antonio.coluccia@uniroma1.it's picture

Tutti i giorni previo appuntamento via mail.
Venerdì 10.00 - 12.00

He graduated at La Sapienza, University of Roma in 2004, he obtained his Ph.D in 2008 working on a project on Non-nucleosidic Inhibitors of HIV reverse transcriptase at Rome Centre of Molecular Design of La Sapienza University. He then moves to the Cardiff Welsh school of Pharmacy funded by Pasteur Institute Fondazione Cenci Bolognetti (Borsa di studio per ricerche estero 2007). In Cardiff he worked as Post Doc researcher at the development of small molecules as tubulin polymerization inhibitors. In 2010 he was awarded by Pasteur Institute Fondazione Cenci Bolognetti (Borsa di studio per ricerche italia 2010) of a two years post-doc bursary to work on the development of novel anti tubulin binding agents. In 2012 Department of Chimica e Tecnologie del Farmaco of La Sapienza University of Rome granted him with a one year research bursary titled: Application of computational procedures in the design of new antimicrobial agents.
Since April 2015 he is researcher (RTD-A) at the Dip. of Chimica e Tecnologie del Farmaco of La Sapienza University of Rome
Since July 2020 he is researcher (RTD-B) at the Dip. of Chimica e Tecnologie del Farmaco of La Sapienza University of Rome

Course Code Year Course - Attendance
ANALYSIS OF MEDICINAL PRODUCTS WITH LABORATORY 10595409 2021/2022 Pharmacy
PHARMACEUTICAL AND TOXICOLOGICAL ANALYSIS WITH LABORATORY 1026150 2020/2021 Pharmacy
PHARMACEUTICAL AND TOXICOLOGICAL ANALYSIS WITH LABORATORY 1026150 2019/2020 Pharmacy
PHARMACEUTICAL AND TOXICOLOGICAL ANALYSIS WITH LABORATORY 1026150 2018/2019 Pharmacy
PHARMACEUTICAL AND TOXICOLOGICAL ANALYSIS WITH LABORATORY 1026150 2017/2018 Pharmacy
PHARMACEUTICAL AND TOXICOLOGICAL ANALYSIS WITH LABORATORY 1026150 2016/2017 Pharmacy
Title Journal Year
Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2021
Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2020
Discovery of Zika virus NS2B/NS3 inhibitors that prevent mice from fife-threatening infection and brain damage ACS MEDICINAL CHEMISTRY LETTERS 2020
New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2020
Enzymatic kinetic resolution of desmethylphosphinothricin indicates that phosphinic group is a bioisostere of carboxyl group COMMUNICATIONS CHEMISTRY 2020
Modeling Epac1 interactions with the allosteric inhibitor AM-001 by co-solvent molecular dynamics JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN 2020
Sulfonamide inhibitors of beta-Catenin signaling as anticancerAgents with different output on c-Myc CHEMMEDCHEM 2020
Mutational analysis of the essential lipopolysaccharide-transport protein LptH of Pseudomonas aeruginosa to uncover critical oligomerization sites SCIENTIFIC REPORTS 2020
Targeting the interaction between the SH3 domain of Grb2 and Gab2 CELLS 2020
Drug design and synthesis of first in class PDZ1 targeting NHERF1 inhibitors as anticancer agents ACS MEDICINAL CHEMISTRY LETTERS 2019
Towards modern anticancer agents that interact with tubulin EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 2019
Nox2-mediated platelet activation by glycoprotein (GP) VI: Effect of rivaroxaban alone and in combination with aspirin BIOCHEMICAL PHARMACOLOGY 2019
Small molecule inhibitors of KDM5 histone demethylases increase the radiosensitivity of breast cancer cells overexpressing Jarid1b MOLECULES 2019
Switching on the activity of 1,5-diaryl-pyrrole derivatives against drug-resistant ESKAPE bacteria: structure-activity relationships and mode of action studies EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2019
Identification of a pharmacological inhibitor of Epac1 that protects the heart against acute and chronic models of cardiac stress CARDIOVASCULAR RESEARCH 2019
β-catenin knockdown promotes nherf1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy ONCOGENE 2018
New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2018
Treating chronic myeloid leukemia by inhibition of tubulin polymerization 2018
Structure-based drug design of potent pyrazole derivatives against Rhinovirus replication JOURNAL OF MEDICINAL CHEMISTRY 2018
Indolylarylsulfones as novel potent anti-HIV-1 agents 2018
Department
CHIMICA E TECNOLOGIE DEL FARMACO
SSD

CHIM/08