Medicine and Surgery HT

Activity type

Farmacologia, tossicologia e principi di terapia medica

SSD

BIO/14

Year

4th year

Semester

1st semester

CFU

4

Hours distribution

52 classroom hours

Lecturers

ALDO BADIANI
ANTONIA MANDUCA
ROBERTA LATTANZI

Activity type

Attività formative affini o integrative

SSD

ING-IND/06

Year

5th year

Semester

1st semester

CFU

1

Hours distribution

13 classroom hours

Lecturers

LUCA MARINO

Activity type

Attività formative affini o integrative

SSD

ING-INF/02

Year

5th year

Semester

1st semester

CFU

1

Hours distribution

13 classroom hours

Lecturers

FRANCESCA APOLLONIO

Activity type

Farmacologia, tossicologia e principi di terapia medica

SSD

BIO/14

Year

5th year

Semester

1st semester

CFU

6

Hours distribution

78 classroom hours

Lecturers

ALDO BADIANI
ANTONIA MANDUCA

Basic notions of Pharmacodynamics, Pharmacokinetics, and Neuropsychopharmacology

Human Physiology, General Pathology, Clinical Methodology

Module: PHARMACOLOGY 1
INTRODUCTION
Evidence-based medicine. Placebo effect. Introduction to Pharmacology.

PHARMACODYNAMICS
Mechanisms of drug action. Drug targets: G-protein coupled receptors, catalytic receptors, ligand-gated ion channels, other ion channels, nuclear receptors, transporters, enzymes. Drug sensitization and tolerance. Binding curves: definition of orthosteric and allosteric binding sites and ligands. Graduated concentration-response curves: definition of agonist, partial agonist, inverse agonists, antagonist.

PHARMACOKINETICS
Routes of administration. Absorption. Distribution. Biotransformation. Renal and extrarenal excretion of drugs. Pharmacokinetics parameters: bioavailability, compartments, volume of distribution, plasma half-life, clearance.

CLINICAL PHARMACOLOGY
Mechanisms of drug interaction mechanisms. Individual differences in pharmacology. Quantal dose-response curves.

PHYSIO-PHARMACOLOGY OF NEURAL TRANSMISSION

NEUROPHARMACOLOGY OF PAIN
Definition of pain. Pain receptors and pain pathways. Opioid and non opioid analgesics. Definition of anesthesia. General anesthetics. Local anesthetics.

NEUROPHARMACOLOGY OF NEURODEGENERATIVE DISORDERS
Dopaminergic system. Parkinson's Disease.

NEUROPSYCHOPHARMACOLOGY
Antipsychotics. Antidepressants. Anxiolytics. Substances of abuse: psychostimulants, opioids, alcohol, tobacco, cannabis, hallucinogenic drugs. Drug reward. Drug harm (including drug addiction). Drug addiction treatment.


Module: ADVANCED PHARMACOLOGICAL TECHNOLOGIES
N/D
Module: Drug-delivery techniques mediated by electromagnetic fields
-Introduction to aspects of drug delivery
-E-field mediated drug delivery
-electroporation
-electrochemotherapy
-examples of applications
-H-field mediated drug delivery
-coupling mechanisms with magnetic NPs
-magnetoliposomes
-examples of applications


Module: Biofluiddynamics and drug delivery
N/D

Module: PHARMACOLOGY 1
Goodman and Gilman's The Pharmacological Basis of Therapeutics, 14th Edition. Laurence Brunton, Bjorn Knollmann (Ed.) McGraw Hill (29 Mar. 2023)

or

Katzung's Basic and Clinical Pharmacology, 16th Edition. Todd W. Vanderah (Ed.). McGraw Hill (19 Jan. 2024)


Module: ADVANCED PHARMACOLOGICAL TECHNOLOGIES
N/D
Module: Drug-delivery techniques mediated by electromagnetic fields
Lecturer's handout and some reference review papers; all the material is available on the elearning website related
to the course


Module: Biofluiddynamics and drug delivery
N/D

Module: PHARMACOLOGY 1
N/D
Module: ADVANCED PHARMACOLOGICAL TECHNOLOGIES
N/D
Module: Drug-delivery techniques mediated by electromagnetic fields
N/D
Module: Biofluiddynamics and drug delivery
N/D

Module: PHARMACOLOGY 1
N/D
Module: ADVANCED PHARMACOLOGICAL TECHNOLOGIES
N/D
Module: Drug-delivery techniques mediated by electromagnetic fields
N/D
Module: Biofluiddynamics and drug delivery
N/D

Lecture attendance is mandatory

Exam questions will concern basic knowledge of pharmacology relevant to medical practice

Module: PHARMACOLOGY 1
N/D
Module: ADVANCED PHARMACOLOGICAL TECHNOLOGIES
N/D
Module: Drug-delivery techniques mediated by electromagnetic fields
N/D
Module: Biofluiddynamics and drug delivery
N/D

Module: PHARMACOLOGY 1

• Lectures on: Introduction, Pharmacodynamics, Drug development, Pharmacovigilance,  Pharmacokinetics, Individual differences in Pharmacology, Pain and analgesia, Analgesics, Pharmacology of Parkinson's Disease, Antipsychotics, Substances of abuse, Substance use disorders, Drug harm, Treatment of substance use disorders, Antidepressants, Anxiolytics

• Module 1 - Introduction to
  Biofluid Dynamics (2 h)
  Fundamental fluid dynamics
  concepts applied to biological
  systems Properties of
  biological fluids: blood, lymph,
  interstitial fluids Flow regimes:
  laminar, pulsatile, turbulent in
  blood vessels
  • Books: Fung, Y.C. -
    
    Biomechanics:
    
    Circulation, Springer,
    
    1997 Pozrikidis, C. -
    
    Introduction to
    
    Theoretical and
    
    Computational
    
    Biophysical Fluid
    
    Dynamics, Oxford
    
    University Press, 2010
    
    Lustig, S. & Jain, R.K. -
    
    Principles of Drug
    
    Delivery, Cambridge
    
    University Press, 2022


• Module 2 - Blood Flow
  Dynamics and Solute Transport
  (2 h) Hemodynamic models
  (Poiseuille flow, pulsatile flow,
  non-Newtonian effects)
  Diffusion, convection, and
  permeability across biological
  membranes Factors influencing
  molecular and drug transport in
  the bloodstream
  • Books: Fung, Y.C. -
    
    Biomechanics:
    
    Circulation, Springer,
    
    1997 Pozrikidis, C. -
    
    Introduction to
    
    Theoretical and
    
    Computational
    
    Biophysical Fluid
    
    Dynamics, Oxford
    
    University Press, 2010
    
    Lustig, S. & Jain, R.K. -
    
    Principles of Drug
    
    Delivery, Cambridge
    
    University Press, 2022


• Module 3 - Principles of
  Pharmacokinetics and Drug
  Distribution (2 h)
  Compartmental
  pharmacokinetic models
  (ADME: Absorption, Distribution,
  Metabolism, Elimination)
  Interaction between blood flow
  and drug distribution
  Transcapillary transport and the role of oncotic and hydrostatic
  pressures
  • Books: Fung, Y.C. - Biomechanics: Circulation, Springer, 1997 Pozrikidis, C. - Introduction to Theoretical and Computational Biophysical Fluid Dynamics, Oxford University Press, 2010 Lustig, S. & Jain, R.K. - Principles of Drug Delivery, Cambridge University Press, 2022


• Module 4 - Clinical
  Applications and Advanced
  Models (2 h) Targeted drug
  delivery (nanoparticles,
  controlled release systems)
  Biofluid dynamics and
  biological barriers (BBB -
  blood-brain barrier) Case studies in oncology and
  cardiovascular pharmacology
  • Books: Fung, Y.C. - Biomechanics: Circulation, Springer, 1997 Pozrikidis, C. - Introduction to Theoretical and Computational Biophysical Fluid Dynamics, Oxford University Press, 2010 Lustig, S. & Jain, R.K. - Principles of Drug Delivery, Cambridge University Press, 2022

• Introduction to aspects of drug delivery
  • Books: Lecturer's handout and some reference review papers; all the
    
    material is available on the elearning website related to the course
    
    
    
     


•  E-field mediated drug delivery       
  -electroporation        -electrochemotherapy   
      -examples of applications 
  • Books: Lecturer's handout and some reference review papers; all the
    
    material is available on the elearning website related to the course
    
    
    
     


•  H-field mediated drug delivery     
   -coupling mechanisms with           
  magnetic NPs       -magnetoliposomes     
   -examples of applications
  • Books: Lecturer's handout and some reference review papers; all the
    
    material is available on the elearning website related to the course