Medicine and Surgery "E" - Pontine Campus

ANNA SCOTTO D'ABUSCO
ANNA SCOTTO D'ABUSCO

Based on the attachments to Ministerial Decree no. 418 of May 30, 2025, the syllabus for this course is uniform nationwide and has the following general objectives:

To provide the basis for understanding the fundamental laws governing matter and its transformations, with particular attention to biological phenomena at the atomic and molecular level, in relation to biomedical applications.

1. Understand the importance of chemical bonds and how they stabilize molecular structures. Acquire theoretical knowledge of the principles that regulate the formation and stability of molecules. Understand the importance of molecular structures, with particular attention to the structure-function relationships of simple and complex molecules. 2. Understand the meaning of chemical equilibrium and chemical kinetics.
3. Know the main functional groups of organic molecules and the mechanisms of the main reactions so as to be able to subsequently understand the mechanisms of enzymatic catalysis.
4. Know how to use the knowledge acquired to solve numerical and/or chemical logic problems. Know how to present topics orally in an organized and coherent way, using appropriate scientific language.
5. Recognize the possible applications of the skills acquired in a future medical career.

Notions of algebra, physics and chemistry at the secondary school level

Program of General Chemistry module.
The matter: atomic and molecular orbitals; Periodic Table.
Chemical bonds, strong and weak interactions, states of matter.
The behaviour of Gases: ideal/real gas laws,solubility of gases in liquids
Solutions: definition and properties.
Concentration; vapour pressure; electrolytes; dissociation equilibrium;
colligative properties; osmosis.
Redox reactions and electron transfer; biological relevance.
Thermodynamics: enthalpy, entropy, free energy and temperature. Equilibrium.
Chemical reactions: equilibrium and kinetics; the
mass action low and the equilibrium constant.
Water solutions: acids, bases strength and pH;
buffers, the interaction of salts with water.

Program of Bio-organic Chemistry module

The biomolecules: classification, shape and conformation.
Hydrocarbon compounds, linear and cyclic, saturated and unsaturated, homocyclic and heterocyclic: nomenclature, classification, properties.
Functional groups, chemical properties and biomedical relevance: the carbonyl group, aldehides and ketons; the carboxylic group, the alcoholic hydroxyl- , the amino- and the sulphydril- group; ethers and esters.
Glucides: nomenclature and classification.
Structure stabilization and stereochemistry, anomeric carbons and mutarotation. Redox properties of saccharides.
Mono-, di- and polysaccharides: structural properties and stabilizing bonds.
Aminoacids: nomenclature and classification. Structure stabilization and stereochemistry.
The functional groups and the a-Carbon properties. Protonation and deprotonation equilibria.
Proteins: primary, secondary, tertiary and quaternary structure; denaturation and folding.
Lipids: nomenclature and classification. Fatty acids, mono- di- tri-glycerides; basic structure of phospholipids and bio-membranes. Cholesterol.
Seminars and video tutorials.

Quantitative analysis of solutions (acids, bases, salt and buffer solutions).
Classroom tests.

T. Bellini - Chimica Medica e Propedeutica Biochimica – ed. Zanichelli
F.A. Bettelheim – Chimica e Propedeutica Biochimica - ed. EDISES
S. Marini, F. Malatesta, E. Santaniello, et al. - Chimica Propedeutica Biochimica – ed. Piccin
AAVV – Chimica per il Semestre filtro – ed. EDRA

Lectures in blended mode, in person and at a distance

Mandatory

Tests provided by the Ministry

Tests provided by the Ministry