Ritratto di roberto.rizzi@uniroma1.it

 

PATOLOGIA GENERALE E MOLECOLARE CON TERMINOLOGIA MEDICA 1038200    

Chimica e tecnologia farmaceutiche (Latina)

TECNOLOGIE AVANZATE NELLA DIAGNOSTICA DI LABORATORIO 1035176   

Tecniche di laboratorio biomedico (abilitante alla professione sanitaria di Tecnico di laboratorio biomedico) - Corso di laurea C - ASL Latina (distretto nord)

Insegnamento Codice Anno Corso - Frequentare Bacheca
PATOLOGIA GENERALE E MOLECOLARE CON TERMINOLOGIA MEDICA 10611094 2023/2024
BASI FISIOPATOLOGICHE DELLE MALATTIE 1036417 2023/2024
BIOINGEGNERIA CELLULARE TISSUTALE E D'ORGANO. TECNICHE BIOTECNOLOGICHE IN CHIRURGIA 10600243 2023/2024
TECNOLOGIE AVANZATE NELLA DIAGNOSTICA DI LABORATORIO 1035176 2023/2024
PATOLOGIA GENERALE E MOLECOLARE CON TERMINOLOGIA MEDICA 1038200 2023/2024
BASI FISIOPATOLOGICHE DELLE MALATTIE 1036417 2022/2023
TECNOLOGIE AVANZATE NELLA DIAGNOSTICA DI LABORATORIO 1035176 2022/2023
PATOLOGIA GENERALE E MOLECOLARE CON TERMINOLOGIA MEDICA 1038200 2022/2023

Roberto Rizzi, Ph.D.

roberto.rizzi@uniroma1.it
rizzi@ingm.org
rbt.rizzi@pec.it

Orcid ID: 0000-0001-6084-7199

WEBSITE: https://ingm.org/en/rizzi_lab_eng/

Sex Male | Date of birth 12/01/1973 | Nationality Italian

RESEARCH INTERESTS
Development of innovative biotechnologies for regenerative medicine and modelling
Personalized organs generation in vitro
Stem Cell and Bio Additive-based therapies for cardiac and skeletal muscles regeneration
Biomaterials for tissue engineering and organoids 2.0 generation
Strategic consulting for 3D Bio-fabricated disease modelling

WORK EXPERIENCE
2022 present Tenure track (RTD-B) Assistant Professor 06-N1- Med46
Department of Medical Surgical Sciences and Biotechnologies
Faculty of Pharmacy and Medicine
La Sapienza University of Rome
P.le Aldo Moro 5 Roma, Italia
Regenerative Medicine
Business or sector Biotech/Medical

2021 present Head of Bioprinting and Biofabrication Unit
Organoids Center -Invernizzi Foundation c/o INGM
Via Francesco Sforza, 35 20122 Milano, Italia
https://ingm.org/en/organoid-center/
Hi-fidelity modelling for Immunology
Business or sector Biotech

2019 present Project Leader-PI
National Institute of Molecular Genetics Foundation (INGM)
Head of Rigenerative Medicine Unit
Via Francesco Sforza, 35 20122 Milano, Italia
https://ingm.org/en/rizzi_lab_eng/
Development of innovative biotechnologies for regenerative medicine
Business or sector Biotech/ Medical

2008 - 2022 Researcher (Permanent)
National Research Council (CNR) of Italy
Institute of Biomedical Technologies (ITB): 10/2019 05/2022
Institute of Cell Biology and Neurobiology (IBCN): 10/2008 09/2019
7 Aldo Moro Square Rome, Italy
https://www.itb.cnr.it/laboratori/ingegneria-tissutale/
Stem cells supported by innovative biomaterials in regenerative medicine
Business or sector Medical
2009 - 2015 Consultant: Researcher- Group Leader
IRCCS MultiMedica
16/15 Fantoli Street Milan, Italy
Generation of induced pluripotent stem cells for personalized medicine approaches
Business or sector Health and life science
2007 - 2008 Post-Doc
Harvard Medical School
Brigham and Women's Hospital
75 Francis Street Boston, Massachusetts, USA
Characterization of calcium channels in cardiac differentiation
Business or sector Medical
2006 2007 Post-Doc
New York Medical College
40 Sunshine Cottage Road Valhalla, New York, USA
Identification of a population of cardiac progenitors residing in the human heart
Business or sector Medical
2005 2006 Post-Doc
Istituto Dermopatico dell'Immacolata (IDI)
Via dei Monti di Creta 104 - Rome, Italy
Regeneration of muscle tissues
Business or sector Medical
2004 Post-Doc
University of Rome "Tor Vergata"
Via O. Raimondo, 8 Loc. La Romanina - Rome, Italy
Biological effects of peptides VGF-derived
Business or sector Medical

EDUCATION, TRAINING
EDUCATION
2018 ASN- National Scientific Qualification
CALL D.D. 1532/2016 Eligibility Associate Professor -Sector 06/N1
(Med 46 -Med 47 -Med 48 -Med 50)
Science of health professions and applied medical technologies
2005 Specialty in Clinical Sexology
Clinical Sexology Institute - Rome, Italy
2003 Ph.D. in Psychobiology and Psychopharmacology
Psychobiology and Psychopharmacology Institute, University of Rome "La Sapienza"
Piazza Aldo Moro, 5 - Rome, Italy
1999 Master s degree in Clinical Psychology
University of Rome "La Sapienza"
Piazza Aldo Moro, 5 - Rome, Italy

TRAINING
2009 EUGENEheart Mouse phenotyping-Catheter-based in vivo hemodynamics of murine hearts , under the supervision of Mylene Pezet, PhD, Consulting Engineer, Bichat Hospital, Paris.
2009 EUGENEheart Mouse phenotyping- small rodens echocardiography, under the supervision of Dr. Brigitte Escoubet, cardiologist, MD, PhD, Bichat Hospital, Paris.
2002 Physiology of pain under the supervision of Prof. Giancarlo Carli, Nuovi Istituti Biologici, University of Siena.
PERSONAL SKILLS

Mother tongue(s) Italian
Other language(s) UNDERSTANDING SPEAKING WRITING
Listening Reading Spoken interaction Spoken production
English C1 C1 C1 C1 C2
Levels: A1/A2: Basic user - B1/B2: Independent user - C1/C2 Proficient user

Communication skills Excellent communication skills gained through my experience as researcher in national and international laboratories, particularly in:
leadership, exchange constructive feedback and delegating responsibilities
working independently and as a team member
Competitive attitude, self-motivated, and strong work ethic.
Organisational/managerial skills Excellent organizational and administrative skills:
Group Leader (currently responsible for a team of 10 people)
Capable to write grants and papers
Experienced in managing several projects and collaborations in parallel
Able to prioritize, set realistic objectives and planning work to achieve goals and targets
Proven ability to train, supervise, motivate Post Doc, PhD students, technicians stimulating discussion
Job-related skills Management of research projects: grants application, articles writing and conferences participations
Data handling: data interpretation, statistical analysis
Biofabrication
Bioprinting
Molecular Biology techniques
Cell Culture techniques
Tissue engineering technique
Animal surgery
Digital competence Very good knowledge of Windows operating system, Office (Word, Excel, PowerPoint, Movie Maker), Adobe Photoshop CS, Image J, EndNote and software for molecular analysis (Primer 3, Ensembl, GeneSifter)
SCIENTIFIC PUBBLICATIONS
SONIA SPINELLI, LUCREZIA GUIDA, TIZIANA VIGLIAROLO, MARIO PASSALACQUA, GIULIA BEGANI, MIRKO MAGNONE, LAURA STURLA, ANDREA BENZI, PIETRO AMERI, EDOARDO LAZZARINI, CLAUDIA BEARZI, ROBERTO RIZZI AND ELENA ZOCCHI. The ABA-LANCL1/2 Hormone-Receptors System Protects H9c2 Cardiomyocytes from Hypoxia-Induced Mitochondrial Injury via an AMPK- and NO-Mediated Mechanism. Cells 2022, 11, 2888. https://doi.org/10.3390/cells11182888.
PIANCA N, SACCHI F, UMANSKY KB, CHIRIVÌ M, IOMMARINI L, DA PRA S, PAPA V, BONGIOVANNI C, MIANO C, PONTIS F, BRAGA L, TASSINARI R, PANTANO E, PATNALA RS, MAZZESCHI M, CENACCHI G, PORCELLI AM, LAURIOLA M, VENTURA C, GIACCA M, RIZZI R, TZAHOR E, D UVA G. Glucocorticoid receptor antagonization propels endogenous cardiomyocyte proliferation and cardiac regeneration. Nat Cardiovasc Res. 2022 1, pages 617 633 (2022). https://doi.org/10.1038/s44161-022-00090-0
MAILA CHIRIVÌ, CLAUDIA BEARZI, PAOLO ROSA, SELENIA MIGLIETTA, FRANCESCA PETRONELLA, ELENA DE FALCO, ANTONELLA CALOGERO, ROBERTO PANI, VINCENZO PETROZZA, GIOVANNI PEROTTO, ROBERTO RIZZI AND LUCIANO DE SIO. Biomimetic Keratin-Coated Gold Nanoparticles for Photo-Thermal Therapy in a 3D Bioprinted Glioblastoma Tumor Model. Int. J. Mol. Sci. 2022, 23, 9528.
VERONICA DE PAOLIS, FABIO MAIULLARI, MAILA CHIRIVÌ, MARIKA MILAN, CHIARA CORDIGLIERI, FRANCESCA PAGANO, ALESSANDRA RITA LA MANNA, ELENA DE FALCO, CLAUDIA BEARZI, ROBERTO RIZZI*, AND CHIARA PARISI*, . Unusual Association of NF- B Components in Tumor-Associated Macrophages (TAMs) Promotes HSPG2-Mediated Immune-Escaping Mechanism in Breast Cancer. Int. J. Mol. Sci. 2022, 23, 7902. https://doi.org/10.3390/ijms23147902
ANTONELLA BORDIN, MAILA CHIRIVÌ, FRANCESCA PAGANO, MARIKA MILAN, MARCO IULIANO, ELEONORA SCACCIA, ORAZIO FORTUNATO, GIORGIO MANGINO, XHULIO DHORI, ELISABETTA DE MARINIS, ALESSANDRA D AMICO, SELENIA MIGLIETTA, VITTORIO PICCHIO, ROBERTO RIZZI, GIOVANNA ROMEO, FABIO PULCINELLI, ISOTTA CHIMENTI, GIACOMO FRATI, ELENA DE FALCO. Human platelet lysate derived extracellular vesicles enhance angiogenesis through miR-126. Cell Proliferation, 2022 Aug 9; e13312.doi: 10.1111/cpr.13312
FORNETTI E, TESTA S, DE PAOLIS F, FUOCO C, BERNARDINI S, POZO DEVOTO V, GORAZD B S, GIANNITELLI S, RAINER A, BIGOT A, ZOCCALI C, BALDI J, SANDONA D, RIZZI R, BEARZI C, FORTE G, CANNATA S, GARGIOLI C. Dystrophic muscle affects motoneuron axon outgrowth and NMJ assembly. Advanced Materials Technologies, March 2022, DOI.org/10.1002/admt.202101216
STIRM M, FONTEYNE LM, SHASHIKADZE B, LINDNER M, CHIRIVI M, LANGE A, KAUFHOLD C, MAYER C, MEDUGORAC I, KESSLER B, KUROME M, ZAKHARTCHENKO V, HINRICHS A, KEMTER E, KRAUSE S, WANKE R, ARNOLD G, WESS G, NAGASHIMA H, HRABE DE ANGELIS M, FLENKENTHALER F, KOBELKE LA, BEARZI C, RIZZI R, BAEHR A, REESE S, MATIASEK K, WALTER MC, KUPATT C, ZIEGLER S, BARTENSTEIN P, FROHLICH T, KLYMIUK N, BLUTKE A, WOLF E. A scalable, clinically severe pig model for Duchenne muscular dystrophy. Disease Models & Mechanisms. 2021 Nov 19; dmm.049285. doi: 10.1242/dmm.049285
CELIKKIN N, PRESUTTI D, MAIULLARI F, FORNETTI E, AGARWAL T, PARADISO A, VOLPI M, WI SZKOWSKI W, BEARZI C, BARBETTA A, ZHANG YS, GARGIOLI C, RIZZI R AND COSTANTINI M. Tackling Current Biomedical Challenges With Frontier Biofabrication and Organ-On-A-Chip Technologies. Front. Bioeng. Biotechnol. 9:732130. 2021. doi: 10.3389/fbioe.2021.732130.
CANONICO F, CHIRIVI M, MAIULLARI F, MILAN M, RIZZI R, ARCUDI A, GALLI M, PANE M, GOWRAN A, POMPILIO G, MERCURI E, CREA F, BEARZI C, D AMARIO D. Focus on the Road to Modelling Cardiomyopathy in Muscular Dystrophy. Cardiovascular Research. 2021 Jul 12:cvab232. doi: 10.1093/cvr/cvab232. Epub ahead of print. PMID: 34254111.
CHIRIVÌ M, MAIULLARI F, MILAN M, PRESUTTI D, CORDIGLIERI C, CROSTI M, SARNICOLA ML, SOLURI A, VOLPI M, WI SZKOWSKI W, PRATI D, RIZZI M, COSTANTINI M, SELIKTAR D, PARISI C, BEARZI C, RIZZI R*. Tumor Extracellular Matrix Stiffness Promptly Modulates the Phenotype and Gene Expression of Infiltrating T Lymphocytes. Int J Mol Sci. 2021 May 30;22(11):5862. doi: 10.3390/ijms22115862. PMID: 34070750; PMCID: PMC8198248.
LUCÀ R, ASSENZA MR, MAIULLARI F, PIERONI L, MAIULLARI S, FEDERICI G, MARINI F, RIZZI R, URBANI A, SODDU S, MORETTI F. Inhibition of the mTOR pathway and reprogramming of protein synthesis by MDM4 reduce ovarian cancer metastatic properties. Cell Death Dis. 2021 May 29;12(6):558. doi: 10.1038/s41419-021-03828-z. PMID: 34052831.
PEGOLI G, MILAN M, MANTI PG, BIANCHI A, LUCINI F, SANTARELLI P, BEARZI C, RIZZI R, LANZUOLO C. Role of Cdkn2a in the Emery-Dreifuss Muscular Dystrophy Cardiac Phenotype. Biomolecules. 2021 Apr 6;11(4):538. doi: 10.3390/biom11040538. PMID: 33917623; PMCID: PMC8103514.
MAIULLARI F, CHIRIVÌ M, COSTANTINI M, FERRETTI AM, RECCHIA S, MAIULLARI S, MILAN M, PRESUTTI D, PACE V, RASPA M, SCAVIZZI F, MASSETTI M, PETRELLA L, FANELLI M, RIZZI M, FORTUNATO O, MORETTI F, CARADONNA E, BEARZI C, RIZZI R*. In vivo organized neovascularization induced by 3D bioprinted endothelial-derived extracellular vesicles. Biofabrication 2021 Apr 7;13(3). doi: 10.1088/1758-5090/abdacf. IF: 8,213.
MACCARI S, PACE V, BARBAGALLO F, STATI T, AMBROSIO C, VEZZI V, GRO C, CATALANO L, MATARRESE P, MOLINARI P, RIZZI R, MARANO G. Daily intermittent -blockade improves cardiac function in post-infarction heart failure. Eur J Pharmacol. 2020 Jun 22;882:173287. doi: 10.1016/j.ejphar.2020.173287. PMID: 32585157
BACI D, CHIRIVÌ M, PACE V, MAIULLARI F, MILAN M, RAMPIN A, SOMMA P, PRESUTTI D, GARAVELLI S, BRUNO A, CANNATA S, LANZUOLO C, GARGIOLI C, RIZZI R*, BEARZI C. Extracellular Vesicles from skeletal muscle cells efficiently promote myogenesis in induced pluripotent stem cells. Cells. 2020 Jun 23;9(6):1527. doi: 10.3390/cells9061527.
BIANCHI A, MOZZETTA C, PEGOLI G, LUCINI F, VALSONI S, ROSTI V, PETRINI C, CORTESI A, GREGORETTI F, ANTONELLI L, OLIVA G, DE BARDI M, RIZZI R, BODEGA B, PASINI D, FERRARI F, BEARZI C, LANZUOLO C. Dysfunctional polycomb transcriptional repression contributes to Lamin A/C dependent muscular dystrophy. J Clin Invest. 2020 Jan 30. pii: 128161. doi: 10.1172/JCI128161.
MAIULLARI F, COSTANTINI M, MILAN M, PACE V, CHIRIVÌ M, MAIULLARI S, BACI D, MAREI HE, SELIKTAR D, RAINER A, GARGIOLI C, BEARZI C, RIZZI R*. A multi-cellular 3D bioprinting approach for vascularized heart tissue engineering based on HUVECs and iPSC-derived cardiomyocytes. SCI REP. 2018 SEP 10;8(1):13532. DOI: 10.1038/S41598-018-31848-X.
MILAN M, PACE V, MAIULLARI F, CHIRIVÌ M, BACI D, MAIULLARI S, MADARO L, MACCARI S, STATI T, MARANO G, FRATI G, PURI PL, DE FALCO E, BEARZI C, RIZZI R*. Givinostat reduces adverse cardiac remodeling through regulating fibroblasts activation. CELL DEATH DIS. 2018 JAN 25; 9(2):108.
MAREI H, RIZZI R, ALTHANI A, AFFIFI N, CENCIARELLI C, CACECI T, SHUAIB A. Potential of stem cell-based therapy for ischemic stroke. FRONT NEUROL. 2018 FEB 6; 9:34. DOI: 10.3389/FNEUR.2018.00034
SOHAIL MU, ALTHANI A, ANWAR H, RIZZI R, MAREI HE. Role of the gastrointestinal tract microbiome in the pathophysiology of diabetes mellitus. J Diabetes Res. 2017; 2017:9631435. doi: 10.1155/2017/9631435. Epub 2017 Sep 26. Review. PubMed PMID: 29082264; PubMed Central PMCID: PMC5634576.
MAREI HE, SHOUMAN Z, ALTHANI A, AFIFI N, A AE, LASHEN S, HASAN A, CACECI T, RIZZI R, CENCIARELLI C, CASALBORE P. Differentiation of human olfactory bulb-derived neural stem cells toward oligodendrocyte. J CELL PHYSIOL. 2018 FEB; 233(2):1321-1329. DOI: 10.1002/JCP.26008. EPUB 2017 JUN 22. PUBMED PMID: 28500734.
RONCA A, MAIULLARI F. MILAN M, PACE V, GLORIA A, RIZZI R, DE SANTIS R, AMBROSIO L. Surface functionalization of acrylic based photocrosslinkable resin for 3D printing application. BIOACTIVE MATERIALS. 2017, 2(3): 131 137. doi:10.1016/j.bioactmat.2017.04.002
CARLOMOSTI F, D AGOSTINO M, BEJI S, TORCINARO A, RIZZI R, ZACCAGNINI G, MAIMONE B, DI STEFANO V, DE SANTA F, CORDISCO S, ANTONINI A, CIARAPICA R, DELLAMBRA E, MARTELLI F, AVITABILE D, CAPOGROSSI MC, MAGENTA A. Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1 and eNOS. Antioxid Redox Signal. 2016 Dec 13.
MACCARI S, BUONCERVELLO M, RAMPIN A, SPADA M, MACCHIA D, GIORDANI L, STATI T, BEARZI C, CATALANO L, RIZZI R, GABRIELE L, MARANO G. Biphasic effects of propranolol on tumour growth in B16F10 melanoma-bearing mice. Br J Pharmacol. 2016 Oct 28. doi: 10.1111/bph.13662. [Epub ahead of print] PubMed PMID: 27792834.
VONO R, FUOCO C, TESTA S, PIRRÒ S, MASELLI D, MC COLLOUGH DF, SANGALLI E, PINTUS G, GIORDO R, FINZI G, SESSA F, CARDANI R, GOTTI A, LOSA S, CESARENI G, RIZZI R, BEARZI C, CANNATA S, SPINETTI G, GARGIOLI C, MADEDDU P. Activation of the Pro-Oxidant PKC II-p66Shc Signaling Pathway Contributes to Pericyte Dysfunction in Skeletal Muscles of Diabetic Patients with Critical Limb Ischemia. 2016. Diabetes. 65:3691-704.
NARDELLA M, GUGLIELMI L, MUSA C, IANNETTI I, MARESCA G, AMENDOLA D, PORRU M, CARICO E, SESSA G, CAMERLINGO R, DOMINICI C, MEGIORNI F, MILAN M, BEARZI C, RIZZI R, PIROZZI G, LEONETTI C, BUCCI B, MERCANTI D, FELSANI A AND D AGNANO I. Down regulation of the Lamin A/C in neuroblastoma triggers the expansion of tumor initiating cells. 2015. Oncotarget. 6, 32821-32840.
VANNOZZI L, RICOTTI L, CIANCHETTI M, BEARZI C, GARGIOLI C, RIZZI R, DARIO P AND MENCIASSI A. Self-assembled polydimethylsiloxane structures from 2D to 3D for bio-hybrid actuation. Bioinspir Biomim. 2015 Aug 20;10(5):056001. doi: 10.1088/1748-3190/10/5/056001.
FUOCO C, RIZZI R, BIONDO A, LONGA E, MASCARO A, SHAPIRA-SCHWEITZER K, KOSSOVAR O, BENEDETTI S, SALVATORI ML, SANTOLERI S, TESTA S, BERNARDINI S, BOTTINELLI R, BEARZI C, CANNATA SM, SELIKTAR D, COSSU G, GARGIOLI C. In vivo generation of an artificial, functional skeletal muscle. EMBO Mol Med. 7:411-22, 2015.
CATTANEO P, KUNDERFRANCO P, GRECO C, GUFFANTI A, STIRPARO GG, RUSCONI F, RIZZI R, DI PASQUALE E, LOCATELLI SL, LATRONICO MV, BEARZI C, PAPAIT R, CONDORELLI G. DOT1L-mediated H3K79me2 modification critically regulates gene expression during cardiomyocyte differentiation. 2014. Cell Death Differ. 23, 555-564.
FUOCO C, SANGALLI E, VONO R, SACCHETTI B, MADEDDU P, CESARENI G, SELIKTAR D, RIZZI R, BEARZI C, CANNATA S, SPINETTI G, GARGIOLI C. 3D hydrogel environment rejuvenates aged pericytes for skeletal muscle tissue engineering. Front Physiol. 2014 May 30;5:203. doi: 10.3389/fphys.2014.00203.
AMENDOLA D, NARDELLA M, GUGLIELMI L, CERQUETTI L, CARICO E, RIZZI R, BEARZI C, D AGNANO I, STIGLIANO A, NOVELLI G, BUCCI B. Human placenta-derived neurospheres are susceptible to transformation after extensive in vitro expansion. Stem Cell Research & Therapy 2014, 5:55 doi:10.1186/scrt444.
BEARZI C, GARGIOLI C, BACI D, FORTUNATO O, SHAPIRA-SCHWEITZER K, KOSSOVER O, LATRONICO MVG, SELIKTAR D, CONDORELLI G, RIZZI R*. PlGF MMP9-engineered cardiomyocyte-derived iPS cells supported on a PEG fibrinogen hydrogel scaffold possess an enhanced capacity to repair damaged myocardium. Cell Death Dis. 2014 Feb 13;5:e1053. doi: 10.1038/cddis.2014.12.
FAGOONEE S, BEARZI C, DI CUNTO F, CLOHESSY JG, RIZZI R, RESCHKE M, TOLOSANO E, PROVERO P, PANDOLFI PP, SILENGO L, ALTRUDA F. The RNA binding protein ESRP1 fine-tunes the expression of pluripotency-related factors in mouse embryonic stem cells. PLoS One. 8:e72300, 2013.
SANDRI M, RIZZI R, SCHIATTARELLA GG, LEVIALDI GHIRON JH, LATRONICO MVG, PIRONTI G, CHIARIELLO GA, ESPOSITO G, TAMPIERI A and CONDORELLI G. A collagen membrane-based engineered heart tissue improbe cardiac function in ischemic rat hearts. Bioinspired, Biomimetic and Nanobiomaterials. 10.1680/bbn.12.00028, 2012.
RIZZI R, BEARZI C, MAURETTI A, BERNARDINI S, CANNATA S and GARGIOLI C. Tissue engineering for skeletal muscle re generation. Muscle, Ligaments and Tendons J. 2:230-4, 2012.
RIZZI R, DI PASQUALE E, PORTARARO P, PAPAIT R, CATTANEO P, LATRONICO MVG, ALTOMARE C, SALA L, ZAZA A, HIRSCH E, NALDINI L, CONDORELLI G, BEARZI C. Post-natal cardiomyocytes can generate iPS cells with an enhanced capacity toward cardiomyogenic re-differentiation. Cell Death Differ. 19:1162-74, 2012.
ZHANG D, CONTU R, LATRONICO MVG, ZHANG J, RIZZI R, CATALUCCI D, MIYAMOTO S, HUANG K, CECI M, GU Y, DALTON ND, PETERSON KL, GUAN K, BROWN JH, CHEN J, SONENBERG N and CONDORELLI G. MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J Clin Invest. 120:2805-16, 2010.
DE FALCO E, AVITABILE D, TOTTA P, STRAINO S, SPALLOTTA F, CENCIONI C, TORELLA AR, RIZZI R, PORCELLI D, ZACHEO A, DI VITO L, POMPILIO G, NAPOLITANO M, MELILLO G, CAPOGROSSI MC and PESCE M. Altered SDF-1-mediated differentiation of bone marrow-derived endothelial progenitor cells in diabetes mellitus. J Cell Mol Med. 13:3405-14, 2009.
FERREIRA-MARTINS J, RONDON-CLAVO C, TUGAL D, KORN JA, RIZZI R, PADIN-IRUEGAS ME, OTTOLENGHI S, DE ANGELIS A, URBANEK K, IDE-IWATA N, D'AMARIO D, HOSODA T, LERI A, KAJSTURA J, ANVERSA P and ROTA M. Spontaneous calcium oscillations regulate human cardiac progenitor cell growth. Circ Res. 105:764-74, 2009.
BONI A, URBANEK K, NASCIMBENE A, HOSODA T, ZHENG H, DELUCCHI F, AMANO K, GONZALEZ A, VITALE S, OJAIMI C, RIZZI R, BOLLI R, YUTZEY KE, ROTA M, KAJSTURA J, ANVERSA P, LERI A. Notch1 regulates the fate of cardiac progenitor cells. Proc Natl Acad Sci U S A. 105:15529-34, 2008.
RIZZI R, BARTOLOMUCCI A, MOLES A, D'AMATO F, SACERDOTE P, LEVI A, LA CORTE G, CIOTTI MT, POSSENTI R and PAVONE F. The VGF-derived peptide TLQP-21: a new modulatory peptide for inflammatory pain. Neurosci Lett. 441:129-33, 2008.
ROTA M, KAJSTURA J, HOSODA T, BEARZI C, VITALE S, ESPOSITO G, IAFFALDANO G, PADIN-IRUEGAS ME, GONZALEZ A, RIZZI R, SMALL N, MURASKI J, ALVAREZ R, CHEN X, URBANEK K, BOLLI R, HOUSER SR, LERI A, SUSSMAN MA and ANVERSA P. Bone marrow cells adopt the cardiomyogenic fate in vivo. Proc Natl Acad Sci. 104(45); p. 17783, 2007.
ROTA M, HOSODA T, DE ANGELIS A, ARCARESE ML, ESPOSITO G, RIZZI R, TILLMANNS J, TUGAL D, MUSSO E, RIMOLDI O, BEARZI C, URBANEK K, ANVERSA P, LERI A and KAJSTURA J. The young mouse heart is composed of myocytes heterogeneous in age and function. Circ Res. 101:387-99, 2007.
BARTOLOMUCCI A, LA CORTE G, POSSENTI R, LOCATELLI V, RIGAMONTI AE, TORSELLO A, BRESCIANI E, BULGARELLI I, RIZZI R, PAVONE F, D'AMATO FR, SEVERINI C, MIGNOGNA G, GIORGI A, SCHININÀ ME, ELIA G, BRANCIA C, FERRI GL, CONTI R, CIANI B, PASCUCCI T, DELL'OMO G, MULLER EE, LEVI A and MOLES A. TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity. Proc Natl Acad Sci. 103:14584-9, 2006.
MOLES A, BARTOLOMUCCI A, GARBUGINO L, CONTI R, CAPRIOLI A, COCCURELLO R, RIZZI R, CIANI B and D'AMATO FR. Psychosocial stress affects energy balance in mice: modulation by social status. Psychoneuroendocrinology. 31:623-33, 2006.
D'AMATO FR, RIZZI R, MOLES A. Aggression and anxiety in pregnant mice are modulated by offspring characteristics. Animal Behaviour. 72 (4):773-780, 2006. ISSN 0003-3472. https://doi.org/10.1016/j.anbehav.2005.11.022.
MOLES A, RIZZI R and D AMATO FR. Postnatal Stress in mice: Does stressing the mother have the same effect as stressing in pups? Dev Psychobiol. 44:230-7, 2004.
MOLES A, RIZZI R and D AMATO FR. The number of male pups within the bitter of NMRI mice is associated with the dam s food preferences late in pregnancy. Psychoneuroendocrinology. 28:250-60, 2003.
D AMATO FR, RIZZI R, MOLES A. A model of social stress in dominant mice: effects on sociosexual behaviour. Physiol Behav. 73:421-6, 2001.
BOOK CHAPTER
1. BEARZI C, PARISI C, RIZZI R*. (2021) Modelli sperimentali avanzati per lo studio delle patologie psichiatriche. In: Brambilla P, editor. Neuroscienze psichiatriche e computazionali. Torino: Edizioni Minerva Medica; 2021. ISBN: 978-88-5532-068-9.
2. BEARZI C, RIZZI R*. (2019) The Heart-Brain Connection in Patients with Duchenne Muscular Dystrophy. In: Govoni S, Politi P, Vanoli E. (eds) Brain and Heart Dynamics. Springer, Cham. DOI: https://doi.org/10.1007/978-3-319-90305-7_64-1.
H-INDEX
26 (https://www.scopus.com/freelookup/form/author.uri)
RIZZI S LAB FOUNDED PROJECTS
2022-2023, PROGETTI DI RICERCA@CNR -call., Dipartimento Scienze Biomediche Human 3D myocardium-integrated competent coronary vessel to unveil epigenetics dynamics of Sars-CoV-2 infection on heart (197/2021 del 21/12/2021). Euro 209.000.
2020-2023, MINISTRY OF DEFENCE GRENADE Generazione di tessuti individuo-specifici per il riparo di organi danneggiati prot. M_D GCOM REG2020 0009780 23-06-2020 Euro 597.000.
2020-2023, FONDAZIONE REGIONALE per la RICERCA BIOMEDICA, Bando Giovani Early Career Award : Chondroitin sulfate proteoglycan 4, secreted by a binding imbalance between SP1 and NF kB on CHST11 gene, triggers sympathetic cardiac denervation in Duchenne Muscular Dystrophy ID 1731651. Euro 600.000.
2020-2023, CARIPLO FOUNDATION The role of microRNA-34 in regulating autoimmune T cell response in the depressive syndrome prot. 2019-3392. Euro 300.000.
2020-2023, Ricerca Finalizzata Giovani, Ministero della Salute: Engineered T cells (CAR-T) for the treatment of cardiac fibrosis in Duchenne Muscular Dystrophy ID SG-2019-12368961. Euro 140.000.
2018-2021, Roche: Caratterizzazione degli effetti dell HDACi Givinostat nel ripristino della funzionalità della sinapsi neurocardiacadel topo mdx, attraverso la modulazione dell espressione di NGF nei fibroblasti interstiziali cardiaci - ID CNR 0004002. Euro 50.000.
2018-2020, LAZIOINNOVA SATISFY Generazione di tessuti umani individuo-specifici per test di efficacia di nuovi farmaci prot. 85-2017-15095. Euro 150.000.
2017-2020, PARENT PROJECT, Role of the HDAC inhibitor givinostat in cardiac remodelling in mdx mice. Euro 60.000.
2017-2018, ITALFARMACO, ACE and HDAC inhibitors effects after myocardial infarction . Euro 45.000.
2014-2017, Cluster ALISEI IRMI Project, ITALIAN MINISTRY OF EDUCATION, UNIVERSITY AND RESEARCH, Creation of a multiregional infrastructure for the development of advanced therapies for organ and tissue regeneration prot. CTN01 00177 888744. Euro 100.000.
2013-2015, Lombardy Region, Framework agreement, RSPPTech Research and development of products and technological platforms for the competitiveness of the lombard industry prot. 18095. Euro 250.000.
2011-2014, Lombardy Region, Superpig 2010, Technological platform for using the pig model in biomedical (organ and tissue transplantation) and biotechnological (animal model) fields prot. 14388. Euro 599.000.
2008-2012, EC | FP7 | SP1 | NMP, Angiogenesis-inducing Bioactive and Bioresponsive Scaffolds in Tissue Engineering . ID: 214402. Euro 500.000