular vesicles enhance angiogenesis through miR-126. Cell Proliferation, 2022 Aug 9; e13312.doi: 10.1111/cpr.13312
• FORNETTI E, TESTA S, DE PAOLIS F, FUOCO C, BERNARDINI S, POZO DEVOTO V, GORAZD B S, GIANNITELLI S, RAINER A, BIGOT A, ZOCCALI C, BALDI J, SANDONA D, RIZZI R, BEARZI C, FORTE G, CANNATA S, GARGIOLI C. Dystrophic muscle affects motoneuron axon outgrowth and NMJ assembly. Advanced Materials Technologies, March 2022, DOI.org/10.1002/admt.202101216
• STIRM M, FONTEYNE LM, SHASHIKADZE B, LINDNER M, CHIRIVI M, LANGE A, KAUFHOLD C, MAYER C, MEDUGORAC I, KESSLER B, KUROME M, ZAKHARTCHENKO V, HINRICHS A, KEMTER E, KRAUSE S, WANKE R, ARNOLD G, WESS G, NAGASHIMA H, HRABE DE ANGELIS M, FLENKENTHALER F, KOBELKE LA, BEARZI C, RIZZI R, BAEHR A, REESE S, MATIASEK K, WALTER MC, KUPATT C, ZIEGLER S, BARTENSTEIN P, FROHLICH T, KLYMIUK N, BLUTKE A, WOLF E. A scalable, clinically severe pig model for Duchenne muscular dystrophy. Disease Models & Mechanisms. 2021 Nov 19; dmm.049285. doi: 10.1242/dmm.049285
• CELIKKIN N, PRESUTTI D, MAIULLARI F, FORNETTI E, AGARWAL T, PARADISO A, VOLPI M, ŚWIĘSZKOWSKI W, BEARZI C, BARBETTA A, ZHANG YS, GARGIOLI C, RIZZI R AND COSTANTINI M. Tackling Current Biomedical Challenges With Frontier Biofabrication and Organ-On-A-Chip Technologies. Front. Bioeng. Biotechnol. 9:732130. 2021. doi: 10.3389/fbioe.2021.732130.
• CANONICO F, CHIRIVI M, MAIULLARI F, MILAN M, RIZZI R, ARCUDI A, GALLI M, PANE M, GOWRAN A, POMPILIO G, MERCURI E, CREA F, BEARZI C, D’AMARIO D. Focus on the Road to Modelling Cardiomyopathy in Muscular Dystrophy. Cardiovascular Research. 2021 Jul 12:cvab232. doi: 10.1093/cvr/cvab232. Epub ahead of print. PMID: 34254111.
• CHIRIVÌ M, MAIULLARI F, MILAN M, PRESUTTI D, CORDIGLIERI C, CROSTI M, SARNICOLA ML, SOLURI A, VOLPI M, ŚWIĘSZKOWSKI W, PRATI D, RIZZI M, COSTANTINI M, SELIKTAR D, PARISI C, BEARZI C, RIZZI R*. Tumor Extracellular Matrix Stiffness Promptly Modulates the Phenotype and Gene Expression of Infiltrating T Lymphocytes. Int J Mol Sci. 2021 May 30;22(11):5862. doi: 10.3390/ijms22115862. PMID: 34070750; PMCID: PMC8198248.
• LUCÀ R, ASSENZA MR, MAIULLARI F, PIERONI L, MAIULLARI S, FEDERICI G, MARINI F, RIZZI R, URBANI A, SODDU S, MORETTI F. Inhibition of the mTOR pathway and reprogramming of protein synthesis by MDM4 reduce ovarian cancer metastatic properties. Cell Death Dis. 2021 May 29;12(6):558. doi: 10.1038/s41419-021-03828-z. PMID: 34052831.
• PEGOLI G, MILAN M, MANTI PG, BIANCHI A, LUCINI F, SANTARELLI P, BEARZI C, RIZZI R, LANZUOLO C. Role of Cdkn2a in the Emery-Dreifuss Muscular Dystrophy Cardiac Phenotype. Biomolecules. 2021 Apr 6;11(4):538. doi: 10.3390/biom11040538. PMID: 33917623; PMCID: PMC8103514.
• MAIULLARI F, CHIRIVÌ M, COSTANTINI M, FERRETTI AM, RECCHIA S, MAIULLARI S, MILAN M, PRESUTTI D, PACE V, RASPA M, SCAVIZZI F, MASSETTI M, PETRELLA L, FANELLI M, RIZZI M, FORTUNATO O, MORETTI F, CARADONNA E, BEARZI C, RIZZI R*. In vivo organized neovascularization induced by 3D bioprinted endothelial-derived extracellular vesicles. Biofabrication 2021 Apr 7;13(3). doi: 10.1088/1758-5090/abdacf. IF: 8,213.
• MACCARI S, PACE V, BARBAGALLO F, STATI T, AMBROSIO C, VEZZI V, GRO’ C, CATALANO L, MATARRESE P, MOLINARI P, RIZZI R, MARANO G. Daily intermittent β-blockade improves cardiac function in post-infarction heart failure. Eur J Pharmacol. 2020 Jun 22;882:173287. doi: 10.1016/j.ejphar.2020.173287. PMID: 32585157
• BACI D, CHIRIVÌ M, PACE V, MAIULLARI F, MILAN M, RAMPIN A, SOMMA P, PRESUTTI D, GARAVELLI S, BRUNO A, CANNATA S, LANZUOLO C, GARGIOLI C, RIZZI R*, BEARZI C. Extracellular Vesicles from skeletal muscle cells efficiently promote myogenesis in induced pluripotent stem cells. Cells. 2020 Jun 23;9(6):1527. doi: 10.3390/cells9061527.
• BIANCHI A, MOZZETTA C, PEGOLI G, LUCINI F, VALSONI S, ROSTI V, PETRINI C, CORTESI A, GREGORETTI F, ANTONELLI L, OLIVA G, DE BARDI M, RIZZI R, BODEGA B, PASINI D, FERRARI F, BEARZI C, LANZUOLO C. Dysfunctional polycomb transcriptional repression contributes to Lamin A/C dependent muscular dystrophy. J Clin Invest. 2020 Jan 30. pii: 128161. doi: 10.1172/JCI128161.
• MAIULLARI F, COSTANTINI M, MILAN M, PACE V, CHIRIVÌ M, MAIULLARI S, BACI D, MAREI HE, SELIKTAR D, RAINER A, GARGIOLI C, BEARZI C, RIZZI R*. A multi-cellular 3D bioprinting approach for vascularized heart tissue engineering based on HUVECs and iPSC-derived cardiomyocytes. SCI REP. 2018 SEP 10;8(1):13532. DOI: 10.1038/S41598-018-31848-X.
• MILAN M, PACE V, MAIULLARI F, CHIRIVÌ M, BACI D, MAIULLARI S, MADARO L, MACCARI S, STATI T, MARANO G, FRATI G, PURI PL, DE FALCO E, BEARZI C, RIZZI R*. Givinostat reduces adverse cardiac remodeling through regulating fibroblasts activation. CELL DEATH DIS. 2018 JAN 25; 9(2):108.
• MAREI H, RIZZI R, ALTHANI A, AFFIFI N, CENCIARELLI C, CACECI T, SHUAIB A. Potential of stem cell-based therapy for ischemic stroke. FRONT NEUROL. 2018 FEB 6; 9:34. DOI: 10.3389/FNEUR.2018.00034
• SOHAIL MU, ALTHANI A, ANWAR H, RIZZI R, MAREI HE. Role of the gastrointestinal tract microbiome in the pathophysiology of diabetes mellitus. J Diabetes Res. 2017; 2017:9631435. doi: 10.1155/2017/9631435. Epub 2017 Sep 26. Review. PubMed PMID: 29082264; PubMed Central PMCID: PMC5634576.
• MAREI HE, SHOUMAN Z, ALTHANI A, AFIFI N, A AE, LASHEN S, HASAN A, CACECI T, RIZZI R, CENCIARELLI C, CASALBORE P. Differentiation of human olfactory bulb-derived neural stem cells toward oligodendrocyte. J CELL PHYSIOL. 2018 FEB; 233(2):1321-1329. DOI: 10.1002/JCP.26008. EPUB 2017 JUN 22. PUBMED PMID: 28500734.
• RONCA A, MAIULLARI F. MILAN M, PACE V, GLORIA A, RIZZI R, DE SANTIS R, AMBROSIO L. Surface functionalization of acrylic based photocrosslinkable resin for 3D printing application. BIOACTIVE MATERIALS. 2017, 2(3): 131–137. doi:10.1016/j.bioactmat.2017.04.002
• CARLOMOSTI F, D’AGOSTINO M, BEJI S, TORCINARO A, RIZZI R, ZACCAGNINI G, MAIMONE B, DI STEFANO V, DE SANTA F, CORDISCO S, ANTONINI A, CIARAPICA R, DELLAMBRA E, MARTELLI F, AVITABILE D, CAPOGROSSI MC, MAGENTA A. Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1 and eNOS. Antioxid Redox Signal. 2016 Dec 13.
• MACCARI S, BUONCERVELLO M, RAMPIN A, SPADA M, MACCHIA D, GIORDANI L, STATI T, BEARZI C, CATALANO L, RIZZI R, GABRIELE L, MARANO G. Biphasic effects of propranolol on tumour growth in B16F10 melanoma-bearing mice. Br J Pharmacol. 2016 Oct 28. doi: 10.1111/bph.13662. [Epub ahead of print] PubMed PMID: 27792834.
• VONO R, FUOCO C, TESTA S, PIRRÒ S, MASELLI D, MC COLLOUGH DF, SANGALLI E, PINTUS G, GIORDO R, FINZI G, SESSA F, CARDANI R, GOTTI A, LOSA S, CESARENI G, RIZZI R, BEARZI C, CANNATA S, SPINETTI G, GARGIOLI C, MADEDDU P. Activation of the Pro-Oxidant PKCβII-p66Shc Signaling Pathway Contributes to Pericyte Dysfunction in Skeletal Muscles of Diabetic Patients with Critical Limb Ischemia. 2016. Diabetes. 65:3691-704.
• NARDELLA M, GUGLIELMI L, MUSA C, IANNETTI I, MARESCA G, AMENDOLA D, PORRU M, CARICO E, SESSA G, CAMERLINGO R, DOMINICI C, MEGIORNI F, MILAN M, BEARZI C, RIZZI R, PIROZZI G, LEONETTI C, BUCCI B, MERCANTI D, FELSANI A AND D’AGNANO I. Down regulation of the Lamin A/C in neuroblastoma triggers the expansion of tumor initiating cells. 2015. Oncotarget. 6, 32821-32840.
• VANNOZZI L, RICOTTI L, CIANCHETTI M, BEARZI C, GARGIOLI C, RIZZI R, DARIO P AND MENCIASSI A. Self-assembled polydimethylsiloxane structures from 2D to 3D for bio-hybrid actuation. Bioinspir Biomim. 2015 Aug 20;10(5):056001. doi: 10.1088/1748-3190/10/5/056001.
• FUOCO C, RIZZI R, BIONDO A, LONGA E, MASCARO A, SHAPIRA-SCHWEITZER K, KOSSOVAR O, BENEDETTI S, SALVATORI ML, SANTOLERI S, TESTA S, BERNARDINI S, BOTTINELLI R, BEARZI C, CANNATA SM, SELIKTAR D, COSSU G, GARGIOLI C. In vivo generation of an artificial, functional skeletal muscle. EMBO Mol Med. 7:411-22, 2015.
• CATTANEO P, KUNDERFRANCO P, GRECO C, GUFFANTI A, STIRPARO GG, RUSCONI F, RIZZI R, DI PASQUALE E, LOCATELLI SL, LATRONICO MV, BEARZI C, PAPAIT R, CONDORELLI G. DOT1L-mediated H3K79me2 modification critically regulates gene expression during cardiomyocyte differentiation. 2014. Cell Death Differ. 23, 555-564.
• FUOCO C, SANGALLI E, VONO R, SACCHETTI B, MADEDDU P, CESARENI G, SELIKTAR D, RIZZI R, BEARZI C, CANNATA S, SPINETTI G, GARGIOLI C. 3D hydrogel environment rejuvenates aged pericytes for skeletal muscle tissue engineering. Front Physiol. 2014 May 30;5:203. doi: 10.3389/fphys.2014.00203.
• AMENDOLA D, NARDELLA M, GUGLIELMI L, CERQUETTI L, CARICO E, RIZZI R, BEARZI C, D’AGNANO I, STIGLIANO A, NOVELLI G, BUCCI B. Human placenta-derived neurospheres are susceptible to transformation after extensive in vitro expansion. Stem Cell Research & Therapy 2014, 5:55 doi:10.1186/scrt444.
• BEARZI C, GARGIOLI C, BACI D, FORTUNATO O, SHAPIRA-SCHWEITZER K, KOSSOVER O, LATRONICO MVG, SELIKTAR D, CONDORELLI G, RIZZI R*. PlGF–MMP9-engineered cardiomyocyte-derived iPS cells supported on a PEG–fibrinogen hydrogel scaffold possess an enhanced capacity to repair damaged myocardium. Cell Death Dis. 2014 Feb 13;5:e1053. doi: 10.1038/cddis.2014.12.
• FAGOONEE S, BEARZI C, DI CUNTO F, CLOHESSY JG, RIZZI R, RESCHKE M, TOLOSANO E, PROVERO P, PANDOLFI PP, SILENGO L, ALTRUDA F. The RNA binding protein ESRP1 fine-tunes the expression of pluripotency-related factors in mouse embryonic stem cells. PLoS One. 8:e72300, 2013.
• SANDRI M, RIZZI R, SCHIATTARELLA GG, LEVIALDI GHIRON JH, LATRONICO MVG, PIRONTI G, CHIARIELLO GA, ESPOSITO G, TAMPIERI A and CONDORELLI G. A collagen membrane-based engineered heart tissue improbe cardiac function in ischemic rat hearts. Bioinspired, Biomimetic and Nanobiomaterials. 10.1680/bbn.12.00028, 2012.
• RIZZI R, BEARZI C, MAURETTI A, BERNARDINI S, CANNATA S and GARGIOLI C. Tissue engineering for skeletal muscle re generation. Muscle, Ligaments and Tendons J. 2:230-4, 2012.
• RIZZI R, DI PASQUALE E, PORTARARO P, PAPAIT R, CATTANEO P, LATRONICO MVG, ALTOMARE C, SALA L, ZAZA A, HIRSCH E, NALDINI L, CONDORELLI G, BEARZI C. Post-natal cardiomyocytes can generate iPS cells with an enhanced capacity toward cardiomyogenic re-differentiation. Cell Death Differ. 19:1162-74, 2012.
• ZHANG D, CONTU R, LATRONICO MVG, ZHANG J, RIZZI R, CATALUCCI D, MIYAMOTO S, HUANG K, CECI M, GU Y, DALTON ND, PETERSON KL, GUAN K, BROWN JH, CHEN J, SONENBERG N and CONDORELLI G. MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J Clin Invest. 120:2805-16, 2010.
• DE FALCO E, AVITABILE D, TOTTA P, STRAINO S, SPALLOTTA F, CENCIONI C, TORELLA AR, RIZZI R, PORCELLI D, ZACHEO A, DI VITO L, POMPILIO G, NAPOLITANO M, MELILLO G, CAPOGROSSI MC and PESCE M. Altered SDF-1-mediated differentiation of bone marrow-derived endothelial progenitor cells in diabetes mellitus. J Cell Mol Med. 13:3405-14, 2009.
• FERREIRA-MARTINS J, RONDON-CLAVO C, TUGAL D, KORN JA, RIZZI R, PADIN-IRUEGAS ME, OTTOLENGHI S, DE ANGELIS A, URBANEK K, IDE-IWATA N, D'AMARIO D, HOSODA T, LERI A, KAJSTURA J, ANVERSA P and ROTA M. Spontaneous calcium oscillations regulate human cardiac progenitor cell growth. Circ Res. 105:764-74, 2009.
• BONI A, URBANEK K, NASCIMBENE A, HOSODA T, ZHENG H, DELUCCHI F, AMANO K, GONZALEZ A, VITALE S, OJAIMI C, RIZZI R, BOLLI R, YUTZEY KE, ROTA M, KAJSTURA J, ANVERSA P, LERI A. Notch1 regulates the fate of cardiac progenitor cells. Proc Natl Acad Sci U S A. 105:15529-34, 2008.
• RIZZI R, BARTOLOMUCCI A, MOLES A, D'AMATO F, SACERDOTE P, LEVI A, LA CORTE G, CIOTTI MT, POSSENTI R and PAVONE F. The VGF-derived peptide TLQP-21: a new modulatory peptide for inflammatory pain. Neurosci Lett. 441:129-33, 2008.
• ROTA M, KAJSTURA J, HOSODA T, BEARZI C, VITALE S, ESPOSITO G, IAFFALDANO G, PADIN-IRUEGAS ME, GONZALEZ A, RIZZI R, SMALL N, MURASKI J, ALVAREZ R, CHEN X, URBANEK K, BOLLI R, HOUSER SR, LERI A, SUSSMAN MA and ANVERSA P. Bone marrow cells adopt the cardiomyogenic fate in vivo. Proc Natl Acad Sci. 104(45); p. 17783, 2007.
• ROTA M, HOSODA T, DE ANGELIS A, ARCARESE ML, ESPOSITO G, RIZZI R, TILLMANNS J, TUGAL D, MUSSO E, RIMOLDI O, BEARZI C, URBANEK K, ANVERSA P, LERI A and KAJSTURA J. The young mouse heart is composed of myocytes heterogeneous in age and function. Circ Res. 101:387-99, 2007.
• BARTOLOMUCCI A, LA CORTE G, POSSENTI R, LOCATELLI V, RIGAMONTI AE, TORSELLO A, BRESCIANI E, BULGARELLI I, RIZZI R, PAVONE F, D'AMATO FR, SEVERINI C, MIGNOGNA G, GIORGI A, SCHININÀ ME, ELIA G, BRANCIA C, FERRI GL, CONTI R, CIANI B, PASCUCCI T, DELL'OMO G, MULLER EE, LEVI A and MOLES A. TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity. Proc Natl Acad Sci. 103:14584-9, 2006.
• MOLES A, BARTOLOMUCCI A, GARBUGINO L, CONTI R, CAPRIOLI A, COCCURELLO R, RIZZI R, CIANI B and D'AMATO FR. Psychosocial stress affects energy balance in mice: modulation by social status. Psychoneuroendocrinology. 31:623-33, 2006.
• D'AMATO FR, RIZZI R, MOLES A. Aggression and anxiety in pregnant mice are modulated by offspring characteristics. Animal Behaviour. 72 (4):773-780, 2006. ISSN 0003-3472. https://doi.org/10.1016/j.anbehav.2005.11.022.
• MOLES A, RIZZI R and D’AMATO FR. Postnatal Stress in mice: Does stressing the mother have the same effect as stressing in pups? Dev Psychobiol. 44:230-7, 2004.
• MOLES A, RIZZI R and D’AMATO FR. The number of male pups within the bitter of NMRI mice is associated with the dam’s food preferences late in pregnancy. Psychoneuroendocrinology. 28:250-60, 2003.
• D’AMATO FR, RIZZI R, MOLES A. A model of social stress in dominant mice: effects on sociosexual behaviour. Physiol Behav. 73:421-6, 2001.

BOOK CHAPTER
BEARZI C, PARISI C, RIZZI R*. Modelli sperimentali avanzati per lo studio delle patologie psichiatriche. In: Brambilla P, editor. Neuroscienze psichiatriche e computazionali. Torino: Edizioni Minerva Medica; 2021. ISBN: 978-88-5532-068-9.
BEARZI C, RIZZI R*. (2019) The Heart-Brain Connection in Patients with Duchenne Muscular Dystrophy. In: Govoni S, Politi P, Vanoli E. (eds) Brain and Heart Dynamics. Springer, Cham. DOI: https://doi.org/10.1007/978-3-319-90305-7_64-1.