CELLULAR AND MOLECULAR BASIS OF LIFE Single channel

Chair (Coordinator) and Rapporteur: MARCO ARTINI

Module 1: APPLIED BIOLOGY

Activity type
Scienze biomediche
SSD
BIO/13
Year
1st year
Semester
1st semester
CFU
2
Hours distribution
20 classroom hours
Lecturers
ROBERTO CARNEVALE

Module 2: GENETICS

Activity type
Scienze biomediche
SSD
MED/03
Year
1st year
Semester
1st semester
CFU
1
Hours distribution
10 classroom hours
Lecturers
ANTONIO PIZZUTI

Module 3: GENERAL PATHOLOGY

Activity type
Scienze biomediche
SSD
MED/04
Year
1st year
Semester
1st semester
CFU
2
Hours distribution
20 classroom hours
Lecturers
PATRIZIA MANCINI
PATRIZIA MANCINI

Module 4: MICROBIOLOGY

Activity type
Scienze biomediche, Scienze dell' igiene dentale
SSD
MED/07, MED/07
Year
1st year
Semester
1st semester
CFU
2
Hours distribution
20 classroom hours
Lecturers
MARCO ARTINI

Objectives

At the end of the course the student must know morpho-functional and metabolic characteristics of the prokaryotic cell
and eukaryotic, the fundamentals of the genetic code and of the regulation of gene expression, of the mechanisms of inheritance e
the nature of gene mutation, aspects of genetic pathology and of development, of molecular and cell pathology and of environmental pathology; acquires knowledge of the fundamentals of neoplastic transformation and inflammation, of pathogenic microorganisms for humans, of relationships between host and pathogenic organisms; the main techniques of classical microbiology and the general principles of immunology.
At the end of the course the student must demonstrate that he has acquired the critical skills and tools necessary to understand the evolutionary approach to biological phenomena; must be able to distinguish the main genetic diseases; be able to distinguish genetic and developmental pathologies, molecular, cellular, environmental, neoplastic and inflammatory pathologies; be able to recognize the morphological, structural and genetic characteristics of microorganisms and their pathogenicity, to understand the mechanisms of action of the main antibacterial and antiviral drugs and be able to distinguish the prevention tools such as vaccines.

Learning outcomes

Module: APPLIED BIOLOGY
N/D
Module: GENETICS
genetic bases of human diseases


Module: GENERAL PATHOLOGY
The General Pathology module aims to provide the basic knowledge to make the student able to understand the molecular and cellular mechanisms that regulate pathological processes in humans. The aim of the knowledge of the etiopathogenetic bases of diseases and pathological processes constitutes the indispensable substrate for the laboratory approach for the prevention, therapy and clinical aspect of human pathologies.


Module: MICROBIOLOGY
General knowledge on microbiology and clinical microbiology

Prerequisites

Module: APPLIED BIOLOGY
N/D
Module: GENETICS

bases of cellular biology


Module: GENERAL PATHOLOGY
In order to understand the teaching contents and achieve the learning objectives, at the beginning of the didactic activities foreseen by the didactic module the student must possess basic school knowledge relating to biology, chemistry and biochemistry.


Module: MICROBIOLOGY
Basic skills in biology and chemistry

Programme

Module: APPLIED BIOLOGY
N/D
Module: GENETICS
Formal characteristics of Mendelian diseases Mitochondrial genetics Cytogenetics principles and methods Multifactorial diseases Epigenetics Genetic testing




Module: GENERAL PATHOLOGY
Etiology and pathogenesis. Concept of health and disease.
Adaptive responses to cell damage: hypertrophy, hyperplasia, atrophy, metaplasia.
Cell death: necrosis, apoptosis.
Physical agents as the cause of disease. Exciting and ionizing radiation. Thermal energy transfer disorders.
Chemical agents as the cause of disease. Environmental pollution.
Body defenses against etiological agents of diseases: innate response, acute and chronic inflammation.
Healing of tissue injuries.
Pathophysiology of fever.


Module: MICROBIOLOGY
History of Microbiology
Hints on bacteriology referred to dentistry
Hints on Virology
Hints on micology
Antibiotics
Vaccines and other forms of immunization


Books

Module: APPLIED BIOLOGY
N/D
Module: GENETICS
Genetica e biologia molecolare
Piccin-Nuova Libraria


Module: GENERAL PATHOLOGY
N/D
Module: MICROBIOLOGY
EUDES LANCIOTTI:
MICROBIOLOGIA CLINICA ultima edizione
Casa Editrice AMBROSIANA


Bibliography

Module: APPLIED BIOLOGY
N/D
Module: GENETICS
N/D
Module: GENERAL PATHOLOGY
N/D
Module: MICROBIOLOGY
N/D

Lessons mode

Module: APPLIED BIOLOGY
N/D
Module: GENETICS
The student will acquire basic knowledge in the field of medical genetics with particular attention to the pathogenetic mechanisms underlying the various genetic diseases (hereditary and acquired) and their transmission according to Mendel's laws


Module: GENERAL PATHOLOGY
The teacher delivers the frontal teaching in the traditional way, with audiovisual aids and with the scheduling of the lessons.


Module: MICROBIOLOGY
Frontal lessons with slides
self evaluation test at the end of each lesson


Frequency

Module: APPLIED BIOLOGY
N/D
Module: GENETICS
in person


Module: GENERAL PATHOLOGY
The attendance is mandatory. The student can take the exam if he reaches 67% of the total number of admissions.


Module: MICROBIOLOGY
At least 66% of lessons

Exam mode

Module: APPLIED BIOLOGY
N/D
Module: GENETICS
Multiple choice


Module: GENERAL PATHOLOGY
The assessment of knowledge will be verified through an oral interview, during which the candidate must demonstrate that he has acquired the knowledge and ability to critically interpret the topics and problems taken into consideration during the course.
To pass the exam it is necessary to achieve a score of no less than 18/30. To achieve a score of 30/30 cum laude, the student must demonstrate that he has acquired excellent knowledge of all the topics covered during the course, being able to connect them in a logical and coherent way, explaining the topics clearly and with appropriate terminology.


Module: MICROBIOLOGY
Quiz with multiple answers
Oral exam in the same day


Example exam questions

Module: APPLIED BIOLOGY
N/D
Module: GENETICS
1. Among the following anomalies, which one cannot be identified by genome sequencing
a) Nonsense variant in the coding sequence of a gene
b) Copy Number Variants (microdeletions and microduplications)
c) Splicing mutation
d) Robertsonian translocation
e) Uniparental disomy of a chromosome (Loss of Heterozygosis)

2. THE risk for multifactorial pathologies is said
a) empirical
b) simple Mendelian
c) compound Mendelian
d multifactorial
e) genomic



Module: GENERAL PATHOLOGY
The questions focus on the topics covered in class and present in the program that is provided to the student at the beginning of the lessons.


Module: MICROBIOLOGY
Bacteria responsible of periodontitis
Herpes viruses


Arguments

Module: APPLIED BIOLOGY
N/D
Module: GENETICS
N/D
Module: GENERAL PATHOLOGY
N/D
Module: MICROBIOLOGY
N/D

  • Academic year2024/2025
  • Degree program to which the course belongsDental Hygiene
  • Mandatory presenceNo
  • Languageita
  • CFU7 CFU, distributed among 4 integrated didactic modules
  • Total duration70 hours