Bruno.Botta@uniroma1.it's picture

Le lezioni di Organic Chemistry (Bioinformatics) saranno tenute in modalità mista (in presenza e a distanza) e verranno trasmesse al seguente link Zoom:

https://uniroma1.zoom.us/j/3484727876?pwd=MkdiNG1EL2ZBWlBTVW5oS1J4a0gzdz09

 

The lessons of Organic Chemistry (Bioinformatics) will be held in mixed mode (in room and remotely) and will be available at the following Zoom link:

https://uniroma1.zoom.us/j/3484727876?pwd=MkdiNG1EL2ZBWlBTVW5oS1J4a0gzdz09

 

 

 

Le lezioni di Chimica Organica (Farmacia) in modalità a distanza verranno trasmesse al seguente link Meet:

 

meet.google.com/ica-krhb-yii

 

Course Code Year Course - Attendance Bulletin board
FORENSIC CHEMISTRY 10603368 2023/2024
ORGANIC AND INORGANIC CHEMISTRY 1049372 2022/2023
CHIMICA ORGANICA 1008170 2022/2023
CHIMICA ORGANICA 1008170 2021/2022
ORGANIC AND INORGANIC CHEMISTRY 1049372 2021/2022
CHIMICA ORGANICA 1008170 2020/2021
ORGANIC AND INORGANIC CHEMISTRY 1049372 2020/2021
CHIMICA ORGANICA 1008170 2019/2020
ORGANIC AND INORGANIC CHEMISTRY 1049372 2019/2020
CHIMICA ORGANICA 1008170 2018/2019
ORGANIC AND INORGANIC CHEMISTRY 1049372 2018/2019
CHIMICA ORGANICA 1008170 2017/2018
ORGANIC AND INORGANIC CHEMISTRY 1049372 2017/2018
ORGANIC AND INORGANIC CHEMISTRY 1049372 2016/2017
CHIMICA ORGANICA 1008170 2016/2017

Per appuntamento, previo accordo via mail.

Bruno Botta è nato nel 1954 e si è laureato in Chimica nel 1977 presso Sapienza Università di Roma. Dal 1981 al 1992 è stato ricercatore universitario presso l'Università Cattolica di Roma. Dal 1984 al 1985 ha svolto un periodo di post-dottorato presso il Dipartimento di Chimica della University of British Columbia (UBC, Vancouver, Canada) lavorando sulla sintesi e biosintesi di alcaloidi antitumorali della famiglia della vinblastina-vincristina. Nel 1992 diventa Professore Associato presso la Facoltà di Farmacia di Sapienza Università di Roma e dal 2001 è Professore Ordinario. Dal 2011 al 2020 è stato Direttore del Dipartimento di Chimica e Tecnologie del Farmaco presso Sapienza Università di Roma. Da Novembre 2014 a Ottobre 2023 è stato Prorettore alle Politiche per l Internazionalizzazione presso Sapienza Università di Roma.
Dal 2015 al 2019 ha ricoperto il ruolo di Chair della Azione COST 1407 "Challenging organic syntheses inspired by nature - from natural products chemistry to drug discovery".
Ha visitato le seguenti università: Michigan State University (USA), Wofford College Spartanburg (USA), The Scripps Research Institute, La Jolla (USA), University of British Columbia (Vancouver, Canada), Universidad de Montevideo (Uruguay), Universidade Federal de Pernambuco (Brasile), Toho University, Chiba, Tokyo (Japan). È coautore di più di 200 pubblicazioni e di 8 brevetti (nazionali e internazionali USA e Europa). Inoltre, è coautore di 6 capitoli di libri e curatore di due testi didattici di Chimica Organica per la casa editrice Edi-Ermes.

Bruno Botta was born in 1954 and got his graduation in Chemistry in 1977 at "Sapienza" University of Rome. From 1981 to 1992 he was appointed as assistant professor at the Catholic University of Rome. During the years 1984-1985, he was appointed as postdoctoral associate at the Department of Chemistry of the University of British Columbia (UBC, Vancouver, Canada) working on the synthesis and biosynthesis of clinically important anticancer alkaloids of the vinblastine-vincristine family. From 1992 to 2001 he was appointed as associate professor at "Sapienza" University of Rome (Faculty of Pharmacy) and became full professor at the same University in 2001. Since 2011 to 2020, he was Head of the Department of Chemistry and Technology of Drugs and from November 2014 to October 2023 he was Deputy Provost for the International Affairs at "Sapienza" University of Rome.
From 2015 to 2019, he was Chair of the COST Action CM-1407 "Challenging organic syntheses inspired by nature - from natural products chemistry to drug discovery".
He was visiting professor at the following universities: Michigan State University (USA), Wofford College Spartanburg (SC, USA), The Scripps Research Institute, La Jolla (CA, USA), University of British Columbia (Vancouver, Canada), Universidad de Montevideo (Uruguay), Universidade Federal de Pernambuco (Brazil), Toho University, Chiba, Tokyo (Japan).
He is co-author of more than 200 publications and 8 patents (national and international USA and Europe). Moreover, he is co-author of 6 book chapters and editor of 2 textbooks of Organic Chemistry for the Italian publishing house Edi-Ermes.

Selected Publications (2023-2010)

Nygaard, R., Graham, C. L. B., Belcher Dufrisne, M., Colburn, J. D., Pepe, J., Hydorn, M. A., Corradi, S., Brown, C. M., Ashraf, K. U., Vickery, O. N., Briggs, N. S., Deering, J. J., Kloss, B., Botta, B., Clarke, O. B., Columbus, L., Dworkin, J., Stansfeld, P. J., Roper, D. I., Mancia, F., Structural basis of peptidoglycan synthesis by E. coli RodA-PBP2 complex, Nature Communications 2023, 14, 5151.
Quaglio, D., Infante, P., Cammarone, S., Lamelza, L., Conenna, M., Ghirga, F., Adabbo, G., Pisano, L., Di Marcotullio, L., Botta, B., Mori M., Exploring the potential of anthraquinone-based hybrids for identifying a novel generation of antagonists for the Smoothened receptor in HH-dependent tumour, Chemistry - A European Journal 2023, e202302237.
Salha, M., Adenusi, H., Dupuis, J. H., Bodo E., Botta, B., McKenzie, I. Yada, R. Y., Farrar, D. H., Magolan, J., Tian, K. V., Chass, G. A. Bioactivity of the cannabigerol cannabinoid and its analogues theroleof3-dimensional conformation, Org. Biomol. Chem. 2023, 21 (22), 4683 4693.
Polli, F., Cianfoni, G., Elnahas, R., Mangiardi, L., Scaramuzzo, F. A., Cammarone, S., Quaglio, D., Calcaterra, A., Pierini, M., Mazzei, F., Zanoni, R., Botta, B., Ghirga, F., Resorc[4]arene Modifiers for Supramolecular Site-Directed Immobilization of Antibodies on Multi-Walled Carbon Nanotubes, ChemBioChem 2023, 24 (9), e2023000.
Rogati, F., Maioli, C., Lauro, G., Caprioglio, D., Imperio, D., Del Grosso, E., Botta, B., Mannina, L., Bifulco, G., Ingallina, C., Minassi, A., A Classic Photochemical Approach Inducing an Unexpected Rearrangement: Exploring the Photoreactivity of Pentacyclic Triterpenic Acids, J. Nat. Prod. 2023, 86 (4), 1025 1032.
Calcaterra, A., Cianfoni, G., Tortora, C., Manetto, S., Grassi, G., Botta, B., Gasparrini, F., Mazzoccanti, G., Appendino, G., Natural Cannabichromene (CBC) Shows Distinct Scalemicity Grades and Enantiomeric Dominance in Cannabis sativa Strains, J. Nat. Prod. 2023, 86 (4), 909 914.
Platella, C., Ghirga, F., Musumeci, D., Quaglio, D., Zizza, P., Iachettini, S., D Angelo, C., Biroccio, A., Botta, B., Mori, M., Montesarchio, D., Selective Targeting of Cancer-Related G-Quadruplex Structures by the Natural Compound Dicentrine, Int. J. Mol. Sci. 2023, 24 (4), 4070.
Mori, M., Quaglio, D., Calcaterra, A., Ghirga, F., Sorrentino, L., Cammarone, S., Fracella, M., D Auria, S., Frasca, F., Criscuolo, E., Clementi, N., Mancini, N., Botta, B., Antonelli, G., Pierangeli, A., Scagnolari, C., Natural Flavonoid Derivatives Have Pan-Coronavirus Antiviral Activity, Microorganisms 2023, 11 (2), 314.
Cimino, G., Sorrenti, S., Murciano, M, Galoppi, P, Ascenzioni, F., Botta, B., Brunelli, R., Cavinato, L., Cerrato, A., Cianfoni, G., D Ambrosio, V., De Luca, F. Use of elexacaftor/tezacaftor/ivacaftor combination in pregnancy, Arch Gynecol Obstet. 2023 Mar 13, doi: 10.1007/s00404-023-06962-5.
Calcaterra, A., Polli, F., Lamelza, L., Del Plato, C., Cammarone, S., Ghirga. F., Botta, B., Mazzei, F., Quaglio, D. Resorc[4]arene-Modified Gold-Decorated Magnetic Nanoparticles for Immunosensor Development, Bioconjug Chem. 2023, 34 (3), 529 537.
Spano, M., Di Matteo, G., Ingallina, C., Sobolev, A. P., Giusti, A. M., Vinci, G., Cammarone, S., Tortora, C., Lamelza, L., Prencipe, S. A., Gobbi, L., Botta B., Marini, F., Campiglia, E., Mannina, L. Industrial Hemp (Cannabis sativa L.) Inflorescences as Novel Food: The Effect of Different Agronomical Practices on Chemical Profile, Foods 2022, 11, 3658.
Tortora, C., Pisano, L., Vergine V., Ghirga, F., Iazzetti, A., Calcaterra, A., Markovic, V., Botta, B., Quaglio, D. Synthesis, Biosynthesis, and Biological Activity of Diels Alder Adducts from Morus Genus: An Update, Molecules 2022, 27, 7580.
Soloperto, A., Quaglio, D., Baiocco, P., Romeo, I., Mori, M., Ardini, M., Presutti, C., Sannino I., Ghirga, S., Iazzetti, A., Ippoliti, R., Ruocco, G., Botta, B., Ghirga, F., Di Angelantonio, S., Boffi A. Rational design and synthesis of a novel BODIPY based probe for selective imaging of tau tangles in human iPSC derived cortical neurons, Scientifc Reports 2022, 12, 5257.
Casciaro, B., Ghirga, F., Cappiello, F., Vergine, V., Loffredo, M. R., Cammarone, S., Puglisi, E., Tortora, C., Quaglio, D., Mori, M., Botta B., Mangoni M. L. The Triprenylated Anthranoid Ferruginin A, a Promising Scaffold for the Development of Novel Antibiotics against Gram-Positive Bacteria. Antibiotics 2022, 11, 84.
Ferrera. L, Cappiello, F., Lofredo, M. R., Puglisi, E., Casciaro, B., Botta, B., Galietta, L. J. V., Mori, M., Mangoni, M. L. Esc peptides as novel potentiators of defective cystic fibrosis transmembrane conductance regulator: an unprecedented property of antimicrobial peptides. Cellular and Molecular Life Sciences 2022, 79 (1), 67.
Quaglio, D., Polli, F., Del Plato, C., Cianfoni, G., Tortora, C., Mazzei, F., Botta, B., Calcaterra, A., Ghirga F. Calixarene: a versatile scaffold for the development of highly sensitive biosensors. Supramolecular Chemistry 2021, DOI 10.1080/10610278.2021.2011283, 1-25.
Buonsenso, F., Ghirga, F., Romeo, I., Siani, G., Pilato, S., Quaglio, D., Pierini, M., Botta, B., Calcaterra, A. Exploring the Assembly of Resorc[4]arenes for the Construction of Supramolecular Nano-Aggregates. Int. J. Mol. Sci. 2021, 22, 11785.
Mangoni, M. L., Bhunia, A., Botta, B., Ghirga F. Editorial: Secondary Metabolites and Peptides as Unique Natural Reservoirs of New Therapeutic Leads for Treatment of Cancer and Microbial Infections Front. Chem. 2021, 9, art. no. 748180.
Platella, C., Ghirga, F., Zizza, P., Pompili, L., Marzano, S., Pagano, B., Quaglio, D., Vergine, V., Cammarone, S., Botta, B., Biroccio, A., Mori, M., Montesarchio, D. Identification of Effective Anticancer G-Quadruplex-Targeting Chemotypes through the Exploration of a High Diversity Library of Natural Compounds. Pharmaceutics 2021, 13 (10), art. no. 1611.
Schafroth, M. A., Mazzoccanti, G., Reynoso-Moreno, I., Erni, R., Pollastro, F., Caprioglio, D., Botta, B., Allegrone, G., Grassi, G., Chicca, A., Gasparrini, F., Gertsch, J., Carreira, E. M., Appendino, G. 9-cis-Tetrahydrocannabinol: Natural Occurrence, Chirality, and Pharmacology. J. Nat. Prod. 2021, 84 (9), 2502 2510.
D Alessandro, G., Lauro, C., Quaglio, D., Ghirga, F., Botta, B., Trettel, F., Limatola, C. Neuro-Signals from Gut Microbiota: Perspectives for Brain Glioma. Cancers 2021, 13 (11), art. no. 2810.
Spano, M., Di Matteo, G., Ingallina, C., Botta, B., Quaglio, D., Ghirga, F., Balducci, S., Cammarone, S., Campiglia, E., Giusti, A. M., Vinci, G., Rapa, M., Ciano, S., Mannina, L., Sobolev, A. P. A Multimethodological Characterization of Cannabis sativa L. Inflorescences from Seven Dioecious Cultivars Grown in Italy: The Effect of Different Harvesting Stages. Molecules 2021, 26 (10), art. no. 2912.
Zheng, Y., Yang, X.-W., Schols, D., Mori, M., Botta, B., Chevigné, A., Mulinge, M., Steinmetz, A., Schmit, J.-C., Seguin-Devaux C. Active Components from Cassia abbreviata Prevent HIV-1 Entry by Distinct Mechanisms of Action. Int. J. Mol. Sci. 2021, 22 (9), art. no. 5052.
Bonandi, E., Mori, M., Infante, P., Basili, I., Di Marcotullio, L., Calcaterra, A., Catti, F., Botta, B., Passarella, D. Design and Synthesis of New Withaferin A Inspired Hedgehog Pathway Inhibitors. Chem. Eur. J. 2021, 27 (32), pp 8350 8357.
Pediconi, N., Ghirga, F., Del Plato, C., Peruzzi, G., Athanassopoulos, C. M., Mori, M., Crestoni, M. E., Corinti, D., Ugozzoli, F., Massera, C., Arcovito, A., Botta, B., Boffi, A., Quaglio, D., Baiocco, P. Design and Synthesis of Piperazine-Based Compounds Conjugated to Humanized Ferritin as Delivery System of siRNA in Cancer Cells. Bioconjugate Chem. 2021, 32 (6), pp 1105 1116.
Ghirga, F., Quaglio, D., Mori, M., Cammarone, S., Iazzetti, A., Goggiamani, A., Ingallina, C., Botta B., Calcaterra, A. A unique high-diversity natural product collection as a reservoir of new therapeutic leads. Organic Chemistry Frontiers 2021, 8 (5), pp 996-1025.
Infante, P., Malfanti, A., Quaglio, D., Balducci, S., De Martin, S., Bufalieri, F., Mastrotto, F., Basili, I., Garofalo, M., Lospinoso Severini, L., Mori, M., Manni, I., Moretti, M., Nicoletti, C., Piaggio, G., Caliceti, P., Botta, B., Ghirga, F., Salmaso, S., Di Marcotullio, L. Glabrescione B delivery by self-assembling micelles efficiently inhibits tumor growth in preclinical models of Hedgehog-dependent medulloblastoma. Cancer Letters 2021, 499, pp. 220-231.
Petrovi , M. M., Roschger, C., Chaudary, S., Zierer, A., Mladenovi , M., Jakovljevi , K., Markovi , V., Botta, B., Joksovi , M.D. Potent human dihydroorotate dehydrogenase inhibitory activity of new quinoline-4-carboxylic acids derived from phenolic aldehydes: Synthesis, cytotoxicity, lipophilicity and molecular docking studies. Bioorganic Chemistry 2020, 105, art. no. 104373.
Caggiano, C., Guida, E., Todaro, F., Bielli, P., Mori, M., Ghirga, F., Quaglio, D., Botta, B., Moretti, F., Grimaldi, P., Rossi, P., Jannini, E.A., Barchi, M., Dolci, S. Sempervirine inhibits RNA polymerase I transcription independently from p53 in tumor cells. Cell Death Discovery 2020, 6 (1), art. no. 111.
Montone, C.M., Cerrato, A., Botta, B., Cannazza, G., Capriotti, A.L., Cavaliere, C., Citti, C., Ghirga, F., Piovesana, S., Laganà, A. Improved identification of phytocannabinoids using a dedicated structure-based workflow. Talanta 2020, 219, 121310.
Quaglio, D., Mangoni, M.L., Stefanelli, R., Corradi, S., Casciaro, B., Vergine, V., Lucantoni, F., Cavinato, L., Cammarone, S., Loffredo, M.R., Cappiello, F., Calcaterra, A., Erazo, S., Ghirga, F., Mori, M., Imperi, F., Ascenzioni, F., Botta, B. Ent-Beyerane Diterpenes as a Key Platform for the Development of ArnT-Mediated Colistin Resistance Inhibitors. Journal of Organic Chemistry 2020, 85 (16), pp. 10891-10901.
Casciaro, B., Mangiardi, L., Cappiello, F., Romeo, I., Loffredo, M.R., Iazzetti, A., Calcaterra, A., Goggiamani, A., Ghirga, F., Mangoni, M.L., Botta, B., Quaglio, D. Naturally-occurring alkaloids of plant origin as potential antimicrobials against antibiotic-resistant infections. Molecules 2020, 25 (16), art. no. 3619.
Quaglio, D., Mangiardi, L., Venditti, G., Del Plato, C., Polli, F., Ghirga, F., Favero, G., Pierini, M., Botta, B., Mazzei, F. Site-Directed Antibody Immobilization by Resorc[4]arene-Based Immunosensors. Chemistry - A European Journal 2020, 26 (38), pp. 8400-8406.
Cappiello, F., Loffredo, M.R., Plato, C.D., Cammarone, S., Casciaro, B., Quaglio, D., Mangoni, M.L., Botta, B., Ghirga, F. The revaluation of plant-derived terpenes to fight antibiotic-resistant infections. Antibiotics 2020, 9 (6), art. no. 325.
Maj, P., Mori, M., Sobich, J., Markowicz, J., Uram, ., Zielinski, Z., Quaglio, D., Calcaterra, A., Cau, Y., Botta, B., Rode, W. Alvaxanthone, a thymidylate synthase inhibitor with nematocidal and tumoricidal activities. Molecules 2020, 25 (12), 2894.
Quaglio, D., Corradi, S., Erazo, S., Vergine, V., Berardozzi, S., Sciubba, F., Cappiello, F., Crestoni, M.E., Ascenzioni, F., Imperi, F., Delle Monache, F., Mori, M., Loffredo, M.R., Ghirga, F., Casciaro, B., Botta, B., Mangoni, M.L. Structural Elucidation and Antimicrobial Characterization of Novel Diterpenoids from Fabiana densa var. ramulosa. ACS Medicinal Chemistry Letters 2020, 11 (5), pp. 760-765.
Diukendjieva, A., Zaharieva, M.M., Mori, M., Alov, P., Tsakovska, I., Pencheva, T., Najdenski, H., K en, V., Felici, C., Bufalieri, F., Di Marcotullio, L., Botta, B., Botta, M., Pajeva, I. Dual smo/braf inhibition by flavonolignans from silybum marianum. Antioxidants 2020, 9 (5), art. no. 384.
Quaglio, D., Infante, P., Di Marcotullio, L., Botta, B., Mori, M. Hedgehog signaling pathway inhibitors: an updated patent review (2015 present). Expert Opinion on Therapeutic Patents 2020, 30 (4), pp. 235-250.
Ourabah, A., Atmani-Kilani, D., Debbache-Benaida, N., Kolesova, O., Azib, L., Yous, F., Benloukil, M., Botta, B., Atmani, D., Simonetti, G. Anti-Candida albicans biofilm activity of extracts from two selected indigenous Algerian plants: Clematis flammula and Fraxinus angustifolia. Journal of Herbal Medicine 2020, 20, 100319.
Ingallina, C., Sobolev, A.P., Circi, S., Spano, M., Fraschetti, C., Filippi, A., Di Sotto, A., Di Giacomo, S., Mazzoccanti, G., Gasparrini, F., Quaglio, D., Campiglia, E., Carradori, S., Locatelli, M., Vinci, G., Rapa, M., Ciano, S., Giusti, A.M., Botta, B., Ghirga, F., Capitani, D., Mannina, L. Cannabis sativa L. inflorescences from monoecious cultivars grown in central Italy: An untargeted chemical characterization from early flowering to ripening. Molecules 2020, 25 (8), 1908.
Calcaterra, A., Mangiardi, L., Monache, G.D., Quaglio, D., Balducci, S., Berardozzi, S., Iazzetti, A., Franzini, R., Botta, B., Ghirga, F. The pictet-spengler reaction updates its habits. Molecules 2020, 25 (2), 414.
Cirigliano, A., Amelina, A., Biferali, B., Macone, A., Mozzetta, C., Bianchi, M.M., Mori, M., Botta, B., Pick, E., Negri, R., Rinaldi, T. Statins interfere with the attachment of S. cerevisiae mtDNA to the inner mitochondrial membrane. Journal of Enzyme Inhibition and Medicinal Chemistry 2020, 35 (1), pp. 129-137.
Ghirga, F., Stefanelli, R., Cavinato, L., Lo Sciuto, A., Corradi, S., Quaglio, D., Calcaterra, A., Casciaro, B., Loffredo, M.R., Cappiello, F., Morelli, P., Antonelli, A., Rossolini, G.M., Mangoni, M., Mancone, C., Botta, B., Mori, M., Ascenzioni, F., Imperi, F. A novel colistin adjuvant identified by virtual screening for ArnT inhibitors. Journal of Antimicrobial Chemotherapy 2020, 75 (9), pp. 2564-2572.
Mori, M., Manetti, F., Botta, B., Tafi, A. In Memory of Maurizio Botta: His Contribution to the Development of Computer-Aided Drug Design. Journal of Chemical Information and Modeling 2019, 59 (12), pp. 4961-4967.
D. Corinti; A. Maccelli; M.E. Crestoni; S. Cesa; D. Quaglio; B. Botta; C. Ingallina; L. Mannina; A. Tintaru; B. Chiavarino; S. Fornarini. IR ion spectroscopy in a combined approach with MS/MS and IM-MS to discriminate epimeric anthocyanin glycosides (cyanidin 3-O-glucoside and -galactoside). International Journal of Mass Spectrometry 2019, 444, 116179.
L.L. Severini; D. Quaglio; I. Basili; F. Ghirga; F. Bufalieri; M. Caimano; S. Balducci; M. Moretti; I. Romeo; E. Loricchio; M. Maroder; B. Botta; M. Mori; P. Infante; L. Di Marcotullio. A Smo/Gli Multitarget Hedgehog Pathway Inhibitor Impairs Tumor Growth. Cancers 2019, 11:1518.
B. Casciaro, A. Calcaterra, F. Cappiello, M. Mori, M.R. Loffredo, F. Ghirga, M.L. Mangoni, B. Botta, D. Quaglio. Nigritanine as a New Potential Antimicrobial Alkaloid for the Treatment of Staphylococcus aureus-Induced Infections. Toxins (Basel) 2019, 11 (9), 511.
G. D'Alessandro; D. Quaglio, L. Monaco; C. Lauro; F. Ghirga; C. Ingallina; M. De Martino; S. Fucile; A. Porzia; M.A. Di Castro; F. Bellato; F. Mastrotto; M. Mori; P. Infante; P. Turano; S. Salmaso; P. Caliceti; L. Di Marcotullio; B. Botta; V. Ghini; C. Limatola. 1H-NMR metabolomics reveals the Glabrescione B exacerbation of glycolytic metabolism beside the cell growth inhibitory effect in glioma. Cell Communication and Signaling 2019, 17, 108.
K. Jakovljevi ; M.D. Joksovi ; B. Botta; L.S. Jovanovi ; E. Avdovi ; Z. Markovi ; V. Mihailovi ;
M. Andri ; S. Trifunovi ; V. Markovi . Novel 1, 3, 4-thiadiazole conjugates derived from protocatechuic acid: Synthesis, antioxidant activity, and computational and electrochemical studies. Comptes Rendus Chimie 2019, 22 (8), pp. 585-598.
D. Quaglio; N. Zhdanovskaya; G. Tobajas; V. Cuartas; S. Balducci; M. S. Christodoulou; G. Fabrizi; M. Gargantilla; E.-M. Priego;Á. C. Pestaña; D. Passarella; I. Screpanti; B. Botta; R. Palermo; M. Mori; F. Ghirga; M.-J. Pérez-Pérez. Chalcones and Chalcone-mimetic Derivatives as Notch Inhibitors in a Model of T-cell Acute Lymphoblastic Leukemia. ACS Med. Chem. Lett. 2019, 10 (4), pp. 639-643.
Savoia, M., Cencioni, C., Mori, M., Atlante, S., Zaccagnini, G., Devanna, P., Di Marcotullio, L., Botta, B., Martelli, F., Zeiher, A.M., Pontecorvi, A., Farsetti, A., Spallotta, F., Gaetano, C. P300/CBP-associated factor regulates transcription and function of isocitrate dehydrogenase 2 during muscle differentiation. The FASEB Journal 2019, 33 (3), pp. 4107-4123.
Quaglio D., Zappia G., De Paolis E., Balducci S., Botta B., Ghirga F., Olefin metathesis reaction as a locking tool for macrocycle and mechanomolecule construction. Organic Chemistry Frontiers 2018, 5, pp. 3022-3055.
Berardozzi, S., Bernardi, F., Infante, P., Ingallina, C., Toscano, S., De Paolis, E., Alfonsi, R., Caimano, M., Botta, B., Mori, M., Di Marcotullio, L., Ghirga, F., Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold, European Journal of Medicinal Chemistry 2018, 156, pp. 554-562.
Krasilnikova, J., Lauberte, L., Stoyanova, E., Abadjieva, D., Chervenkov, M., Mori, M., De Paolis, E., Mladenova, V., Telysheva, G., Botta, B., Kistanova, E., Oregonin from Alnus incana bark affects DNA methyltransferases expression and mitochondrial DNA copies in mouse embryonic fibroblasts, Journal Of Enzyme Inhibition and Medicinal Chemistry 2018, 33 (1), pp. 1055 1063.
Sobolev, A.P., Mannina, L., Capitani, D., Sanzò, G., Ingallina, C., Botta, B., Fornarini, S., Crestoni, M.E., Chiavarino, B., Carradori, S., Locatelli, M., Giusti, A.M., Simonetti, G., Vinci, G., Preti, R., Toniolo, C., Reverberi, M., Scarpari, M., Parroni, A., Abete, L., Natella, F., Di Sotto, A. A multi-methodological approach in the study of Italian PDO Cornetto di Pontecorvo red sweet pepper 2018 Food Chemistry, 255, pp. 120-131.
Cevatemre, B., Erkisa, M., Aztopal, N., Karakas, D., Alper, P., Tsimplouli, C., Sereti, E., Dimas, K., Armutak, E.I.I., Gurevin, E.G., Uvez, A., Mori, M., Berardozzi, S., Ingallina, C., D Acquarica, I., Botta, B., Ozpolat, B., Ulukaya, E. A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer. Pharmacological Research 2018, 129, pp. 500-514.
Mascarello, A., Orbem Menegatti, A.C., Calcaterra, A., Martins, P.G.A., Chiaradia-Delatorre, L.D., D Acquarica, I., Ferrari, F., Pau, V., Sanna, A., De Logu, A., Botta, M., Botta, B., Terenzi, H., Mori, M. Naturally occurring Diels-Alder-type adducts from Morus nigra as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B. European Journal of Medicinal Chemistry 2018, 144, pp. 277-288.
Spallotta, F., Cencioni, C., Atlante, S., Garella, D., Cocco, M., Mori, M., Mastrocola, R., Kuenne, C., Guenther, S., Nanni, S., Azzimato, V., Zukunft, S., Kornberger, A., Sürün, D., Schnütgen, F., Von Melchner, H., Di Stilo, A., Aragno, M., Braspenning, M., Van Criekinge, W., De Blasio, M.J., Ritchie, R.H., Zaccagnini, G., Martelli, F., Farsetti, A., Fleming, I., Braun, T., Beiras-Fernandez, A., Botta, B., Collino, M., Bertinaria, M., Zeiher, A.M., Gaetano, C. Stable Oxidative Cytosine Modifications Accumulate in Cardiac Mesenchymal Cells from Type2 Diabetes Patients: Rescue by -Ketoglutarate and TET-TDG Functional Reactivation. Circulation Research 2018, 122 (1), pp. 31-46.
Calcaterra, A., Iovine, V., Botta, B., Quaglio, D., D Acquarica, I., Ciogli, A., Iazzetti, A., Alfonsi, R., Lospinoso Severini, L., Infante, P., Di Marcotullio, L., Mori, M., Ghirga, F. Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61. Journal of Enzyme Inhibition and Medicinal Chemistry 2018, 33 (1), pp. 349-358.
Ricci, F., Carrassa, L., Christodoulou, M. S., Passarella, D., Michel, B., Benhida, R., Martinet, N., Hunyadi, A., Ioannou, E., Roussis, V., Musso, L., Dallavalle, S., Silvestri, R., Westwood, N., Mori, M., Ingallina, C., Botta, B., Kavetsou, E., Detsi A., Majer, Z., Hudecz, F., B sze, S., Kaminska, B., Hansen, T.V., Bertrand, P., Athanassopoulos, C. M., Damia G. A High-throughput Screening of a Chemical Compound Library in Ovarian Cancer Stem Cells. Combinatorial Chemistry & High Throughput Screening 2018, 21, pp. 50-56.
Al Sharif, M., Alov, P., Vitcheva, V., Diukendjieva, A., Mori, M., Botta, B., Tsakovska, I., Pajeva,
Natural modulators of nonalcoholic fatty liver disease: Mode of action analysis and in silico ADME-Tox prediction. Toxicology and Applied Pharmacology 2017, 337, pp. 45-66.
Mori, M., Tottone, L., Quaglio, D., Zhdanovskaya, N., Ingallina, C., Fusto, M., Ghirga, F., Peruzzi, G., Crestoni, M.E., Simeoni, F., Giulimondi, F., Talora, C., Botta, B., Screpanti, I., Palermo, R. Identification of a novel chalcone derivative that inhibits Notch signaling in T-cell acute lymphoblastic leukemia. Scientific Reports 2017, 7, 2213.
Ghirga, F., Bonamore, A., Calisti, L., D Acquarica, I., Mori, M., Botta, B., Boffi, A., Macone, A. Green routes for the production of enantiopure benzylisoquinoline alkaloids. International Journal of Molecular Sciences 2017, 18 (11), 2464.
Pingwara, R., Witt-Jurkowska, K., Ulewicz, K., Mucha, J., Tonecka, K., Pilch, Z., Taciak, B., Zabielska-Koczywas, K., Mori, M., Berardozzi, S., Botta, B., Rygiel, T.P., Krol, M. Interferon lambda 2 promotes mammary tumor metastasis via angiogenesis extension and stimulation of cancer cell migration. Journal of Physiology and Pharmacology 2017, 68 (4), pp. 573-583.
Ingallina, C., Costa, P.M., Ghirga, F., Klippstein, R., Wang, J.T., Berardozzi, S., Hodgins, N., Infante, P., Pollard, S.M., Botta, B., Al-Jamal, K.T. Polymeric glabrescione B nanocapsules for passive targeting of Hedgehog-dependent tumor therapy in vitro. Nanomedicine 2017, 12 (7), pp. 711- 728.
Alfonsi, R., Botta, B., Cacchi, S., Di Marcotullio, L., Fabrizi, G., Faedda, R., Goggiamani, A., Iazzetti, A., Mori, M. Design, Palladium-Catalyzed Synthesis, and Biological Investigation of 2- Substituted 3-Aroylquinolin-4(1H)-ones as Inhibitors of the Hedgehog Signaling Pathway. Journal of Medicinal Chemistry 2017, 60 (4), pp. 1496-1477.
Aiello, F., Balzano, F., Ghirga, F., D Acquarica, I., Botta, B., Uccello-Barretta, G., Quaglio, D. First detection of a Ruthenium-carbene-resorc[4]arene complex during the progress of a metathesis reaction. EUR Journal of Organic Chemistry 2017, (17), pp. 2407-2415.
Evain-Bana, E., Schiavo, L., Bour, C., Lanfranchi, D-A, Berardozzi, S., Ghirga, F., Bagrel, D., Botta, B., Hanquet, G., Mori, M. Synthesis, biological evaluation and molecular modeling studies on novel quinonoid inhibitors of CDC25 phosphatases. Journal of enzyme inhibition and medicinal chemistry 2017, 32 (1), pp. 113-118.
Zwergel, C., Czepukojc, B., Evain-Bana, E., Xu, Z., Stazi, G., Mori, M., Patsilinakos, A., Mai, A., Botta, B., Ragno, R., Bagrel, D., Kirsch, G., Meiser, P., Jacob, C., Montenarh, M., Valente, S. Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells. European Journal of Medicinal Chemistry 2017, 34, pp. 316-333.
Iovine, V., Benni, I., Sabia, R., D Acquarica, I., Fabrizi, G., Botta, B., Calcaterra, A. Total Synthesis of (±)-Kuwanol E. Journal of Natural Product 2016, 79 (10), pp. 2495-2503.
Cevatemre, B., Botta, B., Mori, M., Berardozzi, S., Ingallina, C., Ulukaya, E. The plant-derived triterpenoid tingenin B is a potent anticancer agent due to its cytotoxic activity on cancer stem cells of breast cancer in vitro. Chemico-Biological Interactions 2016, 260, pp. 248-255.
Infante, P., Alfonsi, R., Ingallina, C., Quaglio, D., Ghirga, F., D Acquarica, I., Di Magno, L., Canettieri, G., Screpanti, I., Gulino, A., Botta, B., Mori, M., Di Marcotullio, L. Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype. Cell Death & Disease 2016, 7 (9), e2376.
Ingallina, C., Rinaldi, F., Bogni, A., Ponti, J., Passeri, D., Reggente, M., Rossi, M., Kinsner- Ovaskainen, A.; Mehn, D., Rossi, F., Botta, B., Carafa, M., Marianecci, C. Niosomal approach to brain delivery: Development, characterization and in vitro toxicological studies. International journal of pharmaceutics 2016, 511 (2), pp. 969-982.
Uccello Barretta, G., Balzano, F., Aiello, F., Nardelli, F., Ciogli, A., Calcaterra, A., Botta, B. Covalently assembled resorcin[4]arenes and molecular tweezers: a chiral recognition rationale by NMR. Supramolecular chemistry 2016, 21 (7-8), pp. 647-655.
Ghirga, F., Quaglio, D., Ghirga, P., Berardozzi, S., Zappia, G., Botta, B., Mori, M., D Acquarica, I. Occurrence of Enantioselectivity in Nature: The Case of (S)-Norcoclaurine. Chirality 2016, 28 (3), pp. 169-180.
Comba, A., Ainnada, L. L., Tolosa, E. J., Iguchi, E., Marks, D. L., Messler, M. V., Silva, R., Fernandez-Barrena, M. G., Enriquez-Hesles, E., Vrabel, A. L., Botta, B., Di Marcotulio, L., Ellenrieder, V., Eynard, A. R., Pasqualini, M. E., Fernandez-Zapico, M. E. Nuclear Factor of Activated T Cells-dependent Down-regulation of the Transcription Factor Glioma-associated Protein 1 (GLI1) Underlies the Growth Inhibitory Properties of Arachidonic Acid. Journal of biological chemistry 2016, 291 (4), pp. 1933-1947.
Bonamore, A., Calisti, L., Calcaterra, A., Ismail, O.H., Gargano, M., D Acquarica, I., Botta, B., Boffi, A., Macone, A. A Novel Enzymatic Strategy for the Synthesis of Substituted Tetrahydroisoquinolines. Chemistry Select 2016, 1 (8), pp. 1525-1528.
Cirigliano, A., Stirpe, A., Menta, S., Mori, M., Dell Edera, D., Pick, E., Negri, R., Botta, B., Rinaldi, T. Yeast as a tool to select inhibitors of the cullin deneddylating enzyme Csn5. Journal of enzyme inhibition and medicinal chemistry 2016, 31 (6), pp. 1632-1637.
Navakauskiene, R., Mori, M., Christodoulou, M. S., Zentelyte, A., Botta, B., Dalla Via, L., Ricci, F., Damia, G., Passarella, D., Zilio, C., Martinet, N. Histone demethylating agents as potential S- adenosyl-L-methionine-competitors. Medicinal Chemical Communications 2016, 7 (6), pp. 1245- 1255.
Mascarello, A., Chiaradia-Delatorre, L. D., Mori, M., Terenzi, H., Botta, B. Mycobacterium tuberculosis-Secreted Tyrosine Phosphatases as Targets Against Tuberculosis: Exploring Natural Sources in Searching for New Drugs. Current pharmaceutical design 2016, 22 (12), pp. 1561-1569.
Iovine, V., Mori, M., Calcaterra, A., Berardozzi, S., Botta, B. One Hundred Faces of Cyclopamine. Current pharmaceutical design 2016, 22 (12), pp. 1658-1681.
D Acquarica, I., Ghirga, F., Quaglio, D., Cerreto, A., Ingallina, C., Tafi, A., Botta, B. Molecular Recognition of Natural Products by Resorc[4]arene Receptors. Current pharmaceutical design 2016, 22 (12), pp. 1715-1729.
Khan, M. I., Sobocinska, A. A., Czarnecka, A. M., Krol, M., Botta, B., Szczylik, C. The Therapeutic Aspects of the Endocannabinoid System (ECS) for Cancer and their Development: From Nature to Laboratory. Current pharmaceutical design 2016, 22 (12), pp. 1756-1766.
Ingallina, C., D Acquarica, I., Monache, G.D., Ghirga, F., Quaglio, D., Ghirga, P., Berardozzi, S., Markovic, V., Botta, B., The pictet-spengler reaction still on stage. Current Pharmaceutical Design 2016, 22 (12), pp. 1808-1850.
Esposito, F., Tintori, C., Martini, R., Christ, F., Debyser, Z., Ferrarese, R., Cabiddu, G., Corona, A., Ceresola, E. R., Calcaterra, A., Iovine, V., Botta, B., Clementi, M., Canducci, F., Botta, M., Tramontano, E. Kuwanon-L as a New Allosteric HIV-1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation. ChemBioChem 2015, 16 (17), pp. 2507-2512.
Martins, P. G. A., Mori, M., Chiaradia-Delatorre, L. D., Menegatti, A. C. O., Mascarello, A., Botta, B., Benitez, J., Gambino, D., Terenzi, H. Exploring Oxidovanadium(IV) Complexes as YopH Inhibitors: Mechanism of Action and Modeling Studies. ACS Medicinal Chemistry Letters 2015, 6 (10), pp. 1035-1040.
Christodoulou, M. S., Mori, M., Pantano, R., Alfonsi, R., Infante, P., Botta, M., Damia, G., Ricci, F., Sotiropoulou, P. A., Liekens, S., Botta, B., Passarella, D., Click Reaction as a Tool to Combine Pharmacophores: The Case of Vismodegib. ChemPlusChem 2015, 80 (6), pp. 938-943.
Infante, P., Alfonsi, R., Botta, B., Mori, M., Di Marcotullio, L. Targeting GLI factors to inhibit the Hedgehog pathway. Trends in Pharmacological Sciences 2015, 36 (8), pp. 547-558.
Infante, P., Mori, M., Alfonsi, R., Ghirga, F., Aiello, F., Toscano S., Ingallina C., Siler M., Cucchi D., Po A., Miele E., D Amico D., Canettieri, G., De Smaele, E., Ferretti, E., Screpanti, I., Uccello Barretta, G., Botta, M., Botta, B., Gulino, A., Di Marcotullio, L. Gli1/DNA interaction is a druggable target for Hedgehog dependent tumors. EMBO Journal 2015 34 (2), pp. 200-217.
Uccello-Barretta, G., Balzano, F., Aiello, F., Vanni, L., Mori, M., Menta, S., Calcaterra, A., Botta, B., Hydrolytic inhibition of -chymotrypsin by 2,8,14,20-tetrakis(d-leucyl-d-valinamido) resorc[4]arenecarboxylic acid: a spectroscopic NMR and computational combined approach. Organic & Biomolecular Chemistry 2015, 13 (3), pp. 916-924.
Ghirga, F., Quaglio, D., Iovine, V., Botta, B., Pierini, M., Mannina, L., Sobolev, A. P., Ugozzoli, F., D Acquarica, I. Synthesis of a Double-Spanned-Resorc[4]arene via Ring-Closing Metathesis and Calculation of Aggregation Propensity. Journal of Organic Chemistry 2014, 79 (22), pp. 11051- 11060.
D Acquarica, I., Calcaterra, A., Sacco, F., Balzano, F., Aiello, F., Tafi, A., Pesci, N., Uccello- Barretta, G., Botta, B. Stereochemical preference of 2 -deoxycytidine for chiral bis(diamido)- bridged basket resorcin[4]arenes. Chirality 2013, 25 (12), pp. 840-851.
Cerreto, A., Corrente, F., Botta, B., Pacelli, S., Paolicelli, P., Mannina, L., Casadei, M.A. NMR Characterization of Carboxymethyl Scleroglucan. International Journal of Polymer Analysis and Characterization 2013, 18 (8), pp. 587-595.
Ghirga, F., D Acquarica, I., Delle Monache, G., Toscano, S., Mannina, L., Sobolev, A.P., Ugozzoli, F., Crocco, D., Antiochia, R., Botta, B. Undecenyl resorc[4]arene in the chair conformation as preorganized synthon for olefin metathesis. RSC Advances 2013, 3 (38), pp. 17567-17576.
Mascarello, A., Mori, M., Chiaradia-Delatorre, L.D., Menegatti, A.C.O., de Monache, F., Ferrari, F., Yunes, R.A., Nunes, R.J., Terenzi, H., Botta, B., Botta, M. Discovery of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B (PtpB) Inhibitors from Natural Products. PLoS ONE 2013, 8 (10), art. no. e77081.
Rondino, F., Ciavardini, A., Satta, M., Paladini, A., Fraschetti, C., Filippi, A., Botta, B., Calcaterra, A., Speranza, M., Giardini, A., Piccirillo, S. Ultraviolet and infrared spectroscopy of neutral and ionic non-covalent diastereomeric complexes in the gas phase. Rendiconti Lincei 2013, 24 (3), pp. 259-267.
Ghirga, F., D Acquarica, I., Delle Monache, G., Mannina, L., Molinaro, C., Nevola, L., Sobolev, A.P., Pierini, M., Botta, B. Reaction of nitrosonium cation with resorc[4]arenes activated by supramolecular control: Covalent bond formation. Journal of Organic Chemistry 2013, 78 (14), pp. 6935-6946.
Friggeri, L., Scipione, L., Costi, R., Kaiser, M., Moraca, F., Zamperini, C., Botta, B., Di Santo, R., De Vita, D., Brun, R., Tortorella, S. New promising compounds with in vitro nanomolar activity against Trypanosoma cruzi. ACS Medicinal Chemistry Letters 2013, 4 (6), pp. 538-541.
Filippi, A., Fraschetti, C., Piccirillo, S., Rondino, F., Botta, B., D Acquarica, I., Calcaterra, A., Speranza, M. Chirality effects on the IRMPD spectra of basket resorcinarene/nucleoside complexes. Chemistry A European Journal 2012, 18 (27), pp. 8320-8328.
D Acquarica, I., Cerreto, A., Delle Monache, G., Subrizi, F., Boffi, A., Tafi, A., Forli, S., Botta, B. N-linked peptidoresorc[4]arene-based receptors as noncompetitive inhibitors for -chymotrypsin. Journal of Organic Chemistry 2011, 76 (11), pp. 4396-4407.
Macone, A., Fontana, M., Barba, M., Botta, B., Nardini, M., Ghirga, F., Calcaterra, A., Pecci, L., Matarese, R.M. Antioxidant properties of aminoethylcysteine ketimine decarboxylated dimer: A review. International Journal of Molecular Sciences 2011, 12 (5), pp. 3072-3084.
Botta, B., Fraschetti, C., D Acquarica, I., Sacco, F., Mattay, J., Letzel, M.C., Speranza, M. Unprecedented gas-phase chiroselective logic gates. Organic and Biomolecular Chemistry 2011, 9 (6), pp. 1717-1719.
Bonamore, A., Rovardi, I., Gasparrini, F., Baiocco, P., Barba, M., Molinaro, C., Botta, B., Boffi, A., MacOne, A. An enzymatic, stereoselective synthesis of (S)-norcoclaurine. Green Chemistry 2010, 12 (9), pp. 1623-1627.
Basile, A., Botta, B., Bruno, M., Rigano, D., Sorbo, S., Conte, B., Rosselli, S., Senatore, F. Effects of air pollution on production of essential oil in Feijoa Sellowiana Berg. grown in the Italian triangle of death . International Journal of Environment and Health 2010, 4 (2-3), pp. 250-259.
Bonamore, A., Barba, M., Botta, B., Boffi, A., Macone, A. Norcoclaurine synthase: Mechanism of an enantioselective Pictet-Spengler catalyzing enzyme. Molecules 2010, 15 (4), pp. 2070-2078.
Speranza, M., D Acquarica, I., Fraschetti, C., Botta, B., Tafi, A., Bellucci, L., Zappia, G. Diastereoselectivegas-phase ion/molecule reactions of ethanolamine neurotransmitter/amido[4]resorcinarene adducts. International Journal of Mass Spectrometry 2010, 291 (1-2), pp. 84-89.

Patents

B. Botta, F. Ghirga, D. Quaglio, A. Calcaterra, C. Del Plato, F. Mazzei, F. Polli. Electrochemical type biosensors comprising resorcarenes. Priority: IT202200001490. Published as: WO2023144748A1. From 03-08-2023 to today.
Coauthor of the following patent family: F. Imperi, F. Ascenzioni, M. Mori, F. Ghirga, D. Quaglio, S. Corradi, A. LoSciuto, B. Botta, A. Calcaterra, R. Stefanelli. Inhibitors of antibiotic resistance mediated by ArnT. Priority: IT102019000012888 · 2019-09-25. Published as: WO2021014422A1. From 25-09-2019 to today.
Coauthor of the following patent family: C. Limatola, G. D Alessandro, L. Di Marcotullio, P. Infante, B. Botta, M. Mori, F. Ghirga, C. Ingallina e S. Berardozzi. Compounds for use in the treatment of brain diseases. Priority: IT201800002402A · 2018-02-05. Published as: IT201800002402A1·2019-08-05; WO2019149962A1·2019-08-08. From 05-02-2018 to today.
Coauthor of the following patent family: B. Botta, I. Screpanti, L. Tottone, N. Zhadanoskaya, C. Ingallina, F. Giulimondi, D. Quaglio, R. Palermo, M. Mori, F. Ghirga. NOTCH inhibitors for use in the treatment of T-cell acute lymphoblastic leukemia. Priority: IT201600132360A · 2016-12-29; IB2017058204W·2017-12-20. Published as: T201600132360A1 ·2018-06-29; WO2018122689A1·2018-07-05; EP3562803A1·2019-11-06; IUS2019337916A1·2019-11-07. From 29-12-2016 to today.
Coauthor of the following patent family: B. Botta, A. Gulino, M. Botta, M. Mori, L. Di Marcotullio, P. Infante, F. Ghirga, S. Toscano, C. Ingallina, R. Alfonsi. Multitarget hedgehog pathway inhibitors and uses thereof. Priority: ITRM20130366A · 2013-06-25; EP2014063449W · 2014-06-25. Published as: ITRM20130366A1·2014-12-26 (released on 30-09-2015); WO2014207069A1·2014- 12-31; CA2914794A1· 2014-12-31 (Canada, released CA2914794 C 2023/03/14); EP3013331A1 · 2016-05-04 (Europe, released EP3013331B1 2023/03/01); US2016368886A1·2016-12-22; US10093642B2· 09-10-2018 (released). From 25-06-2013 to today.
Coauthor of the following patent family: B. Botta; G. Cancelliere; M. Cassani; I. D Acquarica; G. Delle Monache; F. Gasparrini; G. Lionetti; L. Nevola; A. Nunziata: E. Pierri; D. Subissati; C. Villani. Method of reducing the level of nitrogen oxides in a medium by absorption with resorcin[4]arenes. Priority: EP05425433A·2005-06-17 Published as: AR057375A1; BRPI0612143A2; CA2606974A1; EP1738821A1; EP1896169A1; RU2008100586A; RU2414962C2; SG162802A1; UA92019C2; WO2006136950A1. From 17-06-2005 to today.
Coauthor of the following patent family: S. C. Bonnevaux; B. Botta; M. Carmignani; C. De Luca; R. Espinal; F. Delle Monache; G. Delle Monache. Guanidine derivatives having hypotensive activity, composition containing them and process for obtaining them. Priority: IT4766588A·1988-02-24. Published as: DE330629T1; EP0330629A2; EP0330629A3; ES2013585A4; GR900300066T1; IT1219846B; JPH023661A; US5059624A. From 24-02-1988 to 29-01-2018.
F. Delle Monache, B. Botta, G. Delle Monache, G. B. Marini Bettolo. Estratti di Vismieae contenenti vismioni ad attività citostatica e relativi procedimenti di purificazione. Priority: IT48034/84A 1984-04-13. Published: IT8448034D0; IT8448034A1; IT1177659B.

Book Chapters

Mannina, L., Sobolev, A. P., Aru, V., Bellomaria, A., Bertocchi, F., Botta, B., Cagliani, L. R., Caligiani, A., Capozzi, F., Çela, D., Cesare Marincola, F., Ciampa, A., Del Coco, L., Consonni, R., Corsaro, C., Delfini, M., Di Tullio, V., Fanizzi, F. P., Gallo, V., Ghirga, F., Gianferri, R., Girelli, C. R., Ingallina, C., Laghi, L., Latronico, M., Longobardi, F., Luchinat, C., Mallamace, D., Mammi,S., Mandaliti, W., Marini, F., Mastrorilli, P., Mazzei, P., Miccheli, A., Micozzi, A., Milone, S., Mucci, A., Nepravishta, R., Paci, M., Palisi, A., Piccolo, A., Picone, G., Proietti, N., Randazzo, A., Righi, V., Rotondo, A., Salvo, A., Savorani, F., Scano, P., Schievano, E., Sciubba, F., Tenori, L., Trimigno, A., Turano, P., Vasi, S., & Capitani, D. NMR applications in food analysis. In book: Analytical Chemistry: Developments, Applications and Challenges in Food Science 2017, pp. 103-156.
Sobolev, A.P., Mannina, L., Aru, V., Bellomaria, A., Bertocchi, F., Botta, B., Cagliani, L.R., Caligiani, A., Capozzi, F., Çela, D., Marincola, F.C., Ciampa, A., Del Coco, L., Consonni, R., Corsaro, C., Delfini, M., Di Tullio, V., Fanizzio, F.P., Gallo, V., Ghirga, F., Gianferri, R., Girellio, C.R., Ingallina, C., Laghi, L., Latronico, M., Longobardi, F., Luchinat, C., Mallamace, D., Mammi, S., Mandaliti, W., Marini, F., Mastrorilli, P., Mazzei, P., Miccheli, A., Micozzio, A., Miloneo, S., Mucci, A., Nepravishta, R., Paci, M., Palisi, A., Piccolo, A., Picone, G., Proietti, N., Randazzo, A., Righi, V., Rotondo, A., Salvo, A., Savorani, F., Scano, P., Schievano, E., Sciubba, F., Tenori, L., Trimigno, A., Turano, P., Vasi, S., Capitani, D. NMR applications in food analysis: Part A. In book: Analytical Chemistry: Developments, Applications and Challenges in Food Analysis 2017, pp. 157-253.
Proietti, N., Capitani, D., Aru, V., Bellomaria, A., Bertocchi, F., Botta, B., Cagliani, L.R., Caligiani, A., Capozzi, F., Çela, D., Marincola, F.C., Ciampa, A., Coco, L.D., Consonni, R., Corsaro, C., Delfini, M., Fanizzio, F.P., Gallo, V., Ghirga, F., Gianferri, R., Girellio, C.R., Ingallina, C., Laghi, L., Latronico, M., Longobardi, F., Luchinat, C., Mallamace, D., Mammi, S., Mandaliti, W., Mannina, L., Marini, F., Mastrorilli, P., Mazzei, P., Miccheli, A., Micozzio, A., Miloneo, S., Mucci, A., Nepravishta, R., Paci, M., Palisi, A., Sobolev, A.P., Piccolo, A., Picone, G., Randazzo, A., Righi, V., Rotondo, A., Salvo, A., Savorani, F., Scano, P., Schievano, E., Sciubba, F., Tenori, L., Trimigno, A., Turano, P., Vasi, S., Tullio, V.D. NMR applications in food analysis: Part B. In book: Analytical Chemistry: Developments, Applications and Challenges in Food Analysis 2017, pp. 255-296.
D Acquarica, I., Ghirga, F., Ingallina, C., Quaglio, D., Zappia, G., Uccello-Barretta, G., Balzano, F., Botta, B. Resorc[4]arenes as preorganized synthons for surface recognition and host-guest chemistry. In book: Calixarenes and Beyond 2016, pp. 175-193.
G. Zappia, C. Ingallina, F. Ghirga, B. Botta. Oxazolidin-2-ones: antibacterial activity and chemistry. In book: Antimicrobials: New and Old Molecules in the Fight Against Multi-resistant Bacteria. 2014, pp. 247-266.
Menendez, P., D Acquarica, I., Delle Monache, G., Ghirga, F., Calcaterra, A., Barba, M., Macone, A., Boffi, A., Bonamore, A., Botta, B. Production of Bioactives Compounds: The Importance of Pictet-Spengler Reaction in the XXI Century. In book: Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives 2012, pp. 453-487.

Edited books

Botta et al, Chimica Organica, Edi-Ermes, 2016, Milano (II ed.)
Botta B. et al, Chimica Organica Essenziale, Edi-Ermes, 2018, Milano (II ed.)

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