Characterizing protein-RNA associations is key to unravel the complexity and functionality of mammalian genomes and could open up therapeutic avenues for the treatment of a broad range of neurodegenerative disorders. My laboratory (and related teaching) deals with onassociations of non-coding RNAs, such as Xist, with proteins involved in transcriptional and translational regulation as well as neurodegenerative diseases (examples include Parkinson’s SNCA, FXTAS’ FMRP, ALS-related TDP-43 and FUS). We aim to discover the involvement of RNA (coding, non-coding, viral) molecules in regulatory networks. More specifically, we are interested in understanding mechanisms whose alteration lead to aberrant accumulation of proteins. One part of our research is dedicated to ribonucleoprotein granules and their implication for cell function.
Mercoledi' mattina alle 11.
I graduated at the University Sapienza in the academic year 1999-2000 with a thesis on mathematical modeling of neurons (Physics department).
Between 2001 and 2005, I carried out my doctoral studies at the University of Zurich CH (Biochemistry department) focusing on the folding and misfolding of proteins associated with neurodegenerative disorders. As an associate researcher, I worked at the University of Cambridge UK (Chemistry and Genetics departments) under the supervision of Chris Dobson and Michele Vendruscolo.
In the period 2005-2010, I participated in several computational and experimental studies on amyloidosis. I am life member of the Clare Hall College in Cambridge UK since 2011.
Since 2010 I am a PI at the Centre for Genomic Regulation (CRG) in Barcelona. My group is composed of 5 post-doctoral researchers, 6 doctoral students and 2 technicians. The doctoral and post-doctoral researches hold competitive fellowships from Marie Curie, Ministry of Science and La Caixa bank. In 2013, I have been awarded an ERC starting grant for the studies on the role of coding and non-coding transcripts in regulation of amyloid genes.
Since 2014, I am tenured in Catalonia as ICREA professor of Life and Medical Sciences. In 2018, I became full professor in Biochemistry at Sapienza.
|Modelling of SHMT1 riboregulation predicts dynamic changes of serine and glycine levels across cellular compartments||COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL||2021|
|HOTAIRM1 regulates neuronal differentiation by modulating NEUROGENIN 2 and the downstream neurogenic cascade||CELL DEATH & DISEASE||2020|
|Structural analysis of SARS-CoV-2 genome and predictions of the human interactome||NUCLEIC ACIDS RESEARCH||2020|
|RNA as the stone guest of protein aggregation||NUCLEIC ACIDS RESEARCH||2020|
|Long non-coding RNA-polycomb intimate rendezvous||OPEN BIOLOGY||2020|
|RNA-binding and prion domains: the Yin and Yang of phase separation||NUCLEIC ACIDS RESEARCH||2020|
|Zooming in on protein–RNA interactions: a multilevel workflow to identify interaction partners||BIOCHEMICAL SOCIETY TRANSACTIONS||2020|
|Transcriptomic differences in MSA clinical variants||SCIENTIFIC REPORTS||2020|
|The protective role of m1A during stress-induced granulation||JOURNAL OF MOLECULAR CELL BIOLOGY||2020|
|In silico, in vitro, and in vivo approaches to identify molecular players in fragile X tremor and Ataxia syndrome||FRONTIERS IN MOLECULAR BIOSCIENCES||2020|
|Long non-coding RNA uc.291 controls epithelial differentiation by interfering with the ACTL6A/BAF complex||EMBO REPORTS||2020|
|Proteome-wide observation of the phenomenon of life on the edge of solubility||PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA||2020|
|BacFITBase: A database to assess the relevance of bacterial genes during host infection||NUCLEIC ACIDS RESEARCH||2020|
|RNA-centric approaches to study RNA-protein interactions in vitro and in silico||METHODS||2020|
|CROSSalive: A web server for predicting the in vivo structure of RNA molecules||BIOINFORMATICS||2020|
|Design and functional validation of a mutant variant of the lncRNA HOTAIR to counteract Snail function in Epithelial-to-Mesenchymal Transition||CANCER RESEARCH||2020|
|Insights on protein thermal stability: a graph representation of molecular interactions||BIOINFORMATICS||2019|
|The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism||NUCLEIC ACIDS RESEARCH||2019|
|RNAct: Protein-RNA interaction predictions for model organisms with supporting experimental data||NUCLEIC ACIDS RESEARCH||2019|
|RNA as a key factor in driving or preventing self-assembly of the TAR DNA-binding protein 43||JOURNAL OF MOLECULAR BIOLOGY||2019|