PHYSIOPATHOLOGIC BASES OF DISEASES Single channel

Chair (Coordinator) and Rapporteur: ROBERTA SANTARELLI

Module 1: Technical sciences of laboratory medicine

Activity type
Attività formative affini o integrative
SSD
MED/46
Year
1st year
Semester
2nd semester
CFU
1
Hours distribution
12 classroom hours
Lecturers
ALESSANDRA ZINGONI

Module 2: Pathology and pathophysiology

Activity type
Scienze biomediche
SSD
MED/04
Year
1st year
Semester
2nd semester
CFU
2
Hours distribution
24 classroom hours
Lecturers
ROBERTA SANTARELLI
MARIA GIUSEPPINA DI NIRO

Module 3: Microbiology

Activity type
Scienze biomediche
SSD
MED/07
Year
1st year
Semester
2nd semester
CFU
2
Hours distribution
24 classroom hours
Lecturers
GIOVANNA SIMONETTI

Module 4: Anatomo pathology bases

Activity type
Scienze medico - chirurgiche
SSD
MED/08
Year
1st year
Semester
2nd semester
CFU
1
Hours distribution
12 classroom hours
Lecturers
CIRA ROSARIA TIZIANA DI GIOIA

Learning outcomes

Module: Technical sciences of laboratory medicine
N/D
Module: Pathology and pathophysiology
N/D
Module: Microbiology

Learning outcomes

Acquired knowledge
Students who have passed the exam will have a critical understanding of the fundamental concepts of Microbiology, including virology, bacteriology, mycology, and parasitology. They will have acquired knowledge about host-parasite interactions. They will also be familiar with the main characteristics of drugs and medical devices available to combat infections.

Acquired skills
Upon completion of the course, students will be able to:
Evaluate and interpret key microbiological information. Analyze critical factors determining the "contagion" and spread of microorganisms and parasites. Communicate microbiological concepts clearly and concisely.


Module: Anatomo pathology bases
N/D

Prerequisites

Module: Technical sciences of laboratory medicine
N/D
Module: Pathology and pathophysiology
N/D
Module: Microbiology
Basic knowledge of cellular biology


Module: Anatomo pathology bases
N/D

Programme

Module: Technical sciences of laboratory medicine
Inglese: Introduction to laboratory medicine. Definition of a biological sample. Screening test, meaning and examples. The medical report and the reference values. Complete blood count. Haematocrit, VES. Immunoematology; blood transfusion, donation of blood in apheresis. Blood derivatives. Blood groups (AB0 and Rh). Blood typing and Coombs test. The transfusion reaction and its pathological significance. Analysis of plasma proteins: the protidogram, its relevance in clinical diagnosis, examples of medical reports. The main plasma proteins . Urine test: chemical, physical, microscopic; meaning in clinical diagnosis. Laboratory diagnosis of infectious diseases: direct and indirect diagnosis. Examples: HIV tests and hepatitis B tests and COVID-19. ELISA test. Laboratory investigations for allergic diseases (RIST, RAST, Prick test), examples of medical reports.



Module: Pathology and pathophysiology
N/D
Module: Microbiology

Program
The microbial world. The microbial cell. Microorganisms and their natural environments. The impact of microorganisms on humans.
General characteristics of infectious agents
Prions. Viruses: classification, structure, replication, viral genetics. Bacteria: classification; structure; replication; nutrition and growth, growth factors; physical and environmental conditions influencing bacterial growth; growth curve; bacterial spores. Fungi: classification, structure, replication. Brief overview of Parasitology. Protozoa: classification, structure, replication.
Relationship of infectious agents with humans
Definitions; Microbiota and Microbiome; role of microbiota in human health; dysbiosis and disease. Pathogen transmission, colonization, invasiveness, disease. Microbial biofilm. Virulence factors. Exotoxins. Endotoxins. Mycotoxins. Intoxication and foodborne infection. Mechanisms of evasion from antimicrobial defenses. Antigenic variability of microorganisms.
Microbiological diagnostics
Modes of collection and transport of biological samples; direct diagnosis; culture examination; microscopic examination; biochemical techniques; molecular techniques. Indirect diagnosis.
Antimicrobial and antiviral drugs
Definitions; main mechanisms of action. Resistance mechanisms. Prebiotics and probiotics. Efficacy testing of antimicrobial drugs: diffusion and dilution methods, antibiogram, MIC.
Vaccines and serums
Definitions; Characteristics of vaccines; types of vaccines. Serums.
Sterilization, disinfection, and preservation
Definitions. Antiseptic disinfectants and preservatives and factors influencing their activity. Sterilization. Main sterilization methods. Deterioration and preservation of pharmaceutical products.
Biological and occupational risk.
Respiratory tract infections. Central nervous system infections. Genitourinary system infections. Gastrointestinal tract infections. Skin and skin appendage infections. Cardiovascular system infections. Fetal and neonatal infections. Opportunistic infections.


Module: Anatomo pathology bases
N/D

Books

Module: Technical sciences of laboratory medicine
N/D
Module: Pathology and pathophysiology
N/D
Module: Microbiology
N/D
Module: Anatomo pathology bases
N/D

Bibliography

Module: Technical sciences of laboratory medicine
N/D
Module: Pathology and pathophysiology
N/D
Module: Microbiology
N/D
Module: Anatomo pathology bases
N/D

Lessons mode

Module: Technical sciences of laboratory medicine
N/D
Module: Pathology and pathophysiology
N/D
Module: Microbiology
N/D
Module: Anatomo pathology bases
N/D

Frequency

Module: Technical sciences of laboratory medicine
N/D
Module: Pathology and pathophysiology
N/D
Module: Microbiology
Compulsory attendance at lectures


Module: Anatomo pathology bases
N/D

Exam mode

Module: Technical sciences of laboratory medicine
N/D
Module: Pathology and pathophysiology
N/D
Module: Microbiology
Midterm assessment and oral exam


Module: Anatomo pathology bases
N/D

Example exam questions

Module: Technical sciences of laboratory medicine
A typical open question: Describe the significance of biological sample and make some examples.

Multiple choice question:
The leucocyte formula evaluates:
A. The number of leukocytes
B. The number of leucocytes, platelets and erythrocytes
C. The relative percentage of platelets and erytrocytes
D. The relative percentage and the number of each leucocyte type



Module: Pathology and pathophysiology
N/D
Module: Microbiology
N/D
Module: Anatomo pathology bases
N/D

Arguments

Module: Technical sciences of laboratory medicine
N/D
Module: Pathology and pathophysiology
N/D
Module: Microbiology
N/D
Module: Anatomo pathology bases
N/D

  • Academic year2024/2025
  • Degree program to which the course belongsNursing
  • Mandatory presenceYes
  • Languageita
  • CFU6 CFU, distributed among 4 integrated didactic modules
  • Total duration72 hours