PHYSIOPATHOLOGIC BASES OF DISEASES Single channel

Chair (Coordinator) and Rapporteur: MARIA SAVERIA GILARDINI MONTANI

Module 1: Technical sciences of laboratory medicine

Activity type
Attività formative affini o integrative
SSD
MEDS-26/A
Year
1st year
Semester
2nd semester
CFU
1
Hours distribution
12 classroom hours
Lecturers
Maria Teresa Rosati

Module 2: Pathology and pathophysiology

Activity type
Scienze biomediche
SSD
MEDS-02/A
Year
1st year
Semester
2nd semester
CFU
2
Hours distribution
24 classroom hours
Lecturers
MARIA SAVERIA GILARDINI MONTANI

Module 3: Microbiology

Activity type
Scienze biomediche
SSD
MEDS-03/A
Year
1st year
Semester
2nd semester
CFU
2
Hours distribution
24 classroom hours
Lecturers
CARLO ZAGAGLIA

Module 4: Anatomo pathology bases

Activity type
Scienze medico - chirurgiche
SSD
MEDS-04/A
Year
1st year
Semester
2nd semester
CFU
1
Hours distribution
12 classroom hours
Lecturers
MAURO SCHINA

Objectives

Knowledge of the main causes of disease and related etiopathogenetic mechanisms. Fundamental pathophysiological mechanisms of the main devices and systems. Main organisms pathogenic to humans and the biological fundamental mechanisms of defense of the organism. The inflammatory process, the neoplastic transformation. Elements of techniques in pathological anatomy: samples, fixation, preparation of histological preparations and reporting Istologi and cytological examinations. Grading and staging of neoplasms.

Learning outcomes

1. Knowledge and understanding. By the end of the course, students will have understood basic biomedical sciences, enabling them to recognize the physiological and pathological processes associated with health and disease.
2. Ability to apply knowledge and understanding. Students will acquire the ability to utilize a set of theoretical skills derived from nursing, biological, behavioral, and social sciences to recognize the needs of their patients.
3. Independent judgment. Students will be able to make decisions through a scientific approach to solving patient problems.
4. Communication skills. Students will be able to apply the lessons learned, evaluating the most appropriate language to express their knowledge.
5. Learning skills. Students will develop independent study skills; they will acquire the methodological tools to continue their studies.

Prerequisites

To Have basic knowledge of biology, biochemistry, anatomy, and physiology, as well as knowledge of the fundamentals of clinical nursing, as per the first semester program.

Programme

Module: Technical sciences of laboratory medicine
1. Antimicrobial stewardship from theory to diagnostic practice: effective management of bloodstream infections, new molecular biology techniques, best practices for performing blood cultures.
2. Quality Control: what it is, why it is performed, and its significance in diagnostics. Detailed information: statistics, mean, SD, ET, Levey-Jennings charts, Westgard rules, Sigma metrics, EQA, expanded quality control, and corrective actions.
3. Sociology of work: Perceptual Positions model, empathy, metaphor of the social body and the human body: theory and practice.
4. Biomarkers of cellular damage: highly sensitive troponin.
5. Toxicology concepts: toxicology and drugs of abuse; screening technology; cutoffs and cross-reactivity; drugs of abuse; biological matrices: urine, blood, hair



Module: Pathology and pathophysiology
1. Concepts of aetiology and pathogenesis. Environmental pathology from physical agents (transfer of mechanical energy, thermal energy, radiant energy, atmospheric pressure, from electric currents and from gravitational accelerations), from chemical agents (poisons, lead), from malnutrition and microorganisms.
2. Innate immunity; cells and mechanisms of action.
3. Induced immunity; cells and mechanisms of action.
4. Type I, II, III and IV hypersensitivity.
5. Inflammation. Acute inflammation. Vascular phase. Cellular phase. Chronic inflammation. Reparative processes. Granulation tissue. Wound healing.
6. Oncology. Cancer concept. Criteria of benignity and malignancy. Principles of classification and staging of tumors. Epidemiology of tumors. Oncogenes and tumor suppressors.
7. Endocrine pathophysiology: hormones and neurormones, hormonal receptors, signal transduction and cellular response.
8. Pathophysiology of the hypothalamic-pituitary system: hypothalamic hormones, adenohypophyseal and neurohypophyseal hormones. Insipid diabetes and pituitary neoplasms.
9. Pathophysiology of the thyroid and parathyroid glands: Formation and function of thyroid hormones. Hashimoto's thyroiditis and Graves' disease.
10. Pathophysiology of renal function: renal function and structure in all its components. Glomerular and tubular diseases. Adrenal pathophysiology: Synthesis and action of cortical and medullary hormones. Cushing's syndrome and Addison's disease.
11. Pathophysiology of the liver: Steatosis, Hepatitis and Cirrhosis. pathophysiology of the pancreas: diabetes mellitus.
12. Pathophysiology of platelets and haemostasis.



Module: Microbiology
Introduction to Microbiology
BACTERIOLOGY
Morphology, physiology, and reproduction of bacterial cells. – Virulence factors and antimicrobial agents.
Main bacteria of clinical interest
VIROLOGY
General information on viruses. – Pandemic RNA viruses. – DNA viruses.
MYCOLOGY
General information on fungi. – Mycoses.
VACCINES
Evolution of antibacterial and antiviral vaccines. The anti-vax galaxy: vaccine hesitancy and fake news



Module: Anatomo pathology bases
1. Atherosclerosis
2. Atheromatous Plaque
3. Ischemia
4. Infarction
5. Thrombosis
6. Coagulation
7. Disseminated Intravascular Coagulation
8. Myocardial Hypertrophy
9. Pulmonary Embolism
10. Systemic Arterial Hypertension


Books

Module: Technical sciences of laboratory medicine
The study material will be provided by the teacher


Module: Pathology and pathophysiology
Elementi di Patologia generale e di Fisiopatologia generale di Mainiero F., Misasi R., Sorice M.
Edizioni Piccin

During the course the slides shown will be made available and bibliographical indications on specific topics to be explored can be provided.


Module: Microbiology
Material provided by the teacher


Module: Anatomo pathology bases
The study material will be provided by the teacher

Bibliography

Module: Technical sciences of laboratory medicine
N/D
Module: Pathology and pathophysiology
N/D
Module: Microbiology
N/D
Module: Anatomo pathology bases
N/D

Lessons mode

Classes are in-person, in Italian, and are taught face-to-face in the classroom, supported by slides and/or video clips. Interaction with students is planned during the lessons for clarification.

Frequency

Attendance is mandatory and is recorded by signing a register.

Exam mode

The overall structure of the exam is specified in detail during the first lesson by the course coordinator, and each teacher will provide an adequate description of the exam for their module. The exam for each module is a written test. Depending on the module, the exam consists of both closed and open-ended questions covering topics covered in class. Closed-ended answers will be given a score at the discretion of each instructor; for open-ended questions, the instructor will assign a score based on knowledge of the subject matter, clarity of presentation, and the accuracy and appropriateness of the terminology used. A score of 18/30 or higher is considered a pass.

Example exam questions

Acute inflammation, cells of the natural and acquired immune system

Arguments

Module: Technical sciences of laboratory medicine

  • 2 semester lessons once a week
    • Books: The study material will be provided by the teacher



Module: Pathology and pathophysiology
  • 2 semester lessons once a week
    • Books: Elementi di Patologia generale e di Fisiopatologia generale di Mainiero F., Misasi R., Sorice M.



Module: Microbiology
  • 2 semester lessons once a week
    • Books: provided by the teacher



Module: Anatomo pathology bases
  • 2 semester lessons once a week
    • Books: The study material will be provided by the teacher


Sustainability goals

  • Goal3
  • Goal8
  • Goal9
  • Academic year2026/2027
  • Degree program to which the course belongsNursing - Course H - ASL Roma 6 - Nettuno (RM)
  • Languageita
  • CFU6 CFU, distributed among 4 integrated didactic modules
  • Total duration72 hours