Health Assistance

Activity type

Scienze propedeutiche

SSD

FIS/07

Year

1st year

Semester

1st semester

CFU

2

Hours distribution

24 classroom hours

Lecturers

ALESSANDRO SABATINI

Activity type

Scienze propedeutiche

SSD

MED/01

Year

1st year

Semester

1st semester

CFU

2

Hours distribution

24 classroom hours

Lecturers

GIACOMO POLITO

Activity type

Scienze propedeutiche

SSD

CHIM/03

Year

1st year

Semester

1st semester

CFU

1

Hours distribution

12 classroom hours

Lecturers

MARIA ELISA CRESTONI

Activity type

Scienze propedeutiche

SSD

CHIM/06

Year

1st year

Semester

1st semester

CFU

1

Hours distribution

12 classroom hours

Lecturers

ANTONELLA GOGGIAMANI

Module:
N/D
Module:
The statistics course aims to provide students with basic knowledge to develop skills in acquiring, organizing, and processing statistical data from sample surveys, as well as tools for interpreting the summary information obtained, and to provide the theoretical and methodological tools that allow for the understanding and critical reading of scientific evidence described using statistics.The course is structured into various sections, following a logical path that is articulated in a first part, which includes the basic concepts of the research process with concepts and variables; measurement scales; hypothesis testing; empirical evidence; research designs, and continues in a section relating to descriptive and inferential statistics, focusing on the main statistical tests used. A section is related to the epidemiological field, with the identification of various related studies, and the course concludes with a section related to randomized controlled trials (RCTs), systematic reviews, and meta-analyses.


Module:
N/D
Module:
1. Know the structure and chemical-physical properties of the main organic compound classes.
2. Apply key concepts as polar covalent bond, hybridization, sigma and pi bonds, isomerism, and resonance for describing the molecular geometry, recognize functional groups, and to predict their chemical reactivity.
3. Assign a IUPAC name to an organic compound on the base of its molecular structure and viceversa.
4. Analyse critically organic molecules based on their structure, recognizing acidity/basicity, nucleophilicity/electrophilicity and evaluate their reactivity according to their structure and reaction conditions.

Module:
N/D
Module:
High school knowledge of statistics and mathematics


Module:
N/D
Module:
For understanding Organic Chemistry lessons, the student needs to have basic knowledge of general and inorganic chemistry, particularly the periodic table, chemical equilibrium, chemical bonds, and fundamental elements of thermodynamics and chemical kinetics.

Module:
N/D
Module:
1.Introduction to the research process: the research process with concepts and variables; measurement scales; hypothesis testing; empirical evidence; research designs; software used for statistics;
2.Descriptive statistics: data analysis; descriptive statistics; choice of measures of central tendency; measures of variability or dispersion; deviations from the mean; graphical representations (line graphs; box plots; bar charts);
3.Inferential statistics: samples and populations; distributions; statistical significance; hypothesis testing; point estimation, confidence intervals, introduction to conducting a statistical test;
4.Types of statistical tests used: parametric and nonparametric; differences between groups: Student's t-test; Mann-Whitney; ANOVA; Wilcoxon; Kruskal-Wallis; tests of associations between categorical variables: chi-square; correlation techniques: Pearson; Spearman's rho; simple, multiple, and logistic linear regression; survival analysis: Kaplan-Meier; Mantel-Cox test;
5.Epidemiology: estimation of disease prevalence; difficulties in estimation; risk factors and their identification; descriptive studies; case-control study, cohort study; measures of association in epidemiology: odds ratio, relative risk; confounding factors, elements of multivariate models, causality; outcome indicators;
6.Randomized controlled trial (RCT): construction of a research protocol; evidence-based medicine (EBM), guidelines and SOPs; literary review; systematic review; meta-analysis.


Module:
Fundamental laws of chemistry. Atomic structure and atomic orbitals. Atomic mass and
molar mass. Elements and molecules. Periodic properties of elements. Ionic and covalent bonds.
Intermolecular forces. Oxidation number. Ionic equilibria in aqueous solution. Calculating the pH
of solutions of acids, bases, and salts. Solubility equilibria.


Module:
Introduction:
Valence bond theory; ionic and covalent bonds; dipole-dipole bonds, ion-dipole bonds, hydrogen bonds, and Van der Waals forces; carbon hybridization. Classification of organic molecules.
Alkanes and Cycloalkanes
Nomenclature, hybridization, structure, chemical-physical properties, structural isomers, conformation (torsional strain, bond angle strain, briefly), hybridization and bond angle.
Reactions of alkanes: oxidation and radical halogenation [briefly].
Alkenes
Nomenclature, hybridization, structure, chemical-physical properties, stability, geometric isomerism.
Reactions of alkenes: addition of hydrogen halides, water, halogens, hydrogenation catalyzed by transition metals like Pd [briefly].
Alkynes
Nomenclature, hybridization, structure, chemical-physical properties.
Reactions of alkynes: hydrogenation catalyzed by palladium [briefly].
Alkyl Halides
Structure, chemical-physical properties. IUPAC nomenclature.
Alcohols
Nomenclature, chemical-physical properties.
Ethers and Epoxides
Structure. Nomenclature.
Aldehydes and Ketones
Nomenclature, structure, chemical-physical properties. Reactivity [briefly].
Carboxylic Acids
Nomenclature, physical properties. [briefly].
Derivatives of Carboxylic Acids
Acyl halides, anhydrides, esters, amides. Nomenclature, chemical-physical properties.
Aromatic Compounds
Aromatic compounds: benzene.
Amines, Anilines, and Phenols
Nomenclature, structure, chemical-physical properties.
Amino Acids and Carbohydrates
Structure. The peptide bond.

Module:
N/D
Module:
-


Module:
Understanding Chemistry", Zanello, Gobetto, Zanoni, Casa editrice ambrosiana;
Slides provided by the instructor.


Module:
Notes provided by the instructor
For reference:
B. Botta, CHIMICA ORGANICA ESSENZIALE, Edi-Ermes, 2° Ed.

alternatively:
W. H. Brown, T. Poon “INTRODUZIONE ALLA CHIMICA ORGANICA” Terza Edizione, EdiSES, Napoli 2005
H. Hart, L. E. Craine, D. J. Hart, C. M. Hadad “CHIMICA ORGANICA” Sesta Edizione, Zanichelli, Bologna 2008
P. Y. Bruice “ELEMENTI DI CHIMICA ORGANICA” Prima Edizione, EdiSES, Napoli 2007
J. McMurry “FONDAMENTI DI CHIMICA ORGANICA” Terza Edizione, Zanichelli, Bologna 2005

Module:
N/D
Module:
-


Module:
N/D
Module:
N/D

Module:
N/D
Module:
The lessons will be held in person in the University classrooms, and according to the rules established by the University


Module:
N/D
Module:
The course (1 CFU) is delivered through lectures integrated with exercises. The lectures take place in classrooms equipped with devices suitable for projecting the course slides, which are available to registered students on the Sapienza E-learning platform. The exercises, conducted throughout the duration of the course, cover all the topics discussed during the theoretical lessons and prepare students for the written test. Various review sessions are planned, during which different exercises representative of those given in the exams are illustrated.

Module:
N/D
Module:
Required attendance


Module:
N/D
Module:
Attendance to lectures and exercises, very useful for achieving the course's educational objectives, is mandatory.

Module:
N/D
Module:
Written questions that will be assigned a weighted score up to a maximum of 30/30


Module:
N/D
Module:
The objective of the final exam is to certify the student's knowledge of the topics covered during the course. The final exam consists of a written test, which is preparatory to the oral exam.
The written test, with closed questions and closed answers, lasts 30 minutes and consists of a multiple-choice test that can be administered in person or using the Moodle platform. The test is considered passed if the student achieves a score of 18/30 or higher.
The Commission reserves the right to admit to the oral exam students whose written test, although not meeting the above requirements, is overall sufficient.
The oral exam, with closed questions and open answers, concludes with a grade out of thirty, formulated based on the following elements:
1. Overall evaluation of the written test;
2. Preparation on the entire program covered;
3. Expository clarity and ability;
4. Ability to connect and synthesize the various topics.
Passing the exam with the minimum score requires sufficient knowledge of the topics covered in the various parts of the program. To achieve a score of 30/30 cum laude, the student must demonstrate excellent knowledge of all the topics covered during the course and be able to logically and coherently connect them.
There is no maximum number of exam attempts within the academic year.

Module:
N/D
Module:
Questions related to the topics covered during the course


Module:
N/D
Module:
Examples of exercises:
1. IUPAC nomenclature;
2. Calculation of oxidation numbers in organic molecules;
3. Structural isomers.

Frequently asked questions:
1. Description of the chemical and physical properties of the main functional groups;
2. Ionic and covalent bonds;
3. Hydrogen bonding.

Module:
N/D
Module:
N/D
Module:

• 1-3 h
  Introduzione al corso . Leggi fondamentali della chimica; concetto di atomo,
  elemento, molecola, mole, massa atomica e molecolare; numero di ossidazione; equazioni
  chimiche e bilanciamento; cenni di nomenclatura dei composti inorganici.


• 4-6 h Orbitali
  atomici; tavola periodica degli elementi; legame ionico e covalente; geometria
  delle molecole.


• 7-9 h Forze
  intermolecolari; unità di concentrazione delle soluzioni; equilibrio chimico e
  legge di azione di massa; 


• 10-12 h
  Calcolo del pH di soluzioni acquose di acidi, basi e sali; equilibri di
  solubilità

• Introduzione: 1 ora
  Teoria del legame di valenza; legami ionici e covalenti; legami
  dipolo-dipolo, ione dipolo, idrogeno e di Van der Waals; ibridazione del
  carbonio. Classificazione delle molecole organiche.
  • Books: Slides provided by the instructor.


• Alcani e cicloalcani  1 ora   Nomenclatura, ibridazione, struttura, proprietà chimico-fisiche,
  isomeri di struttura, conformazione (tensione torsionale, tensione angolare
  cenni), ibridazione e angolo di legame Reazioni degli alcani: ossidazione e
  alogenazione radicalica [cenni]. 
  • Books: Slides provided by the instructor.


• Alcheni  1 ora Nomenclatura, ibridazione, struttura, proprietà chimico-fisiche,
  stabilità, isomeria geometrica. Reazioni degli alcheni: addizione di acidi
  alogenidrici, acqua, alogeni, idrogenazione catalizzata da metalli di transizione
  Pd [cenni].
  • Books: Slides provided by the instructor.


• Alchini  1 ora Nomenclatura, ibridazione, struttura, proprietà
  chimico-fisiche. Reazioni degli alchini: addizione di idrogeno catalizzata dal
  palladio [cenni]
  • Books: Slides provided by the instructor.


• Alogenuri alchilici  1 ora Struttura, proprietà chimico-fisiche. Nomenclatura IUPAC.
  
  Alcoli
  
  Nomenclatura, proprietà chimico-fisiche
  • Books: Slides provided by the instructor.


• Eteri e epossidi  1 ora Struttura. Nomenclatura.
  • Books: Slides provided by the instructor.


• Aldeidi e chetoni  1 ora  Nomenclatura, struttura, proprietà chimico-fisiche. Reattività
  [cenni]. 
  • Books: Slides provided by the instructor.


• Acidi carbossilici  1 ora  Nomenclatura, proprietà fisiche. [cenni]
  • Books: Slides provided by the instructor.


• Derivati degli acidi carbossilici  1 ora  Alogenuri acilici, anidridi, esteri, ammidi. Nomenclatura, proprietà
  chimico-fisichee. 
  • Books: Slides provided by the instructor.


• Composti aromatici  1 oraComposti aromatici: benzene
  • Books: Slides provided by the instructor.


• Ammine, aniline e fenoli  1 ora  Nomenclatura, struttura, proprietà chimico-fisiche. 
  • Books: Slides provided by the instructor.


• Amminoacidi e carboidrati  1 ora
  
  Struttura. Il legame peptidic.
  • Books: Slides provided by the instructor.