Nursing - Course B - Roma Azienda Policlinico Umberto I

Activity type

Scienze propedeutiche

SSD

PHYS-06/A

Year

1st year

Semester

1st semester

CFU

1

Hours distribution

12 classroom hours

Lecturers

GIULIO CARACCIOLO

Activity type

Scienze biomediche

SSD

BIOS-07/A

Year

1st year

Semester

1st semester

CFU

2

Hours distribution

24 classroom hours

Lecturers

ANDREA BELLELLI

Activity type

Scienze biomediche

SSD

BIOS-10/A

Year

1st year

Semester

1st semester

CFU

2

Hours distribution

24 classroom hours

Lecturers

CATERINA CATALANOTTO

Activity type

Scienze biomediche

SSD

MEDS-01/A

Year

1st year

Semester

1st semester

CFU

1

Hours distribution

12 classroom hours

Lecturers

VALENTINA SILVESTRI

Module:
At the end of the course the student will know and understand the physical, chemical and biochemical bases of physiology, as well as the genetic bases of reproduction.


Module:
At the end of the course the student will know and understand the physical, chemical and biochemical bases of physiology, as well as the genetic bases of reproduction.


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None


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None


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Module:
0) Safety issues in the classroom and in the laboratory
1) Fundamental physical concepts: mass, force, energy. Mechanics: kinematics, statics, dynamics; its application to the human body.
2) Fluidodynamics with special reference to the circulation of blood.
3) Electromagnetism.
4) The atom: nucleus, electrons, orbitals, hybridization. The chemical bond. The molecules. Energy in chemistry: bond energy, heat, temperature.
5) The physical states of matter: gases, liquids, solids. Weak interactions. The concept of the mole; Avogadro's number. Gaseous mixtures. Solutions; their concentration; osmotic pressure.
6) Chemical reactions: equilibrium and kinetics; catalysis. Redox reactions.
7) Chemical equilibrium in solution: electrolytes; autoprotolysis of water. pH: acids and bases (weak and strong); buffers; hydrolysis; titrations.
8) Organic chemistry: the structure of carbon; hydrocarbons; functional groups; isomerism;
9) Introduction to the Biochemistry: glucides; lipids, aminoacids; proteins, enzymes and biological catalysis; nucleotides and nucleic acids. Blood proteins; coagulation, antibodies.
10) Structure and replication of DNA; protein synthesis.
11) Fundamental concepts on metabolism: la glicolysis; beta oxidation; Krebs cycle; oxidative phosphorilation. Energy in biology.
12) Eukaryotes, prokariotes and viruses; their characteristics. Mechanisms cellular replication in these classes of living organisms. Mitosis and meiosis.
13) The organelles of eukaryotic cells and their functions.
14) Nutrition. Turnover of biological components. Vitamins. Hormones.
15) Heredity and evolution.
16) Medical genetics. Fundamentals and terminology.
17) Classification of genetic diseases (mendelian, chromosomal, multi-determined, mitochondrial)
18) Construction of the genealogical tree
19) Genetic transmission; inheritancy.
20) Consanguineity
21) Genteic counseling
22) Medical genetic tests: diagnostic, preclinical, for genetic carriers, of susceptibility, pharmacogenetic.
23) Non medical genetic tests: forensic
24) Pre-natal diagnosis
25) Defects of the sexual development
26) Genetics in onchology


Module:
0) Safety issues in the classroom and in the laboratory
1) Fundamental physical concepts: mass, force, energy. Mechanics: kinematics, statics, dynamics; its application to the human body.
2) Fluidodynamics with special reference to the circulation of blood.
3) Electromagnetism.
4) The atom: nucleus, electrons, orbitals, hybridization. The chemical bond. The molecules. Energy in chemistry: bond energy, heat, temperature.
5) The physical states of matter: gases, liquids, solids. Weak interactions. The concept of the mole; Avogadro's number. Gaseous mixtures. Solutions; their concentration; osmotic pressure.
6) Chemical reactions: equilibrium and kinetics; catalysis. Redox reactions.
7) Chemical equilibrium in solution: electrolytes; autoprotolysis of water. pH: acids and bases (weak and strong); buffers; hydrolysis; titrations.
8) Organic chemistry: the structure of carbon; hydrocarbons; functional groups; isomerism;
9) Introduction to the Biochemistry: glucides; lipids, aminoacids; proteins, enzymes and biological catalysis; nucleotides and nucleic acids. Blood proteins; coagulation, antibodies.
10) Structure and replication of DNA; protein synthesis.
11) Fundamental concepts on metabolism: la glicolysis; beta oxidation; Krebs cycle; oxidative phosphorilation. Energy in biology.
12) Eukaryotes, prokariotes and viruses; their characteristics. Mechanisms cellular replication in these classes of living organisms. Mitosis and meiosis.
13) The organelles of eukaryotic cells and their functions.
14) Nutrition. Turnover of biological components. Vitamins. Hormones.
15) Heredity and evolution.
16) Medical genetics. Fundamentals and terminology.
17) Classification of genetic diseases (mendelian, chromosomal, multi-determined, mitochondrial)
18) Construction of the genealogical tree
19) Genetic transmission; inheritancy.
20) Consanguineity
21) Genteic counseling
22) Medical genetic tests: diagnostic, preclinical, for genetic carriers, of susceptibility, pharmacogenetic.
23) Non medical genetic tests: forensic
24) Pre-natal diagnosis
25) Defects of the sexual development
26) Genetics in onchology


Module:
Introduction to Applied Biology and Cell Organization
1. Characteristics of living organisms
2. Levels of biological organization
3. Prokaryotic and eukaryotic cells
4. General organization of the eukaryotic cell
5. Cellular compartmentalization
6. Cell organelles and their functions
7. Relationship between cell structure and function
Biological Membranes and Cellular Transport
1. Structure of the plasma membrane
2. Fluid mosaic model
3. Membrane lipids
4. Membrane proteins
5. Glycocalyx
6. Selective permeability
7. Simple and facilitated diffusion
8. Osmosis
9. Active transport
10. Ion pumps
11. Endocytosis and exocytosis
12. Transcellular transport across epithelial cells
The Flow of Genetic Information
1. Organization of the human genome
2. Chromatin and chromosomes
3. Genes
4. The central dogma of molecular biology
5. DNA replication
6. Transcription
7. Messenger RNA (mRNA), ribosomal RNA (rRNA), and transfer RNA (tRNA)
8. The genetic code and protein translation
9. Protein structure and function
Regulation of Gene Expression
1. Why different cell types express different genes
2. Transcriptional regulation
3. Epigenetic regulation
4. Post-transcriptional regulation
5. Alternative splicing
6. Translational regulation
7. Protein degradation
Cell Communication and Signal Transduction
1. Homeostasis
2. Cell communication
3. Ligands and receptors
4. Cell surface receptors
5. Intracellular receptors
6. Second messengers

7. Signal transduction pathways
8. Receptor tyrosine kinases and G protein-coupled receptors (GPCRs)
9. Cellular responses
Cell Cycle and Cell Proliferation
1. Phases of the cell cycle: Interphase, Mitosis, and Cytokinesis
2. Cell cycle regulation and checkpoints
3. Cyclins and cyclin-dependent kinases (CDKs)
4. Introduction to cell differentiation, stem cells, and cellular senescence
5. Introduction to cancer as a disease of uncontrolled cell proliferation
Cell Death and Cellular Responses to Damage
1. Cellular injury
2. Cellular adaptations
3. Apoptosis
4. Necrosis
5. Autophagy (overview)
6. Inflammation
7. Tissue repair
8. Regeneration
9. Wound healing
Cell Biology Applied to Nursing Practice
1. Introduction to cancer as a disease of uncontrolled cell proliferation
2. Biology of cancer cells
3. Infections and cellular responses
4. Biological therapies
5. Personalized medicine
6. Cell culture techniques (overview)
7. Applications of molecular biology in diagnostics (e.g., Polymerase Chain Reaction,
PCR)


Module:
N/D

Module:
It is advisable to use a university level reference text, e.g.:
Stefani, Taddei "Chimica, Biochimica e Biologia per le Professioni Sanitarie", Zanichelli
or: Samaja, Paroni "Chimica e Biochimica per le Lauree Triennali dell'area biomedica", Piccin.


Module:
It is advisable to use a university level reference text, e.g.:
Stefani, Taddei "Chimica, Biochimica e Biologia per le Professioni Sanitarie", Zanichelli
or: Samaja, Paroni "Chimica e Biochimica per le Lauree Triennali dell'area biomedica", Piccin.


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N/D
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Module:
The course consists of formal lectures in the classroom. It includes intermediate evaluations.
Attendance is compulsory for at least 75% of the total lectures.


Module:
The course consists of formal lectures in the classroom. It includes intermediate evaluations.
Attendance is compulsory for at least 75% of the total lectures.


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N/D
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Module:
The final evaluation is achieved either via a final examination or via the achievement of all the (written) intermediate evaluations.


Module:
The final evaluation is achieved either via a final examination or via the achievement of all the (written) intermediate evaluations.


Module:
N/D
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N/D

Module:
What is a buffer? Which buffers are present in human blood
What is the osmotic pressure? what is a isotonic solution?
Describe one of the metabolic pathways illustrated during the course


Module:
What is a buffer? Which buffers are present in human blood
What is the osmotic pressure? what is a isotonic solution?
Describe one of the metabolic pathways illustrated during the course


Module:
N/D
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• Lecture 1:Introduction to Applied Biology and Cell OrganizationLecture 2:Biological Membranes and Cellular TransportLecture 3:The Flow of Genetic InformationLecture 4:Regulation of Gene ExpressionLecture 5:Cell Communication and Signal TransductionLecture 6:Cell Cycle and Cell ProliferationLecture 7Cell Death and Cellular Responses to DamageLecture 8Cell Biology Applied to Nursing Practice

• Structure and function of genes and the human genome: DNA, RNA, non-coding RNA, pseudogenes -Variation in the human genome: mutations,
  polymorphisms, repetitive DNA
  • Books: Clementi - Cassina - Di Gianantonio - Salviati – Trevisson. Elementi di
    
    genetica medica Edises 2020  


• Human chromosomes: size and morphology, karyotype analysis 
  • Books: Clementi - Cassina - Di Gianantonio - Salviati – Trevisson. Elementi di
    
    genetica medica Edises 2020  


• Mendelian inheritance and its exceptions: autosomal recessive and autosomal dominant inheritance, X-linked inheritance, genomic imprinting, genetic heterogeneity, reduced penetrance, variable expressivity 
  • Books: Clementi - Cassina - Di Gianantonio - Salviati – Trevisson. Elementi di
    
    genetica medica Edises 2020  


• Genetic counseling and genetic testing
  • Books: Clementi - Cassina - Di Gianantonio - Salviati – Trevisson. Elementi di
    
    genetica medica Edises 2020