Nursing

Activity type

Scienze propedeutiche

SSD

FIS/07

Year

1st year

Semester

1st semester

CFU

1

Hours distribution

12 classroom hours

Lecturers

Saverio Paventi

Activity type

Scienze biomediche

SSD

BIO/10

Year

1st year

Semester

1st semester

CFU

2

Hours distribution

24 classroom hours

Lecturers

SEBASTIANA ANGELACCIO

Activity type

Scienze biomediche

SSD

BIO/13

Year

1st year

Semester

1st semester

CFU

2

Hours distribution

24 classroom hours

Lecturers

VALERIO FULCI

Activity type

Scienze biomediche

SSD

MED/03

Year

1st year

Semester

1st semester

CFU

1

Hours distribution

12 classroom hours

Lecturers

VIVIANA CAPUTO

Principles of basic physics and its applications in the health field . Structure and chemical behavior of molecules . The biochemical basis of metabolism . The water and the properties of aqueous solutions . Amino acids and proteins , nucleic acids , lipids and glucides . Structure and function of the cell . Biological reactions and enzymes . The genetic information in the cell , the cell replication and patterns of genetic transmission .

Module:
Knowledge of the physical phenomena underlying human activities and their applications in Medicine.


Module:
Adequate knowledge of:
• biological macromolecules structure-function relationship, in particular proteins and the composition, organization and dynamics of biological membranes
• metabolic pathways and their integration and regulation
• homeostatic control mechanisms.
At the end of the course, students should have the adequate cultural background to understand specificity of organ and tissue and to address the study in the next courses, in particular general pathology and pharmacology. Furthermore, they should have acquired the critical capacity necessary to recognize and anticipate metabolic adaptation derived from food or environmental changes. This knowledge and skills will be attest by passing of the exam.


Module:
Students are expected to attain a good knowledge of the general organization and structure of prokaryotic and eukaryotic cells and the general features of membrane transport.
Students should prove they understand the biological processes underlying the flow of genetic information (DNA replication, transcription, translation), the cell cycle progression and signal transduction.
Students should be able to report on the structure, function and the relationships between structure and functions of the following organelles: Mitochondria, Endoplasmic reticulum, Gogli apparatus, lysosomes. Students should be able to describe the major components of the cytoskeleton (microtubules, intermediate filaments, microfilaments) and the extracellular matrix. Students should be able to describe cell cycle phases and mitosis.


Module:
KNOWLEDGE AND UNDERSTANDING CAPACITY: Acquisition of theoretical and practical knowledge in the fields of biochemistry, biology, and medical genetics, with a specific focus on biologically relevant topics.
ABILITY TO APPLY KNOWLEDGE AND UNDERSTANDING: Enhancement of skills in applying theoretical knowledge in the fields of biochemistry, biology, and medical genetics to solve exercises and problems, with a specific emphasis on biologically relevant issues.
AUTONOMY OF JUDGMENT: Acquisition of competence in using independent judgment to assess and interpret experimental data and make strategic decisions in novel contexts.
COMMUNICATION SKILLS: Acquisition of skills and tools for effective communication, both in written and oral forms in the Italian language, including the use of graphical and formal languages.
LEARNING SKILLS: Development of autonomous skills in acquiring knowledge and self-assessing one's progress, thereby preparing for the subsequent educational journey with a high level of independence.

Module:
Regular enrollment for the first academic year of the Degree Course


Module:
For a better understanding of the arguments which will be developed during the course, students should have basic knowledge of mathematics and physics.


Module:
Knowledge at secondary school level of biology, chemistry and physics.



Module:
Knowledge of the general aspects of biology.

Module:
Introduction to Physics.
Experimental method.
Sizes and measures.
Definition of vectors and scalars (Mass, Weight, Pressure, Work, Energy).
Mechanics (Kinematics, Dynamics, Static) and its applications in Medicine.
Fluid mechanics in biological systems (viscosity, density, surface tension).
Sedimentation, Electrophoresis and Centrifugation.
Thermology and Thermodynamics (Temperature, Heat).
Physics of elastic waves and biomedical applications.
Electrical phenomena and electromagnetism in biological systems.
The structure of the atom and its applications in medicine.


Module:
Objective of the course is the knowledge of Biochemistry, with particular reference to man: 1) the structure of molecules of biological interest and their dynamic changes in the cell, 2) knowledge of the homeostatic mechanisms that regulate the functioning of the cell and the integration of organs and tissues, 3) methods of investigation at the molecular level, for the understanding of biological phenomena important in medicine.
After completing this module the student of biochemistry will be able to define: 1) the basic elements of Chemistry and Biochemistry, 2) the structure, classification and function of biological macromolecules, 3) the main metabolic pathways.
The Course program (2 CFU) is scheduled as follows:
1.Molecules and life: The fundamental topics of living organisms; Cellular components; Chemical composition of cell; Water
2.Macromolecules – structure-function relationship: Carbohydrates; Lipids; Nucleic acids; Proteins
3. Metabolism; Overview; Main catabolic pathways;Main anabolic pathways
4. Some Biochemical Arguments Important in Medicine: Food digestion;Vitamins and other essential components in diet;Blood clotting;Structure and function of hormones



Module:
-The General Features of Cells. Cell theory. Organization of the prokaryotic and eukaryotic cell.
- Molecular bases of heredity. DNA. The structure of the double helix. DNA replication. DNA repair. Telomerase.
- How Cells Read the Genome: From DNA to Proteins. RNA. Transcription. Processing of eukaryotic mRNAs. The genetic code. tRNAs and ribosomes. Protein synthesis. Control of gene expression in eukaryotes: transcription factors, enhancers, regulation of chromatin structure, post-transcriptional and post-translational control.
- Internal Organization of the Cell. Structure and properties of biological membranes. Cytoplasmic organelles: nucleus, Golgi apparatus, smooth and rough endoplasmic reticulum, ribosomes, mitochondria, lysosomes, peroxisomes. Exocytosis and endocytosis. The cytoskeleton.
- Cell communication. Principles of cell signaling. Classes of receptors. Signal transduction.
- Cell Division. Eukaryotic cell cycle. Mitosis. Sexual reproduction and meiosis



Module:
- DNA: structure and function. Protein synthesis.
- Genes, genome, and genetic mutations.
- Transmission of inherited traits.
- Classification of genetic diseases.
- Examples of monogenic diseases.
- Human chromosomes. Karyotype. Chromosomal anomalies. Chromosomal disorders.
- Recurrence risks of monogenic diseases and chromosomal disorders.
- Diagnosis of monogenic diseases and chromosomal disorders.
- Prenatal diagnosis of genetic diseases.
- Genetic counseling: indications, aims, and methods.

Module:
Notes and slides of the lessons.

D. Scannicchio, E. Giroletti Elementi di Fisica Biomedica Editore Edises ISBN: 9788879598873


Module:
In order to get the final text, it is suggested to study the topics at the beginning of the attendance of the Course.
Texts recommended:
• Chimica & Biochimica - Stefani M. Taddei N. Ed. Zanichelli
• Elementi di Chimica e Biochimica – Chiricozzi et al. Ed. EdiSES
• Appunti di Biochimica - Catani et al., Ed. Piccin

The Course slides are present in e-learning platform Moodle 2.



Module:
Biologia. Come funziona la vita. Cellula - Genetica. James R. Morris, Daniel L. Hartl, Andrew H. Knoll, Robert A Lue, Melissa Michael, ZANICHELLI



Module:
- Elementi di genetica medica, Clementi, Editore: Edises.
- Teaching material provided by the teacher.

Module:
N/D
Module:
N/D
Module:
N/D
Module:
N/D

Module:
N/D
Module:
The teacher delivers lectures with traditional methods with audiovisual aids and scheduling of lessons as reported on GOMP Aule/Orari system, published on the website of the CdS


Module:
In presence. Attendance is compulsory


Module:
The course is structured into 12 hours of educational activities, including theoretical lessons on the program's topics. A portion of each lesson is dedicated to solving genetics problems and questions.

Module:
N/D
Module:
In accordance with the Degree Course Regulations, the frequency is verified by the teachers through signature / appeal sheets. Attendance to the compulsory teaching activities of a course is mandatory for the student to take the exam.


Module:
In person. Attendance is compulsory.


Module:
The course takes place in the classroom through face-to-face lectures.

Module:
In relation to the anti-COVID regulations and / or also based on the number of students booked, the exam could take place with a written pre-selection test and then access the final oral exam or it could take place remotely with a multiple choice test on EXAM platform.


Module:
The final text consists in a written text and an oral one, regarding the total program of the Course "Molecular and Cellular Fundamentals of Life", which includes the following sections: Chemistry and Biochemistry (2 CFU); Applied Biology (2 CFU); Physics (1 CFU) and Medical Genetics (1 CFU).
In order to pass the exam, the student needs to get a score not under 18/30 in the written test (multiple choices). The knowledge's degree of the topics described during the course will be evaluated through an oral test.
In order to get the maximum score (30/30 e lode), students should demonstrate to get an excellent knowledge of all the topics of the complete Course "Molecular and Cellular Fundamentals of Life".


Module:
At the end of the course, the student must be able to demonstrate the knowledge acquired, concerning structure and function of biological macromolecules, structural organization of the cell (membranes, organelles, cytoskeleton), transcription, translation, DNA replication, signal transduction and cell cycle.



Module:
The assessment of learning for the Medical Genetics module will be carried out through a written exam with multiple-choice and open-ended questions covering the entire module program, and, if necessary, an oral examination.

Module:
N/D
Module:
Following are some questions as examples

1) How many anhydride bonds are present respectively in the ATP molecule and in AMP molecule?
a) 2 and 0
b) 0 and 2
c) 1 and 1
d) 2 and 1
e) 1 and 2

2) Triglyceride is formed by:
a) three glucose molecules
b) three glycerol molecules and one fat acid molecule
c) three fat acid molecules and one glycerol molecule
d) three fat acid molecules and three glycerol molecules
e) three glycerol molecules

3) Allosteric enzymes are in key regulator positions in metabolic pathways. Which allosteric enzyme regulars glicolysis?
a) glucose 6-phosphate isomerase
b) hexokinase
c) phosphofructokinase
d) triose-phosphate isomerase
e) glyceraldehyde dehydrogenase




Module:
N/D
Module:
Describe the structure and functions of DNA. Describe protein synthesis. How does the hereditary transmission of traits occur? What are genetic diseases, and how are they classified? Describe some examples of monogenic and chromosomal diseases. Assess the recurrence risks of monogenic and chromosomal diseases given some examples. How is the diagnosis of monogenic and chromosomal diseases performed? How is the diagnosis of genetic diseases done in prenatal stages? What are the indications, purposes, and methods of genetic counseling.

Module:
N/D
Module:



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N/D
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N/D