Alessia.Ciogli@uniroma1.it's picture

Il corso di Chimica organica e chimica delle sostanze organiche naturali  (A-D e P-Z) si svolgerà in modalità mista.

 

I link per accedere alle lezioni a distanza saranno a disposizione per tutto il periodo del corso sulla pagina https://elearning.uniroma1.it/course/view.phpid=2561

 

Saranno organizzate inoltre lezioni interattive via skype o via Google Meet per classi di studenti. La programmazione verrà fatta di volta in volta. 

lunedì ore 10-12, stanza n.1, 3° piano NEC CU032

Actual position: Associate Professor of Organic Chemistry
At Dipartimento di Chimica e tecnologia del farmaco

Education

University graduation 2001 Sapienza
Università di Roma Laurea (master s degree) in Pharmaceutical Chemistry and Technology

Post-graduate studies 2006 Sapienza
Università di Roma PhD in Pharmaceutical Sciences (Dottorato di ricerca in Scienze Farmaceutiche, XVIII Ciclo)

Teaching experience

Year Institution Lecture/Course

2015-present Sapienza
Università di Roma Chimica organica e chimica delle sostanze organiche naturali , canali A-D e P-Z, degree course SFA, 9 CFU
2005-present Sapienza
Università di Roma Esercitazioni di Metodi fisici in chimica organica , master degree course CTF

Research Activities

The research activity can be arranged in two main lines: i) synthesis of chromatographic supports for molecular recognition studies and ii) study of stability/instability of bioactive compounds mainly enantiomers. The first line focuses in the field of separation science and includes as corollary some studies of advanced methodologies in the analysis of chiral and bioactive molecules. The second line is related to stereochemistry and focused in the stability of atropoisomers. From last years, as consequence of interaction or fusion of two research lines, the research has been also dedicated to development of supported organocatalysts for heterogeneous batch and flow catalysis.
Fields of interest:
- synthesis of chromatographic supports for HPLC and UHPLC in order to investigate their recognition properties towards molecules of biological and pharmaceutical interest. (chiral brush-type and receptor-like selectors)
- study of stereochemical stability of bioactive compounds as potential new drugs or organocatalysts in asymmetric synthesis by HPLC and NMR. (off-column method, dynamic HPLC and dynamic NMR)
- development of solid supported catalyst based on silica or polymethacrylate media. (chiral amine as catalysts)

Scientific Production
More than 70 papers, 5 book chapters, 1 patent. H index: 22
Last two-year publications

- Calcaterra, Andrea; Iovine, Valentina et al. Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61. Journal of Enzyme Inhibition and Medicinal Chemistry, 2018 DOI:10.1080/14756366.2017.1419221

- Alessia Ciogli, Omar H. Ismail, Giulia Mazzoccanti, Claudio Villani, Francesco Gasparrini Enantioselective Ultra-High Performance LC and SFC: the race to the shortest chromatogram. J. Separation Science 2018 DOI: 10.1002/jssc.201701406

- Sergio Menta, Alessia Ciogli, Claudio Villani, Francesco Gasparrini, Marco Pierini, Recognition mechanism of aromatic derivatives resolved by argentation chromatography: The driving role played by substituent groups. Analitica chimica Acta 2018 DOI: 10.1016/j.aca.2018.02.038

- Corradi S., Mazzoccanti G., Ghirga F., Quaglio D., Nevola L., Massera C., Ugozzoli F., Giannini G., Ciogli A., D'Acquarica I. Synthesis of Bromoundecyl Resorc[4]arenes and Applications of the Cone Stereoisomer as Selector for Liquid Chromatography Journal of Organic Chemistry, 2018 DOI: 10.1021/acs.joc.8b00488.

- Fabrizi Cacchi, Sandro; Ciogli, Alessia; Demitri, Nicola; Fabrizi, Giancarlo; Ghirga, Francesca; Goggiamani, Antonella; Iazzetti, Antonia; Lamba, Doriano. Copper-Catalyzed C N Bond Formation via C H Functionalization: Facile Synthesis of Multisubstituted Imidazo[1,2-a]pyridines from N-(2-Pyridinyl)enaminones. Synthesis 2018 DOI: 10.1055/s-0037-1610071

- Ceccacci F, Sennato S, Rossi E, Proroga R, Sarti S, Diociaiuti M, Casciardi S, Mussi V, Ciogli A, Bordi F, Mancini G, Bombelli C, Aggregation behaviour of triphenylphosphonium bolaamphiphiles J. of Colloid and Interface Science, 2018 DOI: 10.1016/j.jcis.2018.07.067

- Ismail, O.H., Losacco, G.L., Mazzoccanti, G., Ciogli, A., Villani, C., Catani, M., Pasti, L., Anderson, S., Cavazzini, A., Gasparrini, F. Unmatched kinetic performance in enantioselective supercritical fluid chromatography by combining latest generation whelk-O1 chiral stationary phases with a low-dispersion in-house modified equipment. Anal. Chem. 2018, 90, 10828 10836.

- Ismail OH, Antonelli M, Ciogli A, De Martino M, Catani, M, Villani C, Cavazzini A, Ye M, Bell DS, Gasparrini F, Direct analysis of chiral active pharmaceutical ingredients and their counterions by ultra-high performance liquid chromatography with macrocyclic glycopeptide-based chiral stationary phases, Journal of Chromatography A 2018 DOI: 10.1016/j.chroma.2018.09.029.

- G Manzi, F Buonsenso, OH Ismail, A Ciogli, G Siani, M Pierini, Modular and conservative procedure for the quantification of amino functionalities bonded to solid porous matrices, Analytica chimica acta 2019 1068, 120-130.

- A Ciogli, D Capitani, N Di Iorio, S Crotti, G Bencivenni, MP Donzello, C. Villani. A Silica Supported Catalyst Containing 9 Amino 9 deoxy 9 epi quinine and a Benzoic Acid Derivative for Stereoselective Batch and Flow Heterogeneous Reactions. European Journal of Organic Chemistry 2019 (10), 2020-2028 .

- G Stazi, C Battistelli, V Piano, R Mazzone, B Marrocco, S Marchese, etc, Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells, European journal of medicinal chemistry 2019, 163, 722-735.

- A Arcadi, A Ciogli, G Fabrizi, A Fochetti, R Franzini, F Ghirga, etc, Synthesis of pyrano [2,3-f] chromen-2-ones vs. pyrano [3,2-g] chromen-2-ones through site controlled gold-catalyzed annulations, Organic & biomolecular chemistry 2019, 17 (47), 10065-10072.

- S Manetto, G Mazzoccanti, A Ciogli, C Villani, F Gasparrini, Ultra high performance separation of basic compounds on reversed phase columns packed with fully/superficially porous silica and hybrid particles by using UV transparent, Journal of Separation Science, 2020, DOI: 10.1002/jssc.201901333

Course Code Year Course - Attendance
Training AAF1044 2021/2022 Applied Pharmaceutical Sciences
ELEMENTS OF CHEMISTRY AND ECOLOGY 1036543 2021/2022 Environment and Workplace Prevention Techniques
ORGANIC CHEMISTRY ORGANIC NATURAL COMPOUNDS CHEMISTRY 1036054 2021/2022 Applied Pharmaceutical Sciences
Training AAF1044 2020/2021 Applied Pharmaceutical Sciences
ORGANIC CHEMISTRY ORGANIC NATURAL COMPOUNDS CHEMISTRY 1036054 2020/2021 Applied Pharmaceutical Sciences
Training AAF1044 2019/2020 Applied Pharmaceutical Sciences
ORGANIC CHEMISTRY ORGANIC NATURAL COMPOUNDS CHEMISTRY 1036054 2019/2020 Applied Pharmaceutical Sciences
Training AAF1044 2018/2019 Applied Pharmaceutical Sciences
ORGANIC CHEMISTRY ORGANIC NATURAL COMPOUNDS CHEMISTRY 1036054 2018/2019 Applied Pharmaceutical Sciences
Training AAF1044 2017/2018 Applied Pharmaceutical Sciences
ORGANIC CHEMISTRY ORGANIC NATURAL COMPOUNDS CHEMISTRY 1036054 2017/2018 Applied Pharmaceutical Sciences
ORGANIC CHEMISTRY ORGANIC NATURAL COMPOUNDS CHEMISTRY 1036054 2016/2017 Applied Pharmaceutical Sciences
Title Journal Year
Static vs. Dynamic Electrostatic Repulsion Reversed Phase Liquid Chromatography: Solutions for Pharmaceutical and Biopharmaceutical Basic Compounds SEPARATIONS 2021
Mannosyl, glucosyl or galactosyl liposomes to improve resveratrol efficacy against Methicillin Resistant Staphylococcus aureus biofilm COLLOIDS AND SURFACES. A, PHYSICOCHEMICAL AND ENGINEERING ASPECTS 2021
Salivary caffeine in Parkinson’s disease SCIENTIFIC REPORTS 2021
Chromatographic separation of the interconverting enantiomers of imidazo- and triazole-fused benzodiazepines JOURNAL OF CHROMATOGRAPHY A 2021
Ultra-high performance separation of basic compounds on reversed-phase columns packed with fully/superficially porous silica and hybrid particles by using ultraviolet transparent hydrophobic cationic additives JOURNAL OF SEPARATION SCIENCE 2020
Sulfonamide inhibitors of beta-Catenin signaling as anticancerAgents with different output on c-Myc CHEMMEDCHEM 2020
Molecular Recognition of the HPLC Whelk-O1 Selector towards the Conformational Enantiomers of Nevirapine and Oxcarbazepine INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2020
Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2019
A silica-supported catalyst containing 9-amino-9-deoxy-9-epi-quinine and a benzoic acid derivative for stereoselective batch and flow heterogeneous reactions EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2019
Modular and conservative procedure for the quantification of amino functionalities bonded to solid porous matrices ANALYTICA CHIMICA ACTA 2019
An innovative method for quantification of basic sites linked on solid matrices 2019
Synthesis of pyrano[2,3-: F] chromen-2-ones vs. pyrano[3,2-g] chromen-2-ones through site controlled gold-catalyzed annulations ORGANIC & BIOMOLECULAR CHEMISTRY 2019
Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61 JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2018
Enantioselective ultra high performance liquid and supercritical fluid chromatography: the race to the shortest chromatogram JOURNAL OF SEPARATION SCIENCE 2018
Recognition mechanism of aromatic derivatives resolved by argentation chromatography: The driving role played by substituent groups ANALYTICA CHIMICA ACTA 2018
Stepwise “bridge-to-bridge” reduction of monoclonal antibodies and light chain detection: case studies of tenatumomab and trastuzumab SEPARATION SCIENCE PLUS 2018
Synthesis of bromoundecyl resorc[4]arenes and applications of the cone stereoisomer as selector for liquid chromatography JOURNAL OF ORGANIC CHEMISTRY 2018
Recent developments in chiral separations by supercritical fluid chromatography 2018
Aggregation behaviour of triphenylphosphonium bolaamphiphiles JOURNAL OF COLLOID AND INTERFACE SCIENCE 2018
Unmatched kinetic performance in enantioselective supercritical fluid chromatography by combining latest generation whelk-O1 chiral stationary phases with a low-dispersion in-house modified equipment ANALYTICAL CHEMISTRY 2018
Department
CHIMICA E TECNOLOGIE DEL FARMACO
SSD

CHIM/06