Neurophysiopathology techniques - Roma Azienda Policlinico Umberto I

Activity type

Scienze biomediche

SSD

BIO/13

Year

N/D

Semester

N/D

CFU

2

Hours distribution

20 classroom hours

Lecturers

BRUNELLA CARONTI

Activity type

Scienze biomediche

SSD

MED/03

Year

N/D

Semester

N/D

CFU

1

Hours distribution

10 classroom hours

Lecturers

BRUNELLA CARONTI

Activity type

Scienze biomediche

SSD

MED/04

Year

N/D

Semester

N/D

CFU

2

Hours distribution

20 classroom hours

Lecturers

MARCO CIPPITELLI

Activity type

Scienze biomediche

SSD

MED/07

Year

N/D

Semester

N/D

CFU

2

Hours distribution

20 classroom hours

Lecturers

CAROLINA SCAGNOLARI

- Knowledge and understanding of the structure/function relationship of various cellular components, the main molecular regulatory mechanisms of cellular functions, and the social organization of cells at various levels of biological organization.
- Knowledge and understanding of monogenic, chromosomal, mitochondrial, and multifactorial diseases.
- Knowledge and understanding of the mechanisms underlying disease, including morphological (ultrastructural, cellular), physiological, and biochemical aspects.
- Knowledge and understanding of the structural and molecular organization, metabolism, growth phase, growth conditions, and virulence factors for the diagnosis of the main microorganisms of medical interest.

Basic knowledge of inorganic and organic chemistry, biochemistry, cellular and molecular biology acquired in high school.

Module: APPLIED BIOLOGY
Fundamental characteristics of life. Chemical constituents of living matter. The cell as a biological unit; prokaryotes and eukaryotes; common and differential characteristics of cytotypes. The central dogma of biology: from DNA to RNA to proteins. DNA and RNA: structure and functions. Duplication and transcription. Genetic code and its properties. Protein synthesis: translation, post-translational events and post-synthetic fate of proteins. Regulation of gene expression in prokaryotes and eukaryotes. Biological membranes: plasmalemma and intracytoplasmic systems (structure, functions and specializations). Cellular organelles: structure and functions and specializations. Cytoskeleton: microfilaments, microtubules, intermediate filaments; associated proteins and molecular motors: characteristics and functions common to all cytotypes and differential specializations. Cell cycle; mitosis and meiosis.



Module: GENETICS
The module of Medical Genetics is carried out after that of Applied Biology, so that the student has acquired the knowledge of the structure and functions of DNA and of cell replication modalities (mitosis and meiosis). The program is divided into the study of classical genetics and molecular genetics. Classical genetics: phenotype, genotype, genes, alleles, dominance, recessivity, homozygosity, heterozygosity; codominance, multiple allelia. Genealogical tree. Penetrance, variable expression, late onset pathologies, anticipation. Mendelian inheritance.


Module: GENERAL PATHOLOGY
General pathology is concerned with the mechanisms underlying disease processes, as manifested by morphologic (gross, cellular, and ultrastructural), physiologic, and biochemical changes. The main topics covered are cellular degeneration, inflammation, tissue repair, chemical and physical injury and a brief introduction to neoplasia. Introduction to neuropathology.
Specific points: Cell Injury and Death, Cellular Adaptation, Acute and Chronic Inflammation, Tissue Repair - Cell Regeneration, Fibrosis, Wound Healing. - The Immune System, Disorders of the Immune System. Pathology of Tumors.



Module: MICROBIOLOGY
Microorganisms
- Koch's postulates
- Bacterial structure, function and classification
- General characteristics of prokaryotic organisms
- Bacterial physiology
- Commensal organisms that make up the normal bacterial flora
- Bacterial genetics
- Bacterial toxins
- Pathogenesis of bacteria
- Tuberculosis bacteria
- Infections of SNC
- Nosocomial infections
- Microbiota
- Antimicrobial agents against bacteria
- Structure and classification of viruses
- Replicative cycle of viruses
- Disease patterns and viral pathogenesis
- Covid-19
- Therapy and prophylaxis of viral infections
- Clinical virology (hepatitis viruses; HIV, herpes viruses, papillomavirus, influenza virus, polyomavirus)

Module: APPLIED BIOLOGY
STesti consigliati:
E.P. Solomon, L.R. Berg, D.W. Martin. Elementi di biologia e genetica. EDISES
D. Sadava, D.M. Hillis, H.C. Heller, M.R. Berenbaum. Elementi di biologia e genetica. Zanichelli editore.




Module: GENETICS
N/D
Module: GENERAL PATHOLOGY
Suggested textbook:
G.M. Pontieri
Elementi di
Patologia Generale.
Piccin, Padova.

Maurizio Parola
Patologia Generale.
Edises.

PPT files and literature provided by the teacher.


Module: MICROBIOLOGY
non applicabile

Module: APPLIED BIOLOGY
N/D
Module: GENETICS
N/D
Module: GENERAL PATHOLOGY
N/D
Module: MICROBIOLOGY
not applicable

7 lectures of three hours each on the topics indicated in the program of the Applied Biology module.
7 lectures of three hours each on the topics indicated in the program of the Genetics module.
5 lectures of 4 hours each on the topics indicated in the program of the Microbiology module.
20 lectures of 2 hours each on the topics indicated in the program of the General Pathology module.

Attendance at face-to-face or remote lectures, as per "Sapienza" University regulations for undergraduate and graduate degree programs.

Assessment of knowledge acquired on the topics covered during the Applied Biology and Medical Genetics modules through an oral exam in Italian.

Questions on the topics covered during the lessons of the Applied Biology, Medical Genetics, Microbiology, and General Pathology modules.

Module: APPLIED BIOLOGY

• 7 frontal lectures of 3 hours each on the topics indicated in the program

• 7 frontal lectures of 3 hours each on the topics indicated in the program

• 10 frontal lectures of 2 hours each, corresponding to 2 CFU.
  
  Introduction to General Pathology – Cellular Adaptations
  Pathogenesis of Cellular Injury
  Response to Injury – Cell Death
  Components of the Immune System
  The Complement System
  Plasma Factors of Inflammation
  Cellular Factors of Inflammation
  Vascular Inflammation (Angioflogosis)
  Tissue Inflammation and Healing (Histoflogosis)
  General Aspects of Oncology – Tumors

• 5 lectures of 4 hours each on the topics indicated in the program (2 CFU)