Catalogo dei Corsi di studio

ITALIANO

Stefania Annarita Nottola - Curriculum Vitae

DATI PERSONALI
Anno di nascita: 1958

INDIRIZZO ATTUALE

Dipartimento di Scienze Anatomiche, Istologiche, Medico-Legali e dell Apparato Locomotore
Sezione di Anatomia Umana Unità di Ricerca Microscopia Elettronica
Facoltà di Farmacia e Medicina, Università di Roma La Sapienza
Via A. Borelli 50, 00161 Roma, Italia

Tel.: +39-06-49918072; Fax: +39-06-49918081
e-mail: stefania.nottola@uniroma1.it
sito web: https://sites.google.com/a/uniroma1.it/stefanianottola/
ORCID: orcid.org/0000-0002-4626-6328

OCCUPAZIONE ATTUALE

Dal 3 Settembre 2019: Professore di I fascia, Anatomia Umana (SC 05/H1 ANATOMIA UMANA; SSD BIO/16 ANATOMIA UMANA).

CURRICULUM STUDIORUM

1984: Laurea in Medicina e Chirurgia, con lode, Università di Roma La Sapienza; Abilitazione all esercizio della professione di Medico Chirurgo, Università di Roma La Sapienza. 1990: Titolo di Dottore in Ricerca, Ministero dell Università e della Ricerca Scientifica e Tecnologica.

MADRELINGUA: Italiano

ALTRA LINGUA: Inglese

ATTIVITA DI SERVIZIO

1988-1998: Funzionario Tecnico VIII qualifica, Istituto di Anatomia Umana Normale, Università di Roma La Sapienza, I cattedra, Titolare Prof. Pietro M. Motta; 1998-2000: Ricercatore Universitario, Istituto di Anatomia Umana Normale, Università di Roma La Sapienza. 2000-2019: Professore di II fascia, Anatomia Umana (Settore s/d: BIO/16), Dipartimento di Scienze Anatomiche, Istologiche, Medico-Legali e dell Apparato Locomotore, Università di Roma La Sapienza.

INCARICHI ACCADEMICI

Dal 2021: Responsabile del Laboratorio di Microscopia Elettronica Pietro M. Motta , Dipartimento di Scienze Anatomiche, Istologiche, Medico-Legali e dell Apparato Locomotore;
Dal 2021: Membro del Comitato Scientifico Accordo Quadro tra l Università La Sapienza e la Soprintendenza Archeologia, Belle Arti e Paesaggio per le Province di Frosinone e Latina Ministero per la Cultura;
Dal 2019: Membro della Commissione Ricerca Dipartimentale; Dal 2010: Membro della Commissione Sito Web Dipartimentale;

2021-2023: Membro della Commissione Ricerca di Ateneo;
2011-2015: Coordinatore del Dottorato di Ricerca in Dermatologia, Anatomia e Chirurgia Plastica, Università di Roma La Sapienza;
2011-2014: Membro della Giunta della Facoltà di Farmacia e Medicina, Università di Roma La Sapienza;
2005-2010: Segretario della Commissione Ricerca della I Facoltà di Medicina e Chirurgia, Università di Roma La Sapienza;
2000-2005: Vice-Presidente della suddetta Commissione.

ATTIVITA DIDATTICA

ATTIVITÀ DIDATTICA PRESSO L UNIVERSITÀ DI ROMA LA SAPIENZA:

Corsi di Laurea e Laurea Magistrale

Corso di Laurea Magistrale in Medicina e Chirurgia A : Docente di Anatomia Umana (dal 1999), Coordinatore del Corso Integrato di Anatomia Umana I, I Semestre, I Anno (dal 2010); Coordinatore I Semestre, II anno (dal 2016); Membro della Commissione Paritetica (dal 2002);

Corso di Laurea Magistrale in Medicina e Chirurgia F in lingua Inglese (International Medical School): Docente di Human Anatomy, Coordinatore del Corso Integrato di Human Anatomy II, I Semestre, II Anno (dal 2012);

Corso di Laurea Magistrale in Medicina e Chirurgia Sant Andrea : Docente di Anatomia Umana e Clinica (dal 2021);

Corso di Laurea in Ostetricia A , sede Policlinico Umberto I: Docente di Anatomia Umana (dal 2008), Docente di Istologia (2008-2019), Coordinatore del Corso Integrato di Basi Anatomo-Fisiologiche del Corpo Umano - in precedenza Corso Integrato di Anatomia, Istologia e Fisiologia (dal 2008); Coordinatore I Semestre, I anno (dal 2022);

Corso di Laurea in Tecniche di Radiologia Medica per Immagini e Radioterapia A , sede Policlinico Umberto I: Docente di Anatomia Umana (dal 2001), Docente di Istologia (2005-2019), Coordinatore del Corso Integrato di Basi Morfologiche e Funzionali del Corpo Umano - in precedenza Corso Integrato di Anatomia, Istologia e Fisiologia (dal 2001);

Corso di Laurea in Infermieristica I , sede IFO Regina Elena: Presidente del Corso di Laurea (dal 2017); Docente di Anatomia Umana, Coordinatore del Corso Integrato di Basi Anatomo-Fisiologiche del Corpo Umano - in precedenza Corso Integrato di Anatomia, Istologia e Fisiologia; Coordinatore del I Semestre, I anno (dal 2001).

Dottorato di Ricerca

Membro del Collegio dei Docenti del Dottorato di Ricerca in Tecnologie Innovative nelle Malattie dello Scheletro, della Cute e del Distretto Oro-Cranio-Facciale (dal XXX ciclo); Membro del Collegio dei Docenti del Dottorato di Ricerca in Scienze Morfofunzionali (XXVIII/XXIX ciclo); Coordinatore e Membro del Collegio dei Docenti del Dottorato di Ricerca in Dermatologia, Anatomia e Chirurgia Plastica (fino al XXVII ciclo).

Masters

Master Biologia della Nutrizione per la Riproduzione Umana (Docente, Membro del Comitato Scientifico) (dal 2021).

ATTIVITÀ DIDATTICA PRESSO ALTRE UNIVERSITÀ:

Corsi di Laurea e Laurea Magistrale

Università Cattolica Nostra Signora del Buon Consiglio, Tirana, Albania (dal 2021): Attività di docenza esterna (Docente di Anatomia Umana, Corso di Laurea in Farmacia);

West Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan (2017): Visiting Professor (Docente di Anatomia Umana, lezioni teoriche e pratiche per gli studenti del I anno della Facoltà di Medicina Generale).

Masters

Università Roma Tre (2020-2021): Master Embriologia Umana Applicata (Docente);

Università dell Aquila (2013): Master Gestione della Qualità e Sicurezza nei Processi di Manipolazione e Conservazione di Cellule e Tessuti Umani (Docente) ;

Università dell Aquila (2010-2011): Master Sicurezza e Biotecnologie - Gestione della Qualità e Sicurezza nei Processi di Manipolazione e Conservazione di Cellule e Tessuti Umani (Docente);

Istituto Superiore Universitario di Formazione Interdisciplinare, Università del Salento (2001): Master: Electron Microscopy: a Tool for Industrial Quality and Environmental Monitoring (Docente).

ATTIVITA' DI RICERCA

PRINCIPALI LINEE DI RICERCA

Biologia della riproduzione. Studi al microscopio ottico, elettronico a trasmissione e scansione (convenzionale e a pressione variabile), immunoistochimici e di immunofluorescenza sugli aspetti morfodinamici della fecondazione nella specie umana ed in altri mammiferi, in differenti condizioni ormonali e microambientali, con particolare riferimento a diversi protocolli di fecondazione assistita. Studi ultrastrutturali sulla morfologia dell ovocita umano dopo l applicazione di differenti procedure di criopreservazione. Studi sulla morfologia di ovociti umani e di altri mammiferi immaturi e/o sottoposti a maturazione in vitro. Studi sulla embriogenesi della gonade femminile umana. Studi ultrastrutturali sul complesso luteo-follicolare nell'ovaio umano e di altri mammiferi in condizioni normali, sperimentali (criopreservazione e trapianto di tessuto ovarico, follicologenesi in vitro) e patologiche. Studi ultrastrutturali sulle vie genitali femminili nei mammiferi. Studi sulla vascolarizzazione dell'ovaio e della tuba di mammiferi, effettuati applicando la tecnica della corrosione di calchi vascolari per la microscopia elettronica. Studi sulla morfologia ultrastrutturale di spermatozoi umani sottoposti a differenti protocolli di criopreservazione. Studi sulle caratteristiche morfologiche delle gonadi e dei gameti femminili e maschili di mammifero esposti ad inquinanti ambientali (pesticidi e radiazioni). Studi ultrastrutturali sulla placenta umana (esposizione ad inquinamento da microplastiche).

ALTRE LINEE DI RICERCA

Studi al microscopio ottico, elettronico a scansione e trasmissione, immunoistochimici e di immunofluorescenza in ambito odontostomatologico (tessuti del dente, materiali, strumenti), su biomateriali, nanomateriali, nanoparticelle, su cellule tumorali e su cellule e tessuti degli apparati cardiovascolare, neuroendocrino, digerente.

PUBBLICAZIONI SCIENTIFICHE

Più di 300 lavori scientifici, pubblicati in riviste, libri e proceedings a diffusione nazionale ed internazionale, o pubblicati in abstract books, in seguito alla partecipazione a congressi nazionali ed internazionali, anche su invito.

SINTESI DELLA PRODUZIONE SCIENTIFICA (database: SCOPUS, rif. Settembre 2023)

N° pubblicazioni: 130
N° pubblicazioni (ultimi 10 anni): 62

N° citazioni: 3378
N° citazioni (ultimi 15 anni): 1443

H-index: 35
H-index (ultimi 15 anni): 23

ATTIVITÀ EDITORIALE SCIENTIFICA

Editor-Co-Editor di 8 volumi.

Membro dell Editorial Board delle riviste:

Austin Journal of Reproductive Medicine & Infertility (Austin Publishing Group);
International Journal of Fertility and Sterility (Royan Institute of Iran);
International Journal of Reproductive Medicine (Hindawi Publ. Co.) (fino al 2022);
Journal of Iranian Anatomical Sciences (Iranian Society of Anatomical Sciences);
Journal of Assisted Reproduction and Genetics (Springer) (fino al 2018);
Marcello Malpighi Symposia Series (Rome) (Associate Editor);
Medical Journal of West Kazakhstan (West Kazakhstan Marat Ospanov State Medical University);
Microscopy Research and Technique (Wiley - New York) (Guest Editor);
Reproductive Biology & Endocrinology (BMC, Ltd.) (fino al 2017);
The Open Anatomy Journal (Bentham Science Publishers) (Regional Editor for Europe);
The Open Medicine Journal (Bentham Science Publishers) (Associate Editor).
Referee (Peer Reviewer) per le riviste: Aging, American Journal of Reproductive Immunology, Anatomia Histologia Embryologia, Animal Reproduction, Cell Cycle, Cell Tissue Research, Cryobiology, Cryoletters, Current Stem Cell Research, EOMT, European Biophysics Journal, Fertility and Sterility, Histology & Histopathology, Human Reproduction, International Journal of Developmental Biology, International Journal of Reproductive Medicine, Journal of Assisted Reproduction and Genetics, Life Sciences, Medical Science Monitor, Microscopy & Microanalysis, Molecular Human Reproduction, Plos One, Reproductive BioMedicine Online, Theriogenology, Yakhteh (The Cell), Zygote.

ATTIVITA EDITORIALE DIDATTICA

Autore/Curatore di 8 Volumi (testi e atlanti di Anatomia Umana).

FONDI

Titolare di fondi nazionali ed internazionali per differenti progetti di ricerca (MIUR, PRIN, Università La Sapienza, Ministero degli Affari Esteri, Ministero della Salute, Istituto Superiore di Sanità).

SOGGIORNI ALL'ESTERO

1988-1989: Visiting Investigator in Giappone, presso gli Istituti Anatomici delle Facoltà di Medicina delle seguenti Università: Tottori University, Yonago; Osaka University, Osaka; Okayama University, Okayama.

ASSOCIAZIONI SCIENTIFICHE

Dal 1987: membro della Società Italiana di Anatomia e Istologia (SIAI); dal 1995: membro (socio fondatore e segretario scientifico) della Academia Malpighiana Studiorum Anatomiae Microscopicae; dal 1997 al 2002: membro della Società Internazionale di Medicina della Riproduzione Alpha ; dal 1998: membro (socio fondatore e, dal 2020, membro del comitato scientifico) della Società Italiana di Embriologia, Riproduzione e Ricerca (SIERR); dal 2000: membro della Società Italiana della Riproduzione (SIdR); dal 2005: membro della European Society of Pathology (Electron Microscopy Working Group); dal 2008: membro della Società Italiana di Scienze Microscopiche (SISM); dal 2014: membro del Collegio dei Docenti di Anatomia Umana; dal 2015: membro onorario della Società Argentina di Anatomia Clinica.

ORGANIZZAZIONE DI CONGRESSI E DI SIMPOSI NAZIONALI ED INTERNAZIONALI

Membro del Comitato Organizzatore e Segretario Scientifico in: VIII International Symposium on Morphological Sciences (Roma, 1988), 2nd International Malpighi Symposium (Roma, 1995), 15th Congress of the International Federation of Associations of Anatomists (IFAA) e 4th International Malpighi Symposium (Roma, 1999). Membro del Comitato Scientifico del II Congresso Nazionale SIERR (Napoli, 2003). Membro del Comitato Organizzatore del 5th International Malpighi Symposium (Roma, 2003). Membro dell International Advisory Board del XVIII International Symposium on Morphological Sciences (Belgrado, Serbia, 2005). Organizzatore di Simposi durante il XXI International Symposium on Morphological Sciences (Taormina-Messina, 2010), il 34° Congresso della Società Italiana di Istochimica (S. Benedetto del Tronto, AP, 2011) ed il XXV International Symposium on Morphological Sciences (Xi an, Cina, 2017). Membro dell International Committee del 7th Yazd International Congress and Student Award in Reproductive Medicine (Yazd, Iran, 2017). Membro del Comitato Scientifico del 2°, 3°, 4° e 5° Convegno Chi dice Donna dice. Donna (Casamari, FR, 2018, 2019, 2020, 2021); Membro del Comitato Scientifico del Convegno La Donna ieri e oggi . Il suo tempo, i suoi spazi (Tirana, Albania, 2019). Membro del Comitato Scientifico del IX Congresso Nazionale SIERR (Roma, 2022). Membro del Comitato Scientifico del Convegno Ambiente Donna: dal clima alla salute (Tirana, Albania, 2022).

PARTECIPAZIONE A CONGRESSI E SIMPOSI

Più di 100 Congressi Nazionali ed Internazionali, spesso in qualità di relatore invitato e/o di moderatore.

RECENTI RELAZIONI SU INVITO (SELEZIONE)

1. Electron microscopy studies on cryopreserved gametes and embryos . IVIRMA Global Research Alliance - Procreazione Symposium 2023, Bologna, 21-23 Settembre 2023.
2. Ultrastructural insights in assisted reproduction: The oocyte perspective . XXXIX Congresso della Società Italiana di Istochimica, Vulcano (ME), 14-16 Giugno 2023.
3. Donna, ambiente, salute riproduttiva . Ambiente Donna: dal clima alla salute, Università Cattolica Nostra Signora del Buon Consiglio, Tirana, Albania, 13 Maggio 2022.
4. Electron microscopy and allied disciplines for the study of gametes and embryos . Tecnobios Procreazione (9.Baby) Symposium 2021, Bologna, 16-18 Settembre 2021.
5. Female body identity and transformation after death: The Dance Macabre of Anatomy . XXVII International Symposium on Morphological Sciences, Almaty, Kazakhstan, May 27-31, 2021.
6. Women and Assisted Reproduction: The Oocyte Perspective . Incontro di studio Natalità e Pari Opportunità . Campidoglio - Sala della Protomoteca, Roma, 3 Ottobre 2020.
7. Spermatozoa and oocytes under the electron microscopy lens . Tecnobios Procreazione (9.Baby) Symposium 2020, Bologna, 24-26 Settembre 2020.
8. I mitocondri di Eva, la madre delle madri . Convegno Quando la scienza è donna. Passato, presente e futuro . Campidoglio - Sala della Protomoteca, Roma, 7 Dicembre 2019.
9. La bellezza non svanirà: immagini di figure femminili tra anatomia, scienza e arte . Convegno Donna: la Grande Bellezza , Abbazia di Casamari, Veroli (FR), 23 Novembre 2019.
10. Ultrastructure of human oocytes subjected to different protocols of assisted reproduction . Nanoinnovation 2019. Rome, June 11-14, 2019.
11. I mitocondri di Eva e il cerchio della vita . La donna ieri e oggi. Il suo tempo, i suoi spazi, Università Cattolica Nostra Signora del Buon Consiglio, Tirana, Albania, 12 Aprile 2019.
12. La preservazione della fertilità femminile: stato dell arte e prospettive future . La Donna Oggi per l Europa di Domani, Università Cattolica Nostra Signora del Buon Consiglio, Tirana, Albania, 21 Maggio 2018.
13. The international medical schools in Italy: facts and perspectives . International Scientific and Methodological Conference - Internationalization of Continuing Medical Education: a Prospection. Aktobe, Kazakhstan, April 26-27, 2018.
14. La preservazione della fertilità: aspetti clinici, etici e sociali . 1° Convegno Chi dice donna dice...donna , Abbazia di Casamari, Veroli (FR), 25 Novembre 2017.
15. Influence of different macromolecular supplements on the ultrastructural morphology of the human oocyte during cryopreservation . XXV International Symposium on Morphological Sciences, Xi an, China, July 26-30, 2017.
16. Ultrastructural markers of quality in human metaphase II oocytes cryopreserved with media containing different macromolecular supplements . 7th Yazd International Congress and Student Award in Reproductive Medicine, Yazd, Iran, April 28-30, 2017.
17. Effects of cryopreservation on the ultrastructure of human oocytes in assisted reproductive technology . I International Congress Of Clinical Anatomy, Buenos Aires, Argentina, September 24-26, 2015.
18. Ultrastructural modifications in the organular pattern of human metaphase II oocytes subjected to freeze-thawing . XIV International Symposium on Morphological Sciences, Istanbul, Turkey, September 2-6, 2015.
19. Organelle morphodynamics in human mature oocytes after cryopreservation. Ultrastructural analysis at different time intervals during thawing . 6th Yazd International Congress and Student Award in Reproductive Medicine, Yazd, Iran, April 17-19, 2015.
20. Ultrastructural assessment of quality of in-vitro matured human oocytes . XXIII International Symposium on Morphological Sciences, Niigata, Japan, September 10- 13, 2013.
21. Morphological effects of pesticides on the mammalian ovarian follicle . Conference: Actual problems of experimental and clinical morphology, Aktobe City, Kazakhstan, May 30-31, 2013.
22. Analisi della morfologia ultrastrutturale di ovociti umani maturi crioconservati tramite congelamento lento o vitrificazione . Congresso Nazionale di Medicina della Riproduzione, Riccione (RN), Italy, May 23-25, 2013.
23. Ultrastructural features of human mature (metaphase II) oocytes subjected to slow freezing or vitrification: A comparative analysis . 24th European Congress of Pathology, Prague, September 8-12, 2012.
24. Ultrastruttura del follicolo ovarico di topo coltivato in vitro . Tecnobios Procreazione Symposium 2011. Desenzano del Garda, Italy, September 14-15, 2011.
25. Ultrastructural features and meiotic spindle dynamics in human mature oocytes subjected to different cryopreservation protocols . 34th Congress of the Italian Society of Histochemistry. S. Benedetto del Tronto (AP), Italy, June 7-9, 2011.
26. Ultrastructural features of cryopreserved oocytes after slow freezing and vitrification .
Tecnobios Procreazione Symposium 2010. Bologna, Italy, 24-25 November 2010.
27. Neural stem cells in neurospheres, embryoid bodies and the CNS of advanced human embryos, in vivo (spontaneous differentiation) . Expanding Boundaries in Reproductive Medicine and Technology (5th World Congress of the World Association of Reproductive Medicine). Moscow, Russia, October 10-13, 2010.
28. Ultrastructural markers of quality in human vitrified oocytes . Expanding Boundaries in Reproductive Medicine and Technology (5th World Congress of the World Association of Reproductive Medicine). Moscow, Russia, October 10-13, 2010.
29. Ultrastructural analysis of cryopreserved oocytes after slow cooling and vitrification . XXI International Symposium on Morphological Sciences. Taormina (Messina), Italy, September 18-22, 2010.
30. Sperm selection for ART: fine structure and sperm contribution to fertility . IMSI: New
Advances. Rome, Italy, 25-26 June 2010.
31. Ovarian tissue cryopreservation and grafting: an ultrastructural approach . 10th
Royan Congress on Reproductive Biomedicine, Tehran, Iran, September 23-25, 2009.
32. Ultrastructure of human preovulatory oocyte in assisted reproduction protocols . 10th
Royan Congress on Reproductive Biomedicine, Tehran, Iran, September 23-25, 2009. 30. Ultrastructural markers of quality in human vitrified oocytes . 13th World Congress on
Human Reproduction, Venice, Italy, March 5-8, 2009.
31. The preservation of fertility in humans: Ultrastructural analysis of different approaches . In-vitro Embryology: New Trends in Reproductive Medicine (3rd World Congress of the World Association of Reproductive Medicine), Rome, Italy, 27 September-1 October 2006.
32. Behaviour of the oocyte surfaces from early gonadal development to fertilization: A review by scanning electron microscopy . The 16th International Microscopy Congress, Sapporo, Japan, September 3-8, 2006.
33. Ultrastructural morphology of the oocyte from its stem origin to fertilization . International Symposium on Recent Advances in Animal Science, Joint Meeting of 2nd IS-AS and -3rd IS-IFS, Sendai, Japan, 16-18 November 2005.
34. Ultrastructure of the human oocyte . 12th World Congress on Human Reproduction, Venice, Italy, March 10-13, 2005.
35. Ultrastructure of human cryopreserved ovarian tissue and oocyte . Tohoku University,
Sendai, Japan, August 20, 2004.
36. The ovary: from germ cells to mature oocytes a long journey . 1st World Congress on Ovarian Cryopreservation and Ovarian Transplantation, Bruxelles, Belgium, June 27-28, 2003.
37. Morphodynamics of human oocytes in vivo and during ART protocols . ESHRE Campus 2003 Mammalian Oogenesis and Folliculogenesis: in vivo and in vitro Approaches -, Frascati (Rome), Italy, 10-12 April 2003.
38. Ultrastructure of fresh and cryopreserved ovarian tissue and oocyte . 2° Congresso
Naz. SIERR, Naples, Italy, 30 Genuary-1st February 2003.

COLLABORAZIONI SCIENTIFICHE

Dipartimento di Medicina Clinica, Sanità Pubblica, Scienze della Vita e dell Ambiente, Università dell Aquila (Prof. G. Macchiarelli: Ultrastruttura dell ovaio, della tuba uterina e dell ovocita; ultrastruttura degli spermatozoi; microscopia elettronica a scansione di calchi vascolari corrosi nell ovaio e nella tuba uterina)
Dipartimento di Scienze Ginecologico-Ostetriche e Scienze Urologiche, Università di Roma La Sapienza (Prof. C. Aragona, Dott. G. Micara, Dott. A. Linari: Ultrastruttura dell ovocita umano)
CNESPS, Istituto Superiore di Sanità, Roma (Dott. G. Scaravelli: Studio multicentrico
sulla criopreservazione dell ovocita umano)
Dipartimento di Biologia Animale, Università di Sassari (Prof. S. Naitana, Prof. G. Leoni, Prof. F. Berlinguer: Microscopia ottica, elettronica e confocale di ovociti di pecora prepubere e adulta)
Dipartimento di Scienze Biomediche Comparate, Università di Teramo (Prof. B.
Barboni: Angiogenesi nell ovaio di pecora e di maiale)
Dipartimento di Biologia e Biotecnologie Lazzaro Spallanzani ; Università di Pavia (Prof. M. Zuccotti, Prof. S. Garagna: Ovogenesi nei mammiferi)
Tecnobios Procreazione, Bologna (Dott. A. Borini, Dott. G. Coticchio: Ultrastruttura dell ovocita umano criopreservato; ultrastruttura dell ovocita umano dopo maturazione in vitro)
Centro Scienze della Natalità, Ospedale S. Raffaele, Milano (Dott. L. De Santis: Studio su ovociti umani criopreservati con diversi supporti macromolecolari)
Reparto di Ostetricia e Ginecologia, Ospedale Fatebenefratelli, Roma (Prof. A. Ragusa: Microplastiche e salute riproduttiva, studi ultrastrutturali sulla placenta umana)
Yazd Institute for Reproductive Sciences, Shaid Sadoughi University of Medical Sciences, Yazd, Iran (Prof. M.A. Khalili: Morfologia di ovociti criopreservati e/o maturati in vitro; morfologia di spermatozoi umani criopreservati)
Department of Anatomy, West Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan; Department of Gynecology, Al-Farabi Kazakh National University, Almaty, Kazakhstan (Prof. G. Zhurabekova & Coll: Pesticidi e salute riproduttiva)
Faculty of Agriculture, Niigata University, Niigata, Japan (Dr. H. Yamashiro: Studio degli effetti delle radiazioni sugli spermatozoi di macaco)
Obstetrics, Gynecology & Reproductive Science, University of California San Francisco, USA (Prof. P. Rinaudo: Coltura in vitro di embrioni murini in differenti concentrazioni di ossigeno)
Dipartimento di Scienze Anatomiche, Istologiche, Medico-Legali e dell Apparato Locomotore Sezione di Istologia, Università di Roma La Sapienza (Prof. F. Fazi: Meccanismi di regolazione della proliferazione cellulare nei tumori)
Dipartimento di Scienze Odontostomatologiche e Maxillo Facciali, Università di Roma La Sapienza (Proff. A. Polimeni, G. Gambarini, L. Testarelli: Analisi ultrastrutturale delle strutture anatomiche del dente e dei materiali utilizzati in Odontoiatria)
Dipartimento di Neuroscienze Umane, Università di Roma La Sapienza (Prof. A. Santoro: Analisi ultrastrutturali nell ambito di patologie del tessuto nervoso cerebrale)
Dipartimento di Biologia Ambientale, Università di Roma La Sapienza (Prof. L. Sadori: Analisi ultrastrutturali nell ambito della Paleobotanica)
Dipartimento di Chimica, Università di Roma La Sapienza (Prof. I. Fratoddi: Analisi ultrastrutturali su nanoparticelle)
Dipartimento di Scienze e Tecnologie Chimiche, Università di Tor Vergata, Roma (Prof. Valeria Beatrice Conte, Prof. Federica Valentini: Analisi di nanomateriali)
Istituto di Struttura della Materia, Consiglio Nazionale delle Ricerche, Roma (Dott. Julietta Rau: Ultrastruttura di biomateriali)
Soprintendenza Archeologia, Belle Arti e Paesaggio per le Province di Frosinone e Latina Ministero per la Cultura (Prof. M. Rubini: Analisi ultrastrutturale di denti e frammenti ossei fossili)

PUBBLICAZIONI SCIENTIFICHE (SELEZIONE)

1. Liccardo F, niegocka M, Tito C, Iaiza A, Ottone T, Divona M, Travaglini S, Mattei M, Cicconi R, Miglietta S, Familiari G, Nottola SA, Petrozza V, Tamagnone L, Voso MT, Masciarelli S, Fazi F. Retinoic acid and proteotoxic stress induce AML cell death overcoming stromal cell protection. J Exp Clin Cancer Res. 2023 Aug 31;42(1):223. doi: 10.1186/s13046-023-02793-z.
2. Koohestanidehaghi Y, Khalili MA, Fesahat F, Seify M, Mangoli E, Kalantar SM, Nottola SA, Macchiarelli G, Grazia Palmerini M. Detrimental effects of radiofrequency electromagnetic waves emitted by mobile phones on morphokinetics, oxidative stress, and apoptosis in mouse preimplantation embryos. Environ Pollut. 2023 Aug 18;336:122411. doi: 10.1016/j.envpol.2023.122411.
3. Tito C, Genovese I, Giamogante F, Benedetti A, Miglietta S, Barazzuol L, Cristiano L, Iaiza A, Carolini S, De Angelis L, Masciarelli S, Nottola SA, Familiari G, Petrozza V, Lauriola M, Tamagnone L, Ilari A, Calì T, Valdivia HH, Valdivia CR, Colotti G, Fazi F. Sorcin promotes migration in cancer and regulates the EGF-dependent EGFR signaling pathways. Cell Mol Life Sci. 2023 Jul 13;80(8):202. doi: 10.1007/s00018-023-04850-4.
4. Miglietta S, Cristiano L, Espinola MSB, Masiello MG, Micara G, Battaglione E, Linari A, Palmerini MG, Familiari G, Aragona C, Bizzarri M, Macchiarelli G, Nottola SA. Effects of Simulated Microgravity In Vitro on Human Metaphase II Oocytes: An Electron Microscopy-Based Study. Cells. 2023 May 9;12(10):1346. doi: 10.3390/cells12101346.
5. Pescosolido F, Montaina L, Carcione R, Politi S, Matassa R, Carotenuto F, Nottola SA, Nardo PD, Tamburri E. A New Strong-Acid Free Route to Produce Xanthan Gum-PANI Composite Scaffold Supporting Bioelectricity. Macromol Biosci. 2023 Jul 3:e2300132. doi: 10.1002/mabi.202300132.
6. Salamone TA, Rutigliano L, Pennacchi B, Cerra S, Matassa R, Nottola S, Sciubba F, Battocchio C, Marsotto M, Del Giudice A, Chumakov A, Davydok A, Grigorian S, Canettieri G, Agostinelli E, Fratoddi I. Thiol functionalised gold nanoparticles loaded with methotrexate for cancer treatment: From synthesis to in vitro studies on neuroblastoma cell lines. J Colloid Interface Sci. 2023 Nov;649:264-278. doi: 10.1016/j.jcis.2023.06.078.
7. Familiari P, Lapolla P, Picotti V, Palmieri M, Pesce A, Carosi G, Relucenti M, Nottola S, Gianno F, Minasi S, Antonelli M, Frati A, Santoro A, D'Andrea G, Bruzzaniti P, LA Pira B. Role of 1p/19q Codeletion in Diffuse Low-grade Glioma Tumour Prognosis. Anticancer Res. 2023 Jun;43(6):2659-2670. doi: 10.21873/anticanres.16432.
8. Gatti M, Belli M, De Rubeis M, Khalili MA, Familiari G, Nottola SA, Macchiarelli G, Hajderi E, Palmerini MG. Ultrastructural Evaluation of Mouse Oocytes Exposed In Vitro to Different Concentrations of the Fungicide Mancozeb. Biology (Basel). 2023 May 10;12(5):698. doi: 10.3390/biology12050698.
9. Familiari P, Lapolla P, Relucenti M, Battaglione E, Cristiano L, Sorrentino V, Aversa S, D'Amico A, Puntorieri P, Bruzzaniti L, Mingoli A, Brachini G, Barbaro G, Scafa AK, D'Andrea G, Frati A, Picotti V, Berra LV, Petrozza V, Nottola S, Santoro A, Bruzzaniti P. Cortical atrophy in chronic subdural hematoma from ultra-structures to physical properties. Sci Rep. 2023 Feb 28;13(1):3400. doi: 10.1038/s41598-023-30135-8.
10. Cerra S, Dini V, Salamone TA, Hajareh Haghighi F, Mercurio M, Cartoni A, Del Giudice A, Marsotto M, Venditti I, Battocchio C, Scaramuzzo FA, Matassa R, Nottola S, Faccini R, Mirabelli R, Fratoddi I. Acrylates-based hydrophilic co-polymeric nanobeads as nanocarriers for imaging agents. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2023, 674,131829. doi: 10.1016/j.colsurfa.2023.131829
11. Cerra S, Carlini L, Salamone TA, Hajareh Haghighi F, Mercurio M, Pennacchi B, Sappino C, Battocchio C, Nottola S, Matassa R, Fratoddi I. Noble Metal Nanoparticles Networks Stabilized by Rod-Like Organometallic Bifunctional Thiols. ChemistrySelect 2023, 8(135),e202300874. doi: 10.1002/slct.202300874.
12. Brioual B, Ghannam H, Rossi Z, Aouni A, El-Habib A, Diani M, Addou M, Matassa R, Nottola S, Jbilou M. Effect of In-doping on electrochromic behavior of NiO thin films. Materialia 2023, 30,101832. doi: 10.1016/j.mtla.2023.101832.
13. Ragusa A, Matta M, Cristiano L, Matassa R, Battaglione E, Svelato A, De Luca C, D'Avino S, Gulotta A, Rongioletti MCA, Catalano P, Santacroce C, Notarstefano V, Carnevali O, Giorgini E, Vizza E, Familiari G, Nottola SA. Deeply in Plasticenta: Presence of Microplastics in the Intracellular Compartment of Human Placentas. Int J Environ Res Public Health. 2022 Sep 14;19(18):11593. doi: 10.3390/ijerph191811593.
14. Fortugno P, Monetta R, Belli M, Botti E, Angelucci F, Palmerini MG, Nottola SA, De Luca C, Ceccarini M, Salvatore M, Bianchi L, Macioce P, Teson M, Ricci F; Italian Undiagnosed Diseases Network, Macchiarelli G, Didona B, Costanzo A, Castiglia D, Brancati F. RIPK4 regulates cell-cell adhesion in epidermal development and homeostasis. Hum Mol Genet. 2022 Aug 17;31(15):2535-2547. doi: 10.1093/hmg/ddac046.
15. Palmerini MG, Antonouli S, Macchiarelli G, Cecconi S, Bianchi S, Khalili MA, Nottola SA. Ultrastructural Evaluation of the Human Oocyte at the Germinal Vesicle Stage during the Application of Assisted Reproductive Technologies. Cells 2022 May 2; 11 (10): 1636. 10.3390/cells11101636.
16. Bhandi S, Seracchiani M, Donfrancesco O, Reda R, Mazzoni A, Nottola S, Familiari G, Testarelli L, Gambarini G. Nickel-Titanium Rotary Instruments: An In Vitro Comparison (Torsional Resistance of Two Heat-treated Reciprocating Files). J Contemp Dent Pract. 2021 Apr 1;22(4):361-364.

17. Belli M, Palmerini MG, Bianchi S, Bernardi S, Khalili MA, Nottola SA, Macchiarelli G. Ultrastructure of mitochondria of human oocytes in different clinical conditions during assisted reproduction. Arch Biochem Biophys. 2021 May 30;703:108854. doi: 10.1016/j.abb.2021.108854. Epub 2021 Mar 30.

18. Rau JV, De Stefanis A, Barbaro K, Fosca M, Yankova VG, Matassa R, Nottola SA, Nawaz Q, Ali MS, Peukert W, Boccaccini AR. Adipogenic, chondrogenic, osteogenic, and antimicrobial features of glass ceramic material supplemented with manganese. J Non- Crystalline Solids 2021 May 1; 559:120709.

19. Omidi M, Khalili MA, Agha-Rahimi A, Nottola S, Anbari F, Faramarzi A, Palmerini MG. Efficacy of the in vitro splitting of human preimplantation embryos from ART programs. Turk J Med Sci. 2021 Feb 26;51(1):68-75. doi: 10.3906/sag-1710-194.

20. Zeka K, Marrazzo P, Micucci M, Ruparelia KC. Arroo RRJ, Macchiarelli G, Nottola SA, Continenza MA, Chiarini A, Angeloni C, Hrelia S, Budriesi R. Activity of antioxidants from crocus sativus l. Petals: Potential preventive effects towards cardiovascular system. Antioxidants. 2020; 9 (11):1102, 1-18. doi:10.3390/antiox9111102.

21. Mahaldashtian M, Khalili MA, Nottola SA, Woodward B, Macchiarelli G, Miglietta S.Does in vitro application of pentoxifylline have beneficial effects in assisted male reproduction? Andrologia. 2020 Oct 28:e13722. doi: 10.1111/and.13722.

22. Belli M, Rinaudo P, Palmerini MG, Ruggeri E, Antonouli S, Nottola SA, Macchiarelli G. Pre-Implantation Mouse Embryos Cultured In Vitro under Different Oxygen Concentrations Show Altered Ultrastructures. Int J Environ Res Public Health. 2020 May 13;17(10). pii: E3384. doi: 10.3390/ijerph17103384.

23. Belli M, Antonouli S, Palmerini MG, Bianchi S, Bernardi S, Khalili MA, Donfrancesco O, Nottola SA, Macchiarelli G. The effect of low and ultra-low oxygen tensions on mammalian embryo culture and development in experimental and clinical IVF. Syst Biol Reprod Med. 2020 May 7;66(4): 229-235. doi: 10.1080/19396368.2020.1754961.

24. Antonouli S, Palmerini MG, Bianchi S, Rossi G, Cecconi S, Belli M, Bernardi S, Khalili MA, Familiari G, Nottola SA, Macchiarelli G. Repeated hyperstimulation affects the ultrastructure of mouse fallopian tube epithelium. J Reprod Dev. 2020 Apr 28; 66(4): 387-397.doi: 10.1262/jrd.2019-147. [Epub ahead of print]

25. Bianchi S, Nottola SA, Torge D, Palmerini MG, Necozione S, Macchiarelli G. Association between Female Reproductive Health and Mancozeb: Systematic Review of Experimental Models. Int J Environ Res Public Health. 2020 Apr 9;17(7). pii: E2580. doi: 10.3390/ijerph17072580.

26. De Santis L, Nottola SA, Coticchio G, Borini A, Iussig B, Miglietta S, Macchiarelli G. Type of protein supplement in cryopreservation solutions impacts on the degree of ultrastructural damage in frozen-thawed human oocytes. Cryobiology. 2020 Mar 31; 95: 143-150. pii: S0011-2240(20)30084-5. doi: 10.1016/j.cryobiol.2020.03.010.

27. Emidio GD, Placidi M, Rea F, Rossi G, Falone S, Cristiano L, Nottola S, D'Alessandro AM, Amicarelli F, Palmerini MG, Tatone C. Methylglyoxal-Dependent Glycative Stress and Deregulation of SIRT1 Functional Network in the Ovary of PCOS Mice. Cells. 2020 Jan 14;9(1). pii: E209. doi: 10.3390/cells9010209.

28. Rossi LF, Nottola S, Miglietta S, Macchiarelli G, Luaces JP, Merico V, Merani S, Garagna S, Zuccotti M. Germ cell cysts, a fetal feature in mammals, are constitutively present in the adult armadillo. Mol Reprod Dev. 2020 Jan;87(1):91-101. doi: 10.1002/mrd.23296. Epub 2019 Nov 20.

29. Rossi G, Di Nisio V, Macchiarelli G, Nottola SA, Halvaei I, De Santis L, Cecconi S. Technologies for the production of fertilizable mammalian oocytes. Appl Sci. 2019 9 (8): 1536. doi: 10.3390/app9081536.

30. Antonouli S, Papatheodorou A, Panagiotidis Y, Petousis S, Prapas N, Nottola SA, Palmerini MG, Macchiarelli G, Prapas Y. The impact of sperm DNA fragmentation on ICSI outcome in cases of donated oocytes. Arch Gynecol Obstet. 2019 Jul;300(1):207- 215. doi: 10.1007/s00404-019-05133-9. Epub 2019 Apr 2.
31. Omidi M, Khalili MA, Agha-Rahimi A, Nottola S, Anbari F, Faramarzi A, Palmerini MG. Efficacy of the in vitro splitting of human preimplantation embryos from ART programs. Turk J Med Sci. 2019 Mar 14;19(2). doi: 10.3906/sag-1710-194. [Epub ahead of print]

32. Belli M, Zhang L, Liu X, Donjacour A, Ruggeri E, Palmerini MG, Nottola SA, Macchiarelli G, Rinaudo P. Oxygen concentration alters mitochondrial structure and function in in vitro fertilized preimplantation mouse embryos. Hum Reprod. 2019 Apr 1;34(4):601- 611. doi: 10.1093/humrep/dez011.

33. Halvaei I, Ghazali S, Nottola SA, Khalili MA. Cleavage-stage embryo micromanipulation in the clinical setting. Syst Biol Reprod Med. 2018 Jun;64(3):157-168. doi: 10.1080/19396368.2017.1422197. Epub 2018 Jan 3.

34. Palmerini MG, Belli M, Nottola SA, Miglietta S, Bianchi S, Bernardi S, Antonouli S, Cecconi S, Familiari G, Macchiarelli G. Mancozeb impairs the ultrastructure of mouse granulosa cells in a dose-dependent manner. J Reprod Dev. 2018 Feb 27;64(1):75-82. doi: 10.1262/jrd.2017-143. Epub 2017 Dec 11.

35. Palmerini MG, Zhurabekova G, Balmagambetova A, Nottola SA, Miglietta S, Belli M, Bianchi S, Cecconi S, Di Nisio V, Familiari G, Macchiarelli G. The pesticide Lindane induces dose-dependent damage to granulosa cells in an in vitro culture. Reprod Biol. 2017 Dec;17(4):349-356. doi: 10.1016/j.repbio.2017.09.008. Epub 2017 Oct 10.

36. Khalili MA, Shahedi A, Ashourzadeh S, Nottola SA, Macchiarelli G, Palmerini MG. Vitrification of human immature oocytes before and after in vitro maturation: a review. J Assist Reprod Genet. 2017 Nov;34(11):1413-1426. doi: 10.1007/s10815-017-1005-
4. Epub 2017 Aug 18.

37. Nabi A, Khalili MA, Talebi AR, Mangoli E, Yari N, Nottola SA, Miglietta S, Taheri F. In- Vitro Application of Pentoxifylline Preserved Ultrastructure of Spermatozoa After Vitrification in Asthenozoospermic Patients. Urol J. 2017 Jul 2;14(4):4038-4043.

38. Safari S, Khalili MA, Barekati Z, Halvaei I, Anvari M, Nottola SA. Cosmetic micromanipulation of vitrified-warmed cleavage stage embryos does not improve ART outcomes: An ultrastructural study of fragments. Reprod Biol. 2017 Sep;17(3):210- 217. doi: 10.1016/j.repbio.2017.05.003. Epub 2017 May 18.

39. Palmerini MG, Nottola SA, Tunjung WA, Kadowaki A, Bianchi S, Cecconi S, Sato E, Macchiarelli G. EGF-FSH supplementation reduces apoptosis of pig granulosa cells in co-culture with cumulus-oocyte complexes. Biochem Biophys Res Commun. 2016 Dec 2;481(1-2):159-164. doi: 10.1016/j.bbrc.2016.10.151.

40. Halvaei I, Khalili MA, Esfandiari N, Safari S, Talebi AR, Miglietta S, Nottola SA. Ultrastructure of cytoplasmic fragments in human cleavage stage embryos. J Assist Reprod Genet. 2016 Dec;33(12):1677-1684.

41. Nottola SA, Albani E, Coticchio G, Palmerini MG, Lorenzo C, Scaravelli G, Borini A, Levi- Setti PE, Macchiarelli G. Freeze/thaw stress induces organelle remodeling and membrane recycling in cryopreserved human mature oocytes. J Assist Reprod Genet. 2016 Dec;33(12):1559-1570.
42. Agha-Rahimi A, Khalili MA, Nottola SA, Miglietta S, Moradi A. Cryoprotectant-free vitrification of human spermatozoa in new artificial seminal fluid. Andrology. 2016 Nov; 4(6): 1037-1044. doi: 10.1111/andr.12212.

43. Halvaei I, Khalili MA, Nottola SA. A novel method for transmission electron microscopy study of cytoplasmic fragments from preimplantation human embryos. Microsc Res Tech. 2016 Jun;79(6):459-62. doi: 10.1002/jemt.22657.

44. Coticchio G, Dal Canto M, Fadini R, Mignini Renzini M, Guglielmo MC, Miglietta S, Palmerini MG, Macchiarelli G, Nottola SA. Ultrastructure of human oocytes after in vitro maturation. Mol Hum Reprod. 2016 Feb;22(2):110-8. doi: 10.1093/molehr/gav071.

45. Bianchi S, Macchiarelli G, Micara G, Linari A, Boninsegna C, Aragona C, Rossi G, Cecconi S, Nottola SA. Ultrastructural markers of quality are impaired in human metaphase II aged oocytes: a comparison between reproductive and in vitro aging. J Assist Reprod Genet. 2015 Sep;32(9):1343-58. doi: 10.1007/s10815-015-0552-9. Epub 2015 Aug 15.

46. Leoni GG, Palmerini MG, Satta V, Succu S, Pasciu V, Zinellu A, Carru C, Macchiarelli G, Nottola SA, Naitana S, Berlinguer F. Differences in the Kinetic of the First Meiotic Division and in Active Mitochondrial Distribution between Prepubertal and Adult Oocytes Mirror Differences in their Developmental Competence in a Sheep Model. PLoS One. 2015 Apr 20;10(4):e0124911. doi: 10.1371/journal.pone.0124911. eCollection 2015.

47. Palmerini MG, Nottola SA, Leoni GG, Succu S, Borshi X, Berlinguer F, Naitana S, Bekmukhambetov Y, Macchiarelli G. In vitro maturation is slowed in prepubertal lamb oocytes: ultrastructural evidences. Reprod Biol Endocrinol. 2014 Nov 24;12:115. doi: 10.1186/1477-7827-12-115.

48. Bianchi V, Macchiarelli G, Borini A, Lappi M, Cecconi S, Miglietta S, Familiari G, Nottola SA. Fine morphological assessment of quality of human mature oocytes after slow freezing or vitrification with a closed device: a comparative analysis. Reprod Biol Endocrinol. 2014 Nov 24;12:110. doi: 10.1186/1477-7827-12-110.

49. Palmerini MG, Antinori M, Maione M, Cerusico F, Versaci C, Nottola SA, Macchiarelli G, Khalili MA, Antinori S. Ultrastructure of immature and mature human oocytes after cryotop vitrification. J Reprod Dev. 2014 Dec 27;60(6):411-20. doi: 10.1262/jrd.2014-
027. Epub 2014 Aug 28.

50. Di Luigi G, Rossi G, Castellucci A, Leocata P, Carta G, Canipari R, Nottola SA, Cecconi S. Repeated ovarian stimulation does not affect the expression level of proteins involved in cell cycle control in mouse ovaries and fallopian tubes. J Assist Reprod Genet. 2014 Jun;31(6):717-24. doi: 10.1007/s10815-014-0198-z. Epub 2014 Mar 12.

51. Halvaei I, Khalili MA, Razi MH, Agha-Rahimi A, Nottola SA. Impact of different embryo loading techniques on pregnancy rates in in vitro fertlization/embryo transfer cycles. J Hum Reprod Sci. 2013 Jan;6(1):65-9. doi: 10.4103/0974-1208.112385.

52. Shahedi A, Hosseini A, Khalili MA, Norouzian M, Salehi M, Piriaei A, Nottola SA. The effect of vitrification on ultrastructure of human in vitro matured germinal vesicle oocytes. Eur J Obstet Gynecol Reprod Biol. 2013 Mar;167(1):69-75. doi: 10.1016/j.ejogrb.2012.11.006. Epub 2012 Dec 21.

53. Macchiarelli G, Palmerini MG, Nottola SA, Cecconi S, Tanemura K, Sato E. Restoration of corpus luteum angiogenesis in immature hypothyroid rdw rats after thyroxine treatment: morphologic and molecular evidence. Theriogenology. 2013 Jan 1;79(1):116-26. doi: 10.1016/j.theriogenology.2012.09.016. Epub 2012 Nov 2.

54. Khalili MA, Maione M, Palmerini MG, Bianchi S, Macchiarelli G, Nottola SA. Ultrastructure of human mature oocytes after vitrification. Eur J Histochem. 2012 Aug 10;56(3):e38. doi: 10.4081/ejh.2012.e38.

55. Halvaei I, Ali Khalili M, Razi MH, Nottola SA. The effect of immature oocytes quantity on the rates of oocytes maturity and morphology, fertilization, and embryo development in ICSI cycles. J Assist Reprod Genet. 2012 Aug;29(8):803-10. doi: 10.1007/s10815-012-9799-6. Epub 2012 May 30.

56. Nottola SA, Cecconi S, Bianchi S, Motta C, Rossi G, Continenza MA, Macchiarelli G. Ultrastructure of isolated mouse ovarian follicles cultured in vitro. Reprod Biol Endocrinol. 2011 Jan 13;9:3. doi: 10.1186/1477-7827-9-3.

57. Coticchio G, Borini A, Distratis V, Maione M, Scaravelli G, Bianchi V, Macchiarelli G, Nottola SA. Qualitative and morphometric analysis of the ultrastructure of human oocytes cryopreserved by two alternative slow cooling protocols. J Assist Reprod Genet. 2010 Apr;27(4):131-40. doi: 10.1007/s10815-010-9394-7. Epub 2010 Feb 23.

58. Nottola SA, Coticchio G, Sciajno R, Gambardella A, Maione M, Scaravelli G, Bianchi S, Macchiarelli G, Borini A. Ultrastructural markers of quality in human mature oocytes vitrified using cryoleaf and cryoloop. Reprod Biomed Online. 2009;19 Suppl 3:17-27.

59. Martelli A, Palmerini MG, Russo V, Rinaldi C, Bernabò N, Di Giacinto O, Berardinelli P, Nottola SA, Macchiarelli G, Barboni B. Blood vessel remodeling in pig ovarian follicles during the periovulatory period: an immunohistochemistry and SEM-corrosion casting study. Reprod Biol Endocrinol. 2009 Jul 16;7:72. doi: 10.1186/1477-7827-7-72.

60. Jiang JY, Miyabayashi K, Nottola SA, Umezu M, Cecconi S, Sato E, Macchiarelli G. Thyroxine treatment stimulated ovarian follicular angiogenesis in immature hypothyroid rats. Histol Histopathol. 2008 Nov;23(11):1387-98.

61. Nottola SA, Coticchio G, De Santis L, Macchiarelli G, Maione M, Bianchi S, Iaccarino M, Flamigni C, Borini A. Ultrastructure of human mature oocytes after slow cooling cryopreservation with ethylene glycol. Reprod Biomed Online. 2008 Sep;17(3):368-77.

62. Camboni A, Martinez-Madrid B, Dolmans MM, Amorim CA, Nottola SA, Donnez J, Van Langendonckt A. Preservation of fertility in young cancer patients: contribution of transmission electron microscopy. Reprod Biomed Online. 2008 Jul;17(1):136-50.

63. Sathananthan AH, Nottola SA. Digital imaging of stem cells by electron microscopy. Methods Mol Biol. 2007;407:21-41. doi: 10.1007/978-1-59745-536-7_3.

64. Camboni A, Martinez-Madrid B, Dolmans MM, Nottola S, Van Langendonckt A, Donnez J. Autotransplantation of frozen-thawed ovarian tissue in a young woman: ultrastructure and viability of grafted tissue. Fertil Steril. 2008 Oct;90(4):1215-8. Epub 2007 Dec 21.

65. Nottola SA, Camboni A, Van Langendonckt A, Demylle D, Macchiarelli G, Dolmans MM, Martinez-Madrid B, Correr S, Donnez J. Cryopreservation and xenotransplantation of human ovarian tissue: an ultrastructural study. Fertil Steril. 2008 Jul;90(1):23-32. Epub 2007 Aug 30.

66. Martinez-Madrid B, Camboni A, Dolmans MM, Nottola S, Van Langendonckt A, Donnez J. Apoptosis and ultrastructural assessment after cryopreservation of whole human ovaries with their vascular pedicle. Fertil Steril. 2007 May;87(5):1153-65. Epub 2007 Jan 18.

67. Nottola SA, Macchiarelli G, Coticchio G, Bianchi S, Cecconi S, De Santis L, Scaravelli G, Flamigni C, Borini A. Ultrastructure of human mature oocytes after slow cooling cryopreservation using different sucrose concentrations. Hum Reprod. 2007 Apr;22(4):1123-33. Epub 2006 Dec 11.

68. Nottola SA, Heyn R, Camboni A, Correr S, Macchiarelli G. Ultrastructural characteristics of human granulosa cells in a coculture system for in vitro fertilization. Microsc Res Tech. 2006 Jun;69(6):508-16.

69. Macchiarelli G, Jiang JY, Nottola SA, Sato E. Morphological patterns of angiogenesis in ovarian follicle capillary networks. A scanning electron microscopy study of corrosion cast. Microsc Res Tech. 2006 Jun;69(6):459-68.

70. Familiari G, Heyn R, Relucenti M, Nottola SA, Sathananthan AH. Ultrastructural dynamics of human reproduction, from ovulation to fertilization and early embryo development. Int Rev Cytol. 2006;249:53-141.

71. Coticchio G, De Santis L, Rossi G, Borini A, Albertini D, Scaravelli G, Alecci C, Bianchi V, Nottola S, Cecconi S. Sucrose concentration influences the rate of human oocytes with normal spindle and chromosome configurations after slow-cooling cryopreservation. Hum Reprod. 2006 Jul;21(7):1771-6. Epub 2006 Mar 20.

72. Dolmans MM, Michaux N, Camboni A, Martinez-Madrid B, Van Langendonckt A, Nottola SA, Donnez J. Evaluation of Liberase, a purified enzyme blend, for the isolation of human primordial and primary ovarian follicles. Hum Reprod. 2006 Feb;21(2):413-20. Epub 2005 Sep 30.

73. Nottola SA, Makabe S, Stallone T, Familiari G, Correr S, Macchiarelli G. Surface morphology of the zona pellucida surrounding human blastocysts obtained after in vitro fertilization. Arch Histol Cytol. 2005 Jun;68(2):133-41.

74. Motta PM, Nottola SA, Familiari G, Makabe S, Stallone T, Macchiarelli G. Morphodynamics of the follicular-luteal complex during early ovarian development and reproductive life. Int Rev Cytol. 2003;223:177-288.

75. Macchiarelli G, Ohtani O, Nottola SA, Stallone T, Camboni A, Prado IM, Motta PM. A micro-anatomical model of the distribution of myocardial endomysial collagen. Histol Histopathol. 2002;17(3):699-706.

76. Nottola SA, Makabe S, Stallone T, Macchiarelli G, Correr S, Motta PM. Ultrastructure and distribution of interstitial glandular cells and associated elements in human fetal ovaries. Arch Histol Cytol. 2000 Oct;63(4):345-55.

77. Motta PM, Nottola SA, Makabe S, Heyn R. Mitochondrial morphology in human fetal and adult female germ cells. Hum Reprod. 2000 Jul;15 Suppl 2:129-47.

78. Fabbri R, Porcu E, Marsella T, Primavera MR, Cecconi S, Nottola SA, Motta PM, Venturoli S, Flamigni C. Human embryo development and pregnancies in an homologous granulosa cell coculture system. J Assist Reprod Genet. 2000 Jan;17(1):1-12.

79. Familiari G, Verlengia C, Nottola SA, Tripodi A, Hyttel P, Macchiarelli G, Motta PM. Ultrastructural features of bovine cumulus-corona cells surrounding oocytes, zygotes and early embryos. Reprod Fertil Dev. 1998;10(4):315-26.

80. Motta PM, Nottola SA, Makabe S. Natural history of the female germ cell from its origin to full maturation through prenatal ovarian development. Eur J Obstet Gynecol Reprod Biol. 1997 Dec;75(1):5-10.

81. Motta PM, Makabe S, Nottola SA. The ultrastructure of human reproduction. I. The natural history of the female germ cell: origin, migration and differentiation inside the developing ovary. Hum Reprod Update. 1997 May-Jun;3(3):281-95.

82. Nottola SA, Macchiarelli G, Motta PM. The angioarchitecture of estrous, pseudopregnant and pregnant rabbit ovary as seen by scanning electron microscopy of vascular corrosion casts. Cell Tissue Res. 1997 May;288(2):353-63.

83. Familiari G, Verlengia C, Nottola SA, Renda T, Micara G, Aragona C, Zardi L, Motta PM. Heterogeneous distribution of fibronectin, tenascin-C, and laminin immunoreactive material in the cumulus-corona cells surrounding mature human oocytes from IVF-ET protocols--evidence that they are composed of different subpopulations: an immunohistochemical study using scanning confocal laser and fluorescence microscopy. Mol Reprod Dev. 1996 Mar;43(3):392-402.

84. Motta PM, Nottola SA, Pereda J, Croxatto HB, Familiari G. Ultrastructure of human cumulus oophorus: a transmission electron microscopic study on oviductal oocytes and fertilized eggs. Hum Reprod. 1995 Sep;10(9):2361-7.

85. Familiari G, Caggiati A, Nottola SA, Ermini M, Di Benedetto MR, Motta PM. Ultrastructure of human ovarian primordial follicles after combination chemotherapy for Hodgkin's disease. Hum Reprod. 1993 Dec;8(12):2080-7.

86. Macchiarelli G, Nottola SA, Vizza E, Familiari G, Kikuta A, Murakami T, Motta PM. Microvasculature of growing and atretic follicles in the rabbit ovary: a SEM study of corrosion casts. Arch Histol Cytol. 1993 Mar;56(1):1-12.

87. Familiari G, Nottola SA, Macchiarelli G, Familiari A, Motta PM. A technique for exposure of the glycoproteic matrix (zona pellucida and mucus) for scanning electron microscopy. Microsc Res Tech. 1992 Nov 1;23(3):225-9.

88. Familiari G, Nottola SA, Macchiarelli G, Micara G, Aragona C, Motta PM. Human zona pellucida during in vitro fertilization: an ultrastructural study using saponin, ruthenium red, and osmium-thiocarbohydrazide. Mol Reprod Dev. 1992 May;32(1):51-61.

89. Macchiarelli G, Vizza E, Nottola SA, Familiari G, Motta PM. Cellular and microvascular changes of the ovarian follicle during folliculogenesis: a scanning electron microscopic study. Arch Histol Cytol. 1992;55 Suppl:191-204.

90. Macchiarelli G, Nottola SA, Vizza E, Kikuta A, Murakami T, Motta PM. Ovarian microvasculature in normal and hCG stimulated rabbits. A study of vascular corrosion casts with particular regard to the interstitium. J Submicrosc Cytol Pathol. 1991 Jul;23(3):391-5.

91. Nottola SA, Familiari G, Micara G, Aragona C, Motta PM. The ultrastructure of human cumulus-corona cells at the time of fertilization and early embryogenesis. A scanning and transmission electron microscopic study in an in vitro fertilization program. Arch Histol Cytol. 1991 May;54(2):145-61.

92. Familiari G, Nottola SA, Familiari A, Motta PM. The three-dimensional structure of the zona pellucida in growing and atretic ovarian follicles of the mouse. Scanning and transmission electron-microscopic observations using ruthenium red and detergents. Cell Tissue Res. 1989 Aug;257(2):247-53.

93. Nottola SA, Familiari G, Micara G, Aragona C, Motta PM. The role of the cumulus- corona cells surrounding in vitro human oocytes and polypronuclear ova: an ultrastructural study. Prog Clin Biol Res. 1989;296:345-54.

94. Familiari G, Nottola SA, Micara G, Aragona C, Motta P. Human in vitro fertilization: the fine three-dimensional architecture of the zona pellucida. Prog Clin Biol Res. 1989;296:335-44.

95. Familiari G, Nottola SA, Micara G, Aragona C, Motta PM. Is the sperm-binding capability of the zona pellucida linked to its surface structure? A scanning electron microscopic study of human in vitro fertilization. J In Vitro Fert Embryo Transf. 1988 Jun;5(3):134-43.

96. Motta PM, Nottola SA, Micara G, Familiari G. Ultrastructure of human unfertilized oocytes and polyspermic embryos in an IVF-ET program. Ann N Y Acad Sci. 1988;541:367-83.

97. Familiari G, Nottola SA, Motta PM. Focal cell contacts detected by ruthenium red, triton X100 and saponin in the granulosa cells of mouse ovary. Tissue Cell. 1987;19(2):207- 15.

Link pagina personale di Scopus (ID: 6604078973): https://www.scopus.com/results/results.uri?sort=plf- f&src=s&st1=nottola&st2=s&nlo=1&nlr=100&nls=&sid=D500D89B5D6B555491447A3E81133DAD.wsnAw8kc dt7IPYLO0V48gA%3a102&sot=anl&sdt=aut&sl=46&s=AU- ID%28%22Nottola%2c+Stefania+Annarita%22+6604078973%29&partialQuery=&txGid=D500D89B5D6B55 5491447A3E81133DAD.wsnAw8kcdt7IPYLO0V48gA%3a10

Data: 30/09/2023

Firmato:
Stefania Annarita Nottola

.................................................................................................

ENGLISH

Stefania Annarita Nottola, M.D., Ph.D. - Curriculum Vitae

PERSONAL DATA

Year of birth: 1958

CURRENT ADDRESS

Department of Anatomy, Histology, Forensic Medicine and Orthopaedics
Section of Human Anatomy, Electron Microscopy Unit
Faculty of Pharmacy and Medicine
University La Sapienza , Via Alfonso Borelli 50, Rome 00161, Italy.

Phone: +39-06-4991.80.72; Fax: +39-06-4991.80.81
e-mail: stefania.nottola@uniroma1.it
web site: https://sites.google.com/a/uniroma1.it/stefanianottola-eng/
ORCID: orcid.org/0000-0002-4626-6328

PRESENT APPOINTMENT

From September 3rd, 2019: Full Professor of Human Anatomy (full time position), sector 05/H1-BIO/16 (Human Anatomy)

CURRICULUM STUDIORUM

1984: M.D. Medicine and Surgery (cum laude), University La Sapienza , Rome, Italy; qualified to practice Medicine, University La Sapienza , Rome, Italy; 1990: Research Doctorate degree (Ph.D.), Ministry of University and of Scientific and Technological Research, Italy.

MOTHER TONGUE: Italian

OTHER LANGUAGE: English

PROFESSIONAL TRAINING

2000-2019: Associate Professor of Human Anatomy, Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, University La Sapienza , Rome, Italy; 1998-2000: Assistant professor (researcher), Department of Anatomy, University La Sapienza , Rome, Italy; 1988-1998: Funzionario Tecnico VIII qualifica (role equivalent to assistant professor), Department of Anatomy, University La Sapienza , Rome, Italy.

ACADEMIC APPOINTMENTS

2021 today: Head of the Laboratory for Electron Microscopy Pietro M. Motta , Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, University La Sapienza , Rome, Italy;
2021 today: Member of the Scientific Committee Framework agreement between University La Sapienza and Archaeology, Fine Arts and Landscape Superintendency for the Provinces of Latina and Frosinone, Ministry of Culture, Italy;
2019 today: Member of the Research Committee of the Department;
2017 - today: President of the Nursing Degree Course I , I.F.O. Regina Elena Hospital, Faculty of Medicine and Dentistry, University La Sapienza , Rome, Italy;
2010 - today: Member of the Web Site Committee of the Department.

2021 2023: Member of the Scientific Research Committee of University La Sapienza ;
2011 - 2015: Coordinator of the Research Doctorate in Dermatology, Anatomy and Plastic Surgery, University La Sapienza , Rome, Italy.
2011 - 2014: Elected Member of the Committee of the Faculty Council, Faculty of Pharmacy and Medicine, University La Sapienza , Rome, Italy.
Secretary (2005 - 2010) and Vice-president (2000 - 2005) of the Research Committee of the I Faculty of Medicine, University La Sapienza , Rome, Italy.

TEACHING APPOINTMENTS

MAIN DIDACTICAL ACTIVITIES AT THE UNIVERSITY LA SAPIENZA

Degree Courses

2021 today: Human and Clinical Anatomy / Degree Course in Medicine and Surgery Sant Andrea . Lectures: Human Anatomy II;

2012 today: Human Anatomy / Degree Course in Medicine and Surgery F, International Medical School. Lectures: Human Anatomy II, III Coordinator of Human Anatomy II course;

2008 today: Anatomo-Physiological Bases of the Human Body / Degree Course in Obstetrics A, Policlinico Umberto I. Lectures: Human Anatomy (since 2008) and Histology (2008-2019) Course Coordinator; Coordinator of the I semester I year of the Degree Course (since 2022);

2001 today: Morphological and Functional Bases of the Human Body / Degree Course in Techniques in Radiology, Imaging and Radiotherapy A, Policlinico Umberto I. Lectures: Human Anatomy (since 2001) and Histology (2005-2019) Course Coordinator;

2001 today: Anatomo-Physiological Bases of the Human Body / Nursing Degree Course I, I.F.O. Regina Elena Hospital. Lectures: Human Anatomy Course Coordinator;

1999 today: Human Anatomy / Degree Course in Medicine and Surgery A. Lectures: Human Anatomy I, II, III Member of the joint teaching committee (commissione didattica paritetica) (since 2002); Coordinator of Human Anatomy I course (since 2010); Coordinator of the I semester II year of the Degree Course (since 2016).

Research Doctorate

Member of the Teaching Body of the Research Doctorate in Innovative Technologies in Disease of the Skeleton, of the Skin and of the Oro-Maxillofacial District, University La Sapienza , Rome, Italy (since XXX Cycle - today); Member of the Teaching Body of the Research Doctorate in Morphofunctional Sciences, University La Sapienza , Rome, Italy (XXVIII/XXIX Cycle); Coordinator and Member of the Teaching Body of the Research Doctorate in Dermatology, Anatomy and Plastic Surgery, University La Sapienza , Rome, Italy (up to XXVII Cycle).

Masters

2021 today: Biologia della Nutrizione per la Riproduzione Umana Teacher, Member of the Scientific Committee.

MAIN DIDACTICAL ACTIVITIES IN OTHER ITALIAN OR FOREIGN UNIVERSITIES

Degree Courses

2021 today: Human Anatomy / Degree Course in Pharmacy. Catholic University Our Lady of Good Counsel , Tirana, Albania (external teaching activity);

2017: Human Anatomy / West Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan. Lectures and practical lessons for students of General Medicine Faculty (visiting professor).

Masters

University Roma Tre (2020-2021): Master Embriologia Umana Applicata ;

University of L Aquila (2013): Master Gestione della Qualità e Sicurezza nei Processi di Manipolazione e Conservazione di Cellule e Tessuti Umani;

University of L Aquila (2010-2011): Master Sicurezza e Biotecnologie - Gestione della Qualità e Sicurezza nei Processi di Manipolazione e Conservazione di Cellule e Tessuti Umani ;

Istituto Superiore Universitario di Formazione Interdisciplinare, University of Salento (2001): Master: Electron Microscopy: a Tool for Industrial Quality and Environmental Monitoring.

RESEARCH ACTIVITY

MAIN RESEARCH FIELD

Biology of reproduction. Specific research interests: morphodynamics of the fertilization process, in human and other mammals, as it occurs in different hormonal and microenvironmental conditions, with particular regard to protocols of assisted reproduction; ultrastructural morphology of the human oocyte subjected to different cryopreservation procedures; morphological features of oocytes of different mammals including human, immature and/or subjected to in vitro maturation; embryogenesis of the human female gonad; ultrastructure of the follicular-luteal complex, in human and other mammals, in normal, experimental (ovarian tissue cryopreservation and grafting, in vitro culture of ovarian follicles) and pathological conditions; ultrastructural studies on the mammalian female genital tract; vascularization of the ovary and oviduct in mammals; ultrastructural morphology of human spermatozoa treated with different cryopreservation protocols. morphological features of mammalian female and male gonads and gametes subjected to environmental pollution (radiations and pesticides); ultrastructural studies on human placenta exposed to environmental pollution (microplastics).

OTHER RESEARCH FIELDS

Dentistry (evaluation of tooth anatomical structures, materials, and instruments); biomaterials; nanomaterials; nanoparticles; cancer cells; cells and tissues belonging to cardiovascular, neuroendocrine, and digestive systems.

INSTRUMENTATION AND TECHNIQUES EMPLOYED

Light microscopy, transmission electron microscopy, scanning electron microscopy (conventional and variable pressure), confocal laser scanning microscopy, immunocytochemistry, immunofluorescence.

PUBLICATIONS, BOOKS, EDITORIAL BOARDS

More than 300 publications (about 100 peer-reviewed full papers), including invited papers and lectures, published in national and international journals and books, or in proceedings and abstract books of national and international congresses and symposia.

Editor/Co-Editor of 8 scientific volumes and Author/Editor of 8 didactic volumes.

Member of the Editorial Board of:
Austin Journal of Reproductive Medicine & Infertility (Austin Publishing Group);
International Journal of Fertility and Sterility (Royan Institute of Iran);
International Journal of Reproductive Medicine (Hindawi Publ. Co.) (until 2022);
Journal of Iranian Anatomical Sciences (Iranian Society of Anatomical Sciences);
Journal of Assisted Reproduction and Genetics (Springer) (until 2018);
Marcello Malpighi Symposia Series (Rome) (Associate Editor);
Medical Journal of West Kazakhstan (West Kazakhstan Marat Ospanov State Medical University);
Microscopy Research and Technique (Wiley - New York) (Guest Editor);
Reproductive Biology & Endocrinology (BMC, Ltd.) (until 2017);
The Open Anatomy Journal (Bentham Science Publishers) (Regional Editor for Europe);
The Open Medicine Journal (Bentham Science Publishers) (Associate Editor).

Referee (Peer Reviewer) for: Aging, American Journal of Reproductive Immunology, Anatomia Histologia Embryologia, Animal Reproduction, Cell Cycle, Cell Tissue Research, Cryobiology, Cryoletters, Current Stem Cell Research, EOMT, European Biophysics Journal, Fertility and Sterility, Histology & Histopathology, Human Reproduction, International Journal of Developmental Biology, International Journal of Reproductive Medicine, Journal of Assisted Reproduction and Genetics, Life Sciences, Medical Science Monitor, Microscopy & Microanalysis, Molecular Human Reproduction, Plos One, Reproductive BioMedicine Online, Theriogenology, Yakhteh (The Cell), Zygote.

SUMMARY OF SCIENTIFIC ACHIEVEMENTS (database: SCOPUS, September 2023)

N° publications: 130
N° publications (last 10 years): 62

N° citations: 3378
N° citations (last 15 years): 1443

H-index: 35
H-index (last 15 years): 23

GRANTS

Recipient of national and international grants for numerous research projects (MIUR, PRIN, University La Sapienza , Ministry of Foreign Affairs, Ministry of Health, National Health Institute funds).

SCIENTIFIC TRAINING ABROAD

1988-1989: Visiting investigator in Japan, at the Departments of Anatomy of the Schools of Medicine of the Tottori University (Yonago), Osaka University (Osaka), Okayama University (Okayama).

SCIENTIFIC MEMBERSHIPS

From 1987: member of the Italian Society of Anatomy and Histology (SIAI); from 1995: founding member and scientific secretary of the Malpighi Academy for the Study of Microscopic Anatomy; from 1997 to 2002: member of the International Society of Reproductive Medicine Alpha ; from 1998: member (founding member and, since 2020, member of the scientific committee) of the Italian Society of Embryology, Reproduction and Research (SIERR); from 2000: member of the Italian Society of Reproduction (SIdR); from 2005: member of the European Society of Pathology (Electron Microscopy Working Group); from 2008: member of the Italian Society of Microscopic Sciences (SISM); from 2014: member of the Committee of Teachers of Human Anatomy; from 2015: honorary member of the Argentine Society of Clinical Anatomy.

ORGANIZATION OF NATIONAL AND INTERNATIONAL CONGRESSES AND SYMPOSIA

Member of the Organizing Committee and scientific secretary of the VIII International Symposium on Morphological Sciences (Rome, Italy, 1988), 2nd International Malpighi Symposium (Rome, Italy, 1995), 15th Congress of the International Federation of Associations of Anatomists (IFAA) and 4th International Malpighi Symposium (Rome, Italy, 1999). Member of the Scientific Committee of the II SIERR National Congress (Naples, Italy, 2003). Member of the Organizing Committee of the 5th International Malpighi Symposium (Rome, Italy, 2003). Member of the International Advisory Board of the XVIII International Symposium on Morphological Sciences (Belgrade, Serbia, 2005). Organizer of Symposia during the XXI International Symposium on Morphological Sciences (Taormina-Messina, Italy, 2010), the 34° Congress of the Italian Society of Histochemistry (S. Benedetto del Tronto, AP, Italy, 2011) and the XXV International Symposium on Morphological Sciences (Xi an, China, 2017). Member of the International Committee of the 7th Yazd International Congress and Student Award in Reproductive Medicine (Yazd, Iran, 2017). Member of the Scientific Board of the 2nd, 3rd, 4th and 5th Meeting Chi dice Donna dice. Donna (Casamari, FR, Italy, 2018, 2019, 2020, 2021); Member of the Scientific Board of the Meeting La Donna ieri e oggi . Il suo tempo, i suoi spazi (Tirana, Albania, 2019); Member of the Scientific Committee of the IX SIERR National Congress (Rome, Italy, 2022); Member of the Scientific Board of the Meeting Ambiente Donna: dal clima alla salute (Tirana, Albania, 2022).

PARTICIPATION TO CONGRESSES AND SYMPOSIA

More than 100 National and International Congresses, often as Invited Speaker and/or Session Chairman.

MOST RECENT SELECTED INVITED LECTURES

1. Electron microscopy studies on cryopreserved gametes and embryos . IVIRMA Global Research Alliance - Procreazione Symposium 2023, Bologna, 21-23 Settembre 2023.
2. Ultrastructural insights in assisted reproduction: The oocyte perspective . XXXIX Congresso della Società Italiana di Istochimica, Vulcano (ME), 14-16 Giugno 2023.
3. Donna, ambiente, salute riproduttiva . Ambiente Donna: dal clima alla salute, Università Cattolica Nostra Signora del Buon Consiglio, Tirana, Albania, 13 Maggio 2022.
4. Electron microscopy and allied disciplines for the study of gametes and embryos . Tecnobios Procreazione (9.Baby) Symposium 2021, Bologna, 16-18 Settembre 2021.
5. Female body identity and transformation after death: The Dance Macabre of Anatomy . XXVII International Symposium on Morphological Sciences, Almaty, Kazakhstan, May 27-31, 2021.
6. Women and Assisted Reproduction: The Oocyte Perspective . Incontro di studio Natalità e Pari Opportunità . Campidoglio - Sala della Protomoteca, Roma, 3 Ottobre 2020.
7. Spermatozoa and oocytes under the electron microscopy lens . Tecnobios Procreazione (9.Baby) Symposium 2020, Bologna, 24-26 Settembre 2020.
8. I mitocondri di Eva, la madre delle madri . Convegno Quando la scienza è donna. Passato, presente e futuro . Campidoglio - Sala della Protomoteca, Roma, 7 Dicembre 2019.
9. La bellezza non svanirà: immagini di figure femminili tra anatomia, scienza e arte . Convegno Donna: la Grande Bellezza , Abbazia di Casamari, Veroli (FR), 23 Novembre 2019.
10. Ultrastructure of human oocytes subjected to different protocols of assisted reproduction . Nanoinnovation 2019. Rome, June 11-14, 2019.
11. I mitocondri di Eva e il cerchio della vita . La donna ieri e oggi. Il suo tempo, i suoi spazi, Università Cattolica Nostra Signora del Buon Consiglio, Tirana, Albania, 12 Aprile 2019.
12. La preservazione della fertilità femminile: stato dell arte e prospettive future . La Donna Oggi per l Europa di Domani, Università Cattolica Nostra Signora del Buon Consiglio, Tirana, Albania, 21 Maggio 2018.
13. The international medical schools in Italy: facts and perspectives . International Scientific and Methodological Conference - Internationalization of Continuing Medical Education: a Prospection. Aktobe, Kazakhstan, April 26-27, 2018.
14. La preservazione della fertilità: aspetti clinici, etici e sociali . 1° Convegno Chi dice donna dice...donna , Abbazia di Casamari, Veroli (FR), 25 Novembre 2017.
15. Influence of different macromolecular supplements on the ultrastructural morphology of the human oocyte during cryopreservation . XXV International Symposium on Morphological Sciences, Xi an, China, July 26-30, 2017.
16. Ultrastructural markers of quality in human metaphase II oocytes cryopreserved with media containing different macromolecular supplements . 7th Yazd International Congress and Student Award in Reproductive Medicine, Yazd, Iran, April 28-30, 2017.
17. Effects of cryopreservation on the ultrastructure of human oocytes in assisted reproductive technology . I International Congress Of Clinical Anatomy, Buenos Aires, Argentina, September 24-26, 2015.
18. Ultrastructural modifications in the organular pattern of human metaphase II oocytes subjected to freeze-thawing . XIV International Symposium on Morphological Sciences, Istanbul, Turkey, September 2-6, 2015.
19. Organelle morphodynamics in human mature oocytes after cryopreservation. Ultrastructural analysis at different time intervals during thawing . 6th Yazd International Congress and Student Award in Reproductive Medicine, Yazd, Iran, April 17-19, 2015.
20. Ultrastructural assessment of quality of in-vitro matured human oocytes . XXIII International Symposium on Morphological Sciences, Niigata, Japan, September 10-13, 2013.
21. Morphological effects of pesticides on the mammalian ovarian follicle . Conference: Actual problems of experimental and clinical morphology, Aktobe City, Kazakhstan, May 30-31, 2013.
22. Analisi della morfologia ultrastrutturale di ovociti umani maturi crioconservati tramite congelamento lento o vitrificazione . Congresso Nazionale di Medicina della Riproduzione, Riccione (RN), Italy, May 23-25, 2013.
23. Ultrastructural features of human mature (metaphase II) oocytes subjected to slow freezing or vitrification: A comparative analysis . 24th European Congress of Pathology, Prague, September 8-12, 2012.
24. Ultrastruttura del follicolo ovarico di topo coltivato in vitro . Tecnobios Procreazione Symposium 2011. Desenzano del Garda, Italy, September 14-15, 2011.
25. Ultrastructural features and meiotic spindle dynamics in human mature oocytes subjected to different cryopreservation protocols . 34th Congress of the Italian Society of Histochemistry. S. Benedetto del Tronto (AP), Italy, June 7-9, 2011.
26. Ultrastructural features of cryopreserved oocytes after slow freezing and vitrification . Tecnobios Procreazione Symposium 2010. Bologna, Italy, 24-25 November 2010.
27. Neural stem cells in neurospheres, embryoid bodies and the CNS of advanced human embryos, in vivo (spontaneous differentiation) . Expanding Boundaries in Reproductive Medicine and Technology (5th World Congress of the World Association of Reproductive Medicine). Moscow, Russia, October 10-13, 2010.
28. Ultrastructural markers of quality in human vitrified oocytes . Expanding Boundaries in Reproductive Medicine and Technology (5th World Congress of the World Association of Reproductive Medicine). Moscow, Russia, October 10-13, 2010.
29. Ultrastructural analysis of cryopreserved oocytes after slow cooling and vitrification . XXI International Symposium on Morphological Sciences. Taormina (Messina), Italy, September 18-22, 2010.
30. Sperm selection for ART: fine structure and sperm contribution to fertility . IMSI: New Advances. Rome, Italy, 25-26 June 2010.
31. Ovarian tissue cryopreservation and grafting: an ultrastructural approach . 10th Royan Congress on Reproductive Biomedicine, Tehran, Iran, September 23-25, 2009.
32. Ultrastructure of human preovulatory oocyte in assisted reproduction protocols . 10th Royan Congress on Reproductive Biomedicine, Tehran, Iran, September 23-25, 2009.
33. Ultrastructural markers of quality in human vitrified oocytes . 13th World Congress on Human Reproduction, Venice, Italy, March 5-8, 2009.
34. The preservation of fertility in humans: Ultrastructural analysis of different approaches . In-vitro Embryology: New Trends in Reproductive Medicine (3rd World Congress of the World Association of Reproductive Medicine), Rome, Italy, 27 September-1 October 2006.
35. Behaviour of the oocyte surfaces from early gonadal development to fertilization: A review by scanning electron microscopy . The 16th International Microscopy Congress, Sapporo, Japan, September 3-8, 2006.
36. Ultrastructural morphology of the oocyte from its stem origin to fertilization . International Symposium on Recent Advances in Animal Science, Joint Meeting of 2nd IS-AS and -3rd IS-IFS, Sendai, Japan, 16-18 November 2005.
37. Ultrastructure of the human oocyte . 12th World Congress on Human Reproduction, Venice, Italy, March 10-13, 2005.
38. Ultrastructure of human cryopreserved ovarian tissue and oocyte . Tohoku University, Sendai, Japan, August 20, 2004.
39. The ovary: from germ cells to mature oocytes a long journey . 1st World Congress on Ovarian Cryopreservation and Ovarian Transplantation, Bruxelles, Belgium, June 27-28, 2003.
40. Morphodynamics of human oocytes in vivo and during ART protocols . ESHRE Campus 2003 Mammalian Oogenesis and Folliculogenesis: in vivo and in vitro Approaches -, Frascati (Rome), Italy, 10-12 April 2003.
41. Ultrastructure of fresh and cryopreserved ovarian tissue and oocyte . 2° Congresso Naz. SIERR, Naples, Italy, 30 Genuary-1st February 2003.

SCIENTIFIC COLLABORATIONS

Department of Life, Health and Environmental Sciences, University of L'Aquila, Italy (Prof. G. Macchiarelli: Ultrastructure of the ovary, Fallopian tube and oocyte; Ultrastructure of the spermatozoa; Scanning electron microscopy of vascular corrosion casts in the ovary and Fallopian tube)
Department of Gynaecology-Obstetrics & Urology, University La Sapienza , Rome, Italy (Prof. C. Aragona, Dr. G. Micara, Dr. A. Linari: Ultrastructure of the human oocyte)
CNESPS, Italian National Health Institute, Rome, Italy (Dr. G. Scaravelli: Multicentric study on human oocyte cryopreservation)
Department of Animal Biology, University of Sassari, Italy (Prof. S. Naitana, Prof. G. Leoni, Prof. F. Berlinguer: Light, electron and confocal microscopy of prepubertal and adult sheep oocytes)
Department of Comparative Biomedical Sciences, University of Teramo, Italy (Prof. B. Barboni: Angiogenesis in sheep and pig ovary)
Department of Biology and Biotechnology Lazzaro Spallanzani , University of Pavia, Italy (Prof. M. Zuccotti, Prof. S. Garagna: Oogenesis in mammals)
Tecnobios Procreazione, Bologna, Italy (Dr. A. Borini, Dr. G. Coticchio: Ultrastructure of the human cryopreserved oocyte; ultrastructure of the human oocyte after in vitro maturation)
Ob/Gyn IVF UNIT, San Raffaele Scientific Institute, Milan, Italy (Dr. L. De Santis: Human oocytes cryopreserved with different macromolecular supplements)
Obstetrics and Gynaecology, Fatebenefratelli Hospital, Rome, Italy (Prof. A. Ragusa: microplastics and reproductive health, ultrastructural studies on the human placenta)
Yazd Institute for Reproductive Sciences, Shaid Sadoughi University of Medical Sciences, Yazd, Iran (Prof. M.A. Khalili: Morphology of cryopreserved and in vitro-matured human oocytes; morphology of cryopreserved human spermatozoa)
Department of Anatomy, West Kazakhstan Marat Ospanov State Medical University, Aktobe, Kazakhstan; Department of Gynaecology, Al-Farabi Kazakh National University, Almaty, Kazakhstan (Prof. G. Zhurabekova & coworkers: Pesticides and reproductive health)
Faculty of Agriculture, Niigata University, Niigata, Japan (Dr. H. Yamashiro: Effects of radiations on Japanese macaque spermatozoa)
Obstetrics, Gynecology & Reproductive Science, University of California San Francisco, USA (Prof. P. Rinaudo: In vitro culture of mouse embryos under different oxygen saturations)
Department of Anatomy, Histology, Forensic Medicine and Orthopaedics - Section of Histology, University La Sapienza , Rome, Italy (Prof. F. Fazi: Mechanisms of regulation of cell growth in tumors)
Department of Oral and Maxillo-Facial Sciences, University La Sapienza , Rome, Italy (Proff. A. Polimeni, G. Gambarini, L. Testarelli: Ultrastructural evaluation of tooth anatomical structures and materials used in dentistry)
Department of Human Neurosciences, University La Sapienza , Rome, Italy (Prof. A. Santoro: Ultrastructural analysis of the cerebral nervous tissue affected by different pathologies)
Department of Environmental Biology, University La Sapienza , Rome, Italy (Prof. L. Sadori: Ultrastructural analyses in Paleobotanic)
Department of Chemistry, University La Sapienza , Rome, Italy (Prof. I. Fratoddi: Ultrastructural analyses on nanoparticles)
Department of Chemical Sciences and Technologies, Tor Vergata University, Rome, Italy (Prof. Valeria Beatrice Conte, Prof. Federica Valentini: Analysis of nanomaterials)
Institute of Structure of Matter, Italian National Research Council, Rome, Italy (Dr. Julietta Rau: Ultrastructure of biomaterials)
Archaeology, Fine Arts and Landscape Superintendency for the Provinces of Latina and Frosinone, Ministry of Culture, Italy (Prof. M. Rubini: Ultrastructural analysis of fossil teeth and bone fragments)

SELECTED SCIENTIFIC PUBLICATIONS

1. Liccardo F, niegocka M, Tito C, Iaiza A, Ottone T, Divona M, Travaglini S, Mattei M, Cicconi R, Miglietta S, Familiari G, Nottola SA, Petrozza V, Tamagnone L, Voso MT, Masciarelli S, Fazi F. Retinoic acid and proteotoxic stress induce AML cell death overcoming stromal cell protection. J Exp Clin Cancer Res. 2023 Aug 31;42(1):223. doi: 10.1186/s13046-023-02793-z.
2. Koohestanidehaghi Y, Khalili MA, Fesahat F, Seify M, Mangoli E, Kalantar SM, Nottola SA, Macchiarelli G, Grazia Palmerini M. Detrimental effects of radiofrequency electromagnetic waves emitted by mobile phones on morphokinetics, oxidative stress, and apoptosis in mouse preimplantation embryos. Environ Pollut. 2023 Aug 18;336:122411. doi: 10.1016/j.envpol.2023.122411.
3. Tito C, Genovese I, Giamogante F, Benedetti A, Miglietta S, Barazzuol L, Cristiano L, Iaiza A, Carolini S, De Angelis L, Masciarelli S, Nottola SA, Familiari G, Petrozza V, Lauriola M, Tamagnone L, Ilari A, Calì T, Valdivia HH, Valdivia CR, Colotti G, Fazi F. Sorcin promotes migration in cancer and regulates the EGF-dependent EGFR signaling pathways. Cell Mol Life Sci. 2023 Jul 13;80(8):202. doi: 10.1007/s00018-023-04850-4.
4. Miglietta S, Cristiano L, Espinola MSB, Masiello MG, Micara G, Battaglione E, Linari A, Palmerini MG, Familiari G, Aragona C, Bizzarri M, Macchiarelli G, Nottola SA. Effects of Simulated Microgravity In Vitro on Human Metaphase II Oocytes: An Electron Microscopy-Based Study. Cells. 2023 May 9;12(10):1346. doi: 10.3390/cells12101346.
5. Pescosolido F, Montaina L, Carcione R, Politi S, Matassa R, Carotenuto F, Nottola SA, Nardo PD, Tamburri E. A New Strong-Acid Free Route to Produce Xanthan Gum-PANI Composite Scaffold Supporting Bioelectricity. Macromol Biosci. 2023 Jul 3:e2300132. doi: 10.1002/mabi.202300132.
6. Salamone TA, Rutigliano L, Pennacchi B, Cerra S, Matassa R, Nottola S, Sciubba F, Battocchio C, Marsotto M, Del Giudice A, Chumakov A, Davydok A, Grigorian S, Canettieri G, Agostinelli E, Fratoddi I. Thiol functionalised gold nanoparticles loaded with methotrexate for cancer treatment: From synthesis to in vitro studies on neuroblastoma cell lines. J Colloid Interface Sci. 2023 Nov;649:264-278. doi: 10.1016/j.jcis.2023.06.078.
7. Familiari P, Lapolla P, Picotti V, Palmieri M, Pesce A, Carosi G, Relucenti M, Nottola S, Gianno F, Minasi S, Antonelli M, Frati A, Santoro A, D'Andrea G, Bruzzaniti P, LA Pira B. Role of 1p/19q Codeletion in Diffuse Low-grade Glioma Tumour Prognosis. Anticancer Res. 2023 Jun;43(6):2659-2670. doi: 10.21873/anticanres.16432.
8. Gatti M, Belli M, De Rubeis M, Khalili MA, Familiari G, Nottola SA, Macchiarelli G, Hajderi E, Palmerini MG. Ultrastructural Evaluation of Mouse Oocytes Exposed In Vitro to Different Concentrations of the Fungicide Mancozeb. Biology (Basel). 2023 May 10;12(5):698. doi: 10.3390/biology12050698.
9. Familiari P, Lapolla P, Relucenti M, Battaglione E, Cristiano L, Sorrentino V, Aversa S, D'Amico A, Puntorieri P, Bruzzaniti L, Mingoli A, Brachini G, Barbaro G, Scafa AK, D'Andrea G, Frati A, Picotti V, Berra LV, Petrozza V, Nottola S, Santoro A, Bruzzaniti P. Cortical atrophy in chronic subdural hematoma from ultra-structures to physical properties. Sci Rep. 2023 Feb 28;13(1):3400. doi: 10.1038/s41598-023-30135-8.
10. Cerra S, Dini V, Salamone TA, Hajareh Haghighi F, Mercurio M, Cartoni A, Del Giudice A, Marsotto M, Venditti I, Battocchio C, Scaramuzzo FA, Matassa R, Nottola S, Faccini R, Mirabelli R, Fratoddi I. Acrylates-based hydrophilic co-polymeric nanobeads as nanocarriers for imaging agents. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2023, 674,131829. doi: 10.1016/j.colsurfa.2023.131829
11. Cerra S, Carlini L, Salamone TA, Hajareh Haghighi F, Mercurio M, Pennacchi B, Sappino C, Battocchio C, Nottola S, Matassa R, Fratoddi I. Noble Metal Nanoparticles Networks Stabilized by Rod-Like Organometallic Bifunctional Thiols. ChemistrySelect 2023, 8(135),e202300874. doi: 10.1002/slct.202300874.
12. Brioual B, Ghannam H, Rossi Z, Aouni A, El-Habib A, Diani M, Addou M, Matassa R, Nottola S, Jbilou M. Effect of In-doping on electrochromic behavior of NiO thin films. Materialia 2023, 30,101832. doi: 10.1016/j.mtla.2023.101832.

13. Ragusa A, Matta M, Cristiano L, Matassa R, Battaglione E, Svelato A, De Luca C, D'Avino S, Gulotta A, Rongioletti MCA, Catalano P, Santacroce C, Notarstefano V, Carnevali O, Giorgini E, Vizza E, Familiari G, Nottola SA. Deeply in Plasticenta: Presence of Microplastics in the Intracellular Compartment of Human Placentas. Int J Environ Res Public Health. 2022 Sep 14;19(18):11593. doi: 10.3390/ijerph191811593.

14. Fortugno P, Monetta R, Belli M, Botti E, Angelucci F, Palmerini MG, Nottola SA, De Luca C, Ceccarini M, Salvatore M, Bianchi L, Macioce P, Teson M, Ricci F; Italian Undiagnosed Diseases Network, Macchiarelli G, Didona B, Costanzo A, Castiglia D, Brancati F. RIPK4 regulates cell-cell adhesion in epidermal development and homeostasis. Hum Mol Genet. 2022 Aug 17;31(15):2535-2547. doi: 10.1093/hmg/ddac046.

15. Palmerini MG, Antonouli S, Macchiarelli G, Cecconi S, Bianchi S, Khalili MA, Nottola SA. Ultrastructural Evaluation of the Human Oocyte at the Germinal Vesicle Stage during the Application of Assisted Reproductive Technologies. Cells 2022 May 2; 11 (10): 1636. 10.3390/cells11101636.

16. Bhandi S, Seracchiani M, Donfrancesco O, Reda R, Mazzoni A, Nottola S, Familiari G, Testarelli L, Gambarini G. Nickel-Titanium Rotary Instruments: An In Vitro Comparison (Torsional Resistance of Two Heat-treated Reciprocating Files). J Contemp Dent Pract. 2021 Apr 1;22(4):361-364.

17. Belli M, Palmerini MG, Bianchi S, Bernardi S, Khalili MA, Nottola SA, Macchiarelli G. Ultrastructure of mitochondria of human oocytes in different clinical conditions during assisted reproduction. Arch Biochem Biophys. 2021 May 30;703:108854. doi: 10.1016/j.abb.2021.108854. Epub 2021 Mar 30.

18. Rau JV, De Stefanis A, Barbaro K, Fosca M, Yankova VG, Matassa R, Nottola SA, Nawaz Q, Ali MS, Peukert W, Boccaccini AR. Adipogenic, chondrogenic, osteogenic, and antimicrobial features of glass ceramic material supplemented with manganese. J Non- Crystalline Solids 2021 May 1; 559:120709.

19. Omidi M, Khalili MA, Agha-Rahimi A, Nottola S, Anbari F, Faramarzi A, Palmerini MG. Efficacy of the in vitro splitting of human preimplantation embryos from ART programs. Turk J Med Sci. 2021 Feb 26;51(1):68-75. doi: 10.3906/sag-1710-194.

20. Zeka K, Marrazzo P, Micucci M, Ruparelia KC. Arroo RRJ, Macchiarelli G, Nottola SA, Continenza MA, Chiarini A, Angeloni C, Hrelia S, Budriesi R. Activity of antioxidants from crocus sativus l. Petals: Potential preventive effects towards cardiovascular system. Antioxidants. 2020; 9 (11):1102, 1-18. doi:10.3390/antiox9111102.

21. Mahaldashtian M, Khalili MA, Nottola SA, Woodward B, Macchiarelli G, Miglietta S.Does in vitro application of pentoxifylline have beneficial effects in assisted male reproduction? Andrologia. 2020 Oct 28:e13722. doi: 10.1111/and.13722.

22. Belli M, Rinaudo P, Palmerini MG, Ruggeri E, Antonouli S, Nottola SA, Macchiarelli G. Pre-Implantation Mouse Embryos Cultured In Vitro under Different Oxygen Concentrations Show Altered Ultrastructures. Int J Environ Res Public Health. 2020 May 13;17(10). pii: E3384. doi: 10.3390/ijerph17103384.

23. Belli M, Antonouli S, Palmerini MG, Bianchi S, Bernardi S, Khalili MA, Donfrancesco O, Nottola SA, Macchiarelli G. The effect of low and ultra-low oxygen tensions on mammalian embryo culture and development in experimental and clinical IVF. Syst Biol Reprod Med. 2020 May 7;66(4): 229-235. doi: 10.1080/19396368.2020.1754961.

24. Antonouli S, Palmerini MG, Bianchi S, Rossi G, Cecconi S, Belli M, Bernardi S, Khalili MA, Familiari G, Nottola SA, Macchiarelli G. Repeated hyperstimulation affects the ultrastructure of mouse fallopian tube epithelium. J Reprod Dev. 2020 Apr 28; 66(4): 387-397.doi: 10.1262/jrd.2019-147. [Epub ahead of print]

25. Bianchi S, Nottola SA, Torge D, Palmerini MG, Necozione S, Macchiarelli G. Association between Female Reproductive Health and Mancozeb: Systematic Review of Experimental Models. Int J Environ Res Public Health. 2020 Apr 9;17(7). pii: E2580. doi: 10.3390/ijerph17072580.

26. De Santis L, Nottola SA, Coticchio G, Borini A, Iussig B, Miglietta S, Macchiarelli G. Type of protein supplement in cryopreservation solutions impacts on the degree of ultrastructural damage in frozen-thawed human oocytes. Cryobiology. 2020 Mar 31. pii: S0011-2240(20)30084-5. doi: 10.1016/j.cryobiol.2020.03.010. [Epub ahead of print]

27. Emidio GD, Placidi M, Rea F, Rossi G, Falone S, Cristiano L, Nottola S, D'Alessandro AM, Amicarelli F, Palmerini MG, Tatone C. Methylglyoxal-Dependent Glycative Stress and Deregulation of SIRT1 Functional Network in the Ovary of PCOS Mice. Cells. 2020 Jan 14;9(1). pii: E209. doi: 10.3390/cells9010209.

28. Rossi G, Di Nisio V, Macchiarelli G, Nottola SA, Halvaei I, De Santis L, Cecconi S. Technologies for the production of fertilizable mammalian oocytes. Appl Sci. 2019 9 (8): 1536. doi: 10.3390/app9081536.

29. Antonouli S, Papatheodorou A, Panagiotidis Y, Petousis S, Prapas N, Nottola SA, Palmerini MG, Macchiarelli G, Prapas Y. The impact of sperm DNA fragmentation on ICSI outcome in cases of donated oocytes. Arch Gynecol Obstet. 2019 Apr 2. doi: 10.1007/s00404-019-05133-9. [Epub ahead of print]

30. Omidi M, Khalili MA, Agha-Rahimi A, Nottola S, Anbari F, Faramarzi A, Palmerini MG. Efficacy of the in vitro splitting of human preimplantation embryos from ART programs. Turk J Med Sci. 2019 Mar 14;19(2). doi: 10.3906/sag-1710-194. [Epub ahead of print]

31. Belli M, Zhang L, Liu X, Donjacour A, Ruggeri E, Palmerini MG, Nottola SA, Macchiarelli G, Rinaudo P. Oxygen concentration alters mitochondrial structure and function in in vitro fertilized preimplantation mouse embryos. Hum Reprod. 2019 Apr 1;34(4):601-611. doi: 10.1093/humrep/dez011.

32. Halvaei I, Ghazali S, Nottola SA, Khalili MA. Cleavage-stage embryo micromanipulation in the clinical setting. Syst Biol Reprod Med. 2018 Jun;64(3):157-168. doi: 10.1080/19396368.2017.1422197. Epub 2018 Jan 3.

33. Palmerini MG, Belli M, Nottola SA, Miglietta S, Bianchi S, Bernardi S, Antonouli S, Cecconi S, Familiari G, Macchiarelli G. Mancozeb impairs the ultrastructure of mouse granulosa cells in a dose-dependent manner. J Reprod Dev. 2018 Feb 27;64(1):75-82. doi: 10.1262/jrd.2017-143. Epub 2017 Dec 11.

34. Palmerini MG, Zhurabekova G, Balmagambetova A, Nottola SA, Miglietta S, Belli M, Bianchi S, Cecconi S, Di Nisio V, Familiari G, Macchiarelli G. The pesticide Lindane induces dose-dependent damage to granulosa cells in an in vitro culture. Reprod Biol. 2017 Dec;17(4):349-356. doi: 10.1016/j.repbio.2017.09.008. Epub 2017 Oct 10.

35. Khalili MA, Shahedi A, Ashourzadeh S, Nottola SA, Macchiarelli G, Palmerini MG. Vitrification of human immature oocytes before and after in vitro maturation: a review. J Assist Reprod Genet. 2017 Nov;34(11):1413-1426. doi: 10.1007/s10815-017-1005-4. Epub 2017 Aug 18.

36. Nabi A, Khalili MA, Talebi AR, Mangoli E, Yari N, Nottola SA, Miglietta S, Taheri F. In-Vitro Application of Pentoxifylline Preserved Ultrastructure of Spermatozoa After Vitrification in Asthenozoospermic Patients. Urol J. 2017 Jul 2;14(4):4038-4043.

37. Safari S, Khalili MA, Barekati Z, Halvaei I, Anvari M, Nottola SA. Cosmetic micromanipulation of vitrified-warmed cleavage stage embryos does not improve ART outcomes: An ultrastructural study of fragments. Reprod Biol. 2017 Sep;17(3):210-217. doi: 10.1016/j.repbio.2017.05.003. Epub 2017 May 18.

38. Palmerini MG, Nottola SA, Tunjung WA, Kadowaki A, Bianchi S, Cecconi S, Sato E, Macchiarelli G. EGF-FSH supplementation reduces apoptosis of pig granulosa cells in co-culture with cumulus-oocyte complexes. Biochem Biophys Res Commun. 2016 Dec 2;481(1-2):159-164. doi: 10.1016/j.bbrc.2016.10.151.

39. Halvaei I, Khalili MA, Esfandiari N, Safari S, Talebi AR, Miglietta S, Nottola SA. Ultrastructure of cytoplasmic fragments in human cleavage stage embryos. J Assist Reprod Genet. 2016 Dec;33(12):1677-1684.

40. Nottola SA, Albani E, Coticchio G, Palmerini MG, Lorenzo C, Scaravelli G, Borini A, Levi-Setti PE, Macchiarelli G. Freeze/thaw stress induces organelle remodeling and membrane recycling in cryopreserved human mature oocytes. J Assist Reprod Genet. 2016 Dec;33(12):1559-1570.

41. Agha-Rahimi A, Khalili MA, Nottola SA, Miglietta S, Moradi A. Cryoprotectant-free vitrification of human spermatozoa in new artificial seminal fluid. Andrology. 2016 Nov; 4(6): 1037-1044. doi: 10.1111/andr.12212.

42. Halvaei I, Khalili MA, Nottola SA. A novel method for transmission electron microscopy study of cytoplasmic fragments from preimplantation human embryos. Microsc Res Tech. 2016 Jun;79(6):459-62. doi: 10.1002/jemt.22657.

43. Coticchio G, Dal Canto M, Fadini R, Mignini Renzini M, Guglielmo MC, Miglietta S, Palmerini MG, Macchiarelli G, Nottola SA. Ultrastructure of human oocytes after in vitro maturation. Mol Hum Reprod. 2016 Feb;22(2):110-8. doi: 10.1093/molehr/gav071.

44. Bianchi S, Macchiarelli G, Micara G, Linari A, Boninsegna C, Aragona C, Rossi G, Cecconi S, Nottola SA. Ultrastructural markers of quality are impaired in human metaphase II aged oocytes: a comparison between reproductive and in vitro aging. J Assist Reprod Genet. 2015 Sep;32(9):1343-58. doi: 10.1007/s10815-015-0552-9. Epub 2015 Aug 15.

45. Leoni GG, Palmerini MG, Satta V, Succu S, Pasciu V, Zinellu A, Carru C, Macchiarelli G, Nottola SA, Naitana S, Berlinguer F. Differences in the Kinetic of the First Meiotic Division and in Active Mitochondrial Distribution between Prepubertal and Adult Oocytes Mirror Differences in their Developmental Competence in a Sheep Model. PLoS One. 2015 Apr 20;10(4):e0124911. doi: 10.1371/journal.pone.0124911. eCollection 2015.

46. Palmerini MG, Nottola SA, Leoni GG, Succu S, Borshi X, Berlinguer F, Naitana S, Bekmukhambetov Y, Macchiarelli G. In vitro maturation is slowed in prepubertal lamb oocytes: ultrastructural evidences. Reprod Biol Endocrinol. 2014 Nov 24;12:115. doi: 10.1186/1477-7827-12-115.

47. Bianchi V, Macchiarelli G, Borini A, Lappi M, Cecconi S, Miglietta S, Familiari G, Nottola SA. Fine morphological assessment of quality of human mature oocytes after slow freezing or vitrification with a closed device: a comparative analysis. Reprod Biol Endocrinol. 2014 Nov 24;12:110. doi: 10.1186/1477-7827-12-110.

48. Palmerini MG, Antinori M, Maione M, Cerusico F, Versaci C, Nottola SA, Macchiarelli G, Khalili MA, Antinori S. Ultrastructure of immature and mature human oocytes after cryotop vitrification. J Reprod Dev. 2014 Dec 27;60(6):411-20. doi: 10.1262/jrd.2014-027. Epub 2014 Aug 28.

49. Di Luigi G, Rossi G, Castellucci A, Leocata P, Carta G, Canipari R, Nottola SA, Cecconi S. Repeated ovarian stimulation does not affect the expression level of proteins involved in cell cycle control in mouse ovaries and fallopian tubes. J Assist Reprod Genet. 2014 Jun;31(6):717-24. doi: 10.1007/s10815-014-0198-z. Epub 2014 Mar 12.

50. Halvaei I, Khalili MA, Razi MH, Agha-Rahimi A, Nottola SA. Impact of different embryo loading techniques on pregnancy rates in in vitro fertlization/embryo transfer cycles. J Hum Reprod Sci. 2013 Jan;6(1):65-9. doi: 10.4103/0974-1208.112385.

51. Shahedi A, Hosseini A, Khalili MA, Norouzian M, Salehi M, Piriaei A, Nottola SA. The effect of vitrification on ultrastructure of human in vitro matured germinal vesicle oocytes. Eur J Obstet Gynecol Reprod Biol. 2013 Mar;167(1):69-75. doi: 10.1016/j.ejogrb.2012.11.006. Epub 2012 Dec 21.

52. Macchiarelli G, Palmerini MG, Nottola SA, Cecconi S, Tanemura K, Sato E. Restoration of corpus luteum angiogenesis in immature hypothyroid rdw rats after thyroxine treatment: morphologic and molecular evidence. Theriogenology. 2013 Jan 1;79(1):116-26. doi: 10.1016/j.theriogenology.2012.09.016. Epub 2012 Nov 2.

53. Khalili MA, Maione M, Palmerini MG, Bianchi S, Macchiarelli G, Nottola SA. Ultrastructure of human mature oocytes after vitrification. Eur J Histochem. 2012 Aug 10;56(3):e38. doi: 10.4081/ejh.2012.e38.

54. Halvaei I, Ali Khalili M, Razi MH, Nottola SA. The effect of immature oocytes quantity on the rates of oocytes maturity and morphology, fertilization, and embryo development in ICSI cycles. J Assist Reprod Genet. 2012 Aug;29(8):803-10. doi: 10.1007/s10815-012-9799-6. Epub 2012 May 30.

55. Nottola SA, Cecconi S, Bianchi S, Motta C, Rossi G, Continenza MA, Macchiarelli G. Ultrastructure of isolated mouse ovarian follicles cultured in vitro. Reprod Biol Endocrinol. 2011 Jan 13;9:3. doi: 10.1186/1477-7827-9-3.

56. Coticchio G, Borini A, Distratis V, Maione M, Scaravelli G, Bianchi V, Macchiarelli G, Nottola SA. Qualitative and morphometric analysis of the ultrastructure of human oocytes cryopreserved by two alternative slow cooling protocols. J Assist Reprod Genet. 2010 Apr;27(4):131-40. doi: 10.1007/s10815-010-9394-7. Epub 2010 Feb 23.

57. Nottola SA, Coticchio G, Sciajno R, Gambardella A, Maione M, Scaravelli G, Bianchi S, Macchiarelli G, Borini A. Ultrastructural markers of quality in human mature oocytes vitrified using cryoleaf and cryoloop. Reprod Biomed Online. 2009;19 Suppl 3:17-27.

58. Martelli A, Palmerini MG, Russo V, Rinaldi C, Bernabò N, Di Giacinto O, Berardinelli P, Nottola SA, Macchiarelli G, Barboni B. Blood vessel remodeling in pig ovarian follicles during the periovulatory period: an immunohistochemistry and SEM-corrosion casting study. Reprod Biol Endocrinol. 2009 Jul 16;7:72. doi: 10.1186/1477-7827-7-72.

59. Jiang JY, Miyabayashi K, Nottola SA, Umezu M, Cecconi S, Sato E, Macchiarelli G. Thyroxine treatment stimulated ovarian follicular angiogenesis in immature hypothyroid rats. Histol Histopathol. 2008 Nov;23(11):1387-98.

60. Nottola SA, Coticchio G, De Santis L, Macchiarelli G, Maione M, Bianchi S, Iaccarino M, Flamigni C, Borini A. Ultrastructure of human mature oocytes after slow cooling cryopreservation with ethylene glycol. Reprod Biomed Online. 2008 Sep;17(3):368-77.

61. Camboni A, Martinez-Madrid B, Dolmans MM, Amorim CA, Nottola SA, Donnez J, Van Langendonckt A. Preservation of fertility in young cancer patients: contribution of transmission electron microscopy. Reprod Biomed Online. 2008 Jul;17(1):136-50.

62. Sathananthan AH, Nottola SA. Digital imaging of stem cells by electron microscopy. Methods Mol Biol. 2007;407:21-41. doi: 10.1007/978-1-59745-536-7_3.

63. Camboni A, Martinez-Madrid B, Dolmans MM, Nottola S, Van Langendonckt A, Donnez J. Autotransplantation of frozen-thawed ovarian tissue in a young woman: ultrastructure and viability of grafted tissue. Fertil Steril. 2008 Oct;90(4):1215-8. Epub 2007 Dec 21.

64. Nottola SA, Camboni A, Van Langendonckt A, Demylle D, Macchiarelli G, Dolmans MM, Martinez-Madrid B, Correr S, Donnez J. Cryopreservation and xenotransplantation of human ovarian tissue: an ultrastructural study. Fertil Steril. 2008 Jul;90(1):23-32. Epub 2007 Aug 30.

65. Martinez-Madrid B, Camboni A, Dolmans MM, Nottola S, Van Langendonckt A, Donnez J. Apoptosis and ultrastructural assessment after cryopreservation of whole human ovaries with their vascular pedicle. Fertil Steril. 2007 May;87(5):1153-65. Epub 2007 Jan 18.

66. Nottola SA, Macchiarelli G, Coticchio G, Bianchi S, Cecconi S, De Santis L, Scaravelli G, Flamigni C, Borini A. Ultrastructure of human mature oocytes after slow cooling cryopreservation using different sucrose concentrations. Hum Reprod. 2007 Apr;22(4):1123-33. Epub 2006 Dec 11.

67. Nottola SA, Heyn R, Camboni A, Correr S, Macchiarelli G. Ultrastructural characteristics of human granulosa cells in a coculture system for in vitro fertilization. Microsc Res Tech. 2006 Jun;69(6):508-16.

68. Macchiarelli G, Jiang JY, Nottola SA, Sato E. Morphological patterns of angiogenesis in ovarian follicle capillary networks. A scanning electron microscopy study of corrosion cast. Microsc Res Tech. 2006 Jun;69(6):459-68.

69. Familiari G, Heyn R, Relucenti M, Nottola SA, Sathananthan AH. Ultrastructural dynamics of human reproduction, from ovulation to fertilization and early embryo development. Int Rev Cytol. 2006;249:53-141.

70. Coticchio G, De Santis L, Rossi G, Borini A, Albertini D, Scaravelli G, Alecci C, Bianchi V, Nottola S, Cecconi S. Sucrose concentration influences the rate of human oocytes with normal spindle and chromosome configurations after slow-cooling cryopreservation. Hum Reprod. 2006 Jul;21(7):1771-6. Epub 2006 Mar 20.

71. Dolmans MM, Michaux N, Camboni A, Martinez-Madrid B, Van Langendonckt A, Nottola SA, Donnez J. Evaluation of Liberase, a purified enzyme blend, for the isolation of human primordial and primary ovarian follicles. Hum Reprod. 2006 Feb;21(2):413-20. Epub 2005 Sep 30.

72. Nottola SA, Makabe S, Stallone T, Familiari G, Correr S, Macchiarelli G. Surface morphology of the zona pellucida surrounding human blastocysts obtained after in vitro fertilization. Arch Histol Cytol. 2005 Jun;68(2):133-41.

73. Motta PM, Nottola SA, Familiari G, Makabe S, Stallone T, Macchiarelli G. Morphodynamics of the follicular-luteal complex during early ovarian development and reproductive life. Int Rev Cytol. 2003;223:177-288.

74. Macchiarelli G, Ohtani O, Nottola SA, Stallone T, Camboni A, Prado IM, Motta PM. A micro-anatomical model of the distribution of myocardial endomysial collagen. Histol Histopathol. 2002;17(3):699-706.

75. Nottola SA, Makabe S, Stallone T, Macchiarelli G, Correr S, Motta PM. Ultrastructure and distribution of interstitial glandular cells and associated elements in human fetal ovaries. Arch Histol Cytol. 2000 Oct;63(4):345-55.

76. Motta PM, Nottola SA, Makabe S, Heyn R. Mitochondrial morphology in human fetal and adult female germ cells. Hum Reprod. 2000 Jul;15 Suppl 2:129-47.

77. Fabbri R, Porcu E, Marsella T, Primavera MR, Cecconi S, Nottola SA, Motta PM, Venturoli S, Flamigni C. Human embryo development and pregnancies in an homologous granulosa cell coculture system. J Assist Reprod Genet. 2000 Jan;17(1):1-12.

78. Familiari G, Verlengia C, Nottola SA, Tripodi A, Hyttel P, Macchiarelli G, Motta PM. Ultrastructural features of bovine cumulus-corona cells surrounding oocytes, zygotes and early embryos. Reprod Fertil Dev. 1998;10(4):315-26.

79. Motta PM, Nottola SA, Makabe S. Natural history of the female germ cell from its origin to full maturation through prenatal ovarian development. Eur J Obstet Gynecol Reprod Biol. 1997 Dec;75(1):5-10.

80. Motta PM, Makabe S, Nottola SA. The ultrastructure of human reproduction. I. The natural history of the female germ cell: origin, migration and differentiation inside the developing ovary. Hum Reprod Update. 1997 May-Jun;3(3):281-95.

81. Nottola SA, Macchiarelli G, Motta PM. The angioarchitecture of estrous, pseudopregnant and pregnant rabbit ovary as seen by scanning electron microscopy of vascular corrosion casts. Cell Tissue Res. 1997 May;288(2):353-63.

82. Familiari G, Verlengia C, Nottola SA, Renda T, Micara G, Aragona C, Zardi L, Motta PM. Heterogeneous distribution of fibronectin, tenascin-C, and laminin immunoreactive material in the cumulus-corona cells surrounding mature human oocytes from IVF-ET protocols--evidence that they are composed of different subpopulations: an immunohistochemical study using scanning confocal laser and fluorescence microscopy. Mol Reprod Dev. 1996 Mar;43(3):392-402.

83. Motta PM, Nottola SA, Pereda J, Croxatto HB, Familiari G. Ultrastructure of human cumulus oophorus: a transmission electron microscopic study on oviductal oocytes and fertilized eggs. Hum Reprod. 1995 Sep;10(9):2361-7.

84. Familiari G, Caggiati A, Nottola SA, Ermini M, Di Benedetto MR, Motta PM. Ultrastructure of human ovarian primordial follicles after combination chemotherapy for Hodgkin's disease. Hum Reprod. 1993 Dec;8(12):2080-7.

85. Macchiarelli G, Nottola SA, Vizza E, Familiari G, Kikuta A, Murakami T, Motta PM. Microvasculature of growing and atretic follicles in the rabbit ovary: a SEM study of corrosion casts. Arch Histol Cytol. 1993 Mar;56(1):1-12.

86. Familiari G, Nottola SA, Macchiarelli G, Familiari A, Motta PM. A technique for exposure of the glycoproteic matrix (zona pellucida and mucus) for scanning electron microscopy. Microsc Res Tech. 1992 Nov 1;23(3):225-9.

87. Familiari G, Nottola SA, Macchiarelli G, Micara G, Aragona C, Motta PM. Human zona pellucida during in vitro fertilization: an ultrastructural study using saponin, ruthenium red, and osmium-thiocarbohydrazide. Mol Reprod Dev. 1992 May;32(1):51-61.

88. Macchiarelli G, Vizza E, Nottola SA, Familiari G, Motta PM. Cellular and microvascular changes of the ovarian follicle during folliculogenesis: a scanning electron microscopic study. Arch Histol Cytol. 1992;55 Suppl:191-204.

89. Macchiarelli G, Nottola SA, Vizza E, Kikuta A, Murakami T, Motta PM. Ovarian microvasculature in normal and hCG stimulated rabbits. A study of vascular corrosion casts with particular regard to the interstitium. J Submicrosc Cytol Pathol. 1991 Jul;23(3):391-5.

90. Nottola SA, Familiari G, Micara G, Aragona C, Motta PM. The ultrastructure of human cumulus-corona cells at the time of fertilization and early embryogenesis. A scanning and transmission electron microscopic study in an in vitro fertilization program. Arch Histol Cytol. 1991 May;54(2):145-61.

91. Familiari G, Nottola SA, Familiari A, Motta PM. The three-dimensional structure of the zona pellucida in growing and atretic ovarian follicles of the mouse. Scanning and transmission electron-microscopic observations using ruthenium red and detergents. Cell Tissue Res. 1989 Aug;257(2):247-53.

92. Nottola SA, Familiari G, Micara G, Aragona C, Motta PM. The role of the cumulus-corona cells surrounding in vitro human oocytes and polypronuclear ova: an ultrastructural study. Prog Clin Biol Res. 1989;296:345-54.

93. Familiari G, Nottola SA, Micara G, Aragona C, Motta P. Human in vitro fertilization: the fine three-dimensional architecture of the zona pellucida. Prog Clin Biol Res. 1989;296:335-44.

94. Familiari G, Nottola SA, Micara G, Aragona C, Motta PM. Is the sperm-binding capability of the zona pellucida linked to its surface structure? A scanning electron microscopic study of human in vitro fertilization. J In Vitro Fert Embryo Transf. 1988 Jun;5(3):134-43.

95. Motta PM, Nottola SA, Micara G, Familiari G. Ultrastructure of human unfertilized oocytes and polyspermic embryos in an IVF-ET program. Ann N Y Acad Sci. 1988;541:367-83.

96. Familiari G, Nottola SA, Motta PM. Focal cell contacts detected by ruthenium red, triton X100 and saponin in the granulosa cells of mouse ovary. Tissue Cell. 1987;19(2):207-15.

Link to Scopus (personal page, ID: 6604078973):
https://www.scopus.com/results/results.uri?sort=plf-f&src=s&st1=nottola&...

Date: September 30, 2023

Signed:
Stefania Annarita Nottola