Pathophysiological mechanisms of basic and major organs and systems Single channel

Chair (Coordinator) and Rapporteur: MAURIZIO ALIMANDI

Module 1: General pathology

Activity type
Scienze biomediche
SSD
MED/04
Year
1st year
Semester
2nd semester
CFU
2
Hours distribution
24 classroom hours
Lecturers
MAURIZIO ALIMANDI

Module 2: Pathophysiology general

Activity type
Scienze biomediche
SSD
MED/04
Year
1st year
Semester
2nd semester
CFU
1
Hours distribution
12 classroom hours
Lecturers
MAURIZIO ALIMANDI

Module 3: Clinical pathology

Activity type
Scienze biomediche
SSD
MED/04
Year
1st year
Semester
2nd semester
CFU
1
Hours distribution
12 classroom hours
Lecturers
ROBERTA SANTARELLI

Module 4: Clinical biochemistry

Activity type
Prevenzione servizi sanitari e radioprotezione
SSD
BIO/12
Year
1st year
Semester
2nd semester
CFU
1
Hours distribution
12 classroom hours
Lecturers
GIOVANNA GENTILE

Module 5: Immunology

Activity type
Scienze medico - chirurgiche
SSD
MED/05
Year
1st year
Semester
2nd semester
CFU
1
Hours distribution
12 classroom hours
Lecturers
ELENI ANASTASIADOU

Learning outcomes

Module: General pathology
N/D
Module: Pathophysiology general
N/D
Module: Clinical pathology
The expected learning outcomes require the student to acquire the ability to describe the organization and functioning of our immune system, both the innate component and the specific one, as well as to describe and understand the etiopathogenetic bases and manifestations of the main immunopathological frameworks


Module: Clinical biochemistry
At the end of the course students must have a clear understanding of the notions of clinical biochemistry, be able to make logical connections within the topics studied during the course.


Module: Immunology
The student will be able to describe a course topic and explain its importance to the course's subject.

Prerequisites

Module: General pathology
knowledge of cell physiology, chemistry and cell biology


Module: Pathophysiology general
knowledge of cell physiology, chemistry and cell biology


Module: Clinical pathology
In order to understand the teaching content and to achieve the learning objectives, at the beginning of the didactic activities foreseen by the didactic module the student must possess basic knowledge of hystology and anatomy.



Module: Clinical biochemistry
The students are required to know the basics of biochemistry.


Module: Immunology
Be enrolled in the degree course.

Programme

Module: General pathology
Planning for aims

Knowing the causes and pathogenic mechanisms of major diseases of man.


Program of the course of examination of General Pathology and Pathophysiology

General endocrine pathophysiology. Changes in the acid-base
General Pathophysiology of hemostasis, blood and circulation.
General pathophysiology of the respiratory system.
General pathophysiology of the heart.
Pathophysiology of the digestive system and the exocrine pancreas.
Diabetes mellitus.
Pathophysiology of the liver and biliary tract.
Renal Pathophysiology.



Module: Pathophysiology general
Planning for aims

Knowing the causes and pathogenic mechanisms of major diseases of man.


Program of the course of examination of General Pathology and Pathophysiology

General endocrine pathophysiology. Changes in the acid-base
General Pathophysiology of hemostasis, blood and circulation.
General pathophysiology of the respiratory system.
General pathophysiology of the heart.
Pathophysiology of the digestive system and the exocrine pancreas.
Diabetes mellitus.
Pathophysiology of the liver and biliary tract.
Renal Pathophysiology.



Module: Clinical pathology
Introduction to immunology. Organs and tissues of the immune system. The cellular and molecular components of the immune system. Innate immunity: anatomical and physiological barriers; phagocytosis, professional phagocytes and their receptors; the complement system; cytokines; natural killer (NK) cells. Macrophages M1 and M2. Specific immunity: characteristics and functions. B lymphocytes and their antigen receptor: characteristics of B lymphocytes; secreted antibodies: structure, functions, classification. T lymphocytes: characteristics of helper (CD4 +) and cytotoxic (CD8 +) T lymphocytes. MHC molecules and their role. The cells that present the antigen and their role. The generation of the receptor repertoire and clonal selection. Tolerance: recognition and distinction between self and non-self; self tolerance. The immune response against pathogens. Vaccines, vaccination strategies, types of vaccines. Immunopathology: the alterations of the immune response; classification of immunopathologies; type I hypersensitivity: allergies; hypersensitivity of type II, III and IV; disruption of tolerance and autoimmunity; congenital and acquired immunodeficiencies. Transplant immunology: classification of transplants; types of transplant rejection; GVHD.


Module: Clinical biochemistry
 Introduction: biological samples
 Serum proteins electrophoresis
 Liver function tests
 Enzyme markers tests (tissue damage)
 Lipid metabolism (familial hypercolesterolemia)
 Glucidic metabolism (type 1 and 2 diabetes)
 Acid-base balance (hemogasanalysis interpretation)
 Molecular tests: COVID19 diagnosis, Trombophilic screening and personalyzed medicine



Module: Immunology
N/D

Books

Module: General pathology
suggested manual
G.M. Pontieri - Patologia e fisiopatologia generale II edizione (per i corsi di diploma universitario)-
ed. Piccin.


Module: Pathophysiology general
suggested manual
G.M. Pontieri - Patologia e fisiopatologia generale II edizione (per i corsi di diploma universitario)-
ed. Piccin.


Module: Clinical pathology
j.R. Regueiro Gonzalez-C.Lopez Larrea
Immunologia: biologia e patologia del sistema immunitario
Casa editrice Piccin

The slides presented in class will also be provided.


Module: Clinical biochemistry
Biochimica Clinica e Medicina di Laboratorio – M. Ciaccio e G. Lippi - edizione EdiSES
Elementi di biochimica clinica e medicina di laboratorio - M. Ciaccio - edizione EdiSES


Module: Immunology
N/D

Bibliography

Module: General pathology
suggested manual
G.M. Pontieri - Patologia e fisiopatologia generale II edizione (per i corsi di diploma universitario)-
ed. Piccin.


Module: Pathophysiology general
suggested manual
G.M. Pontieri - Patologia e fisiopatologia generale II edizione (per i corsi di diploma universitario)-
ed. Piccin.


Module: Clinical pathology
N/D
Module: Clinical biochemistry
N/D
Module: Immunology
N/D

Lessons mode

Module: General pathology
Lesson in aula


Module: Pathophysiology general
N/D
Module: Clinical pathology
The teacher delivers lectures with traditional methods (face-to-face), with power point presentation and audiovisual aids, scheduling of lessons as reported on GOMP Aure/Orari system, published on the website of CdS. The e-learning platform will be used as a teaching support

The slides presented in class will also be provided.


Module: Clinical biochemistry
Lessons in classrooms, supported by powerpoint slides.
Attendance in this course is mandatory: students must have 67% attendance to take the exam.


Module: Immunology
N/D

Frequency

Module: General pathology
Lesson in aula


Module: Pathophysiology general
Lesson in aula


Module: Clinical pathology
The student is required to attend educational activities, formal, non-formal, vocational. The frequency is checked by the teachers through signature / updated lists provided by the Academic Office, as established by CCL. The certificate of mandatory attendance to the teaching course is required to the student to be admitted at the final test.


Module: Clinical biochemistry
Lessons will take place in the classroom of CELIO (ROME)


Module: Immunology
N/D

Exam mode

Module: General pathology
Oral dissertation


Module: Pathophysiology general
Oral dissertation


Module: Clinical pathology
At the end of the course, the student should be able to demonstrate: to know the fundamentals of immune responses , as well as of the defense mechanisms against infections, the main alterations of these mechanisms and the related consequences as well.

To pass the exam the student needs to achieve a grade of not less than 18/30.


Module: Clinical biochemistry
Written test with multiple answers, followed by oral examination


Module: Immunology
N/D

Example exam questions

Module: General pathology
N/D
Module: Pathophysiology general
N/D
Module: Clinical pathology
What are the main characteristics of innate immunity?

Causes and mechanisms of type I hypersensitivity


Module: Clinical biochemistry
N/D
Module: Immunology
N/D

Arguments

Module: General pathology
N/D
Module: Pathophysiology general
N/D
Module: Clinical pathology

  • Il corso  si svolgerà in quattro  lezioni di tre ore.
    • Books: j.R. Regueiro Gonzalez-C.Lopez Larrea Immunologia: biologia e patologia del sistema immunitarioCasa editrice Piccin



Module: Clinical biochemistry
  • Il corso si svolgerà in 6 lezioni da due ore



Module: Immunology


  • Academic year2024/2025
  • Degree program to which the course belongsNursing
  • Mandatory presenceYes
  • Languageita
  • CFU6 CFU, distributed among 5 integrated didactic modules
  • Total duration72 hours