Catalogo dei Corsi di studio

https://corsidilaurea.uniroma1.it/it/users/lauraciapponiuniroma1it

https://drosophila-ciapponi-lab9.webnode.it/

CURRICULUM VITAE ET STUDIORUM

NAME: Laura Ciapponi
Place and date of birth: Rome 19-10-1967
Nationality: Italian

CURRENT POSITION
Associate Professor of Genetics at Sapienza, University of Rome, Department of Biology and Biotechnologies, C. Darwin.

PREVIOUS POSITIONS
1998 -2001: Long Term EMBO postdoctoral fellow, EMBL/Heidelberg (Germany), Department of Developmental Biology.
2001-02: Research associate position at the University of Rochester School of Medicine and Dentistry, Department of Biomedical Genetics (USA, NY).
2003-08: Assistant Professor of Genetics at Sapienza, University of Rome, Department of Genetics and Molecular Biology, C. Darwin, with the Rientro dei cervelli program by Ministero dell Istruzione, dell Università e della Ricerca (MIUR).

EDUCATION
1993: Degree in Biology, at Sapienza, University of Rome with the score of 110/110 and honor.
1997: PhD in Genetics and Molecular Biology, Sapienza, University of Rome, at IRBM P. Angeletti-Merck laboratories, Department of Genetics (Italy).

FELLOWSHIPS and GRANTS
2017-2021 Principal investigator grant of The French Muscular Dystrophy Association (AFM-Telethon- 21025)
Principal investigator of several SAPIENZA Ateneo grants
Partner - Fondazione Cenci-Bolognetti-Pasteur Institute (Italy)
Partner - Associazione Italiana Ricerca per il Cancro (AIRC)
Partner - Fondazione Telethon
Rientro dei Cervelli fellowship
EMBO postdoctoral fellow

SCIENTIFIC INTEREST
o DNA repair and telomeres stability in Drosophila melanogaster
o Genetic control of mitosis in Drosophila melanogaster
o Drosophila melanogaster as model of human neurodegenerative disorders
o Specificity of ERK and JNK signal transduction pathways activation during Drosophila melanogaster development
o Epigenetics and gene regulation
TEACHING ACTIVITIES
Lecturer at Sapienza
o Structural and functional analysis of genomes (Biological Science)
o Enviromental mutagenesis (Biological Science)
o Genomics (Biological Science)
o Genetics (Biological Science)
o Genetics and Computational Genomics (Bioinformatics)

2008 pres. Direct supervisor of 3 post-doctoral fellows, some PhD students, and more than 20 undergraduate students.

SELECTED PUBLICATIONS
1. Coni S, Falconio FA, Marzullo M, Munafò M, Zuliani B, Mosti F, Fatica A, Ianniello Z, Bordone R, Macone A, Agostinelli E, Perna A, Matkovic T, Sigrist S, Silvestri G, Canettieri G and Ciapponi L. Translational control of polyamine metabolism by CNBP is required for Drosophila locomotor function doi: https://doi.org/10.1101/2021.04.29.441910
2. Maccallini P, Bavasso F, Scatolini L., Bucciarelli E., Noviello G., Lisi V., Palumbo V., Cacchione S., Cenci G., Ciapponi L., Wakefield J, Gatti M. and Raffa GD Intimate functional interactions between TGS1 and the Smn complex revealed by an analysis of the Drosophila eye development. PLOS GENETICS 2020. doi:10.1371/journal.pgen.1008815.
3. Strah N., Romano G., Introna C., Klima R., Marzullo M., Ciapponi L., Megighian A., Nizzardo M. and Feiguin F. TDP-43 promotes the formation of neuromuscular synapses through the regulationof Disc-large in Drosophila skeletal muscles. BMC Biol. 2020;18(1):34. doi:10.1186/s12915-020-00767-7
4. Bosso G, Cipressa F, Moroni ML, et al. NBS1 interacts with HP1 to ensure genome integrity. Cell Death Dis. 2019;10(12):95. doi:10.1038/s41419-019-2185-x
5. Cicconi A., Micheli E., Vernì F., Jackson A., Gradilla A.C., Cipressa F., Raimondo D., Bosso G., Wakefield J.G., Ciapponi L., Cenci G., Gatti M., Cacchione S., Raffa G.D. The Drosophila telomere-capping protein Verrocchio binds single-stranded DNA and protects telomeres from DNA damage response. Nucleic Acids Res. 2016. doi:10.1093/nar/gkw1244
6. D'Amico D., Antonucci L., Di Magno L., Coni S., Sdruscia G., Macone A., Miele E., Infante P., Di Marcotullio L., De Smaele E., Ferretti E., Ciapponi L., et al. Non-canonical Hedgehog/AMPK-Mediated Control of Polyamine Metabolism Supports Neuronal and Medulloblastoma Cell Growth. Developmental Cell. 2015; 35: 21-35.
7. Cenci G., Ciapponi L*., Marzullo M, Raffa G.D., Morciano P., Raimondo D., Burla R., Saggio I. and Gatti. The analysis of pendolino (peo) mutants reveals differences in the fusigenic potential among Drosophila telomeres. Plos Genetics 2015. 10.1371/journal.pgen.1005260. *Cofirst author
8. Antonucci L., D Amico D, Di Magno L., Coni S., Di Marcotullio L., Cardinali B., Gulino A., *Ciapponi L. and Canettieri L. CNBP regulates wing development in Drosophila melanogaster by promoting IRES-dependent translation of dMyc. Cell Cycle 2013. 13:434-439. doi: 10.4161/cc.27268. *Cocorresponding author.
9. Raffa G.D., Raimondo D., Sorino C., Cugusi S., Cenci G., Cacchione S., Gatti M. and Ciapponi L. Verrocchio, a Drosophila OB fold-containing protein, is a component of the terminin telomere-capping complex. Genes & Development 2010; 24: 1596-1601.
10. Ciapponi L. and Cenci G. Telomere capping and cellular checkpoints: clues from fruit flies. Cytogenet Genome Res. 2008; 122: 365-373.
11. Somma M.P., Ceprani F., Bucciarelli E., Naim V., De Arcangelis V., Piergentili V., Palena A., Ciapponi L. et al. Identification of Drosophila mitotic genes by combining co-expression analysis and RNA interference. Plos Genetics 2008; 4(7): e1000126 doi:10.1371/journal.pgen.1000126.
12. Musarò M., Ciapponi L., Fasulo B., Gatti M. and Cenci G. Unprotected Drosophila telomeres activate the spindle assembly checkpoint. Nature Genetics 2008; 40: 362-366.
13. Ciapponi L., Cenci G., Ducau J., Flores C., Johnson-Schlitz D., Gorski M.M., Engels W.R., Gatti M. Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage. Curr Biol. 2004; 14:1360-1366.
14. Ciapponi L., Jackson D., Mlozik M., and Bohmann D. Drosophila Fos mediates ERK and JNK signals via distinct phosphorylation sites. Genes & Development 2001; 15: 1540-1553.
15. Ciapponi L., Maione D., Scoumanne A., Costa P., Hansen M.B., Svenson M., Bendtzen K., Alonzi T., Paonessa G., Cortese R., Ciliberto G. and Savino R. Induction of interleukin-6 (IL-6) autoantibodies through vaccination with an engineered IL-6 receptor antagonist. Nature Biotechnology 1997; 15: 997-1001