Medical Biotechnology

Short recapitulation of calculus applied to biomechanics Fluid dynamics of the circulatory system; Statics of fluids: hydrostatic pressure; Mechanical balance, application to centrifuges and ultra-centrifuges. Equations of mass conservation, application to blood vessels (stenosis and aneurisms). Equation of momentum conservation, Poiseuille and Hagen-Poiseuille flows, blood vessel bifurcations. Reynolds transport theorem, Navier-Stokes equations; Dimensionless numbers (Reynolds and Womersley numbers and flows in blood vessels). Bernoulli's equation. Stress on the walls of blood vessels; effect of the geometry and elasticity of vessels; fundamentals of blood rheology. Mechanics and fluid dynamics of cardiovascular devices. Fluid dynamics of the respiratory system and of some of its pathologies. Introduction to tribology applied to biomechanics. Overview of micro- and nanotechnologies for medical biotechnologies.

Basic knowledge of calculus. Supplementary classes will be delivered at the beginning of the course to review these topics.

Notes and slides provided by the teacher

Lectures; final group project with presentation

compulsory

Oral exam with the objective of assessing the knowledge of the topics covered during the course. Weight: ca. 40% of the final score. Presentation of a group project analysing a recent research of interest for biofluiddynamics; this part of the exam weighs ca. 60% of the final score and its objective is to assess the capacity to work in a team and to independently apply and communicate the knowledge acquired during the course.

Fung, Y. C. (2013). Biomechanics: circulation. Springer Science & Business Media. Kundu, P. K., Cohen, I. M., & Dowling, D. R. (2012). Fluid Mechanics, V edition. Academic Press Caro, C. G., Pedley, T.J., Schroter, R.C., & Seed, W.A. (2012). The mechanics of the circulation. Cambridge University Press G.R. Barani, M.F. Kiani, S.P. Samuel, “Healthcare and Biomedical Technology in the 21st Century”, Springer 2014 “Basic biomechanics of the musculoskeletal system”, Edited by M. Nordin, V.H. Frankel; Wolters Kluwer, 4th ed., Ch. 3 “Biomechanics of Articular Cartilage" Mow, V.C., Ateshian, G.A. (1997). Lubrication and wear of diarthrodial joints. In V.C. Mow, W.C. Hayes (Eds.). Basic Biomechanics (2nd ed.). Philadelphia: Lippincott–Raven Publishers, 275–315.

Lectures; final group project with presentation