Ritratto di cecilia.battistelli@uniroma1.it
Insegnamento Codice Anno Corso - Frequentare Bacheca
BIOLOGY AND GENETICS 1037599 2023/2024
BASI CELLULARI E MOLECOLARI DELLA VITA 1035043 2023/2024
BASI MOLECOLARI E CELLULARI DELLA VITA 1034944 2023/2024
BIOLOGY AND GENETICS 1037599 2023/2024
BIOLOGY AND GENETICS 1037599 2022/2023
BASI MOLECOLARI E CELLULARI DELLA VITA 1034944 2022/2023
BASI CELLULARI E MOLECOLARI DELLA VITA 1035043 2022/2023
BIOLOGY AND GENETICS 1037599 2022/2023
BASI MOLECOLARI E CELLULARI DELLA VITA 1034944 2021/2022
BASI CELLULARI E MOLECOLARI DELLA VITA 1035043 2021/2022
BASI MOLECOLARI E CELLULARI DELLA VITA 1034944 2020/2021
BASI CELLULARI E MOLECOLARI DELLA VITA 1035043 2020/2021
SCIENZE BIOMEDICHE I 1056296 2020/2021
SCIENZE BIOMEDICHE I 1056296 2019/2020
BASI CELLULARI E MOLECOLARI DELLA VITA 1035043 2019/2020
BASI MOLECOLARI E CELLULARI DELLA VITA 1034944 2019/2020
SCIENZE BIOMEDICHE I 1056296 2018/2019
BASI CELLULARI E MOLECOLARI DELLA VITA 1035043 2018/2019
BIOLOGIA E GENETICA 1026264 2018/2019

Tutti i giorni dalle 10 alle 19 previo appuntamento

CECILIA BATTISTELLI
Curriculum Vitae
Place: Roma
Date: 20/04/2023

Part I General Information
Full Name
Cecilia Battistelli
Date of Birth
27/04/1981
Place of Birth
Narni (TR)
Citizenship
Italian
E-mail
cecilia.battistelli@uniroma1.it
Spoken Languages
Italian (mother tongue), English, French

Part II Education Type Year Institution Notes (Degree, Experience, )
University graduation
2008
Sapienza University of Rome
Biology (LS: Genetics and Molecular Biology), full marks and honors
Italian Biological Licensure (ESAME DI STATO)
2011
Sapienza University of Rome
PhD
2012
Sapienza University of Rome
PhD in Human Biology and Genetics

Part III Appointments

IIIA Academic Appointments
Start End Institution Position
15/07/2021
14/07/2024
Sapienza University of Rome
Ricercatore a tempo determinato (RTD) tipo B BIO13
01/05/2018
30/04/2021
Sapienza University of Rome
Ricercatore a tempo determinato (RTD) tipo A BIO13
18/09/2018
18/09/2027
Abilitazione Scientifica Nazionale 05/F1 II FASCIA
1/6/2017
30/04/2018
Sapienza University of Rome
Research Fellowship (PI: Prof. Marco Tripodi)
1/4/2016
31/03/2017
Sapienza University of Rome
Research Fellowship (PI: Prof. Marco Tripodi)
1/4/2015
31/03/2016
Sapienza University of Rome
Research Fellowship (PI: Prof. Marco Tripodi)
1/4/2014
31/03/2015
Sapienza University of Rome
Research Fellowship (PI: Prof. Marco Tripodi)
1/3/2013
28/02/2014
Sapienza University of Rome
Research Fellowship (PI: Prof. Marco Tripodi)
1/1/2012
31/12/2012
Sapienza University of Rome
Research Fellowship (PI: Prof. Marco Tripodi)

IIIB Other Appointments
Start End Institution Position
1/4/2017
31/05/2017
Pasteur Institute Italy- Cenci Bolognetti Foundation
Research Fellowship (PI: Prof. Marco Tripodi)
1/1/2013
28/02/2013
Pasteur Institute Italy- Cenci Bolognetti Foundation
Research Fellowship (PI: Prof. Marco Tripodi)
1/11/2011
31/12/2011
Pasteur Institute Italy- Cenci Bolognetti Foundation
Research Fellowship (PI: Prof. Rossella Maione)

Part IV Teaching experience
Year Institution Lecture/Course
2018/2019
Sapienza University of Rome
Medicina e Chirurgia (canale C)
Biologia e Genetica I, modulo di Biologia Cellulare (2cfu)
2018/2019
Sapienza University of Rome
Tecniche di Fisiopatologia Cardiocircolatoria e Perfusione Cardiovascolare
Basi cellulari e molecolari della vita, modulo di Biologia Applicata (2cfu)
2018/2019
Sapienza University of Rome
Tecniche Ortopediche
Scienze Biomediche I, modulo di Biologia (2cfu)
2019/2020
Sapienza University of Rome
Tecniche Ortopediche
Scienze Biomediche I, modulo di Biologia (2cfu)
2019/2020
Sapienza University of Rome
Tecniche di Fisiopatologia Cardiocircolatoria e Perfusione Cardiovascolare
Basi cellulari e molecolari della vita, modulo di Biologia Applicata (2cfu)
2019/2020
Sapienza University of Rome
Ostetricia
Basi molecolari e cellulari della vita, modulo di Biologia applicata (2cfu)
2020/2021
Sapienza University of Rome
Tecniche Ortopediche
Scienze Biomediche I, modulo di Biologia (2cfu)
2020/2021
Sapienza University of Rome
Tecniche di Fisiopatologia Cardiocircolatoria e Perfusione Cardiovascolare
Basi cellulari e molecolari della vita, modulo di Biologia Applicata (2cfu)
2020/2021
Sapienza University of Rome
Ostetricia
Basi molecolari e cellulari della vita, modulo di Biologia applicata (2cfu)
2021/2022
Sapienza University of Rome
Tecniche di Fisiopatologia Cardiocircolatoria e Perfusione Cardiovascolare
Basi cellulari e molecolari della vita, modulo di Biologia Applicata (2cfu)
2021/2022
Sapienza University of Rome
Ostetricia
Basi molecolari e cellulari della vita, modulo di Biologia applicata (2cfu)
2022/2023
Sapienza University of Rome
Medicine and Surgery (class F) Dentistry and Dental Prosthodontics
Biology and genetics I
(4cfu)
2022/2023
Sapienza University of Rome
Tecniche di Fisiopatologia Cardiocircolatoria e Perfusione Cardiovascolare
Basi cellulari e molecolari della vita, modulo di Biologia Applicata (2cfu)
2022/2023
Sapienza University of Rome
Ostetricia
Basi molecolari e cellulari della vita, modulo di Biologia applicata (2cfu)

Other Teaching experiences
2013-2022 Participation to ADE/lessons:
Laurea Magistrale A in Medicina e Chirurgia e del corso di Laurea Magistrale in Biotecnologie Mediche (Prof. Marco Tripodi)
Corso di Laurea Magistrale a ciclo unico in Medicina e Chirurgia (Prof. Raffaele Strippoli)
Corso di Laurea Magistrale C e del corso di Laurea Magistrale F in Medicina e Chirurgia (Prof.ssa Franca Citarella)

ASN Simulation (2012-2023) (IRIS database)
Value Description (Threshold)

SECONDA FASCIA
28 Numero articoli ultimi 5 anni (8)
1279 Numero citazioni ultimi 10 anni (307)
20 H index ultimi 10 anni (8)

PRIMA FASCIA
39 Numero articoli ultimi 10 anni (23)
1308 Numero citazioni ultimi 15 anni (770)
20 H index ultimi 15 anni (15)

COMMISSARIO
39 Numero articoli ultimi 10 anni (31)
1308 Numero citazioni ultimi 15 anni (1163)
20 H index ultimi 15 anni (19)

Supervision of thesis (National and International)
2017/2018
Sapienza University of Rome, Facoltà di farmacia e Medicina, Corso di laurea in Biotecnologie
Candidato: Giulio Bontempi

2019/2020
Erasmus Degree Project
Sapienza University of Rome and Universitat de Barcelona (Spain)
Candidato: Claudia Maldonado Torres

2020/2021
Sapienza University of Rome, Facoltà di farmacia e Medicina, Corso di laurea in Biotecnologie mediche
Candidato: Gioele Gaboardi

2020/2021
Sapienza University of Rome, Facoltà di farmacia e Medicina, Corso di laurea in Farmacia
Candidato: Gianna Marrocchino

2021/2022
Sapienza University of Rome, Facoltà di farmacia e Medicina, Corso di laurea in Biotecnologie mediche
Candidato: Sara Minotti

2021/2022
Sapienza University of Rome, Facoltà di farmacia e Medicina, Corso di laurea in Biotecnologie mediche
Candidato: Andrea Melito

Participation to Doctorate programs
Sept.2019/today
Sapienza University of Rome
PhD program in Human Biology and Medical Genetics

Supervision of national and international PhD thesis
2020
Universität des Saarlandes (Germany)
Candidato: Wesam Ali
Thesis: Design and synthesis of novel ligands for serotonin (5-HT6) receptor and inhibitors of ABCB1 efflux pump
2021
Sapienza University of Rome
PhD Student: Francesco Marocco

Supervision of Erasmus+ Students
2019/2020
Sapienza University of Rome and Universitat de Barcelona (Spain)
Candidato: Claudia Maldonado Torres
Erasmus Degree Project: Exosome-mediated intercellular communication, the role of cellular RNA-binding proteins

2022
Istanbul Medeniyet University (Turkey)
Candidato: Erva Esma Y ld r m
Erasmus Project: Study of the role of epitranscriptomic modifications in ncRNA sorting in EVs

2022
Istanbul Medeniyet University (Turkey)
Candidato: Ceren Balo lu
Erasmus Project: Study of the role of epitranscriptomic modifications in ncRNA-RBPs interaction

Part V Society memberships
Year Title
2015-today
ABCD (Associazione di Biologia Cellulare e del Differenziamento)
2018-today
Epigenetics Society
2013-2015
TEMTIA (The EMT International Association)
2020-today
EVIta (Extracellular Vesicle Italy)

Oral Presentations
7-8/6/2021 INVITED SPEAKER III international AICC Exosome Meeting Cell to cell delivery in cancer and therapy: a matter of carriers and messages Virtual Event
6-8/11/2019 1st EVIta Symposium, Palermo
22-24/11/2018 ABCD Meeting: Signal Transduction in Cancer , Turin
23/11/2016 INVITED SPEAKER at the Bambino Gesù Children s Hospital (Rome).
Seminar title: The Snail repressor recruits EZH2 to specific genomic sites through the enrolment of the lncRNA HOTAIR in epithelial-to-mesenchymal transition
20-23/9/2016 XIV FISV Congress Rome 30/9-1/10 2016 XVII AIBG Congress Cagliari
17-19/9/2015 ABCD meeting Bologna
7/9/2015 RNA day 2015, the multi-faceted non coding RNA landscape Rome
24-25-26-27/9/2014 Congress FISV 2014- Pisa
12-13/9/2013 Conference RNA day 2013, the centrality of non coding RNA in gene-regulation - Roma
12-13-14/10/2012 9° annual meeting IIM- Acaya, Lecce.
24-25-26/5/2012 Frontiers in molecular biology SIBBM congress Palermo.
4-5-6/6/2009 Frontiers in molecular biology SIBBM Congress Napoli.

Awards and Honors
Year Title
2019
EVIta (Extracellular Vesicle Italy) award (best oral presentation)
2018
AIRC award at the AIBG (Associazione Italiana Biologia e Genetica) Congress (young investigator award)
2013
TEMTIA (The EMT International Association) award (young investigator award)
2012
IIM (Italian Institute of Myology) award (best oral presentation)
2012
SIBBM (Società Italiana Biofisica Biologia Molecolare) award (best oral presentation)
2011
EMBO award (young investigator award)
2010
Collegio Ghislieri award (young investigator award)

Editorial activity
2016-2017
2017-2018
Academic Editor Mediators of Inflammation
Academic Editor Frontiers in Pharmacology
2019-2020
Academic Editor Frontiers in Pharmacology
2020
Academic Editor Biomedicine
2020
Review Editor for the Cellular Biochemistry section of Frontiers in Cell and Developmental Biology and of Frontiers in Molecular Biosciences

Peer Review activity
Peer review activity for the following journals:
Cell death and Differentiation, Oncogene, Cancers, Sensors, Molecules, Molecular Cancer, International Journal of Molecular Sciences, Cancer Medicine, Experimental and Molecular Pathology, Cellular Physiology and Biochemistry, Clinics and Research in Hepatology and Gastroenterology, Cells, Cell communication and Signalling, International Journal of Cancer, Cell Death and Disease, Gene, Genes, Pharmaceuticals, Oxidative Medicine and Cellular longevity, Cancer Gene Therapy, Frontiers in Cell and Developmental Biology, Cancer Cell International.

Part VI Funding Information [grants as PI-principal investigator or I-investigator]
Year Title Program Grant value
2008
Differenziamento miogenico e neuronale: fattori di regolazione . (I)
Ricerche UNIVERSITARIE (ex ricerche di ATENEO) codice C26A082MNW.
2009-2011
Interplay between myogenic factors and cell cycle control. (I)
Istituto Pasteur Fondazione Cenci Bolognetti
58000
2012-2014
Transcriptional regulation through long-range chromatin interactions in muscle cells: the CDKN1C-KCNQ1 locus. (I)
Istituto Pasteur Fondazione Cenci Bolognetti
60000
2014-2016
Dissecting HNF4 and Snail functions in hepatocyte reprogramming: role in liver cancer and fibrosis (I)
AIRC Investigator Grant n. IG14114
275000
2017-2019
Developing ncRNAs-based strategies to counteract epithelial tumour progression and metastasis (I)
AIRC Investigator Grant n. IG18843
285000
2018
Study of tissue environmental cues inactivating the master regulator of hepatocyte differentiation, Hepatocyte Nuclear Factor 4, in liver diseases (I)
Ricerche UNIVERSITARIE (ex ricerche di ATENEO) codice RM1181643646188C
10000
2019
Molecular strategies to antagonise the epithelial to mesenchymal transition (EMT) by interfering with the function of the lncRNA Hotair (I)
Ricerche UNIVERSITARIE (ex ricerche di ATENEO) codice RM11916B6A80C2CF
10740
2020
Impact of autophagy on extracellular vesicle-mediated cell-to-cell communication in cancer (I)
Ricerche UNIVERSITARIE (ex ricerche di ATENEO)
codice RG120172B73EDDC5
40000
2021
Deciphering the role of m6A on HOTAIR function and EV-compartmentalization (PI)
SEED PNR- Finanziamento di progetti di ricerca su temi di interesse trasversale per il PNR
10000
2022
Piattaforma integrata per la generazione, la coltura e il differenziamento di cellule pluripotenti staminali indotte (cellule iPS) e organoidi (I)
Ricerche UNIVERSITARIE codice MA2221815D2A0829
72638
2022
Dissecting the role of m6A on miRNA function, EV-loading and EV-mediated cell-to-cell communication in hepatocellular carcinoma (PI)
Ricerche UNIVERSITARIE RM12218166AEFC72
10000

Part VII Research Activities
Keywords Brief Description
Transcriptional factors
Cell plasticity
Chromatin
ncRNAs
Cell differentiation
Tumorigenesis
Epithelial-to-mesenchymal transition
Epigenetics
I am interested in molecular mechanisms controlling cell plasticity. In particular I focused my investigation in mechanisms controlling cell differentiation, epithelial-to-mesenchymal transition and tumour onset and dissemination. My collaborators and I elucidated the role of MyoD in the control of p57 (a cyclin-dependent kinase inhibitor) during muscle differentiation through the direct binding to the chromatin, and of CTCF in the reorganisation of chromatin structure in the same phenomenon. In three recent studies, I projected, developed and then elucidated with my team members the role and regulation of a lncRNA, HOTAIR, in the progression of epithelial-to-mesenchymal transition. Specifically, I found that this lncRNA binds to the chromatin, together with the transcriptional factor Snail, in order to recruit chromatin modifiers on the promoters of epithelial genes. Then I focused on its transcriptional regulation, mainly mediated by another transcriptional factor, HNF4a, that binds to its promoter and enhancer and modifies a higher-order chromatin structure promoting HOTAIR transcription. More recently I designed a strategy to counteract HOTAIR function in epithelial-to-mesenchymal transition through an RNA-based approach counteracting HOTAIR-Snail interaction and chromatin modifications on the promoter regions of Snail-target epithelial genes.
I am presently involved in research projects related to the identification of RNA-binding proteins interacting with microRNAs and responsible for microRNAs loading inside extracellular vesicles, specifically into exosomes. In this scenario I am also investigating the role of epitranscriptomics in modulating microRNA-protein interaction both in epithelial-to-mesenchymal transition and during differentiation.
Moreover, I have been implicated in the development and biological application of different epigenetic drugs able to modulate gene expression both in epithelial-to-mesenchymal transition and in tumorigenesis. With respect to this aspect, I focused on the use different inhibitors of chromatin modifiers (DNA methyltransferases, Histone deacetylases, Polycomb repressive complex 2) in order to verify whether they could restore epithelial cell features (and epithelial genes expression rescue) without affecting transcription factor binding to the promoters of several epithelial genes.

Scientific network:
Prof. Andres Ramos, University College of London
Dr. Daniel D Andrea, School of Science and Technology, Nottingham Trent University, Nottingham
Prof. Antonello Mai, Sapienza University of Rome
Prof. Elisabetta Ferretti, Sapienza University of Rome
Prof. Frank J. Gonzalez, Center for Cancer Research, National Cancer Institute, Bethesda
Dr. Rosaria Benedetti, Università degli Studi della Campania "Luigi Vanvitelli, Naples
Prof. Miguel A. Del Pozo, Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid
Prof. Manuel Lopez-Cabrera, Centro De Biología Molecular Severo Ochoa, Madrid
Prof. Jadwiga Handzlik, Jagiellonian University, Kraków, Poland
Prof. Claus Jacob, Universität des Saarlandes, Saarbrücken, Germany

Part VIII Summary of Scientific Achievements (papers published from 2012 to 2023)

Product type Number Data Base
Papers [international] 49 Scopus
https://www.scopus.com/author/submit/profile.uri?authorId=55371458900

Papers [international] 51 Google Scholar
https://scholar.google.it/citations?user=RTOf_14AAAAJ&hl=it&authuser=1&o...

Scopus* Google Scholar*
Total Impact factor 328.906 328.906
Impact factor per product 6.71 6.45
First name products 16 16
Last name products 6 8
Corresponding author products 7 9
Total Citations 1314 1611
Average Citations per Product 26.81 31.59
Hirsch (H) index 20 21
Normalized H index** 1.33 1.40

All data were updated on 20/04/2023
*IF 2021-22
**H index divided by the academic seniority.

Part IX Publications (scopus database):

MyoD regulates p57kip2 expression by interacting with a distant cis-element and modifying a higher order chromatin structure
Authors: A. Busanello*, C. Battistelli*, M. Carbone, C. Mostocotto and R. Maione
*First authors
Nucleic Acids Res.2012 Sep 1;40(17):8266-75. doi:10.1093/nar/gks619. Epub 2012 Jun 26. PMID: 22740650
Journal: Nucleic Acids Research; IF 2012: 8.278

Functional interplay between MyoD and CTCF in regulating long-range chromatin interactions during differentiation
Authors: C. Battistelli, A. Busanello and R. Maione
J Cell Sci. 2014 Sep 1;127(Pt 17):3757-67. doi: 10.1242/jcs.149427. Epub 2014 Jul 7. PMID: 25002401 Journal: Journal of Cell Science; IF 2014: 5.432

Spike-in SILAC proteomic approach reveals the vitronectin as an early molecular signature of liver fibrosis in hepatitis C infections with hepatic iron overload.
Authors: Montaldo C, Mattei S, Baiocchini A, Rotiroti N, Del Nonno F, Pucillo LP, Cozzolino AM, Battistelli C, Amicone L, Ippolito G, van Noort V, Conigliaro A, Alonzi T, Tripodi M, Mancone C.
Proteomics. 2014 May;14(9):1107-15. doi: 10.1002/pmic.201300422. PMID: 24616218
Journal: Proteomics; IF 2014 3.807

Poly(ADP-ribosyl)ation is required to modulate chromatin changes at c-MYC promoter during emergence from quiescence.
Authors: Mostocotto C, Carbone M, Battistelli C, Ciotti A, Amati P, Maione R.
PLoS One. 2014 Jul 21;9(7):e102575. doi: 10.1371/journal.pone.0102575. eCollection 2014. PMID: 25047032
Journal: Plos One; IF 2014 3.234

Epigenetic control of EMT/MET dynamics: HNF4 impacts DNMT3s through miRs-29
Authors: C. Cicchini, V. de Nonno, C. Battistelli, A. M. Cozzolino, M. De Santis Puzzonia, S. A. Ciafrè, C. Brocker, F. J. Gonzalez, L. Amicone, and M. Tripodi
Biochim Biophys Acta. 2015 Aug;1849(8):919-29. doi: 10.1016/j.bbagrm.2015.05.005. Epub 2015 May 21.
PMID: 26003733
Journal: Biochimica et Biophysica Acta - Gene Regulatory Mechanisms; IF 2015: 5.373

SETDB1 is a new promising target in HCC therapy.
Authors: Cicchini C, Battistelli C, Tripodi M.
Chin Clin Oncol. 2016 Dec;5(6):73. doi: 10.21037/cco.2016.05.04. Epub 2016 Jun 3. PMID: 27334461
Journal: Chin Clin Oncol.; IF 2016 n.d.

Modulating the Substrate Stiffness to Manipulate Differentiation of Resident Liver Stem Cells and to Improve the Differentiation State of Hepatocytes
Authors: A. M. Cozzolino, V. Noce, C. Battistelli, A. Marchetti, G. Grassi, C. Cicchini, M. Tripodi, and L. Amicone
Stem Cells Int. 2016;2016:5481493. doi: 10.1155/2016/5481493. Epub 2016 Jan 12. PMID: 27057172 Journal: Stem Cells International; IF 2016: 3.540

Molecular Mechanisms Underlying Peritoneal EMT and Fibrosis
Authors: R. Strippoli, R. Moreno-Vicente, C. Battistelli, C. Cicchini, V. Noce, L. Amicone, A. Marchetti, M. A. del Pozo, and M. Tripodi
Stem Cells Int. 2016;2016:3543678. doi: 10.1155/2016/3543678. Epub 2016 Jan 31. PMID: 26941801 Journal: Stem Cells International; IF 2016: 3.540

The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting
Authors: L. Santangelo, G. Giurato, C. Cicchini, C. Montaldo, C. Mancone, R. Tarallo, C. Battistelli, T. Alonzi, A. Weisz, and M. Tripodi
Cell Rep. 2016 Oct 11;17(3):799-808. doi: 10.1016/j.celrep.2016.09.031. PMID: 27732855
Journal: Cell Reports; IF 2016: 8.282

A cross-talk between DNA methylation and H3 lysine 9 dimethylation at the KvDMR1 region controls the induction of Cdkn1c in muscle cells
Authors: O. Andresini, A. Ciotti, M. N. Rossi, C. Battistelli, M. Carbone, and R. Maione
Epigenetics. 2016 Nov;11(11):791-803. doi: 10.1080/15592294.2016.1230576. Epub 2016 Sep 9. PMID: 27611768
Journal: Epigenetics; IF 2016: 4.394

Promotion of proliferation and metastasis of hepatocellular carcinoma by LncRNA00673 based on the targeted-regulation of notch signaling pathway
Authors: P Magistri 1, C Battistelli, G Assirati, F Mereu, G Tarantino, G P Guerrini, R Ballarin, F Di Benedetto
Eur Rev Med Pharmacol Sci. 2017 Oct;21(19):4261-4262. PMID: 29077173
Journal: Eur Rev Med Pharmacol Sci. IF 2017: 2.387

Targeting of polycombs to DNA in EMT.
Authors: Battistelli C, Tripodi M, Cicchini C.
Oncotarget. 2017 Aug 12;8(35):57936-57937. doi: 10.18632/oncotarget.20211. eCollection 2017 Aug 29.
PMID: 28938527
Journal: Oncotarget; IF 2017 n.d.

Functional Roles and Therapeutic Applications of Exosomes in Hepatocellular Carcinoma
Authors: L. Santangelo, C. Battistelli, C. Montaldo, F. Citarella, R. Strippoli and C. Cicchini
Biomed Res Int. 2017;2017:2931813. doi: 10.1155/2017/2931813. Epub 2017 Feb 7. PMID: 28265569
Journal: BioMed Research International; IF 2017: 2.583

The Snail repressor recruits EZH2 to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-to-mesenchymal transition
Authors: C. Battistelli, C. Cicchini, L. Santangelo, A. Tramontano, L. Grassi, F. J. Gonzalez, V. de Nonno, G. Grassi, L. Amicone and M. Tripodi
Oncogene. 2017 Feb 16;36(7):942-955. doi: 10.1038/onc.2016.260. Epub 2016 Jul 25. PMID: 27452518
Journal: Oncogene; IF 2017: 6.854

The lncRNA H19 positively affects the tumorigenic properties of glioblastoma cells and contributes to NKD1 repression through the recruitment of EZH2 on its promoter.
Authors: Fazi B, Garbo S, Toschi N, Mangiola A, Lombari M, Sicari D, Battistelli C, Galardi S, Michienzi A, Trevisi G, Harari-Steinfeld R, Cicchini C, Ciafrè SA.
Oncotarget. 2018 Feb 14;9(21):15512-15525. doi: 10.18632/oncotarget.24496. eCollection 2018 Mar 20. PMID: 29643989
Journal: Oncotarget; IF 2018 n.d

SMO inhibition modulates cellular plasticity and invasiveness in colorectal cancer
Authors: P. Magistri*, C. Battistelli*, R. Strippoli, N. Petrucciani, T. Pellinen, L. Rossi, L. Mangogna, P. Aurello, F. D Angelo, M. Tripodi, G. Ramacciato and G. Nigri
*First authors
Front Pharmacol. 2018 Feb 2;8:956. doi: 10.3389/fphar.2017.00956. eCollection 2017. PMID: 29456503
Journal: Frontiers in Pharmacology; IF 2018: 3.831

Hepatitis C virus direct-acting antivirals therapy impacts on extracellular vesicles microRNAs content and on their immunomodulating properties
Authors: L. Santangelo, V. Bordoni, C. Montaldo, E. Cimini, A. Zingoni, C. Battistelli, G. D Offizi, M. R. Capobianchi, A. Santoni, M. Tripodi and C. Agrati
Liver Int. 2018 Oct;38(10):1741-1750. doi: 10.1111/liv.13700. Epub 2018 Feb 24. PMID: 29359389
Journal: Liver International; IF 2018: 5.542

HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal
Authors: L. Rossi*, C. Battistelli*, V. de Turris, V. Noce, C. Zwergel, S. Valente, A. Moioli, A. Manzione, M. Palladino, V. Bordoni, A. Domenici, P. Menè, A. Mai, M. Tripodi and R. Strippoli
*First authors
Sci Rep. 2018 May 31;8(1):8492. doi: 10.1038/s41598-018-26319-2. PMID: 29855565
Journal: Scientific Reports; IF 2018: 4.011

A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets
Authors: F. Hobor, A. Dallmann, N. J. Ball, C. Cicchini, C. Battistelli, R. W. Ogrodowicz, E. Christodoulou, S. R. Martin, A. Castello, M. Tripodi, I. A. Taylor and A. Ramos
Nat Commun. 2018 Feb 26;9(1):831. doi: 10.1038/s41467-018-03182-3. PMID: 29483512
Journal: Nature Communications; IF 2018: 11.878

TGF impairs HNF1 functional activity in Epithelial-to-Mesenchymal Transition interfering with the recruitment of CBP/p300 acetyltransferases
Authors: F. Bisceglia*, C. Battistelli*, V. Noce, C. Montaldo, A. Zammataro, R. Strippoli, M. Tripodi, L. Amicone and A. Marchetti
*First authors
Front Pharmacol. 2019 Aug 30;10:942. doi: 10.3389/fphar.2019.00942. eCollection 2019. PMID: 31543815 Journal: Frontiers in Pharmacology; IF 2019: 4.225

Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells
Authors: G. Stazi*, C. Battistelli*, V. Piano, R. Mazzone, B. Marrocco, S. Marchese, S. M. Louie, C. Zwergel, L. Antonini, A. Patsilinakos, R. Ragno, M. Viviano, G. Sbardella, A. Ciogli, G. Fabrizi, R. Cirilli, R. Strippoli, A. Marchetti, M. Tripodi, D. K. Nomura, A. Mattevi, A. Mai and S. Valente
*First authors
Eur J Med Chem. 2019 Feb 1;163:722-735. doi: 10.1016/j.ejmech.2018.11.050. Epub 2018 Nov 28. PMID: 30576903
Journal: European Journal of Medicinal Chemistry; IF 2019: 5.572

The lncRNA HOTAIR transcription is controlled by HNF4 -induced chromatin topology modulation
Authors: C. Battistelli, G. Sabarese, L. Santangelo, C. Montaldo, F. J. Gonzalez, M. Tripodi and C. Cicchini
Cell Death Differ. 2019 May;26(5):890-901. doi: 10.1038/s41418-018-0170-z. Epub 2018 Aug 28. PMID: 30154449
Journal: Cell Death and Differentiation; IF 2019: 10.717

Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells
Authors: C. Zwergel, M. Schnekenburger, F. Sarno, C. Battistelli, M. C. Manara, G. Stazi, R. Mazzone, R. Fioravanti, C. Gros, F. Ausseil, C. Florean, A. Nebbioso, R. Strippoli, T. Ushijima, K. Scotlandi, M. Tripodi, P. B. Arimondo, L. Altucci, M. Diederich, A. Mai and S. Valente
Clin Epigenetics. 2019 May 6;11(1):68. doi: 10.1186/s13148-019-0663-8. PMID: 31060628
Journal: Clinical Epigenetics; IF 2019: 5.028

YAP integrates the regulatory Snail/HNF4 circuitry controlling epithelial/hepatocyte differentiation.
Authors: Noce V, Battistelli C, Cozzolino AM, Consalvi V, Cicchini C, Strippoli R, Tripodi M, Marchetti A, Amicone L.
Cell Death Dis. 2019 Oct 10;10(10):768. doi: 10.1038/s41419-019-2000-8. PMID: 31601778
Journal: Cell Death and Disease; IF 2019: 6.304

Molecular Mechanisms and New Therapeutic Targets in Epithelial to Mesenchymal Transition (EMT) and Fibrosis.
Authors: Battistelli C, Diederich M, Keane TJ, Sandoval P, Valente S, Strippoli R.
Front Pharmacol. 2020 Jan 16;10:1556. doi: 10.3389/fphar.2019.01556. eCollection 2019. PMID: 32009960
Journal: Frontiers in Pharmacology; IF 2020: 4.225

Novel Quinoline Compounds Active in Cancer Cells through Coupled DNA Methyltransferase Inhibition and Degradation.
Authors: Zwergel C, Fioravanti R, Stazi G, Sarno F, Battistelli C, Romanelli A, Nebbioso A, Mendes E, Paulo A, Strippoli R, Tripodi M, Pechalrieu D, Arimondo PB, De Luca T, Del Bufalo D, Trisciuoglio D, Altucci L, Valente S, Mai A.
Cancers (Basel). 2020 Feb 14;12(2):447. doi: 10.3390/cancers12020447. PMID: 32075099
Journal: Cancers; IF 2020: 6.126

Design of First-in-Class Dual EZH2/HDAC Inhibitor: Biochemical Activity and Biological Evaluation in Cancer Cells.
Authors: Romanelli A, Stazi G, Fioravanti R, Zwergel C, Di Bello E, Pomella S, Perrone C, Battistelli C, Strippoli R, Tripodi M, Del Bufalo D, Rota R, Trisciuoglio D, Mai A, Valente S.
ACS Med Chem Lett. 2020 Mar 19;11(5):977-983. doi: 10.1021/acsmedchemlett.0c00014. eCollection 2020 May 14. PMID: 32435414
Journal: ACS Medicinal Chemistry Letters; IF 2020: 3.975

Caveolin1 and YAP drive mechanically-induced mesothelial to mesenchymal transition and fibrosis
Authors: R. Strippoli, P. Sandoval, R. Moreno-Vicente, L. Rossi, C. Battistelli, M. Terri, L. Pascual-Antón, M. Loureiro, F. Matteini, E. Calvo, J. A. Jiménez-Heffernan, M. J. Gómez, V. Jiménez-Jiménez, F. Sánchez-Cabo, J. Vázquez, M. Tripodi, M. López-Cabrera and M. Á. del Pozo
Cell Death Dis. 2020 Aug 3;11(8):647. doi: 10.1038/s41419-020-02822-1. PMID: 32811813
Journal: Cell Death and Disease; IF 2020: 6.304

Discovery of phenylselenoether-hydantoin hybrids as ABCB1 efflux pump modulating agents with cytotoxic and antiproliferative actions in resistant T-lymphoma.
Authors: Ali W, Spengler G, Kincses A, Nové M, Battistelli C, Latacz G, Starek M, D browska M, Honkisz-Orzechowska E, Romanelli A, Rasile MM, Szyma ska E, Jacob C, Zwergel C, Handzlik J.
Eur J Med Chem. 2020 Aug 15;200:112435. doi: 10.1016/j.ejmech.2020.112435. Epub 2020 May 15. PMID: 32505850
Journal: European Journal of Medicinal Chemistry; IF 2020: 5.572

Poly(ADP-ribose) Polymerase 1 (PARP1) restrains MyoD-dependent gene expression during muscle differentiation.
Authors: Matteini F, Andresini O, Petrai S, Battistelli C, Rossi MN, Maione R.
Sci Rep. 2020 Sep 15;10(1):15086. doi: 10.1038/s41598-020-72155-8. PMID: 32934320
Journal: Scientific Reports; IF 2020: 3.998

Design and functional validation of a mutant variant of the lncRNA HOTAIR to counteract Snail function in Epithelial-to-Mesenchymal Transition
Authors: C. Battistelli#, S. Garbo, V. Riccioni, C. Montaldo, L. Santangelo, A. Vandelli, R. Strippoli, G. G. Tartaglia, M. Tripodi# and C. Cicchini
#Corresponding authors
Cancer Res. 2021 Jan 1;81(1):103-113. doi: 10.1158/0008-5472.CAN-20-1764. Epub 2020 Nov 6.
PMID: 33158813 Journal: Cancer Research; IF 2021: 13.312

The innovative potential of selenium-containing agents for fighting cancer and viral infections
Authors: W. Ali, R. Benedetti, J. Handzlik, C. Zwergel and C. Battistelli
Drug Discov Today. 2021 Jan;26(1):256-263. doi: 10.1016/j.drudis.2020.10.014. Epub 2020 Oct 23.
PMID: 33164821
Journal: Drug Discovery Today; IF 2021: 8.369

Nutlin-3a enhances Natural Killer cell-mediated killing of neuroblastoma by restoring p53-dependent expression of ligands for NKG2D and DNAM-1 receptors
Authors: I. Veneziani, P. Infante, E. Ferretti, O. Melaiu, C. Battistelli, V. Lucarini, M. Compagnone, C. Nicoletti, A. Castellano, S. Petrini, M. Ognibene, A. Pezzolo, L. Di Marcotullio, L. Moretta, R. Bei, V. Pistoia, D. Fruci, V. Barnaba, F. Locatelli, and L. Cifaldi
Cancer Immunology Research, 2021, 9(2), pp. 170 183
Journal: Cancer Immunology Resarch, IF 2020: 12.020

Natural Product Epigenetic Modulators and Inhibitors
Authors: Ntie-Kang, F., Karaman Mayack, B., Valente, S., Battistelli, C.
Frontiers in Pharmacology, 2021, 12, 651395
Journal: Frontiers in Pharmacology; IF 2020: 5.988

New Approaches to Tackle EMT and Fibrosis: From Epigenetics to Nanotechnology.
Authors: Battistelli C, Cordani M, Diederich M, Somoza Á, Valente S, Strippoli R.
Front Pharmacol. 2021 Aug 6;12:742777. doi: 10.3389/fphar.2021.742777. eCollection 2021
Journal: Frontiers in Pharmacology; IF 2020: 5.988

m6A RNA methylation and beyond the epigenetic machinery and potential treatment options
Authors: Garbo, S., Zwergel, C., Battistelli, C.
Journal: Drug discovery today; IF 2021: 8.369

Fibrogenic signals persist in DAA-treated HCV patients after sustained virological response.
Authors: Montaldo, C., Terri, M., Riccioni, V., Battistelli, C., Bordoni, V., D'Offizi, G., Prado, M.G., Trionfetti, F., Vescovo, T., Tartaglia, E., Strippoli, R., Agrati, C., Tripodi M.
Journal: Journal of Hepatology; IF 2021: 30.083

SYNCRIP Modulates the Epithelial-Mesenchymal Transition in Hepatocytes and HCC Cells
Authors: Riccioni, V., Trionfetti, F., Montaldo, C., Garbo, S., Marocco, F., Battistelli, C., Marchetti, A., Strippoli, R., Amicone, L., Cicchini, C., Tripodi, M.
Journal: International Journal of Molecular Sciences; IF 2021: 6.208

Next RNA Therapeutics: The mine of non-coding
Authors: Garbo, S., Maione, R., Tripodi, M.#, Battistelli, C#.
#Corresponding authors
Journal: International Journal of Molecular Sciences; IF 2021: 6.208

Persistence of fibrogenic process in direct-acting antiviral (DAA) treated patients?
Authors: Battistelli, C., Tripodi M.
ExRNA 2022 Open Access Volume 4 June 2022 Article number 15
Journal: ExRNA, IF 2020:

Molecular Mechanisms and New Therapeutic Targets in Epithelial to Mesenchymal Transition (EMT) and Fibrosis.
Authors: Battistelli C, Diederich M, Keane TJ, Sandoval P, Valente S, Strippoli R.
Front Pharmacol. 2020 Jan 16;10:1556. doi: 10.3389/fphar.2019.01556. eCollection 2019. PMID: 32009960
Journal: Frontiers in Pharmacology; IF 2020: 4.225

Persistence of Fibrogenic Signals in DAA-Treated HCV Patients In spite of SVR
Authors: Montaldo, C., Terri, M., Battistelli, C., Tripodi, M.
J Liver, Vol.11 Iss.3 No:1000135
Journal: Journal of Liver; IF n.a.

Seleno- vs thioether triazine derivatives in search for new anticancer agents overcoming multidrug resistance
Authors: Ali, W., Garbo, S., Spengler, G., Di Bello, E., Honkisz-Orzechowska, E., Karcz, T., Szyma sk, E., es awska, E., Starek, M., D browska, M., Nitek, W., Kucwaj-Brysz, K., Pyka, P., Haberek, W., Fioravanti, R., Jacob, C., Battistelli, C.#, Zwergel, C. #, Handzlik, J. #
#Corresponding authors
Journal: European Journal of Medicinal Chemistry; IF 2022: 6.525

A novel microRNA signature for the detection of melanoma by liquid biopsy
Authors: Sabato, C., Noviello, T.M.R., Covre, A., Coral, S., Caruso, F.P., Mersini Besharat, Z., Splendiani, E., Masuelli, L., Battistelli, C., Vacca, A., Catanzaro, G., Po, A., Anichini, A., Maio, M., Ceccarelli, M., Di Giacomo, A.M. and Ferretti, E.
Journal: Journal of Translational medicine; IF 2022: 5.531

MyoD-induced trans-differentiation: a paradigm for dissecting the molecular mechanisms of cell commitment, differentiation and reprogramming
Authors: Battistelli, C., Garbo, S., and Maione, R.
Journal: Cells; IF 2022: 7.666

Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells
Authors: Bontempi, G., Terri, M., Garbo, S., Montaldo, C., Mariotti, D., Bordoni, V., Valente, S., Zwergel, C., Mai, A., Marchetti, A., Domenici, A., Mene, P., Battistelli, C., Tripodi, M., Strippoli, R.
Journal: Cell death and disease; IF 2022: 9.705

Extracellular signal-Regulated Kinase 5 (ERK5) is required for the Yes-associated protein (YAP) co-transcriptional activity
Authors: Ippolito, F., Consalvi, V., Noce, V., Battistelli, C., Cicchini, C., Tripodi, M., Amicone, L., Marchetti, A.
Journal: Cell death and disease; IF 2022: 9.705

Selenium-containing agents acting on cancer- a new hope?
Authors: Garbo, S., Di Giacomo, S. a ewska, D., Honkisz-Orzechowska, E., Di Sotto, A., Fioravanti, R., Zwergel, C.* and Battistelli, C.*
*Corresponding authors
Journal: Pharmaceutics; IF 2022: 6.525

In vivo Bioluminescence-Based Monitoring of Liver Metastases from Colorectal Cancer: An Experimental Model.
Authors: Magistri, P.*, Battistelli, C.*, Toietta, G*, Strippoli, R., Sagnotta, A., Forgione, A., Di Benedetto, F., Uccini, S., Vittorioso, P., D'Angelo, F., Aurello, P., Ramacciato, G., Nigri, G.
*First authors
J Microsc Ultrastruct. 2019 Jul-Sep;7(3):136-140. doi: 10.4103/JMAU.JMAU_51_18.

Other publications (pubmed database):

A novel RNA-based approach to counteract EMT.
Authors: Garbo, S., Tripodi, M., Battistelli, C.
Oncoscience. 2021 May 7;8:53-54. doi: 10.18632/oncoscience.532. eCollection 2021.

lncRNA HOTAIR functions and therapeutic perspectives
Authors: Garbo, S., Tripodi, M., and Battistelli, C.
Oncoscience. 2022

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