Nursing and Midwifery Sciences REPLICA B - LAZIO SUD

Activity type

Scienze biomediche

SSD

MED/04

Year

N/D

Semester

N/D

CFU

2

Hours distribution

24 classroom hours

Lecturers

Giovanna Romeo

Activity type

Scienze biomediche

SSD

BIO/14

Year

N/D

Semester

N/D

CFU

2

Hours distribution

24 classroom hours

Lecturers

GIOVANNI SEBASTIANO ALEMA'

Activity type

Scienze biomediche

SSD

MED/07

Year

N/D

Semester

N/D

CFU

2

Hours distribution

24 classroom hours

Lecturers

MARIA ELENA MARCOCCI

Activity type

Scienze biologiche, mediche e chirurgiche

SSD

MED/08

Year

N/D

Semester

N/D

CFU

2

Hours distribution

24 classroom hours

Lecturers

CLAUDIO DI CRISTOFANO

Pharmacology
Upon completion of the course, students should be able to:
- Define the main pharmacokinetic parameters, explain their practical use, and define steady state and how it is achieved.
- Understand the principles of drug response variability and the principles of pharmacogenetics to identify potential applications in the clinical practice of pharmacotherapy.
- Understand the types of Adverse Drug Reactions to distinguish them and assess their severity.
- Understand the methodology of pharmacovigilance and its practical application.
- Understand how drug-drug and drug-food interactions occur, describe their possible pharmacokinetic mechanisms, and list some examples.
- Understand the principles governing drug development in the various phases of preclinical and clinical trials and understand the underlying methodology.
- Understand the basic methodology for the Evaluation Analysis of pharmacological interventions.
- Understand the basic tools for assessing health-related quality of life and the principles of their use. Use in Pharmacoeconomic Analysis
- Understand opioid drugs and their advanced use in pain management.

Students must have basic knowledge of chemistry, biochemistry, anatomy, molecular and cellular biology.
For Pharmacology, no specific knowledge is required other than the general pharmacology topics covered during the three-year Nursing program.

Module: GENERAL PATHOLOGY
General properties of the immune system. Cellular and molecular mechanisms of the immune response and their role in defense against bacterial, viral, and parasitic infections and in immunopathogenic reactions. Vaccines. Advanced vaccine preparation methods. Antibiotic resistance. Characteristics and evolution of antibiotic resistance in major bacterial pathogens through analysis of its origin and spread. Analysis of the molecular techniques used to identify resistance determinants and mechanisms of transfer.


Module: PHARMACOLOGY
Clinical pharmacokinetics
Adverse drug reactions
Principles, methodologies and regulations of pharmacovigilance
Variations of the pharmacological response and principles of pharmacogenetics
Interactions between drugs
Clinical and pre-clinical drug trials
Principles and methodologies of pharmacoeconomics
Tools for assessing the quality of life
Pain therapy


Module: MICROBIOLOGY AND CLINICAL MICROBIOLOGY
Bacteriology. Microorganism–host interaction: resident bacterial flora and exogenous pathogenic bacteria. Mechanisms of bacterial pathogenesis. Bacterial toxins and related diseases. Bacterial spores. Biofilm formation. Antibiotics, chemotherapeutic agents, and mechanisms of resistance to antibacterial agents. Common and emerging nosocomial (hospital-acquired) infections. Overview of the principal medically relevant bacteria.
Virology. General characteristics of viruses: composition, morphology, and structure. Viral replication cycle. Pathogenesis of viral infections. Antiviral drugs. Overview of the principal medically relevant viruses.
Mycology. General characteristics of fungi. Mechanisms of fungal pathogenicity. Superficial and systemic mycoses. Antifungal drugs. Overview of the principal medically relevant fungi.
Basics of Immunology: innate and adaptive defenses against microbial invasion; overview of vaccines and vaccination strategies.



Module: PATHOLOGICAL ANATOMY
- general concepts and context;
- study of the basic elements of disease prevention and screening programs for cervical, breast and colon cancer.

Module: GENERAL PATHOLOGY
Maier-Mariotti Elementi di patologia generale e fisiopatologia McGraw-Hill Ed


Module: PHARMACOLOGY
1. Farmacologia clinica, a cura di Luciano M. Fuccella, Emilio Perucca, Cesare Sirtori; Torino UTET, 1998 Biblioteca Comunale di Aprilia, Inv. 7781, Coll. S. G. 615 MUC 53/02
o Fuccella L.M. Cap. 8 La sperimentazione clinica dei Farmaci, pp 74-84
o Velo G. Conforti A. e Leone R., Cap. 12 Farmacosorveglianza, pp 110-19
o Recchia G., Cap. 24 Principi di farmacoeconomia: Qualità della vita e terapia farmacologica, pp 245-63
o Borghi C., Cap. 25 Il rapporto costo/beneficio nelle terapie farmacologiche, pp 265-76
2. Farmacologia. Meccanismo d'azione dei farmaci a cura di Pratt WB. & Taylor P., Bologna, Zanichelli, 2002 - Nebert DW., e Weber WW.,Cap. 7 Farmacogenetica pp 369-419 Biblioteca Comunale di Latina Aldo Manuzio Inventario LTM 49906 Collocazione LTM 615.1
3. Ingelman-Sundberg M., Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present and future TIPS Vol.25 No.4, 2004, pp 193-200
4. P. G. Davey, M. Malek, T. Dodd, T. MacDonald, Cap. 10 Farmacoeconomia e prescrizione di farmaci, In FARMACOLOGIA E TERAPIA DI AVERY, A cura di Trevor M Speight , Nicholas H.G. Holford, Zanichelli, 2000

On the course website (https://elearning2.uniroma1.it/course/view.php?id=783) there is a complete bibliography for the study of the topics covered in class.


Module: MICROBIOLOGY AND CLINICAL MICROBIOLOGY
Course materials are available on the Google Classroom platform of the course.

For the Microbiology and Clinical Microbiology module, one of the following textbooks is recommended:
- S. De Grazia, D. Ferraro, G. Giammanco - Microbiologia e Microbiologia clinica. Per le professioni sanitarie e Odontoiatra. Pearson.
- E. Lanciotti - Microbiologia clinica. Cea
- Principi di microbiologia medica. Antonelli G, Clementi M, Pozzi G, Rossolini GM. Casa Editrice Ambrosiana




Module: PATHOLOGICAL ANATOMY
For the examination of the exam, we suggest a theoretical deepening already from the beginning of the course attendance.
The topics covered during the course can be downloaded from the sites:
http://www.osservatorionazionalescreening.it/sites/default/files/allegati/ons%20rapporto%202016%20VI.pdf
The teacher uses e-learning Platform.

Module: GENERAL PATHOLOGY
N/D
Module: PHARMACOLOGY
N/D
Module: MICROBIOLOGY AND CLINICAL MICROBIOLOGY
N/D
Module: PATHOLOGICAL ANATOMY
N/D

The course is based on traditional lectures lasting four hours each.
For Pharmacology, lessons will conclude with tests to assess understanding of the topic covered or activities to put the topics covered in class into practice.

Pursuant to the Degree Programme Regulations, students are required to attend the academic and professional development activities of the Course. Attendance is verified by instructors through signature/roll-call sheets, based on updated lists provided by the Academic Secretariat as established by the CCL. A certificate of attendance for the mandatory educational activities of a course is required for students to take the relevant exam.

The exam consists of a written test with multiple-choice questions (8 questions per subject), which must be passed before the oral exam.
To be eligible for the oral exam, at least half of the answers in each subject must be correct.
To pass the exam, students must achieve a grade of at least 18/30 in each module. Students must demonstrate sufficient knowledge of the topics covered during the course. To achieve a grade of 30/30 with honors, students must demonstrate excellent knowledge of all the topics covered during the course, demonstrating a linear argument using technical terms and correct linguistic expressions.

What is the difference between side effects and toxic effects?
What adverse reactions must be reported to pharmacovigilance?
What factors modify drug response?
What are the four phenotypes found in the population regarding the gene expression of drug-metabolizing enzymes?
What is the purpose of Phase 2 drug trials?
What is the difference between the Phase 2 sample and the Phase 3 sample?
What are the main pharmacoeconomic analyses?
What is the difference between direct and indirect costs?
Pathogenic mechanisms and transmission routes of bacteria, viruses, and fungi.
Antibacterial, antiviral, and antifungal drugs and mechanisms of resistance.
Bacterial toxins and related diseases
Immune response to infections and the role of vaccines in prevention.
Nosocomial (hospital-acquired) infections.

Module: GENERAL PATHOLOGY



Module: PHARMACOLOGY



Module: MICROBIOLOGY AND CLINICAL MICROBIOLOGY

• Bacteriology, 10 h
  • Books: - S. De Grazia, D. Ferraro, G. Giammanco - Microbiologia e Microbiologia clinica. Per le professioni sanitarie e Odontoiatra.  Pearson. - E. Lanciotti - Microbiologia clinica. Cea


• Virology, 10 h
  • Books: - S. De Grazia, D. Ferraro, G. Giammanco - Microbiologia e Microbiologia clinica. Per le professioni sanitarie e Odontoiatra.  Pearson.- E. Lanciotti - Microbiologia clinica. Cea


• Mycology, 2 h
  • Books: - S. De Grazia, D. Ferraro, G. Giammanco - Microbiologia e Microbiologia clinica. Per le professioni sanitarie e Odontoiatra.  Pearson.- E. Lanciotti - Microbiologia clinica. Cea


• Basics of
  Immunology. 2 h
  • Books: - S. De Grazia, D. Ferraro, G. Giammanco - Microbiologia e Microbiologia clinica. Per le professioni sanitarie e Odontoiatra.  Pearson.- E. Lanciotti - Microbiologia clinica. Cea