Catalogo dei Corsi di studio

CURRICULUM VITAE
VALENTINA FERRETTI
Dip. Biologia and Biotecnologie
"Charles Darwin", Sapienza Università di Roma
Ed. Fisiologia Generale,
P.le Aldo Moro, 5
00185 Rome (Italy)
Tel.+39 (0)6 49912309
Email: valentina.ferretti@uniroma1.it
ORCID: http://orcid.org/0000-0002-5747-8852

PRESENT POSITION
Ricercatore a t.d. - t.pieno (art. 24 c.3-a L. 240/10) Department of Biology and Biotechnology Charles Darwin Sapienza University of Rome

AFFILIATION
Department of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome
Istituto Italiano di Tecnologia (IIT), Genova
Istituto Italiano di Tecnologia (IIT), Roma

TITLES
2021-2031: Abilitazione scientifica nazionale a professore di II fascia Settore Concorsuale 05/D1 BIO09 Fisiologia (achieved July 2021).
2018-2028: Abilitazione scientifica nazionale a professore di II fascia Settore Concorsuale 11/E1-Psicologia Generale, Psicobiologia E Psicometria; SSD MPSI/02- Psicobiologia E Psicologia Fisiologica (achieved November 2018).
2009: PhD, Psychobiology and Psychopharmacology, Sapienza University of Rome
2005: Master, Université Paul Sabatier, Toulouse, France
2004: Master's degree, Biological Sciences, Sapienza University of Rome

EDUCATION
2004: Master's Degree in Biological Sciences 110/110
2005: Master, Université Paul Sabatier, Toulouse, France
2005-2009: PhD, Psychobiology and Psychopharmacology, Sapienza University of Rome

PREVIOUS APPOINTMENTS
2002-2004: Master thesis Department of Biology and Biotechnology, Sapienza University of Rome
2004: Visiting student, Institute of Cellular Biology, CNR, Monterotondo, Rome
2005: Master student, Centre des Researches sur la Cognition Animal, Universitè Paul Sabatier, Toulouse, France
2005-2009: PhD student, Department of Biology and Biotechnology, Sapienza University of Rome
2009-2010 Visiting scientist, Imperial College, London, UK
2010-2014: Post doc, Department of Life Sciences, Imperial College, London, UK
2014-2019: Senior post doc, Italian Institute of Technology (IIT), Genoa
2020-2021 Senior post doc, Department of Biology and Biotechnology, Sapienza University of Rome

TEACHING
2005-2009: Lectures for Tecniche di studio del comportamento animale , Master's degree in Neurobiology, Sapienza University of Rome
2011-2012: Lectures for the Integrative Cell Biology and Neurobiology course, Imperial College, London
2018: Lectures for Neuroscience Training School (IIT) Genoa
2020: Lecture for Metodi di Neuroscienze Comportamentali Master's degree in Neurobiology, Sapienza University of Rome
2021-2022: Course Fisiologia generale con elementi di fisiologia vegetale , CdL Scienze Naturali (6 CFU), Sapienza University of Rome
2022-2023: Course Fisiologia generale , CdL Scienze Naturali (6 CFU), Sapienza University of Rome

RESEARCH ACTIVITIES
Brain circuits of social behavior
Genetic and pharmacological strategies for the treatment of social and cognitive deficits in animal models of neuropsychiatric disorders (intervention during development; role of immune system)
Molecular substrates of learning and memory processes in healthy and pathological conditions (aging, neurodegenerative diseases); role of sleep in memory modulation; experience-dependent plasticity.

RESEARCH SUPPORT
2021-2023: Studio del ruolo dei circuiti dell ossitocina nelle fasi precoci dello sviluppo in un modello murino
di malattie neuropsichiatriche-SEED-PNR Sapienza (10k )
2022-2023: The endogenous oxytocin system during development as a target for the treatment of social and cognitive symptoms in neuropsychiatric diseases Progetto Ateneo-Medi (co-PI Andrea Mele, Daniele Caprioli), Sapienza Università di Roma.

FELLOWSHIPS AND AWARDS:
2018: Travel Grant for the 11th FENS Forum, Berlin, Germany
2017: Travel Grant from International School of Neuroscience, Catania
2006: Travel Grant for the 5th FENS Forum (Vienna)
2005: PhD fellowship, Department of Biology and Biotechnology, Sapienza University of Rome
2005: Travel fellowship for one year of research training abroad from Sapienza University of Rome
2000: Erasmus fellowship, Sapienza University of Rome

INVITED SPEECH
2019: Oxytocin-dependent emotion recognition in mice , UCL, London, UK
2018: Oxytocin-dependent emotion recognition in mice , MINDSS School, Genova
2015: Alla ricerca di terapie personalizzate per il trattamento della schizofrenia Caffè letterario, Genova
2013: Pint of science : Why do we sleep Science festival, London, UK

ORGANIZATION OF SCIENTIFIC CONFERENCES
2018: Convergence Neuroscience: Phenotyping animal models of neurodevelopmental disorders, Genova
2022: EBPS Biennal workshop: Spanning the spectrum of social behavior: towards more translationally relevant animal models, Roma

REVIEWER ACTIVITY
2015- present: International Grants: French National Research Agency (ANR),
2014-present: Scientific Journals: Physiology & Behaviour, Plos1, Psychopharmacology, Cerebral Cortex, Neuroscience, Scientific Report
REVIEW EDITOR
2020-present: Frontiers in Behavioral Neuroscience, Section Motivation and Reward
2022: Topic editor of the Research Topic: "The Role of Neuropeptides in Drug Addiction and Other Psychiatric Disorders. https://www.frontiersin.org/articles/10.3389/fnbeh.2022.952551.
2019- present: Frontiers in Psychiatry, Section Schizophrenia

BIBLIOMETRIC INDICATORS
22 peer reviewed papers; Total citations 717; H-index 14 (Scopus)

SCIENTIFIC PUBLICATIONS

1. Mastrogiacomo R, Trigilio G, Devroye C, Dautan D, Ferretti V, Losi G, Caffino L, Orso G, Marotta R, Maltese F, Vitali E, Piras G, Forgiarini A, Pacinelli G, Lia, A, Rothmond D, Waddington J, Drago F, Fumagalli F, Papaleo F. (2022). Dysbindin-1A modulation of astrocytic dopamine and basal ganglia dependent behaviors relevant to schizophrenia. Molecular Psychiatry 1-17.doi: 10.1038/s41380-022-01683-8.
2. De Stefano ME, Ferretti V, Mozzetta C (2022) Synaptic alterations as a neurodevelopmental trait of Duchenne muscular dystrophy. Neurobiology of Disease 168, 105718

3. Basilico B, Ferrucci L, Ratano P, Golia MT, Grimaldi A, Rosito M, Ferretti V, Reverte I, Sanchini C, Marrone, MC, Giubettini M, De Turris V, Salerno D, Garofalo S, St-Pierre MK, Carrier M, Renzi M, Pagani F, Modi B, Raspa M, Scavizzi F, Gross C T, Marinelli S, Tremblay ME, Caprioli D, Maggi L, Limatola C, Di Angelantonio S, Ragozzino D. (2021) Microglia control glutamatergic synapses in the adult mouse hippocampus GLIA 70(1):173-195 doi: https://doi.org/10.1002/glia.24101

4. Scheggia D*, Managò F*, Maltese F, Bruni S, Nigro M, Dautan D, Latuske P, Contarini G, Gomez-Gonzalo M, Requie LM, Ferretti V, Castellani G, Mauro D, Bonavia A, Carmignoto G, Yizhar O & Papaleo F (2020). Somatostatin interneurons in the prefrontal cortex control affective state discrimination in mice. Nature Neuroscience 23, 47 60, doi:10.1038/s41593-019-0551-8

5. Leggio GM, Torrisi SA, Mastrogiacomo R, Mauro D, Chisari M, Devroye C, Scheggia D, Nigro M, Geraci F, Pintori N, Giurdanella G, Costa L, Bucolo C, Ferretti V, Sortino MA, Ciranna L, De Luca MA, Mereu M, Managò F, Salomone S, Drago F & Papaleo F (2019). The epistatic interaction between the dopamine D3 receptor and dysbindin-1 modulates higher-order cognitive functions in mice and humans. Molecular Psychiatry doi: 10.1038/s41380-019-0511-4

6. Castellani G, Contarini G, Mereu M, Albanesi E, Devroye C, D'Amore C, Ferretti V, De Martin S, Papaleo F. (2019) Dopamine-mediated immunomodulation affects choroid plexus function. Brain Behaviour and Immununity 81:138-150, doi:10.1016/j.bbi.2019.06.006

7. Contarini, G., Ferretti, V., & Papaleo, F. (2019). Acute administration of Urb597 fatty acid amide hydrolase inhibitor prevents attentional impairments by distractors in adolescent mice. Frontiers in Pharmacology 10, doi:10.3389/fphar.2019.00787

8. Ferretti V*, Maltese F*, Contarini G, Nigro M, Bonavia A, Huang H, Gigliucci V, Morelli G, Scheggia D, Managò F, Castellani G, Lefevre, Cancedda L, Chini B, Grinevich V, Papaleo F. (2019). Oxytocin signaling in the central amygdala modulates mice emotion discrimination. Current Biology 29(12): 1938-1953, doi:10.1016/j.cub.2019.04.070

9. Ferretti V°, Papaleo F°. (2019) Understanding others: emotion recognition abilities in humans and other animals. Genes Brain and Behavior, 18(1) e12544, doi:10.1111/gbb.12544 °co-corresponding author

10. Scheggia D, Zamberletti E, Realini N, Mereu M, Contarini G, Ferretti V, Managò F, Margiani G, Brunoro R, Rubino T, De Luca MA, Piomelli D, Parolaro D, Papaleo F. (2018). Remote memories are enhanced by COMT activity through dysregulation of the endocannabinoid system in the prefrontal cortex. Molecular Psychiatry 23(4): 1040-1050, doi: 10.1038/mp.2017.126

11. Capitano F, Camon J, Licursi V, Ferretti V, Maggi L, Scianni M, Del Vecchio G, Rinaldi A, Mannironi C, Limatola C, Presutti C, Mele A. (2017). MicroRNA-335-5p modulates spatial memory and hippocampal synaptic plasticity. Neurobiology of Learning and Memory 139:63-68, doi:10.1016/j.nlm.2016.12.019

12. Katsageorgiou VM, Zanotto M, Huang H, Ferretti V, F Papaleo, Sona D, Murino V. (2016). Unsupervised mouse behavior analysis: A data-driven study of mice interaction. Proceedings - International Conference on Pattern Recognition 0,925-930, 7899754, doi: 10.1109/ICPR.2016.7899754

13. Capitano F*, Camon J*, Ferretti V*, Licursi V, De Vito F, Rinaldi A, Vincenti S, Mannironi C, Fragapane P, Bozzoni I, Oliverio A, Negri R, Presutti C, Mele A. (2016). MicroRNAs modulate spatial memory in the hippocampus and in the ventral striatum in a region-specific manner. Molecular Neurobiology 53(7): 4618-30, doi:10.1007/s12035-015-9398-5 *co-first author

14. Song S, Grillo FW, Xi J, Ferretti V, Gao G, De Paola V. (2016) EPBscore: a novel method for computer-assisted analysis of axonal structure and dynamics. Neuroinformatics 14(1):121-7, doi:10.1007/s12021-015-9274-5

15. Zhang Z*, Ferretti V*, Güntan , Moro A, Steinberg EA, Ye Z, Zecharia AY, Yu X, Vyssotski AL, Brickley SG, Yustos R, Pillidge ZE, Harding EC, Wisden W, Franks NP. (2015). Neuronal ensembles sufficient for recovery sleep and the sedative actions of 2 adrenergic agonists. Nature Neuroscience 18(4):553-61, doi: 10.1038/nn.3957 *co-first author

16. Gelegen C, Gent TC, Ferretti V, Zhang Z, Yustos R, Lan F, Yang Q, Overington DW, Vyssotski AL, van Lith HA, Wisden W, Franks NP. (2014) Staying awake a genetic region that hinders a2 adrenergic receptor agonist-induced sleep. European Journal of Neuroscience 40(1): 2311-9, doi: 10.1111/ejn.12570

17. Ferretti V*, Perri V*, Cristofoli A, Vetere G, Fragapane P, Oliverio A, Ammassari Teule M, Mele A. (2015). Phosphorylation of S845 GluA1 AMPA receptors modulates spatial memory and structural plasticity in the ventral striatum. Brain Structure and Function 220(5): 2653-61, doi: 10.1007/s00429-014-0816-7

18. Grillo FW, Song S, Teles-Grilo Ruivo LM, Huang L, Gao G, Knott GW, Maco B, Ferretti V, Thompson D, Little GE, De Paola V. (2013) Increased axonal bouton dynamics in the aging mouse cortex. PNAS 110(16):E1514-23, doi: 10.1073/pnas.1218731110

19. Ferretti V, Roullet P., Sargolini F, Rinaldi A, Perri V, Del Fabbro M, Costantini VJA, Annese V, Scesa G, De Stefano ME, Oliverio A, Mele A. (2010). Ventral striatal plasticity and spatial memory. PNAS 107 (17):7945-50, doi:10.1073/pnas.0911757107

20. Ferretti V, Sargolini F, Oliverio A, Mele A and Roullet P (2007). Effects of intra-accumbens NMDA and AMPA receptor antagonists on short-term spatial learning in the Morris water maze task. Behavioral Brain Research 179 (1): 43-9, doi: 10.1016/j.bbr.2007.01.009

21. Ferretti V, Florian C, Costantini VJA, Roullet P, Rinaldi A, De Leonibus E, Oliverio A, Mele A. (2005). Co-activation of glutamate and dopamine receptors within the nucleus accumbens is required for spatial memory consolidation in mice. Psychopharmacology 179: 108-116, doi: 10.1007/s00213-005-2144-3

22. De Leonibus E, Costantini VJA, Castellano C, Ferretti V, Oliverio A, Mele A. (2003) Distinct roles of the different ionotropic glutamate receptors within the nucleus accumbens in passive-avoidance learning and memory in mice European Journal of Neuroscience 18(8): 2365-73, doi: 10.1046/j.1460-9568.2003.02939.x