Ritratto di alessio.paone@uniroma1.it
Insegnamento Codice Anno Corso - Frequentare Bacheca
CHIMICA E PROPEDEUTICA BIOCHIMICA 1025530 2022/2023
BIOCHEMISTRY 10604486 2022/2023
BASI FISICHE E CHIMICHE 1035041 2022/2023
BIOCHEMISTRY 1038227 2022/2023
CELLULAR BIOCHEMISTRY 10598562 2022/2023
CELLULAR BIOCHEMISTRY 10598562 2021/2022
CHIMICA E PROPEDEUTICA BIOCHIMICA 1025530 2021/2022
BASI FISICHE E CHIMICHE 1035041 2021/2022
CHIMICA E PROPEDEUTICA BIOCHIMICA 1025530 2020/2021
CHIMICA E PROPEDEUTICA BIOCHIMICA 1025530 2019/2020
CHIMICA E PROPEDEUTICA BIOCHIMICA 1025530 2018/2019
CHIMICA E PROPEDEUTICA BIOCHIMICA 1025530 2017/2018

Su appuntamento. Prenotabile via e-mail

Alessio Paone
Curriculum Vitae

Part I General Information

Full Name Alessio Paone
Date of Birth
Place of Birth
Citizenship Italian
Permanent Address
Mobile Phone Number
E-mail
Spoken Languages Italian/English

Part II Education

Type Year Institution Notes (Degree, Experience, )
University graduation 2005 Roma3 University of Rome Laurea cum laude in Biology Molecular biology
PhD 2010 La Sapienza University of Rome Dept of Histology and Medical Embryology Scienze e Tecnologie Cellulari (Cell Biology)
Pre-doctorate training 2005-2006 La Sapienza University of Rome Dept of Histology and Medical Embryology Cell Biology/Biochemistry

Part III Appointments

IIIA Academic Appointments

Start End Institution Position
03/08/2020 today La Sapienza University of Rome Dept of Biochemical Sciences A. Rossi Fanelli Research associate Ricercatore a tempo determinato full-time (art. 24 c.3-a L. 240/10) RTDB.
01/10/2017 03/08/2020 La Sapienza University of Rome Dept of Biochemical Sciences A. Rossi Fanelli Research associate Ricercatore a tempo determinato full-time (art. 24 c.3-a L. 240/10) RTDA.
01/04/2013 30/09/2017 La Sapienza University of Rome Dept of Biochemical Sciences A. Rossi Fanelli Postdoctoral Researcher (assegnista di ricerca vincitore di concorso Legge 240/2010)
15/02/2010 15/03/2013 The Ohio State University, Columbus OH, USA Dept. of Molecular Virology, Immunology & Medical Genetics Postdoctoral Researcher

IIIB Other Appointments and Qualifications

31/03/2016 31/03/2026 National Scientific Qualification (ASN) 05/E1 BIO10 Associate professor

Part IV Teaching experience

Year Institution Course
2017-today La Sapienza University of Rome Chemistry and propaedeutic biochemistry Degree course in Medicine and Surgery (2CFU) and member of the examination committee.
2017-2021 La Sapienza University of Rome One Day Lab Safety short course for the Ph.D. School in Biochemistry (1CFU)

Teaching Assistant (TA) and Tutoring (T)
2015-today La Sapienza University of Rome Bioinformatics and Protein Engineering - Degree Courses in Medical Biotechnologies and Pharmaceutical Biotechnologies (TA)
2015-today La Sapienza University of Rome Molecular Biology - Biotechnology Degree Course (TA)
2014-today La Sapienza University of Rome Supervisor of students on thesis and Ph.D. Students (Pontecorvi V., Sun D., Garcia I., Bouzidi A. etc) T
2012-2013 The Ohio State University Rotating scholar supervisor (Sharpnack M.)T
2012-2013 The Ohio State University Supervisor of students on thesis (Riaz S.)T

Part V - Society memberberships, Awards and Honors

Year Title
2019 Italian Society of Biochemistry and Molecular Biology (SIB)
2019 CONFERENCE-Molecular, cellular and translational approaches to differentiation and neoplastic transformation 17th June 2019 Florence. Exploiting serine hydroxymethyltransferase moonlighting function: novel perspectives to target serine metabolism in cancer cells BEST POSTER PRICE

Part VI - Funding Information [grants as PI-principal investigator or I-investigator]

Year Title Program Grant value
2013 Inhibition of serinehydroxymethyltransferase and epigenetic reprogramming in lung cancer cell lines PI Avvio alla ricerca 3000
2013-2015 Probing the metabolic reprogramming of tumor cells by inhibition of Serine Hydroxymethyltransferase I AIRC IG 13150 (2013-2015) 179000
2016-2018 Serine/glycine one-carbon metabolism and cancer: biological role and inhibition of Serine Hydroxymethyltransferase I AIRC IG 16720 (2016-2018)

187000
2017 Infection, inflammation and metabolism: the missing link in prostate cancer I Ateneo Sapienza
RG11816430AF48E1
3000
2018 Dissecting Serine Hydroxymethyltransferase functions to target cancer metabolic reprogramming I Ateneo Sapienza
RP11715C644A5CCE 30000

Part VII Editorial experience
Role journal
Review editor Frontiers Molecular Biosciences
Review editor Frontiers in Genetics
Guest Editor International Journal of Cell Biology (v.2014 ISSN 1687-8876)
Reviewer Oncotarget
Reviewer Frontiers in Genetics
Reviewer Oncoimmunology
Reviewer Journal of Nucleic Acid Investigation
Reviewer Frontiers in Oncology
Reviewer Cellular Physiology and Biochemistry
Reviewer Cancers

Part VIII- Other experience - participation in selection committees

Member of the selection committee for the awarding of a category B research fellowship Type II call N. A / 6/2017 of 28.12.2017 Department of Biochemical Sciences A. Rossi Fanelli Sapienza University of Rome.

Part IX Principal Research Activities

Keywords Brief Description
RNA/protein interaction From the beginning, Alessio Paone's research activity has been focused on the study of the function of proteins involved in tumor processes and their role in cellular metabolic re-programming, with an approach that ranges from the biochemistry of macromolecules and their interactors, to molecular and cellular biology. Currently, he is also directly involved in managing the experimental set up of the HypACB facility at the Department of Biochemical Sciences in Sapienza, whose service is to gain quantitative respiratory/energetic parameters of cellular in normoxia and under hypoxic conditions.
More in detail, his research work spna from two main topics:
1) Mechanism of re-shaping of One carbon Metabolism in cancer.
In the last six years, his work has been focused on proteins involved in cellular serine/glycine-one-carbon-SGOC metabolism as important factor in tumor transformation; his study is mainly (but not only) focused on lung cancer. He is involved in the characterization of the mechanism behind the SGOC metabolic re-programming, in order to identify the metabolic status (and vulnerability) of lung cancer cells required to sustain proliferation. In particular, the role of the enzyme serine hydroxylmethyltransferase (SHMT), which strongly supports the production of key molecules for tumor proliferation such as DNA bases or methyl group donors, has been analyzing by integrating protein biochemistry and engineering with cell biology.
Main achievement of his research:
- Explaining specific role of the cytosolic SHMT in supporting the thymine incorporation during DNA replication in lung cancer cells.
- Characterizing novel role of SHMT as moonlight enzyme. He contributed in showing that SHMTs are able to interact with high affinity with RNA; these interactions is required to control both the expression of the different isoforms of the enzyme and catalysis.
- Identification of novel strategies to target SHMT. Beyond the physiological relevance of the RNA/SHMT interactions, this feature allowed the design of novel tool to inhibit the enzymatic activity of SHMTs. A draft of a patent is currently under evaluation of the Academic committee.
- Connection between the inflammatory mechanisms regulated by the TLRs and the metabolic alterations in the tumor cells.
2) "Toll Like Receptors" (TLR) in cancer cells.
During the first post-DOC period, the research focus has been on a group of proteins called "Toll Like Receptors" (TLR) and their role in cancer cells. TLRs are receptors of innate immunity and represent the first line of defense against pathogen invasion. He contributed in unveiling the mechanism of TLR activation and of the associated signal transduction process upon interaction of these proteins with specific ligands in tumor cells.
Main achievement of his research:
- it has been shown that the activation of these receptors can induce diametrically opposed effects on tumor cells from different tissues causing in some cases apoptosis, in others proliferation, angiogenesis etc.
- identification of novel endogenous ligands for TLR7 / 8 with pro-tumor functions. In a work published in PNAS in 2012 a new family of ligands for hTLR8 and mTLR7 receptors was discovered, including several mature microRNAs, secreted by tumor cells. These molecules were able to activate these receptors expressed on the cells of the immune system inducing a rewiring in the secretoma which in turn support the growth of metastases in the lung.
The results reported were also obtained thanks to the skills acquired by Alessio Paone specifically in the study of:
- protein-protein and protein-RNA interactions;
- signal transduction;
- processes of cell death;
- regulatory metabolic mechanisms.
By taking advantage of his technical expertise in:
-protein biochemistry and engineering: expression and purification of proteins.
-cell biology: cell culture, Western Blotting, RT-PCR, iRNA, fluorescence microscopy, respiratory assays through Seahorse apparatus.
-in vivo: mouse handling, intraperitoneal injections, xenograft tumor inoculation, in vivo angiogenetic assays.
-data handling: standard statistics, seahorse data analysis.

One Carbon Metabolism
Serine hydroxylmethyltransferase
Cancer cells

Part X -Patents
WO Patent WO/2011/128,436 Combination of Hypoxia Inducible Factor -1 inhibitors and Toll-Like Receptor-3 agonists for treating solid tumors
A Filippini, A Riccioli, A Paone, E Ziparo

Part XI Summary of Scientific Achievements

Product type Number Data Base Start End
Papers [international] 33 SCOPUS 2006 2020

Total Impact factor 164 (JCR)
Average Impact factor 5,164
Total Citations 2190 (scopus)
Average Citations per Product 66 (scopus)
Hirsch (H) index 17 (scopus)
Normalized H index* 1,21
Last 10 years Impact factor 150

*H index divided by the academic seniority.

Part XII SELECTED Publications

List of the 12 publications selected for the evaluation (last 10 years).

Notes Reference IF citations
LAST AUTHOR 1)Linking Infection and Prostate Cancer Progression: Toll-like Receptor3 Stimulation Rewires Glucose Metabolism in Prostate Cells.
Magnifico MC, Macone A, Marani M, Bouzidi A, Giardina G, Rinaldo S, Cutruzzolà F, Paone A.
Anticancer Res. 2019 Oct;39(10):5541-5549. doi: 10.21873/anticanres.13747. 1,935 0
In this publication the candidate Alessio Paone should be considered FIRST AUTHOR as the first and second authors (*) contributed equally to the work as reported in the specific journal page. 2) The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism.
Guiducci G*, Paone A*, Tramonti A, Giardina G, Rinaldo S, Bouzidi A, Magnifico MC, Marani M, Menendez JA, Fatica A, Macone A, Armaos A, Tartaglia GG, Contestabile R, Paiardini A, Cutruzzolà F.
Nucleic Acids Res. 2019 Feb 27. pii: gkz129. doi: 10.1093/nar/gkz129. [Epub ahead of print]
11,147 0
In this publication the candidate Alessio Paone should be considered FIRST AUTHOR as the first and second authors (*) contributed equally to the work as reported in the specific journal page. 3) The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells.
Giardina G*, Paone A*, Tramonti A, Lucchi R, Marani M, Magnifico MC, Bouzidi A, Pontecorvi V, Guiducci G, Zamparelli C, Rinaldo S, Paiardini A, Contestabile R, Cutruzzolà F.
FEBS J. 2018 Sep;285(17):3238-3253. doi: 10.1111/febs.14610. Epub 2018 Aug 7. 4,739 2
LAST AND CORRESPONDING AUTHOR 4) Glucose Metabolism in the Progression of Prostate Cancer.
Cutruzzolà F, Giardina G, Marani M, Macone A, Paiardini A, Rinaldo S, Paone A.
Front Physiol. 2017 Feb 21;8:97. doi: 10.3389/fphys.2017.00097. eCollection 2017. Review.PMID: 28270771 3,394 19
In this publication the candidate Alessio Paone should be considered FIRST AUTHOR as the first and second authors (*) contributed equally to the work as reported in the specific journal page. 5) A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells.
Marani M*, Paone A*, Fiascarelli A, Macone A, Gargano M, Rinaldo S, Giardina G, Pontecorvi V, Koes D, McDermott L, Yang T, Paiardini A, Contestabile R, Cutruzzolà F.
Oncotarget. 2016 Jan 26;7(4):4570-83. doi: 10.18632/oncotarget.6726.
5,168 14
6) MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer.
Valeri N, Braconi C, Gasparini P, Murgia C, Lampis A, Paulus-Hock V, Hart JR, Ueno L, Grivennikov SI, Lovat F, Paone A, Cascione L, Sumani KM, Veronese A, Fabbri M, Carasi S, Alder H, Lanza G, Gafa' R, Moyer MP, Ridgway RA, Cordero J, Nuovo GJ, Frankel WL, Rugge M, Fassan M, Groden J, Vogt PK, Karin M, Sansom OJ, Croce CM.
Cancer Cell. 2014 Apr 14;25(4):469-83. doi: 10.1016/j.ccr.2014.03.006.
23,523 173
FIRST AUTHOR 7) SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation.
Paone A, Marani M, Fiascarelli A, Rinaldo S, Giardina G, Contestabile R, Paiardini A, Cutruzzolà F.
Cell Death Dis. 2014 Nov 20;5:e1525. doi: 10.1038/cddis.2014.482. 5,014 30
In this publication the candidate Alessio Paone should be considered FIRST AUTHOR as the first and second authors (*) contributed equally to the work as reported in the specific journal page. 8) Toll-like receptor 3 (TLR3) activation induces microRNA-dependent reexpression of functional RAR and tumor regression.
Galli R*, Paone A*, Fabbri M, Zanesi N, Calore F, Cascione L, Acunzo M, Stoppacciaro A, Tubaro A, Lovat F, Gasparini P, Fadda P, Alder H, Volinia S, Filippini A, Ziparo E, Riccioli A, Croce CM.
Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9812-7. doi: 10.1073/pnas.1304610110. Epub 2013 May 28.

9,809 38
9) miR-EdiTar: A database of predicted A-to-I edited miRNA target sites
Laganà A., Paone A.,Veneziano D., Cascione L.,
Gasparini P., Carasi S., Russo F., Nigita G., Valentina Macca, Giugno R., Pulvirenti A., Shasha D., Ferro A. and Croce C.M.1
Bioinformatics. 2012 Oct 7 [Epub ahead of print] PMID:23044546 5,323 19
In this publication the candidate Alessio Paone should be considered FIRST AUTHOR as the first and second authors (*) contributed equally to the work as reported in the specific journal page. 10) MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response.
Fabbri M*, Paone A*, Calore F, Galli R, Gaudio E, Santhanam R, Lovat F, Fadda P, Mao C, Nuovo GJ, Zanesi N, Crawford M, Ozer GH, Wernicke D, Alder H, Caligiuri MA, Nana-Sinkam P, Perrotti D, Croce CM.
Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):E2110-6. Epub 2012 Jul 2.

Press release/comments in
Cancer Malicious exosomes Anastasiadou E, Slack FJ.
Science. 2014 Dec 19;346(6216):1459-60. doi: 10.1126/science.aaa4024. No abstract available. 9,737 715
11) MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2).
Valeri N, Gasparini P, Braconi C, Paone A, Lovat F, Fabbri M, Sumani KM, Alder H, Amadori D, Patel T, Nuovo GJ, Fishel R, Croce CM.
Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21098-103. Epub 2010 Nov 15. 9,771 248
FIRST AUTHOR 12) Toll-like receptor 3 regulates angiogenesis and apoptosis in prostate cancer cell lines through hypoxia-inducible factor 1 alpha.
Paone A, Galli R, Gabellini C, Lukashev D, Starace D, Gorlach A, De Cesaris P, Ziparo E, Del Bufalo D, Sitkovsky MV, Filippini A, Riccioli A.
Neoplasia. 2010 Jul;12(7):539-49 5,476 60

Part XIII- COMPLETE list of publications

Notes Publication IF Citations
LAST AUTHOR 1)Linking Infection and Prostate Cancer Progression: Toll-like Receptor3 Stimulation Rewires Glucose Metabolism in Prostate Cells.
Magnifico MC, Macone A, Marani M, Bouzidi A, Giardina G, Rinaldo S, Cutruzzolà F, Paone A.
Anticancer Res. 2019 Oct;39(10):5541-5549. doi: 10.21873/anticanres.13747.
1,935 3
2)Fractalkine Modulates Microglia Metabolism in Brain Ischemia
Clotilde Lauro, Giuseppina Chece, Lucia Monaco, Fabrizio Antonangeli, Giovanna Peruzzi, Serena Rinaldo, Alessio Paone, Francesca Cutruzzolà and Cristina Limatola
Front. Cell. Neurosci., 13 September 2019 | https://doi.org/10.3389/fncel.2019.00414 3,900 7
In this publication the candidate Alessio Paone should be considered FIRST AUTHOR as the first and second authors (*) contributed equally to the work as reported in the specific journal page. 3) The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism.
Guiducci G*, Paone A*, Tramonti A, Giardina G, Rinaldo S, Bouzidi A, Magnifico MC, Marani M, Menendez JA, Fatica A, Macone A, Armaos A, Tartaglia GG, Contestabile R, Paiardini A, Cutruzzolà F.
Nucleic Acids Res. 2019 Feb 27. pii: gkz129. doi: 10.1093/nar/gkz129. [Epub ahead of print] 11,147 3
4) Insights into the GTP-dependent allosteric control of c-di-GMP hydrolysis from the crystal structure of PA0575 protein from Pseudomonas aeruginosa.
Mantoni F, Paiardini A, Brunotti P, D'Angelo C, Cervoni L, Paone A, Cappellacci L, Petrelli R, Ricciutelli M, Leoni L, Rampioni G, Arcovito A, Rinaldo S, Cutruzzolà F, Giardina G.
FEBS J. 2018 Oct;285(20):3815-3834. doi: 10.1111/febs.14634. Epub 2018 Sep 7.
4,739 1
5) A novel bacterial l-arginine sensor controlling c-di-GMP levels in Pseudomonas aeruginosa.
Paiardini A, Mantoni F, Giardina G, Paone A, Janson G, Leoni L, Rampioni G, Cutruzzolà F, Rinaldo S.
Proteins. 2018 Oct;86(10):1088-1096. doi: 10.1002/prot.25587. Epub 2018 Sep 8. 2,501 2
In this publication the candidate Alessio Paone should be considered FIRST AUTHOR as the first and second authors (*) contributed equally to the work as reported in the specific journal page. 6) The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells.
Giardina G*, Paone A*, Tramonti A, Lucchi R, Marani M, Magnifico MC, Bouzidi A, Pontecorvi V, Guiducci G, Zamparelli C, Rinaldo S, Paiardini A, Contestabile R, Cutruzzolà F.
FEBS J. 2018 Sep;285(17):3238-3253. doi: 10.1111/febs.14610. Epub 2018 Aug 7. 4,739 2
7) Differential inhibitory effect of a pyrazolopyran compound on human serine hydroxymethyltransferase-amino acid complexes.
Tramonti A, Paiardini A, Paone A, Bouzidi A, Giardina G, Guiducci G, Magnifico MC, Rinaldo S, McDermott L, Menendez JA, Contestabile R, Cutruzzolà F.
Arch Biochem Biophys. 2018 Sep 1;653:71-79. doi: 10.1016/j.abb.2018.07.001. Epub 2018 Jul 4.

3,559 4
8) Beyond nitrogen metabolism: nitric oxide, cyclic-di-GMP and bacterial biofilms.
Rinaldo S, Giardina G, Mantoni F, Paone A, Cutruzzolà F.
FEMS Microbiol Lett. 2018 Mar 1;365(6). doi: 10.1093/femsle/fny029. 1,994 4
9) Discovering Selective Diguanylate Cyclase Inhibitors: From PleD to Discrimination of the Active Site of Cyclic-di-GMP Phosphodiesterases.
Rinaldo S, Giardina G, Mantoni F, Paiardini A, Paone A, Cutruzzolà F.
Methods Mol Biol. 2017;1657:431-453. doi: 10.1007/978-1-4939-7240-1_32. 1
LAST AND CORRESPONDING AUTHOR 10) Glucose Metabolism in the Progression of Prostate Cancer.
Cutruzzolà F, Giardina G, Marani M, Macone A, Paiardini A, Rinaldo S, Paone A.
Front Physiol. 2017 Feb 21;8:97. doi: 10.3389/fphys.2017.00097. eCollection 2017. Review.PMID: 28270771 3,394 19
In this publication the candidate Alessio Paone should be considered FIRST AUTHOR as the first and second authors (*) contributed equally to the work as reported in the specific journal page. 11) A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells.
Marani M*, Paone A*, Fiascarelli A, Macone A, Gargano M, Rinaldo S, Giardina G, Pontecorvi V, Koes D, McDermott L, Yang T, Paiardini A, Contestabile R, Cutruzzolà F.
Oncotarget. 2016 Jan 26;7(4):4570-83. doi: 10.18632/oncotarget.6726. 5,168 14
12) How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state.
Giardina G, Brunotti P, Fiascarelli A, Cicalini A, Costa MG, Buckle AM, di Salvo ML, Giorgi A, Marani M, Paone A, Rinaldo S, Paiardini A, Contestabile R, Cutruzzolà F.
FEBS J. 2015 Apr;282(7):1225-41. doi: 10.1111/febs.13211. Epub 2015 Feb 13.

4,237 30
13) Screening and in vitro testing of antifolate inhibitors of human cytosolic serine hydroxymethyltransferase.
Paiardini A, Fiascarelli A, Rinaldo S, Daidone F, Giardina G, Koes DR, Parroni A, Montini G, Marani M, Paone A, McDermott LA, Contestabile R, Cutruzzolà F.
ChemMedChem. 2015 Mar;10(3):490-7. doi: 10.1002/cmdc.201500028. Epub 2015 Feb 10. 2,980 14
14) MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer.
Valeri N, Braconi C, Gasparini P, Murgia C, Lampis A, Paulus-Hock V, Hart JR, Ueno L, Grivennikov SI, Lovat F, Paone A, Cascione L, Sumani KM, Veronese A, Fabbri M, Carasi S, Alder H, Lanza G, Gafa' R, Moyer MP, Ridgway RA, Cordero J, Nuovo GJ, Frankel WL, Rugge M, Fassan M, Groden J, Vogt PK, Karin M, Sansom OJ, Croce CM.
Cancer Cell. 2014 Apr 14;25(4):469-83. doi: 10.1016/j.ccr.2014.03.006. 23,523 173
FIRST AUTHOR 15) SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation.
Paone A, Marani M, Fiascarelli A, Rinaldo S, Giardina G, Contestabile R, Paiardini A, Cutruzzolà F.
Cell Death Dis. 2014 Nov 20;5:e1525. doi: 10.1038/cddis.2014.482. 5,014 30
16) Cell death.
Giampietri C, Paone A, D'Alessio A.
Int J Cell Biol. 2014;2014:864062. doi: 10.1155/2014/864062. Epub 2014 May 11 3
17) An analysis of genetic factors related to risk of inflammatory bowel disease and colon cancer.
Ryan BM, Wolff RK, Valeri N, Khan M, Robinson D, Paone A, Bowman ED, Lundgreen A, Caan B, Potter J, Brown D, Croce C, Slattery ML, Harris CC.
Cancer Epidemiol. 2014 Oct;38(5):583-90. doi: 10.1016/j.canep.2014.07.003. Epub 2014 Aug 15. 2,711 16
In this publication the candidate Alessio Paone should be considered FIRST AUTHOR as the first and second authors (*) contributed equally to the work as reported in the specific journal page. 18) Toll-like receptor 3 (TLR3) activation induces microRNA-dependent reexpression of functional RAR and tumor regression.
Galli R*, Paone A*, Fabbri M, Zanesi N, Calore F, Cascione L, Acunzo M, Stoppacciaro A, Tubaro A, Lovat F, Gasparini P, Fadda P, Alder H, Volinia S, Filippini A, Ziparo E, Riccioli A, Croce CM.
Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9812-7. doi: 10.1073/pnas.1304610110. Epub 2013 May 28. 9,809 38
19) A new role for microRNAs, as ligands of Toll-like receptors
Muller Fabbri, Alessio Paone, Federica Calore, Roberta Galli and Carlo M. Croce
RNA Biology Volume 10, Issue 2 2013 Feb
5,377 68
20) miR-EdiTar: A database of predicted A-to-I edited miRNA target sites
Alessandro Laganà, Alessio Paone, Dario Veneziano, Luciano Cascione,
Pierluigi Gasparini, Stefania Carasi, Francesco Russo, Giovanni Nigita, Valentina Macca, Rosalba Giugno, Alfredo Pulvirenti, Dennis Shasha, Alfredo Ferro and Carlo M. Croce1
Bioinformatics. 2012 Oct 7 [Epub ahead of print] PMID:23044546 5,323 19
In this publication the candidate Alessio Paone should be considered FIRST AUTHOR as the first and second authors (*) contributed equally to the work as reported in the specific journal page. 21) MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response.
Fabbri M, Paone A, Calore F, Galli R, Gaudio E, Santhanam R, Lovat F, Fadda P, Mao C, Nuovo GJ, Zanesi N, Crawford M, Ozer GH, Wernicke D, Alder H, Caligiuri MA, Nana-Sinkam P, Perrotti D, Croce CM.
Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):E2110-6. Epub 2012 Jul 2.

Press release
Cancer. Malicious exosomes.Anastasiadou E, Slack FJ.
Science. 2014 Dec 19;346(6216):1459-60. doi: 10.1126/science.aaa4024. No abstract available. 9,737 715
22) rs4919510 in hsa-mir-608 Is Associated with Outcome but Not Risk of Colorectal Cancer.
Ryan BM, McClary AC, Valeri N, Robinson D, Paone A, Bowman ED, Robles AI, Croce C, Harris CC.
PLoS One. 2012;7(5):e36306. Epub 2012 May 11. 3,730 51
FIRST AUTHOR 23) MicroRNAs as New Characters in the Plot between Epigenetics and Prostate Cancer.
Paone A, Galli R, Fabbri M.
Front Genet. 2011;2:62. Epub 2011 Sep 6.PMID: 22303357 14
24) MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2).
Valeri N, Gasparini P, Braconi C, Paone A, Lovat F, Fabbri M, Sumani KM, Alder H, Amadori D, Patel T, Nuovo GJ, Fishel R, Croce CM.
Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21098-103. Epub 2010 Nov 15. 9,771 248
25) TLR stimulation of prostate tumor cells induces chemokine-mediated recruitment of specific immune cell types.
Galli R, Starace D, Busà R, Angelini DF, Paone A, De Cesaris P, Filippini A, Sette C, Battistini L, Ziparo E,
Riccioli A.
J Immunol. 2010 Jun 15;184(12):6658-69. Epub 2010 May 17
5,745 44
FIRST AUTHOR 26) Toll-like receptor 3 regulates angiogenesis and apoptosis in prostate cancer cell lines through hypoxia-inducible factor 1 alpha.
Paone A, Galli R, Gabellini C, Lukashev D, Starace D, Gorlach A, De Cesaris P, Ziparo E, Del Bufalo D, Sitkovsky MV, Filippini A, Riccioli A.
Neoplasia. 2010 Jul;12(7):539-49 5,476 60
27) Toll-like receptor 3 activation induces antiviral immune responses in mouse sertoli cells.
Starace D, Galli R, Paone A, De Cesaris P, Filippini A, Ziparo E, Riccioli A.
Biol Reprod. 2008 Oct;79(4):766-75. Epub 2008 Jul 2. 3,469 58
FIRST AUTHOR 28) Toll-like receptor 3 triggers apoptosis of human prostate cancer cells through a PKC-alpha-dependent mechanism.
Paone A, Starace D, Galli R, Padula F, De Cesaris P, Filippini A, Ziparo E, Riccioli A.
Carcinogenesis. 2008 Jul;29(7):1334-42. Epub 2008 Jun 19. 4,930 113
29) c-Flip(L) is expressed in undifferentiated mouse male germ cells.
Giampietri C, Petrungaro S, Coluccia P, Antonangeli F, Paone A, Padula F, De Cesaris P, Ziparo E, Filippini A.
FEBS Lett. 2006 Nov 13;580(26):6109-14. Epub 2006 Oct 16. 3,372 8
30) c-Flip expression and function in fetal mouse gonocytes.
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