PRE-CLINICAL MEDICO-SCIENTIFIC METHODOLOGY Single channel
Chair (Coordinator) and Rapporteur: N/D
Module 1: General Surgery
- Activity type
- Clinica generale medica e chirurgica
- SSD
- MED/18
- Year
- N/D
- Semester
- N/D
- CFU
- 1
- Hours distribution
- 12 classroom hours
- Lecturers
Module 2: Medical Statistics
- Activity type
- Inglese scientifico e abilità linguistiche, informatiche e relazionali, pedagogia medica, tecnologie avanzate e a distanza di informazione e comunicazione, Tirocini formativi e di orientamento
- SSD
- MED/01, MED/01
- Year
- N/D
- Semester
- N/D
- CFU
- 4
- Hours distribution
- 36 classroom hours, 25 others hours
- Lecturers
- PATRIZIO PASQUALETTI
Module 3: Internal Medicine I
- Activity type
- Clinica generale medica e chirurgica
- SSD
- MED/09
- Year
- N/D
- Semester
- N/D
- CFU
- 1
- Hours distribution
- 12 classroom hours
- Lecturers
- LAURA D'ERASMO
Module 4: Internal Medicine II
- Activity type
- Clinica generale medica e chirurgica
- SSD
- MED/09
- Year
- N/D
- Semester
- N/D
- CFU
- 1
- Hours distribution
- 12 classroom hours
- Lecturers
Module 5: Nursing
- Activity type
- Attività formative affini o integrative
- SSD
- MED/45
- Year
- N/D
- Semester
- N/D
- CFU
- 1
- Hours distribution
- 25 others hours
- Lecturers
Module 6: Orthopedics
- Activity type
- Clinica medico-chirurgica dell'apparato locomotore
- SSD
- MED/33
- Year
- N/D
- Semester
- N/D
- CFU
- 1
- Hours distribution
- 12 classroom hours
- Lecturers
Module 7: Anesthesiology
- Activity type
- Tirocini formativi e di orientamento
- SSD
- MED/41
- Year
- N/D
- Semester
- N/D
- CFU
- 1
- Hours distribution
- 25 others hours
- Lecturers
Module 8: English Language
- Activity type
- Inglese scientifico e abilità linguistiche, informatiche e relazionali, pedagogia medica, tecnologie avanzate e a distanza di informazione e comunicazione
- SSD
- L-LIN/12
- Year
- N/D
- Semester
- N/D
- CFU
- 2
- Hours distribution
- 24 classroom hours
- Lecturers
Learning outcomes
Module: General Surgery
N/D
Module: Medical Statistics
Students will have to know the essential statistical methodology to answer fundamental clinical questions: validation of diagnostic tests, measurement of the severity of pathological conditions, identification of risk factors for the onset of the most epidemiologically relevant pathologies, identification of prognostic factors in patients, demonstration of effectiveness of interventions with experimental and observational studies.
Module: Internal Medicine I
N/D
Module: Internal Medicine II
N/D
Module: Nursing
N/D
Module: Orthopedics
N/D
Module: Anesthesiology
N/D
Module: English Language
N/D
Prerequisites
Module: General Surgery
N/D
Module: Medical Statistics
Students must have understood the fundamental elements of descriptive and inferential statistics (illustrated respectively in the Medical Statistics module within the integrated course BASIC SCIENTIFIC MEDICAL METHODOLOGY of the Degree in Medicine and Surgery "D" and in the Medical Statistics module within the course integrated PRE-CLINICAL MEDICAL SCIENTIFIC METHODOLOGY of the Degree in Medicine and Surgery "D")
Module: Internal Medicine I
N/D
Module: Internal Medicine II
N/D
Module: Nursing
N/D
Module: Orthopedics
N/D
Module: Anesthesiology
N/D
Module: English Language
N/D
Programme
Module: General Surgery
N/D
Module: Medical Statistics
1)The design of experiments and observational studies
-Comparison of treatments
-Random allocation
-Stratification
-Intention-to-treat
-Cross-over designs
-Experimental units and randomized group designs
-Sampling in clinical and epidemiological studies
-Cross-sectional studies
-Cohort studies
-Case-control studies
2) Estimation and significance testing
-Sample distributions
-Standard error of the sample mean
-Confidence intervals
-Standard error and confidence intervals for the proportion
-Estimation of the difference between two means and between two proportions
-Testing a Hypothesis
-The Sign Test
-Principles of significance testing
-Significance levels and error types
-Unilateral and bilateral significance tests
-Significant, Real and Important
-Tests for comparing means and proportions
-Tests of significance and confidence intervals
-Analysis of variance and comparison of means after analysis of variance
3) Regression and correlation
-Scatter plot
-Regression
-Method of least squares
-Standard error of the regression coefficient
-Use of the regression line for prediction
-Analysis of Residuals
-Violation of assumptions in regression
-Correlation
-Significance test and confidence interval for r
-Use of correlation coefficient
4)Rank-based methods (non-parametric), analysis of contingency tables and dichotomous variables
-The Mann-Whitney U-test
-Spearman's rank correlation coefficient, r
-Parametric or non-parametric methods?
-The chi-square association test
-Fisher's exact test
-Odds and Odds Ratio
-Logistic regression
5)Clinical measurements
-Repeatability and measurement error
-Accordance between measurements using Cohen's kappa index
-Comparison between two measurement methods
-Sensitivity and specificity
-Reference interval
Module: Internal Medicine I
N/D
Module: Internal Medicine II
N/D
Module: Nursing
N/D
Module: Orthopedics
N/D
Module: Anesthesiology
N/D
Module: English Language
N/D
Books
Module: General Surgery
N/D
Module: Medical Statistics
Douglas Altman: Practical Statistics for Medical Research, Chapman & Hall
Module: Internal Medicine I
N/D
Module: Internal Medicine II
N/D
Module: Nursing
N/D
Module: Orthopedics
N/D
Module: Anesthesiology
N/D
Module: English Language
N/D
Bibliography
Module: General Surgery
N/D
Module: Medical Statistics
-Schulz KF, Altman DG, Moher D, for the CONSORT Group. CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials.
-von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: guidelines for reporting observational studies.
-Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis CA, Glasziou PP, Irwig L, LijmerJG Moher D, Rennie D, de Vet HCW, Kressel HY, Rifai N, Golub RM, Altman DG, Hooft L, Korevaar DA, Cohen JF, For the STARD Group. STARD 2015: An Updated List of Essential Items for Reporting Diagnostic Accuracy Studies.
-Collins GS, Reitsma JB, Altman DG, Moons KG. Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): The TRIPOD statement.
Module: Internal Medicine I
N/D
Module: Internal Medicine II
N/D
Module: Nursing
N/D
Module: Orthopedics
N/D
Module: Anesthesiology
N/D
Module: English Language
N/D
Lessons mode
Module: General Surgery
N/D
Module: Medical Statistics
Lectures and guided exercises on real data
Module: Internal Medicine I
N/D
Module: Internal Medicine II
N/D
Module: Nursing
N/D
Module: Orthopedics
N/D
Module: Anesthesiology
N/D
Module: English Language
N/D
Frequency
Module: General Surgery
N/D
Module: Medical Statistics
Students must attend Medical Statistics lessons for at least 67% of the total hours.
Module: Internal Medicine I
N/D
Module: Internal Medicine II
N/D
Module: Nursing
N/D
Module: Orthopedics
N/D
Module: Anesthesiology
N/D
Module: English Language
N/D
Exam mode
Module: General Surgery
N/D
Module: Medical Statistics
Written test with a combination of multiple-choice questions and questions requiring to perform statistical calculations
Module: Internal Medicine I
N/D
Module: Internal Medicine II
N/D
Module: Nursing
N/D
Module: Orthopedics
N/D
Module: Anesthesiology
N/D
Module: English Language
N/D
Example exam questions
Module: General Surgery
N/D
Module: Medical Statistics
A study involves randomly assigning patients to three different treatments taking into account that the response could be influenced by exposure to a risk factor. What type of experimental procedure should be used?
In a population, a normal (perfect Gaussian) variable Y has a mean of 100 and a standard deviation of 15. What is the probability of observing a value greater than 129.4?
Module: Internal Medicine I
N/D
Module: Internal Medicine II
N/D
Module: Nursing
N/D
Module: Orthopedics
N/D
Module: Anesthesiology
N/D
Module: English Language
N/D
Arguments
Module: General Surgery
N/D
Module: Medical Statistics
- Module 1: Clinical Study Designs
- Module 2: Descriptive and Inferential Statistics
- Module 3: Clinical Biostatistics Techniques and Procedures
Module: Internal Medicine I
- Introduction to the course
- The medical record: a medical, legal and scientific tool
- Anamnesi: listening, observing and interpreting
- Physical examination: listening, observing and interpreting (Part I)
- Physical examination: listening, observing and interpreting (Part II)
- Medical literature search: practical use of PubMed, Google Scholar, and AI tools
Module: Internal Medicine II
N/D
Module: Nursing
N/D
Module: Orthopedics
N/D
Module: Anesthesiology
N/D
Module: English Language
N/D
- Academic year2026/2027
- Degree program to which the course belongsMedicine and Surgery "B" - Roma Azienda Policlinico Umberto I
- Mandatory presenceYes
- Languageita
- CFU12 CFU, distributed among 8 integrated didactic modules
- Total duration183 hours