MATTEO COSTANZO

Work address:

1) Department of Human Neurosciences, Sapienza University of Rome, Viale dell'Università 30, 00185, Rome, Italy

2) Department of Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy

Work experience:

1) Researcher (RTDA)|Department of Human Neurosciences, Sapienza University of Rome | 01/05/2025 - Current | Rome, Italy

2) Research collaborator – “Starting grant for young researchers” | Istituto Superiore di Sanità | 01/11/2023 - Current | Rome, Italy

3) Research fellow for the project titled "Acute Ischemic Stroke Related to Cancer: Investigation of Pathophysiological Mechanisms" | Department of Human Neurosciences, Sapienza University of Rome | 01/05/2023 - 30/04/2024 | Rome, Italy

4) Freelance consultant neurologist | Neurological Centre of Latium | 01/10/2021 - Current | Rome, Italy

5) Consultant neurologist – Clinical Neurophysiology Service | Istituto neurologico mediterraneo Neuromed | 01/01/2021 - 01/2023 | Pozzilli, Italy

6) Freelance consultant neurologist | Istituto di Neuroscienze Neomesia | 01/01/2020 - 01/03/2022 | Rome, Italy

7) Freelance consultant neurologist – Adult Neurorehabilitation Unit | Rehabilitation Center Vaclav Vojta | 01/2020 - 01/12/2021 | Rome, Italy

Education & Training:

1) Medical degree | Sapienza University of Rome | 2015 | Rome, Italy. Final grade: 110 with honors/110 | Thesis: "Studio del tremore nella malattia di Parkinson: caratteristiche cliniche ed epidemiologiche del tremore ri-emergente"

2) Visiting Erasmus student | Università autonoma de Madrid | 2013 - 2014 | Madrid, Spain

3) Specialization in Neurology | Sapienza University of Rome | 2020 | Rome, Italy. Final grade: 70 with honors/70 | Thesis: "Caratteristiche cliniche e fisiopatologiche del tremore ri-emergente nella malattia di Parkinson"

4) PhD in "Sensorimotor neurosciences" | Sapienza University of Rome | 2020 - 25/09/2024 | Rome, Italy. Thesis: Impact of non-motor symptoms on clinical heterogeneity and treatment strategies in patients with cervical dystonia

5) Participation: "MDS-ES 12th Summer school for Young Neurologists" | International Parkinson and Movement Disorder Society | 2019 | Padova, Italy

6) FAD, EEG and Evoked Potentials | Lega Italiana contro l'epilessia e dalla Società Italiana di Neurofisiologia clinica | 12/10/2020 - 19/01/2021 | Rome, Italy

7) Participation: "Valutazione e trattamento ecoguidato del paziente affetto da spasticità focale" | Struttura Riabilitativa Residenziale Poggio Mirteto | 05/11/2021 - 06/11/2021 | Roma, Italy

8) Participation: "Scuola sui Disturbi del movimento" | Società Italiana Parkinson e Disordini del Movimento/LIMPE-DISMOV | 05/2021 - 06/2021 | Cagliari/Genova, Italy

9) Participation: “la scialorrea nel paziente neurologico” | 25/11/2022 | Napoli, Italy

10) Participation: “11th Advanced Course on Diagnosis and Treatment of Movement disorders” | Movement Disorder Society | 02/11/2023 - 05/11/2023 | Catania, Italy

Society memberberships:

Member of the Italian Society of Parkinson and Movement Disorders – LIMPE-DISMOV

Member of the Italian Society of Neurology - SIN

Member of the Movement Disorders Society - MDS

Editorial positions:

Review Editor - Frontiers in Aging Neuroscience - Section: Parkinson's disease and aging-related Movement Disorders

Guest Editor - Toxins - Special Issue : "Botulinum Neurotoxin as a Novel Therapy for Parkinson’s Disease"

Guest Editor - Cells - Special Issue :" Alpha synuclein in Parkinson's Disease"

Publications:

1. Belvisi, D., Conte, A., Bologna, M., Bloise, M. C., Suppa, A., Formica, A., Costanzo, M., Cardone, P., Fabbrini, G., & Berardelli, A. (2017). Re-emergent tremor in Parkinson's disease. Parkinsonism & related disorders,36,4146. https://doi.org/10.1016/j.parkreldis.2016.12.012

2. Belvisi, D., Conte, A., Cutrona, C., Costanzo, M., Ferrazzano, G., Fabbrini, G., & Berardelli, A. (2018). Re-emergent tremor in Parkinson's disease: the effect of dopaminergic treatment. European journal of neurology, 25(6), 799804. https://doi.org/10.1111/ene.13619

3. Berardelli, I., Belvisi, D., Corigliano, V., Costanzo, M., Innamorati, M., Fabbrini, G., Berardelli, A., & Pompili, M. (2018). Suicidal ideation, perceived disability, hopelessness and affective temperaments in patients affected by Parkinson's disease. International journal of clinical practice, e13287. Advance online publication. https://doi.org/10.1111/ijcp.13287

4. Belvisi, D., Berardelli, I., Ferrazzano, G., Costanzo, M., Corigliano, V., Fabbrini, G., Berardelli, A., & Pompili, M. (2019). The clinical correlates of suicidal ideation in Parkinson's disease. Parkinsonism & related disorders, 63, 5459. https://doi.org/10.1016/j.parkreldis.2019.02.047

5. Vivacqua, G., Suppa, A., Mancinelli, R., Belvisi, D., Fabbrini, A., Costanzo, M., Formica, A., Onori, P., Fabbrini, G., & Berardelli, A. (2019). Salivary alpha-synuclein in the diagnosis of Parkinson's disease and Progressive Supranuclear Palsy. Parkinsonism & related disorders, 63, 143148. https://doi.org/ 10.1016/j.parkreldis.2019.02.014

6. Belvisi, D., Fabbrini, A., De Bartolo, M. I., Costanzo, M., Manzo, N., Fabbrini, G., Defazio, G., Conte, A., & Berardelli, A. (2020). The Pathophysiological Correlates of Parkinson's Disease Clinical Subtypes. Movement disorders : official journal of the Movement Disorder Society, 10.1002/mds.28321. Advance online publication. https://doi.org/10.1002/mds.28321

7. Leodori, G., Belvisi, D., De Bartolo, M. I., Fabbrini, A., Costanzo, M., Vial, F., Conte, A., Hallett, M., & Berardelli, A. (2020). Re-emergent Tremor in Parkinson's Disease: The Role of the Motor Cortex. Movement disorders : official journal of the Movement Disorder Society, 35(6), 10021011.

8. Belvisi, D., Pellicciari, R., Fabbrini, A., Costanzo, M., Pietracupa, S., De Lucia, M., Modugno, N., Magrinelli, F., Dallocchio, C., Ercoli, T., Terravecchia, C., Nicoletti, A., Solla, P., Fabbrini, G., Tinazzi, M., Berardelli, A., & Defazio, G. (2020). Risk factors of Parkinson disease: Simultaneous assessment, interactions, and etiologic subtypes. Neurology, 95(18), e2500e2508. https://doi.org/10.1212/WNL. 0000000000010813

9. Tofani, M., Ranieri, A., Fabbrini, G., Berardi, A., Pelosin, E., Valente, D., Fabbrini, A., Costanzo, M., & Galeoto, G. (2020). Efficacy of Occupational Therapy Interventions on Quality of Life in Patients with
Parkinson's Disease: A Systematic Review and Meta-Analysis. Movement disorders clinical practice, 7(8), 891901. https://doi.org/10.1002/mdc3.13089

10. Leodori, G., Fabbrini, A., De Bartolo, M. I., Costanzo, M., Asci, F., Palma, V., Belvisi, D., Conte, A., & Berardelli, A. (2021). Cortical mechanisms underlying variability in intermittent theta-burst stimulation-induced plasticity: A TMS-EEG study. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 132 (10), 2519–2531. https://doi.org/10.1016/ j.clinph.2021.06.021

11. Leodori, G., De Bartolo, M. I., Belvisi, D., Ciogli, A., Fabbrini, A., Costanzo, M., Manetto, S., Conte, A., Villani, C., Fabbrini, G., & Berardelli, A. (2021). Salivary caffeine in Parkinson's disease. Scientific reports, 11(1), 9823. https://doi.org/10.1038/s41598-021-89168-6

12. Costanzo, M., Belvisi, D., Berardelli, I., Maraone, A., Baione, V., Ferrazzano, G., Cutrona, C., Leodori, G., Pasquini, M., Conte, A., Fabbrini, G., Defazio, G., & Berardelli, A. (2021). Effect of Botulinum Toxin
on Non-Motor Symptoms in Cervical Dystonia. Toxins, 13(9), 647. https://doi.org/10.3390/ toxins13090647

13. Costanzo, M., Belvisi, D., Berardelli, I., Maraone, A., D'Antonio, F., Baione, V., Toscano, A., Ferrazzano, G., Pasquini, M., Conte, A., Fabbrini, G., Defazio, G., & Berardelli, A. (2021). Motor and nonmotor subtypes of cervical dystonia. Parkinsonism & related disorders, 88, 108–113. https://doi.org/ 10.1016/j.parkreldis.2021.06.008

14. Ferrazzano, G., Zingaropoli, M. A., Costanzo, M., Belvisi, D., Dominelli, F., Pasculli, P., Ciardi, M. R., Fabbrini, G., Defazio, G., Berardelli, A., & Conte, A. (2022). Neurofilament assessment in patients with cervical dystonia. Parkinsonism & related disorders, 98, 70–71. https://doi.org/10.1016/j.parkreldis. 2022.04.013

15. Leodori, G., Rocchi, L., Mancuso, M., De Bartolo, M. I., Baione, V., Costanzo, M., Belvisi, D., Conte, A., Defazio, G., & Berardelli, A. (2022). The effect of stimulation frequency on transcranial evoked potentials. Translational neuroscience, 13(1), 211–217. https://doi.org/10.1515/tnsci-2022-0235

16. Ferrazzano, G., Belvisi, D., De Bartolo, M. I., Baione, V., Costanzo, M., Fabbrini, G., Defazio, G., Berardelli, A., & Conte, A. (2022). Longitudinal evaluation of patients with isolated head tremor. Parkinsonism & related disorders, 94, 10–12. https://doi.org/10.1016/j.parkreldis.2021.11.018

17. Belvisi, D., Costanzo, M., Pellicciari, R., Modugno, N., Nicoletti, A., Fabbrini, G., Tinazzi, M., Defazio, G., & Berardelli, A. (2022). Reply to "Risk reduction of Parkinson's disease by caffeinated beverage
consumption". Parkinsonism & related disorders, 103, 15–16.

18. Belvisi, D., Canevelli, M., Costanzo, M., Giangrosso, M., Fabbrini, A., Borraccino, A., Bruno, G., Berardelli, A., & Fabbrini, G. (2022). The role of frailty in Parkinson's disease: a cross-sectional study. Journal of neurology, 269(6), 3006–3014. https://doi.org/10.1007/s00415-021-10873-3

19. De Bartolo, M. I., Vivacqua, G., Belvisi, D., Mancinelli, R., Fabbrini, A., Manzo, N., Costanzo, M., Leodori, G., Conte, A., Fabbrini, G., Morini, S., & Berardelli, A. (2022). A Combined Panel of Salivary
Biomarkers in de novo Parkinson's Disease. Annals of neurology, 10.1002/ana.26550. Advance online publication. https://doi.org/10.1002/ana.26550

20. Belvisi, D., Pellicciari, R., Fabbrini, A., Costanzo, M., Ressa, G., Pietracupa, S., De Lucia, M., Modugno, N., Magrinelli, F., Dallocchio, C., Ercoli, T., Nicoletti, A., Zappia, M., Solla, P., Bologna, M., Fabbrini, G., Tinazzi, M., Conte, A., Berardelli, A., & Defazio, G. (2022). Relationship between risk and protective factors and clinical features of Parkinson's disease. Parkinsonism & related disorders, 98, 80–85. https://doi.org/10.1016/j.parkreldis.2022.04.017

21. Leodori, G., De Bartolo, M. I., Fabbrini, A., Costanzo, M., Mancuso, M., Belvisi, D., Conte, A., Fabbrini, G., & Berardelli, A. (2022). The Role of the Motor Cortex in Tremor Suppression in Parkinson's Disease. Journal of Parkinson's disease, 12(6), 1957–1963. https://doi.org/10.3233/ JPD-223316

22. Belvisi, D., Leodori, G., Costanzo, M., Conte, A., & Berardelli, A. (2023). How does botulinum toxin really work?. International review of neurobiology, 169, 441-479. https://doi.org/10.1016/bs.irn. 2023.05.003

23. Costanzo M, Cutrona C, Leodori G, et al. Distal Upper Limb Tremor during Walking in Parkinson's Disease. Mov Disord Clin Pract. 2023;10(8):1198-1202. Published 2023 Jun 22. doi:10.1002/mdc3.13814

24. Costanzo M, Leodori G, Cutrona C, et al. Motor Cortical Correlates of Paired Associative Stimulation Induced Plasticity: A TMS-EEG Study. Brain Sci. 2023;13(6):921. Published 2023 Jun 7. doi:
10.3390/brainsci13060921

25. Pietracupa, S., Belvisi, D., Piervincenzi, C., Tommasin, S., Pasqua, G., Petsas, N., De Bartolo, M. I., Fabbrini, A., Costanzo, M., Manzo, N., Berardelli, A., & Pantano, P. (2023). White and gray matter alterations in de novo PD patients: which matter most?. Journal of neurology, 270(5), 2734–2742. https://doi.org/10.1007/s00415-023-11607-3

26. Cutrona, C., Marchet, F., Costanzo, M., De Bartolo, M. I., Leodori, G., Ferrazzano, G., Conte, A., Fabbrini, G., Berardelli, A., & Belvisi, D. (2023). Exploring the Central Mechanisms of Botulinum Toxin in Parkinson's Disease: A Systematic Review from Animal Models to Human Evidence. Toxins, 16(1), 9. https://doi.org/10.3390/toxins16010009

27. Costanzo M, Galosi E, De Bartolo MI, Gallo G, Leodori G, Belvisi D, Conte A, Fabbrini G, Truini A, Berardelli A, et al. Evaluating the Diagnostic Potential of Combined Salivary and Skin Biomarkers in Parkinson’s Disease. International Journal of Molecular Sciences. 2024; 25(9):4823. https://doi.org/ 10.3390/ijms25094823

28. De Bartolo MI, Belvisi D, Mancinelli R, Costanzo M, Caturano C, Leodori G, Berardelli A, Fabbrini G, Vivacqua G. A systematic review of salivary biomarkers in Parkinson's disease. Neural Regen Res. 2024 Dec 1;19(12):2613-2625. doi: 10.4103/NRR.NRR-D-23-01677.

29. Costanzo M, Aiello F, Poleggi A, Li Voti P, Fabbrini G, Belvisi D. Progressive supranuclear palsy phenotype as an atypical clinical presentation of Creutzfeldt-Jakob disease: A case report and review of the literature. Clin Park Relat Disord. 2024 Mar 5;10:100247. doi: 10.1016/j.prdoa.2024.100247.

30. De Michele M, Piscopo P, Costanzo M, Lorenzano S, Crestini A, Rivabene R, Manzini V, Petraglia L, Iacobucci M, Berto I, Schiavo OG, Conte A, Belvisi D, Berardelli A, Toni D. Can Repetitive Transcranial Magnetic Stimulation (rTMS) Promote Neurogenesis and Axonogenesis in Subacute Human Ischemic Stroke? Biomedicines. 2024 Mar 17;12(3):670. doi: 10.3390/biomedicines12030670.

31. Costanzo M, Cutrona C, Leodori G, et al. Exploring easily accessible neurophysiological biomarkers for predicting Alzheimer's disease progression: a systematic review. Alzheimers Res Ther. 2024;16(1):244. Published 2024 Nov 4. doi:10.1186/s13195-024-01607-4

32. Leodori, G., De Bartolo, M. I., Piervincenzi, C., Mancuso, M., Ojha, A., Costanzo, M., Aiello, F., Vivacqua, G., Fabbrini, G., Conte, A., Pantano, P., Berardelli, A., & Belvisi, D. (2024). Mapping Motor
Cortical Network Excitability and Connectivity Changes in De Novo Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society, 39(9), 1523–1532. https://doi.org/
10.1002/mds.29901

33. Fabbri, M., Ledda, C., Schirinzi, T., Artusi, C. A., Avallone, A. R., Zenuni, H., De Micco, R., Aloisio, S., Cani, I., Malaguti, M. C., Di Biasio, F., Calandra-Buonaura, G...& PSP-NET study group (2024). Multidisciplinary care use in neurodegenerative complex diseases: The example of progressive supranuclear palsy and advanced Parkinson's disease in real-life. Parkinsonism & related disorders,
125, 107047. https://doi.org/10.1016/j.parkreldis.2024.107047

34. De Bartolo, M. I., Ojha, A., Leodori, G., Piervincenzi, C., Vivacqua, G., Pietracupa, S., Costanzo, M., D'Antonio, F., Barbetti, S., Margiotta, R., Bruno, G., Conte, A., Berardelli, A., Fabbrini, G., Pantano, P., & Belvisi, D. (2025). Association of Early fMRI Connectivity Alterations With Different Cognitive Phenotypes in Patients With Newly Diagnosed Parkinson Disease. Neurology, 104(1), e210192.
https://doi.org/10.1212/WNL.0000000000210192

35. Cappiello, A., Cuoco, S., De Micco, R., Satolli, S., Di Biasio, F., Markushi, T. B., Sambati, L., Pilotto, A., Costanzo, M..P. S. P.-N. E. T. study group (2025). Psychometric properties and clinical correlates of the
Frontal Behaviour Inventory in progressive supranuclear palsy: data from the PSP-NET. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical
Neurophysiology, 46(3), 1207–1215. https://doi.org/10.1007/s10072-024-07887-w

36. Salciccia, C., Costanzo, M., Ruocco, G., Porreca, F., Vivacqua, G., Fabbrini, G., Belvisi, D., Ladogana, A., & Poleggi, A. (2025). Proteopathic seed amplification assays in easily accessible specimens for
human synucleinopathies, tauopathies, and prionopathies: A scoping review. Neuroscience and biobehavioral reviews, 169, 105997. https://doi.org/10.1016/j.neubiorev.2024.105997

37. Abate, F., Di Biasio, F., Marchese, R., Markushi, T. B., Ciammola, A., Ticozzi, N., Calandra-Buonaura, G., Cani, I., Sambati, L., Fabbrini, G., Costanzo, M.… PSP-NET study group (2025). Clinical trial eligibility
in PSP: Population representativeness and potential criteria adjustment based on PSP-NET findings. Parkinsonism & related disorders, 131, 107226. https://doi.org/10.1016/j.parkreldis.2024.107226

38. Costanzo, M., Marchet, F., Leodori, G., Cutrona, C., De Bartolo, M. I., Vivacqua, G., Conte, A., Fabbrini, G., Berardelli, A., & Belvisi, D. (2025). Neurophysiological Features of Tremor during Walking
in Parkinson's Disease. Movement disorders clinical practice, 12(2), 226–230. https://doi.org/10.1002/ mdc3.14293

39. Xu, J., Costanzo, M., Avanzino, L., Martino, D., Salehi, P., Standal, S., Manzo, N., Alizadeh, P., Terranova, S., Bonassi, G., Oh, J., Conte, A., & Konczak, J. (2024). Vibro-tactile stimulation of the neck
reduces pain in people with cervical dystonia: a proof-of-concept study. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical
Neurophysiology, 45(10), 4847–4856. https://doi.org/10.1007/s10072-024-07561-1

40. Cutrona, C., Costanzo, M., Leodori, G., De Bartolo, M. I., Liguori, A., Marchet, F., Mancuso, M., Vivacqua, G., Conte, A., Fabbrini, G., Berardelli, A., & Belvisi, D. (2025). The evolution of tremor in
Parkinson's Disease: insights from a 4-year longitudinal assessment. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 46(9), 4397–4403. https://doi.org/10.1007/s10072-025-08363-9

41. Avanzino, L., Xu, J., Martino, D., Conte, A., Standal, S., Salehi, P., Terranova, S., Bonassi, G., Alizadeh, P., Adeoti, J. A., Belvisi, D., Costanzo, M., Oh, J., & Konczak, J. (2025). Vibro-tactile stimulation
of the neck induces head righting in people with cervical dystonia. Parkinsonism & related disorders, 132, 107263. https://doi.org/10.1016/j.parkreldis.2025.107263

42. Pellicano, C., Belvisi, D., Bovenzi, R., Costanzo, M., De Bartolo, M. I., Sommaruga, F., Blandino, J., Modugno, N., Piras, F., Pierantozzi, M., Stefani, A., Fabbrini, G., & Schirinzi, T. (2025). Opicapone in
Parkinson's disease: a real-world, multicenter, retrospective study to identify patient characteristics for sustained treatment benefit. Journal of neural transmission (Vienna, Austria : 1996), 10.1007/
s00702-025-03000-3. https://doi.org/10.1007/s00702-025-03000-3