Nursing and Midwifery Sciences

Activity type

Scienze biomediche

SSD

MED/04

Year

N/D

Semester

N/D

CFU

2

Hours distribution

24 classroom hours

Lecturers

ENRICO DE SMAELE

Activity type

Scienze biomediche

SSD

BIO/14

Year

N/D

Semester

N/D

CFU

2

Hours distribution

24 classroom hours

Lecturers

DANIELA MAFTEI

Activity type

Scienze biomediche

SSD

MED/07

Year

N/D

Semester

N/D

CFU

2

Hours distribution

24 classroom hours

Lecturers

MARIA ELENA MARCOCCI

Activity type

Scienze biologiche, mediche e chirurgiche

SSD

MED/08

Year

N/D

Semester

N/D

CFU

2

Hours distribution

24 classroom hours

Lecturers

FRANCESCA GIANNO

Explore biomedical sciences to acquire advanced care, education, and prevention skills to address the primary health issues of pediatric, adult, and geriatric populations. Understand normal biological processes and the mechanisms responsible for pathologies, and critically evaluate the related diagnostic methods. Understand the main mechanisms of drug action. Understand the transmission mechanisms of the most common microorganisms and control strategies.

A basic knowledge of biology, biochemistry, physiology, and human anatomy is required.

Module: GENERAL PATHOLOGY
As part of the module students will be provided with the tools for an adequate and critical knowledge:
- of the aetiological factors responsible for the alterations of cell function, and of the cellular and molecular pathogenic mechanisms;
- of cell proliferation and apoptosis control;
- of the mechanisms of neoplastic cell transformation, and the new approaches of the personalized medicine;
- Of inflammation processes and fever
- of the Etiology and pathogenesis of immune disorders / autoimmunity,
- of the role of transplant immunology, immune deficiencies and hospital infections.



Module: PHARMACOLOGY
The course includes an introductory section on the fundamental principles of pharmacokinetics and pharmacodynamics, followed by an in-depth study of the main drug classes of specific interest. Particular attention will be given to mechanisms of action, dosage, adverse effects, and drug interactions.


Module: MICROBIOLOGY AND CLINICAL MICROBIOLOGY
Bacteriology. Microorganism–host interaction: resident bacterial flora and exogenous pathogenic bacteria. Mechanisms of bacterial pathogenesis. Bacterial toxins and related diseases. Bacterial spores. Biofilm formation. Antibiotics, chemotherapeutic agents, and mechanisms of resistance to antibacterial agents. Common and emerging nosocomial (hospital-acquired) infections. Overview of the principal medically relevant bacteria.

Virology. General characteristics of viruses: composition, morphology, and structure. Viral replication cycle. Pathogenesis of viral infections. Antiviral drugs. Overview of the principal medically relevant viruses.

Mycology. General characteristics of fungi. Mechanisms of fungal pathogenicity. Superficial and systemic mycoses. Antifungal drugs. Overview of the principal medically relevant fungi.

Basics of Immunology: innate and adaptive defenses against microbial invasion; overview of vaccines and vaccination strategies.



Module: PATHOLOGICAL ANATOMY
1. Definition of pathological anatomy, biopsy materials, and basic methods
2. Inflammation
3. Disorders of cell proliferation and differentiation
4. Neoplasms and TNM classification
5. Cardiovascular disease
6. Thyroid disease
7. Pulmonary disease
8. Gastrointestinal disease
9. Breast disease
10. Skin disease
11. Gynecological disease

Module: GENERAL PATHOLOGY
Pontieri GM. Elementi di Patologia Generale - Per i Corsi di Laurea in Professioni Sanitarie. Edizione Piccin
Jeanette Anne Marie Maier, Massimo Mariotti. Elementi di Patologia generale e Fisiopatologia. McGraw-Hill
Pontieri G.M. Patologia Generale e Fisiopatologia Generale III o IV ed. Piccin



Module: PHARMACOLOGY
Karen Whalen, "The Basics of Pharmacology," with the collaboration of Sarah M. Lerchenfeldt and Chris R. Giordano (Fourth Italian edition)
Katzung, Master, Trevor. "General and Clinical Pharmacology," Piccin Editore (latest edition)



Module: MICROBIOLOGY AND CLINICAL MICROBIOLOGY
Course materials are available on the Google Classroom platform of the course.

For the Microbiology and Clinical Microbiology module, one of the following textbooks is recommended:
- S. De Grazia, D. Ferraro, G. Giammanco - Microbiologia e Microbiologia clinica. Per le professioni sanitarie e Odontoiatra. Pearson.
- E. Lanciotti - Microbiologia clinica. Cea
- Principi di microbiologia medica. Antonelli G, Clementi M, Pozzi G, Rossolini GM. Casa Editrice Ambrosiana



Module: PATHOLOGICAL ANATOMY
L . Ruco- A. Scarpa - Anatomia Patologica Le basi - UTET
Robbins e Cotran. Le basi patologiche delle malattie. Edra Masson.

Module: GENERAL PATHOLOGY
N/D
Module: PHARMACOLOGY
N/D
Module: MICROBIOLOGY AND CLINICAL MICROBIOLOGY
N/D
Module: PATHOLOGICAL ANATOMY
N/D

The lessons will be held in a face-to-face teaching mode, with the support of teaching materials that will be projected in the classroom and subsequently made available to students in digital format.

Class attendance is mandatory.

Knowledge will be assessed through an oral exam that will cover the topics of the various modules in an integrated manner. The assessment will therefore be an overall evaluation of the entire course.

1. What is the purpose of drug metabolism?
2. What is the first-pass effect and why is it important? To which pharmacokinetic parameter is it linked?
3. What are the drug targets? List and briefly describe them, and provide an example for each from subsequent special pharmacology lessons.
4. Explain what an agonist and an antagonist are?
5. NSAIDs: describe the types covered in class.

Module: GENERAL PATHOLOGY

• etiological factors responsible for alterations in cellular function; and cellular and molecular pathogenic mechanisms


• mechanisms controlling cell proliferation and apoptosis


• mechanisms of neoplastic cellular transformation and approaches to personalized therapy


• inflammatory process and fever


• Etiology and pathogenesis of immune/autoimmune diseases


• The role of immunology in transplants, immunodeficiencies, and hospital infections

• Introduction
  to Pharmacology and Pharmacovigilance  2h


• Pharmacokinetics:
  Absorption/placental passage of drugs  2h


• Pharmacokinetics:
  Distribution/Metabolism/Elimination 2h


• Pharmacodynamics  3h


• Central Nervous System Pharmacology: Anxiolytic and hypnotic drugs. General and local anesthetics. 4h


• Nonsteroidal
  Anti-Inflammatory Drugs (NSAIDs) and Steroidal Anti-Inflammatory Drugs (NSAIDs) 4h


• Endocrine
  System Pharmacology: Hypothalamic Hormones:  Insulin. Diabetes. 4h


• Antitumor
  Drugs 3h

• Bacteriology. 10 h
  • Books: - S. De Grazia, D. Ferraro, G. Giammanco - Microbiologia e Microbiologia clinica. Per le professioni sanitarie e Odontoiatra.  Pearson. - E. Lanciotti - Microbiologia clinica. Cea


• Virology. 10 h
  • Books: - S. De Grazia, D. Ferraro, G. Giammanco - Microbiologia e Microbiologia clinica. Per le professioni sanitarie e Odontoiatra.  Pearson. - E. Lanciotti - Microbiologia clinica. Cea


• Mycology. 2 h
  • Books: - S. De Grazia, D. Ferraro, G. Giammanco - Microbiologia e Microbiologia clinica. Per le professioni sanitarie e Odontoiatra.  Pearson. - E. Lanciotti - Microbiologia clinica. Cea


• Basics of
  Immunology. 2 h
  • Books: - S. De Grazia, D. Ferraro, G. Giammanco - Microbiologia e Microbiologia clinica. Per le professioni sanitarie e Odontoiatra.  Pearson. - E. Lanciotti - Microbiologia clinica. Cea

• Definition of Pathological Anatomy, Types of Specimens for Biopsy Examination, and Basic Methodologies. - 3 hours
  • Books: L . Ruco- A. Scarpa - Anatomia Patologica  Le basi - UTETRobbins e Cotran. Le basi patologiche delle malattie. Edra Masson.


• INFLAMMATION - 2 hours


• Disorders of Cell Proliferation and Differentiation. - 2 hours


• Neoplasms and TNM Classification - 2 hours


• Cardiovascular Pathology. - 2 hours


• Thyroid Pathology - 2 hours


• Pulmonary Pathology. - 2 hours


• Breast Pathology - 2 hours


• Gastrointestinal Pathology - 2 hours


• Cutaneous Pathology. - 2 hours


• Gynecological Pathology – 3 hours