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Martedì e Giovedì ore 11-13

Irene Bozzoni
Curriculum Vitae

Education
1979: Specialization in General Pathology (70/70).
1975: MS Degree with honours in Biology, University of Rome (110/110 cum aude)

Current Positions
Since 1994: Full Professor of Molecular Biology, University of Rome.
Since 2018: Senior Researcher at the Italian Institute of Technology (IIT).

Academic career and research experience
2018-present: Collaborator as Senior Researcher with the Italian Institute of Technology
1994-present: Full Professor of Molecular Biology, University of Rome
1993: Visiting Professor at the University of Boulder, Colorado (USA)
1986-1994: Associate Professor of Molecular Biology, University of Rome
1986: Visiting Professor at the National Institute of Health of Bethesda (USA)
1980-1986: Staff scientist at the Center for Nucleic Acid Research, CNR, Rome, Italy
1985: Visiting Scientist at the University of Zurich (CH)
1978-1980: Research fellow at the Centro Acidi Nucleici of C.N.R., Rome
1979: EMBO fellow at the European Molecular Biology Laboratory, Heidelberg (D)
1977-78: Post-doctoral fellow - Institute of Molecular Biology, University of Zurich (CH)

Academic assignments

2016-2018: Director of the School for Advanced Studies of Sapienza, University of Rome
2007- 2018: Director of the Master Degree in Genetics and Molecular Biology, Sapienza University
1994-2016: Director of the PhD Program in Genetics and Molecular Biology, Sapienza University
2011-2016: Deputy Director of the School of Advanced Studies of Sapienza
2013-2016: Member of the PhD Committee of Sapienza University
2011-2014: President of the Evaluation Committee of the Faculty of Sciences, Sapienza University
2009-2012: Member of the Committee for the Innovation of Research and Technology, Sapienza University
2005-2016: Rappresentative of Sapienza University at the Consorzio Interuniversitario per le Biotecnologie .
2007- 2015: Member of the Technical and Scientific Committee of the Consorzio Sapienza Innovazione of the University La Sapienza and of the Italian Federation for Life Sciences.

Non academic engagements

2018-present: Member of the Management Committee of the Human Technopole.
2018-present: Member of the Advisory Committee dell'Armenise-Harvard Foundation.
2017-present: Member of the Board of the Museo Nazionale della Scienza e della Tecnologia, Leonardo da Vinci",
Milan.
2015- present: Member of the Scientific Advisory Board of the Enciclopedia Treccani .
2012-2018: Review panel member of the Rita Levi-Montalcini Program on Young Researchers of the Ministry of Research and University (MIUR).
2016-2018: Member of the National Committee for abilitation of Full and Associate Professors in Molecular Biology
2016: ERC - Review panel member for ERC, LS3 Consolidator Grants (CoG)
2011-2014: Member of the Review panel member of the membership committee of EMBO
2010-2013: Member of the Scientific Advisory Board of the Committee of Experts for the Research Policy (CEPR), consultant of the of the Italian Ministry of University and Research
2009-2012: Member of the Scientific Advisory Board of the Pezcoller Foundation
2005-2008: Member of the Scientific Advisory Board of Armenise-Harvard Foundation
2000-2003: Member of the Scientific Advisory Board of the Fondazione Chiara D'Onofrio
Evaluator for: EU, ESF, AERES, Welcome Trust, EMBO, HFSP, Armenise-Harvard Foundation, AFM and several international scientific institutions.

Memberships, honors and awards
- In 2013 was awarded of an ERC-Advanced Grant
- In 2010 was awarded the "Sapienza Ricerca Award".
- In 2008 was invited to give the Lectio magistralis for the inauguration of the academic year at Sapienza, University of Rome
- In 2003 and 2006 was awarded two Prizes by the Accademia Nazionale dei Lincei.
- Member of European Molecular Biology Organization (EMBO) and of the "Academia Europaea"
- Member of Italian Society for Biophysics and Molecular Biology
- Member of the Accademia Medica of Rome

Research projects coordinated:
- European Union Horizon 2020:
2016 -Marie Sklodowska Curie Actions -ITN, circRTrain
- European Union - VII Research Framework:
i) ERC-Advanced Grant - Muncodd
ii) People-MSCA- ITN, RNATRAIN Project
iii) RIGHT, Integrated Project
iv) SIROCCO, Integrated Project
- European Science Foundation (ESF)
- Human Frontier Science Program (HFSP)
- French Muscular Dystrophy Association (AFM-Téléthon)
- MIUR (PRIN, FIRB)
- Fondazione Telethon
- ARISLA
- Associazione Italiana per la Ricerca Sul Cancro (AIRC)
- Istituto Pasteur, Fondazione Cenci-Bolognetti
- Parent Project ONLUS
- Istituto Italiano di Tecnologie (IIT) SEED projects

Principal fields of interest

Molecular biology of RNA: Discovery of several new classes of non coding RNAs with important functions in cell differentiation and in disease and definition of their mechanism of actions. Among them the identification of circular RNAs with a significant role in muscle homeostasis.

Fazi F., Rosa A., Fatica A., De Marchis M. L., Gelmetti V., Nervi C. and Bozzoni I. (2005) A mini-circuitry comprising microRNA-223 and transcription factors NFI-A and C/EBP regulates human granulopoiesis. Cell, 123: 819-831.
Cesana M., Cacchiarelli D.Legnini I., Santini T., Sthandier O., Chinappi M., Tramontano A. and Bozzoni I. (2011) Key ceRNA role for the long non-codingRNA linc-MD1 in the control of muscle differentiation. Cell, 147: 358-369
Fatica A. and Bozzoni I. (2014) Long non-coding RNAs: new players in cell differentiation and development. Nature Review Genetics, 15:7-21
Legnini I., Morlando M., Mangiavacchi A., Fatica A. and Bozzoni. I.. (2014) A feed forward regulatory loop between the HuR protein and the long non coding RNA linc-MD1 controls early phases of muscle differentiation. Mol. Cell, 53:1 9.
Ballarino M., Morlando M., Fatica A. and Bozzoni I. (2016) Non-coding RNAs in muscle differentiation and musculoskeletal disease. J. Clin Invest, 126: 2021-2030.
Legnini I., Di Timoteo G, Rossi F, Briganti F, Sthandier O, Morlando M, Fatica A, Andronache A, Wade M, Rajewsky N Bozzoni I (2017) circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis, Mol Cell, 66:22-37.
Dimartino D., Colantoni A., Ballarino M., Martone J., Danner J., Mariani D., Bruckmann A., Meister G., Morlando M. and Bozzoni I. (2018). The long non coding RNA lnc-31 interacts with Rock1 mRNA and mediates its YB-1-dependent translation. Cell Reports, 23:733-740.
Ballarino M, Cipriano A, Tita R, Santini T, Desideri F, Morlando M, Colantoni A, Carrieri C, Nicoletti C, Musarò A, Carroll DO, Bozzoni I. (2018) Deficiency in the nuclear long noncoding RNA Charme causes myogenic defects and heart remodeling in mice. EMBO J., 37. pii: e99697
Rossi F., Legnini I., Megiorni F., Colantoni A., Santini T., Morlando M., Di Timoteo G., Dattilo D., Dominici C. and Bozzoni I. (2019). Circ-ZNF609 regulates G1-S progression in rhabdomyosarcoma. Oncogene, in press.

Neuromuscular diseases: Set up a novel strategy for the gene therapy of Duchenne Muscular Dystrophy based on the exon skipping methodology. Identification of new serum biomarkers for the study of the progression of the disease and for testing the outcome of therapeutic treatments.

Denti M.A., Rosa A., D Antona G., Sthandier O., De Angelis F.G., Nicoletti C., Allocca M., Pansarasa O., Parente V., Musarò A., Auricchio A., Bottinelli R. and Bozzoni I. (2006) Body-wide gene therapy of Duchenne Muscular Dystrophy in the mdx mouse model. Proc. Natl. Acad. Sci. USA, 103: 3758-3763.
Cacchiarelli D., Martone J., Girardi E., Cesana M., Incitti T., Nicoletti C., Santini T., Sthandier O., Auricchio A., Musarò A. & Bozzoni I. (2010). microRNAs Involved in Molecular Circuitries Relevant for the Duchenne Muscular Dystrophy Pathogenesis Are Controlled by the Dystrophin/nNOS Pathway. Cell Metabolism, 12:341-51
Cacchiarelli D., Legnini I. Martone J., D Amico A., Bertini E. and Bozzoni I. (2011) miRNAs as serum biomarkers for Duchenne Muscular Dystrophy. EMBO Mol Med., 5:258-265.
Martone J., Briganti F., Legnini I., Morlando M., Picillo E., Sthandier O., Politano L. and Bozzoni I. (2016) The lack of the Celf2a splicing factor converts a Duchenne genotype into a Becker phenotype. Nat Commun. 7:10488.

Neurodegenerative diseases: Production of induced Pluripotent Stem Cells derived from ALS patients as well as from murine models and reconstitution of in vitro motoneuron differentiation. Identification of several molecular pathways altered in specific ALS mutations.

Dini Modigliani S, Morlando M, Errichelli L, Sabatelli M, Bozzoni I. (2014). An ALS-associated mutation in the FUS 3'-UTR disrupts a microRNA-FUS regulatory circuitry. Nat Commun. 5:4335-41.
Lenzi J., De Santis R., de Turris V., Morlando M., Calvo A., Caliendo V., Chiò A., Rosa A. and Bozzoni I. (2015) ALS mutant FUS protein is recruited into stress granules in induced Pluripotent Stem Cells (iPSCs) derived neurons. Dis. Models and Mech., 8:755-66.
Errichelli L., Dini Modigliani S., Laneve P., Colantoni A., Legnini I., Capauto D., Rosa A., De Santis R., Scarfò R., Giovanna P., Lei L., Caffarelli E., Shneider N., Morlando M. and Bozzoni I. (2017) FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. Nat Commun., 30:14741.
De Santis R., Santini L., Colantoni A. , Peruzzi G., de Turris V., Alfano V., Bozzoni I. and Rosa A. (2017) FUS mutant human motoneurons display altered transcriptome and 2 microRNA pathways with implications for ALS pathogenesis. Stem Cell Reports, 9:1450-1462..
Capauto D., Colantoni A., Lu L., Santini T., Peruzzi G., Biscarini S., Morlando M., Shneider N.A., Caffarelli E., Laneve and Bozzoni I. (2018) A regulatory circuitry between Gria2, miR-409 and miR-495 is affected by ALS FUS mutation in ESC-derived motor neurons. Mol Neurobiology, Feb12, doi: 10.1007/s12035-018-0884-4
Biscarini S., Capauto D., Peruzzi G., Lu L., Colantoni A., Santini T., Shneider N., Caffarelli E., Laneve P. and Bozzoni I. (2018) Characterization of the lncRNA transcriptome in mESC-derived motor neurons: implications for FUS-ALS. Stem Cell Research, 27:172-179

Third mission and society

Several patents have been transferred to the industry and one received the Orphan Drug designation from EMEA. These discoveries are related to molecules for therapeutic and diagnostic applications. These activities have been carried out under collaborative efforts with patients associations (Parent Project).
Granted patents.
- EP 1644499 Australia 2004256322 - JP4762897- siRNA expression system Licenced to: Promega . Inventors: Bozzoni I., Denti M. and Rosa A.
- EP1501931 - Chimeric antisense snRNA molecoles against splice junctions of dystrophin and therapeutic implications Licenced to: Amsterdam Molecular Therapeutics (AMT) Inventors: Bozzoni I. and De Angelis G.F.
- WO 2011/154852 Modified snRNAs for the use in Therapy Inventors: Bozzoni I., Incitti T, De Angelis G.F
- PCT/EP2010/057088 - miRNA biomarkers for the diagnosis of Duchenne Muscular Dystrophy progression, for monitoring therapeutic interventions and as therapeutics Licenced to "Ylichron". Inventors: Bozzoni I., Martone J., Cacchiarelli D. and Girardi E.
- PCT/EP2010/057093 - miR-31 in Duchenne Muscolar Dystrophy therapy Inventors: Bozzoni I., Martone J., Cacchiarelli D. and Incitti T.

CURRICULUM VITAE
di Irene Bozzoni

Studi

1979: Specializzazione in Patologia Generale presso la Facoltà di Medicina e Chirurgia dell'Università di Roma "La Sapienza"
1975: Laurea in Scienze Biologiche presso l'Università di Roma "La Sapienza"

Carriera Accademica - Scientifica

2018- presente: Collaboratore Senior Researcher presso l Istituto Italiano di Tecnologie.
1994-presente: Professore Ordinario di Biologia Molecolare, Sapienza Università di Roma.
1986-94: Professore Associato di Biologia Molecolare, Sapienza Università di Roma.
1980-86: Ricercatore C.N.R. presso il Centro di Studio degli Acidi Nucleici del C.N.R. di Roma.
1978-80: Borsista presso il Centro di Studio degli Acidi Nucleici del C.N.R. di Roma.
1977-78: Post-doc EMBO presso l'Istituto di Biologia Molecolare II dell'Università di Zurigo.

Incarichi Accademici

2016-2018: Direttore della Scuola Superiore di Studi Avanzati della Sapienza
2007-2018: Presidente della Laurea Magistrale in Genetica e Biologia Molecolare Sapienza, Università di Roma.
1994-2016: Direttore del corso di Dottorato in Genetica e Biologia Molecolare Sapienza, Università di Roma.
2011-2016: Vice-direttore della Scuola Superiore di Studi Avanzati della Sapienza
2013-2016: Membro della Commissione Dottorati di Ateneo
2009-2012: Membro del Comitato Tecnico Scientifico del Consorzio Sapienza Innovazione della Sapienza
2005-2016: Rappresentante dell'Ateneo nel Consiglio del Consorzio Interuniversitario per le Biotecnologie.
2007-2015: Membro del Comitato per l Innovazione della Ricerca e delle Tecnologie dell Università La Sapienza di Roma.

Partecipazioni in commissioni e società scientifiche

2018- presente: Membro del Comitato di Gestione dello Human Technopole.
2018- presente: Membro dell Advisory Committee dell'Armenise-Harvard Foundation.
2017-presente: Membro del Consiglio di Amministrazione del Museo Nazionale della Scienza e della Tecnologia, Leonardo da Vinci", Milan.
2015- presente: Membro del Comitato Scientifico dell Enciclopedia Treccani .
2012-2018: Membro del Comitato MIUR Rita Levi-Montalcini Programma giovani ricercatori .
2016-2018: Membro della Commissione Nazionale per Concorsi a Professore di Prima e Seconda Fascia per il settore scientifico disciplinare BIO-11
2016: Membro del comitato di valutazione ERC - LS3 Consolidator Grants (CoG)
2011-2014: Membro del membership committee dell EMBO
2010-2013: Membro del Comitato di Esperti per la politica della Ricerca (CEPR), organo di consulenza del MIUR.
2009-2012: Membro del Comitato Scientifico della Pezcoller Foundation
2000-2003: Membro del Comitato Scientifico della Fondazione Chiara D'Onofrio

Ha svolto attività di revisore per: EU, ESF, AERES, Welcome Trust, EMBO, HFSP, Armenise-Harvard Foundation, AFM e per diverse Istituzioni Scientifiche Internazionali.

Premi e riconoscimenti:

2003 Insignita del premio Giovanna Jucci per la Genetica dall Accademia Nazionale dei Lincei
2006: Premio (Tartufari) per studi di Biologia cellulare assegnato dall Accademia Nazionale dei Lincei.
2008: Invitata a tenere la Lectio magistralis per l inaugurazione dell anno accademico 2008-2009 dell Università La Sapienza di Roma.
2010: Sapienza Ricerca Award per il progetto: Ruolo dell'RNA nella regolazione dell'espressione genica e nella terapia di malattie congenite ed acquisite .
2013: Vincitrice di un ERC-Advanced Grant.

Programmi di ricerca coordinati

- European Union Horizon 2020:
2016 -Marie Sklodowska Curie Actions -ITN, circRTrain
- European Union - VII Research Framework:
i) ERC-Advanced Grant - Muncodd
ii) People-MSCA- ITN, RNATRAIN Project
iii) RIGHT, Integrated Project
iv) SIROCCO, Integrated Project
- European Science Foundation (ESF)
- Unione Europea (Progetti integrati della Ricerca - RIGHT e SIROCCO)
- European Science Foundation (ESF)
- Ministero dell'Istruzione, dell'Università e della Ricerca (PRIN e FIRB)
- Progetti di Ateneo
- Associazione Italiana Ricerca Cancro (AIRC)
- Telethon
- Istituto Italiano di Tecnologie (IIT) Progetti SEED
- Parent Project ONLUS
- Istituto Pasteur, Fondazione Cenci-Bolognetti

Pubblicazioni recenti

Fazi F., Rosa A., Fatica A., De Marchis M. L., Gelmetti V., Nervi C. and Bozzoni I. (2005) A mini-circuitry comprising microRNA-223 and transcription factors NFI-A and C/EBP regulates human granulopoiesis. Cell, 123: 819-831.

Denti M.A., Rosa A., D Antona G., Sthandier O., De Angelis F.G., Nicoletti C., Allocca M., Pansarasa O., Parente V., Musarò A., Auricchio A., Bottinelli R. and Bozzoni I. (2006) Body-wide gene therapy of Duchenne Muscular Dystrophy in the mdx mouse model. Proc. Natl. Acad. Sci. USA, 103: 3758-3763.

Rosa A. , Ballarino M., Sorrentino A., Sthandier O. , De Angelis F.G. , Marchioni M., Guarini A., Fatica A., Peschle C. and Bozzoni I. (2007) The interplay between the master transcription factor PU.1 and miR-424 regulates human monocytic differentiation, Proc. Natl. Acad. Sci. USA, 104:19849-54.

Morlando M., Ballarino M., Gromak N., Pagano F., Bozzoni I. and Proudfoot N. (2008) Primary microRNA transcripts are processed co-transcriptionally, Nat Struct. Mol. Biol., 15: 902 909.

Incitti T., De Angelis F.G., Cazzella V., Sthandier O., Pinnarò C., Legnini I., and Bozzoni I. (2010) Exon skipping and Duchenne Muscular Dystrophy therapy: selection of the most active U1 snRNA-antisense able to induce dystrophin exon 51, Mol. Ther., 18:1675-82.

Cacchiarelli D., Martone J., Girardi E., Cesana M., Incitti T., Nicoletti C., Santini T., Sthandier O., Auricchio A., Musarò A. & Bozzoni I. (2010). microRNAs Involved in Molecular Circuitries Relevant for the Duchenne Muscular Dystrophy Pathogenesis Are Controlled by the Dystrophin/nNOS Pathway. Cell Metabolism, 12:341-51

Cacchiarelli D., Incitti T., Martone J., Cesana M., Cazzella V., Santini T., Sthandier O. and Bozzoni I. (2011) miR-31 modulates dystrophin expression: novel implications in Duchenne Muscular Dystrophy therapy. EMBO Rep., 12:136-41

Cacchiarelli D., Legnini I. Martone J., D Amico A., Bertini E. and Bozzoni I. (2011) miRNAs as serum biomarkers for Duchenne Muscular Dystrophy. EMBO Mol Med., 5:258-265.

Cesana M., Cacchiarelli D.Legnini I., Santini T., Sthandier O., Chinappi M., Tramontano A. and Bozzoni I. (2011) Key ceRNA role for the long non-codingRNA linc-MD1 in the control of muscle differentiation. Cell, 147: 358-369.

Morlando M., Dini Modigliani S., Torrelli G., Rosa A., Di Carlo V., Caffarelli E. and Bozzoni I. (2012) FUS stimulates microRNA biogenesis by facilitating co-transcriptional Drosha recruitment. EMBO J. 31:4502-10.

Fatica A. and Bozzoni I. (2014) Long non-coding RNAs: new players in cell differentiation and development. Nature Review Genetics, 15:7-21

Legnini I., Morlando M., Mangiavacchi A., Fatica A. and Bozzoni. I.. (2014) A feed forward regulatory loop between the HuR protein and the long non coding RNA linc-MD1 controls early phases of muscle differentiation. Mol. Cell, 53:1 9.

Course Code Year Course - Attendance
Gene expression regulation of eukaryotes 1051857 2021/2022 Genetics and Molecular Biology
Gene expression regulation of eukaryotes 1051857 2020/2021 Genetics and Molecular Biology
Gene expression regulation of eukaryotes 1051857 2019/2020 Genetics and Molecular Biology
MOLECULAR BIOLOGY 1044546 2018/2019 Physics
Gene expression regulation of eukaryotes 1051857 2018/2019 Genetics and Molecular Biology
MOLECULAR BIOLOGY 1044546 2017/2018 Physics
Gene expression regulation of eukaryotes 1051857 2017/2018 Genetics and Molecular Biology
MOLECULAR BIOLOGY 1044546 2016/2017 Physics
Gene expression regulation of eukaryotes 1051857 2016/2017 Genetics and Molecular Biology
Title Journal Year
A longitudinal study defined circulating microRNAs as reliable biomarkers for disease prognosis and progression in ALS human patients CELL DEATH DISCOVERY 2021
FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retention NUCLEIC ACIDS RESEARCH 2020
Modulation of circRNA Metabolism by m6A Modification CELL REPORTS 2020
SMaRT lncRNA controls translation of a G-quadruplex-containing mRNA antagonizing the DHX36 helicase EMBO REPORTS 2020
Trans-generational epigenetic regulation associated with the amelioration of Duchenne Muscular Dystrophy EMBO MOLECULAR MEDICINE 2020
Proteomics analysis of FUS mutant human motoneurons reveals altered regulation of cytoskeleton and other ALS-linked proteins via 3′UTR binding SCIENTIFIC REPORTS 2020
Intronic Determinants Coordinate Charme lncRNA Nuclear Activity through the Interaction with MATR3 and PTBP1 CELL REPORTS 2020
Circular RNAs in cell differentiation and development DEVELOPMENT 2020
Circ-ZNF609 regulates G1-S progression in rhabdomyosarcoma ONCOGENE 2019
Increased FUS levels in astrocytes leads to astrocyte and microglia activation and neuronal death SCIENTIFIC REPORTS 2019
Dysregulation of Circular RNAs in Myotonic Dystrophy Type 1 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2019
Mutant FUS and ELAVL4 (HuD) aberrant crosstalk in Amyotrophic Lateral Sclerosis CELL REPORTS 2019
miR-135a Regulates Synaptic Transmission and Anxiety-Like Behavior in Amygdala MOLECULAR NEUROBIOLOGY 2018
Protein complex scaffolding predicted as a prevalent function of long non-coding RNAs NUCLEIC ACIDS RESEARCH 2018
A Regulatory Circuitry Between Gria2, miR-409, and miR-495 Is Affected by ALS FUS Mutation in ESC-Derived Motor Neurons MOLECULAR NEUROBIOLOGY 2018
Characterization of the lncRNA transcriptome in mESC-derived motor neurons: Implications for FUS-ALS STEM CELL RESEARCH 2018
The Long Non-coding RNA lnc-31 Interacts with Rock1 mRNA and Mediates Its YB-1-Dependent Translation CELL REPORTS 2018
Deficiency in the nuclear long noncoding RNACharme causes myogenic defects and heart remodeling in mice EMBO JOURNAL 2018
The lncRNA Charme regulates skeletal muscle differentiation and heart development 2018
Non-coding regulation of myogenic chromatin 2018
Department
BIOLOGIA E BIOTECNOLOGIE "CHARLES DARWIN"
SSD

BIO/11