PRE-CLINICAL MEDICO-SCIENTIFIC METHODOLOGY Single channel

Chair (Coordinator) and Rapporteur: N/D

Module 1: General Surgery

Activity type
Clinica generale medica e chirurgica
SSD
MED/18
Year
N/D
Semester
N/D
CFU
1
Hours distribution
12 classroom hours
Lecturers

Module 2: Medical Statistics

Activity type
Inglese scientifico e abilità linguistiche, informatiche e relazionali, pedagogia medica, tecnologie avanzate e a distanza di informazione e comunicazione, Tirocini formativi e di orientamento
SSD
MED/01, MED/01
Year
N/D
Semester
N/D
CFU
4
Hours distribution
36 classroom hours, 25 others hours
Lecturers
PATRIZIO PASQUALETTI

Module 3: Internal Medicine I

Activity type
Clinica generale medica e chirurgica
SSD
MED/09
Year
N/D
Semester
N/D
CFU
1
Hours distribution
12 classroom hours
Lecturers
LAURA D'ERASMO

Module 4: Internal Medicine II

Activity type
Clinica generale medica e chirurgica
SSD
MED/09
Year
N/D
Semester
N/D
CFU
1
Hours distribution
12 classroom hours
Lecturers

Module 5: Nursing

Activity type
Attività formative affini o integrative
SSD
MED/45
Year
N/D
Semester
N/D
CFU
1
Hours distribution
25 others hours
Lecturers

Module 6: Orthopedics

Activity type
Clinica medico-chirurgica dell'apparato locomotore
SSD
MED/33
Year
N/D
Semester
N/D
CFU
1
Hours distribution
12 classroom hours
Lecturers

Module 7: Anesthesiology

Activity type
Tirocini formativi e di orientamento
SSD
MED/41
Year
N/D
Semester
N/D
CFU
1
Hours distribution
25 others hours
Lecturers

Module 8: English Language

Activity type
Inglese scientifico e abilità linguistiche, informatiche e relazionali, pedagogia medica, tecnologie avanzate e a distanza di informazione e comunicazione
SSD
L-LIN/12
Year
N/D
Semester
N/D
CFU
2
Hours distribution
24 classroom hours
Lecturers

Learning outcomes

Module: General Surgery
N/D
Module: Medical Statistics
Students will have to know the essential statistical methodology to answer fundamental clinical questions: validation of diagnostic tests, measurement of the severity of pathological conditions, identification of risk factors for the onset of the most epidemiologically relevant pathologies, identification of prognostic factors in patients, demonstration of effectiveness of interventions with experimental and observational studies.


Module: Internal Medicine I
N/D
Module: Internal Medicine II
N/D
Module: Nursing
N/D
Module: Orthopedics
N/D
Module: Anesthesiology
N/D
Module: English Language
N/D

Prerequisites

Module: General Surgery
N/D
Module: Medical Statistics
Students must have understood the fundamental elements of descriptive and inferential statistics (illustrated respectively in the Medical Statistics module within the integrated course BASIC SCIENTIFIC MEDICAL METHODOLOGY of the Degree in Medicine and Surgery "D" and in the Medical Statistics module within the course integrated PRE-CLINICAL MEDICAL SCIENTIFIC METHODOLOGY of the Degree in Medicine and Surgery "D")


Module: Internal Medicine I
N/D
Module: Internal Medicine II
N/D
Module: Nursing
N/D
Module: Orthopedics
N/D
Module: Anesthesiology
N/D
Module: English Language
N/D

Programme

Module: General Surgery
N/D
Module: Medical Statistics
1)The design of experiments and observational studies
-Comparison of treatments
-Random allocation
-Stratification
-Intention-to-treat
-Cross-over designs
-Experimental units and randomized group designs
-Sampling in clinical and epidemiological studies
-Cross-sectional studies
-Cohort studies
-Case-control studies

2) Estimation and significance testing
-Sample distributions
-Standard error of the sample mean
-Confidence intervals
-Standard error and confidence intervals for the proportion
-Estimation of the difference between two means and between two proportions
-Testing a Hypothesis
-The Sign Test
-Principles of significance testing
-Significance levels and error types
-Unilateral and bilateral significance tests
-Significant, Real and Important
-Tests for comparing means and proportions
-Tests of significance and confidence intervals
-Analysis of variance and comparison of means after analysis of variance

3) Regression and correlation
-Scatter plot
-Regression
-Method of least squares
-Standard error of the regression coefficient
-Use of the regression line for prediction
-Analysis of Residuals
-Violation of assumptions in regression
-Correlation
-Significance test and confidence interval for r
-Use of correlation coefficient
 
4)Rank-based methods (non-parametric), analysis of contingency tables and dichotomous variables
-The Mann-Whitney U-test
-Spearman's rank correlation coefficient, r
-Parametric or non-parametric methods?
-The chi-square association test
-Fisher's exact test
-Odds and Odds Ratio
-Logistic regression

5)Clinical measurements
-Repeatability and measurement error
-Accordance between measurements using Cohen's kappa index
-Comparison between two measurement methods
-Sensitivity and specificity
-Reference interval


Module: Internal Medicine I
N/D
Module: Internal Medicine II
N/D
Module: Nursing
N/D
Module: Orthopedics
N/D
Module: Anesthesiology
N/D
Module: English Language
N/D

Books

Module: General Surgery
N/D
Module: Medical Statistics
Douglas Altman: Practical Statistics for Medical Research, Chapman & Hall


Module: Internal Medicine I
N/D
Module: Internal Medicine II
N/D
Module: Nursing
N/D
Module: Orthopedics
N/D
Module: Anesthesiology
N/D
Module: English Language
N/D

Bibliography

Module: General Surgery
N/D
Module: Medical Statistics
-Schulz KF, Altman DG, Moher D, for the CONSORT Group. CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials.
-von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: guidelines for reporting observational studies.
-Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis CA, Glasziou PP, Irwig L, LijmerJG Moher D, Rennie D, de Vet HCW, Kressel HY, Rifai N, Golub RM, Altman DG, Hooft L, Korevaar DA, Cohen JF, For the STARD Group. STARD 2015: An Updated List of Essential Items for Reporting Diagnostic Accuracy Studies.
-Collins GS, Reitsma JB, Altman DG, Moons KG. Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): The TRIPOD statement.


Module: Internal Medicine I
N/D
Module: Internal Medicine II
N/D
Module: Nursing
N/D
Module: Orthopedics
N/D
Module: Anesthesiology
N/D
Module: English Language
N/D

Lessons mode

Module: General Surgery
N/D
Module: Medical Statistics
Lectures and guided exercises on real data


Module: Internal Medicine I
N/D
Module: Internal Medicine II
N/D
Module: Nursing
N/D
Module: Orthopedics
N/D
Module: Anesthesiology
N/D
Module: English Language
N/D

Frequency

Module: General Surgery
N/D
Module: Medical Statistics
Students must attend Medical Statistics lessons for at least 67% of the total hours.


Module: Internal Medicine I
N/D
Module: Internal Medicine II
N/D
Module: Nursing
N/D
Module: Orthopedics
N/D
Module: Anesthesiology
N/D
Module: English Language
N/D

Exam mode

Module: General Surgery
N/D
Module: Medical Statistics
Written test with a combination of multiple-choice questions and questions requiring to perform statistical calculations


Module: Internal Medicine I
N/D
Module: Internal Medicine II
N/D
Module: Nursing
N/D
Module: Orthopedics
N/D
Module: Anesthesiology
N/D
Module: English Language
N/D

Example exam questions

Module: General Surgery
N/D
Module: Medical Statistics
A study involves randomly assigning patients to three different treatments taking into account that the response could be influenced by exposure to a risk factor. What type of experimental procedure should be used?

In a population, a normal (perfect Gaussian) variable Y has a mean of 100 and a standard deviation of 15. What is the probability of observing a value greater than 129.4?


Module: Internal Medicine I
N/D
Module: Internal Medicine II
N/D
Module: Nursing
N/D
Module: Orthopedics
N/D
Module: Anesthesiology
N/D
Module: English Language
N/D

Arguments

Module: General Surgery
N/D
Module: Medical Statistics

  • Module 1: Clinical Study Designs
    • Books: Douglas Altman: Practical Statistics for Medical Research, Chapman & Hall

  • Module 2: Descriptive and Inferential Statistics
    • Books: Douglas Altman: Practical Statistics for Medical Research, Chapman & Hall

  • Module 3: Clinical Biostatistics Techniques and Procedures
    • Books: Douglas Altman: Practical Statistics for Medical Research, Chapman & Hall



Module: Internal Medicine I
  • Introduction to the course 
    • Books: Teaching materials provided during lessons. Manuale di semeiotica medica. Il metodo clinico passo dopo passo (G. Sesti). Semeiotica medica e metodologia clinica (A. Amoroso). .Semeiotica medica nell'adulto e nell'anziano (G. Fradà) or similar texts

  • The medical record: a medical, legal and scientific tool
    • Books: Teaching materials provided during lessons. Manuale di semeiotica medica. Il metodo clinico passo dopo passo (G. Sesti). Semeiotica medica e metodologia clinica (A. Amoroso). Semeiotica medica nell'adulto e nell'anziano (G. Fradà) or similar texts

  • Anamnesi: listening, observing and interpreting 
    • Books: Teaching materials provided during lessons. Manuale di semeiotica medica. Il metodo clinico passo dopo passo (G. Sesti). Semeiotica medica e metodologia clinica (A. Amoroso).Semeiotica medica nell'adulto e nell'anziano (G. Fradà)  or similar texts

  • Physical examination: listening, observing and interpreting (Part I)
    • Books: Teaching materials provided during lessons. Manuale di semeiotica medica. Il metodo clinico passo dopo passo (G. Sesti). Semeiotica medica e metodologia clinica (A. Amoroso).Semeiotica medica nell'adulto e nell'anziano (G. Fradà)  or similar texts

  • Physical examination: listening, observing and interpreting (Part II)
    • Books: Teaching materials provided during lessons. Manuale di semeiotica medica. Il metodo clinico passo dopo passo (G. Sesti). Semeiotica medica e metodologia clinica (A. Amoroso).Semeiotica medica nell'adulto e nell'anziano (G. Fradà)  or similar texts

  • Medical literature search: practical use of PubMed, Google Scholar, and AI tools
    • Books: Teaching materials provided during lessons. 



Module: Internal Medicine II
N/D
Module: Nursing
N/D
Module: Orthopedics
N/D
Module: Anesthesiology
N/D
Module: English Language
N/D

  • Academic year2026/2027
  • Degree program to which the course belongsMedicine and Surgery "B" - Roma Azienda Policlinico Umberto I
  • Mandatory presenceYes
  • Languageita
  • CFU12 CFU, distributed among 8 integrated didactic modules
  • Total duration183 hours