Catalogo dei Corsi di studio

General Information

Full Name Giulia Di Stefano
Permanent Address Department of Human Neuroscience. Viale Università 30, 00185, Rome
E-mail giulia.distefano@uniroma1.it
Spoken Languages Italian (mother tongue), English (advanced level)

Education

Type Year Institution Notes (Degree, Experience, )
University Graduation 2008 Sapienza, University of Rome Thesis title: Trigeminal neuropathic pain: clinical, neurophysiological and skin biopsy study . 110/110 con lode
Specialty 2014 Sapienza, University of Rome Thesis title: Painful polineurpathy: neurophysiological and istological study . 70/70 con lode
PhD 2019 Sapienza, University of Rome PhD Course: Tecnologie innovative nelle malattie della cute, dello scheletro e del distretto oro-cranio facciale. Thesis title: Trigeminal Neuralgia: from clinical characteristics to pathophysiological mechanisms . Giudizio: con Lode.

Achievement of the Abilitazione Scientifica Nazionale per le funzioni di Professore di Seconda Fascia applicable to the scientific sector: SSD MED/26 Neurologia (valid from 11/09/2019 through 11/09/2025).

Appointments

Academic Appointments

Start End Institution Position

2022 In progress Sapienza, University of Rome Fixed term researcher, type B, Department of Human Neuroscience
2018 2022 Sapienza, University of Rome Fixed term researcher, type A, Department of Human Neuroscience
2022 In progress Sapienza, University of Rome Rappresentante del Comitato Tecnico Scientifico del Sistema Bibliotecario Sapienza
2018 In progress Sapienza, University of Rome Member of the Board of the Department of Human Neuroscience
2019 In progress Sapienza, University of Rome Member of the editorial team of the content exposed on the website of the Department of Human Neuroscience
2016 2017 Sapienza, University of Rome Research Fellow
2013 2014 Department of Neuroscience, Physiology and Pharmacology, University College of London Research Fellowship in Neuroscience

Other Appointments

Start End Institution Position
1/10/2021 In progress Policlinico Umberto I hospital Dirigente Medico at the Department of Human Neuroscience and at the Neuro-Covid ward
01/04/2021 In progress Policlinico Umberto I hospital Execution of neurophysiological exams (electromyographies and laser evoked potentials) at the Department of Human Neurosciences and in the wards of Policlinico Umberto I
1/05/2021 30/09/2021 Policlinico Umberto I hospital Dirigente Medico at the Emergency Unit (UOC in Medicina Emergenza-Urgenza SEAC07)
01/04/2021 30/04/2021 Policlinico Umberto I hospital Dirigente Medico at the Covid ward (UOC Emergenza-Urgenza)

Teaching experience

Year Istitution Lecture/Course
2020/2021 Sapienza, University of Rome Scienze delle professioni sanitarie tecniche diagnostiche. Neurologia
2020/2021 Sapienza, University of Rome Tecniche di neurofisiopatologia. Fisiopatologia del dolore
2020/2021 Sapienza, University of Rome Tecniche di neurofisiopatologia
Fisiopatologia del coma e morte cerebrale
2018/2021 Sapienza, University of Rome Medicina e Chirurgia-Corso di Laurea B-Malattie del Sistema Nervoso
2018/2021 Sapienza, University of Rome Fisioterapia - Corso di laurea D - Roma Azienda S. Camillo Forlanini L/SNT2. Neurologia
2018/2020 Sapienza, University of Rome Infermieristica (abilitante alla professione sanitaria di Infermiere) ROMA - Corso di laurea I - I.F.O. L/SNT1. Neurologia
2018/2020 Sapienza, University of Rome Scienze riabilitative delle professioni sanitarie LM/SNT2. Scienze tecniche mediche applicate
2017/2018 Sapienza, University of Rome Terapia occupazionale sede di Viterbo [L (DM 270/04). Neurologia
2018 Sapienza, University of Rome Lecturer at the Corso di Alta Formazione in Elettromiografiaa Clinica, Modulo 7: Neurofisiologia Neuropatie Craniche
2013 Italian society of clinical neurophysiology Lecturer at the XII Corso di Base in EMG e potenziali evocati (Sorrento, 16- 22 Marzo 2013)
2015 Italian society of clinical neurophysiology Lecturer at the XIV Corso Residenziale di Elettroencefalografia e Tecniche Correlate (Tirrenia, 14 Marzo 2015)

Society memberberships, Awards and Honors

Year Title
Dal 2021 Vice president of Associazione Italiana Dolore Oro-facciale (AIDOF)
Dal 2018 Coordinator of neurophysiology of pain study group of the Italian society of clinical neurophysiology
Dal 2008 Member of the Italian society of clinical neurophysiology (SINC)
Dal 2013 Member of the International Association for the study of Pain (IASP)
Dal 2013 Member of the Neuropathic Pain (NeuPSIG), IASP Special Interest Groups
2022 Winner of the Premio tesi dottorato 2020 Macroarea C. (Sapienza Università Editrice)
2022 The research in the field of trigeminal neuralgia was selected among the ten finalists of the 2021 Prize by the scientific committee of the Aldo Fasolo Prize for communication in Neuroscience.
2021 The paper Diagnostic accuracy of laser-evoked potentials in diabetic neuropathy was selected for publication in PALADINI ITALIANI DELLA SALUTE volume.
2019 Winner of the Premio Minerva alla Ricerca Scientifica II Edizione, Vincitore Macroarea C (Fondazione Roma Sapienza)
2011 EFNS Investigator Awards - EFNS Scientist Panel. Title of the study: Clinical and neurophysiological study of neuropathic pain in patients with multiple sclerosis
2017 NeuPSIG Financial Aid for the 7th International Congress on Neuropathic Pain
2017 EFIC Financial Aid for the 10th Congress of the European Pain Federation
2016 IASP Financial Aid for the 16th World Congress on Pain
2016 Winner of a bursary promoted by the AISNP ( Associazione Italiana Sistema Nervoso Periferico ) for attending the Advanced Training Course on Peripheral Neuropathy Small fiber neuropathies ( Corso teorico pratico di Alta formazione sulle neuropatie periferiche - Modulo neuropatie delle piccole fibre )
2015 Winner of EC-IFCN boursary (Ed. 2015) for the 15th European Congress of Clinical Neurophysiology (ECCN), with the following scientific contribution: Pain-related cortex function in patients with Alzheimer disease ;
2013 Best Scientific Contribution. Contest. Diabetic small fibre neuropathy diagnosis: a comparison between skin biopsy and laser evoked potentials
2009 Best Scientific Contribution. XL Congresso SIN. Topographical distribution of unmyelinated fibres related receptors. Psychophysical study of thermal, nociceptive and itching perception

Funding Information [grants as PI-principal investigator or I-investigator]

Grants as Principal Investigator

Year Title Program Grant value
2022 Progetto Ateneo Progetti piccoli , Sapienza, University of Rome Disclosing pain mechanisms in trigeminal neuralgia 3.500,00
2021 IASP Collaborative Research Grant Disclosing pain mechanisms in trigeminal neuralgia Collaborators: Stephen Waxman, Yale University School of Medicine; Francis O Neill, University of Liverpool; Joanna Zakrzewska, UCLH NHS Foundation Trust; Stine Maarbjerg, University of Copenhagen 15.000,00 $
2016 Progetto Ateneo - Avvio alla ricerca , Sapienza, University of Rome The defensive peripersonal space in patients with trigeminal neuralgia 2.000,00
2013 Giuseppe Ayala scholarship for reserch fellowship, Fondazione Roma Sapienza Research Fellowship in Neuroscience, University College of London 10.000,00

Research Activities
Research fields
Keywords Brief Description
Somatosensory system New technique for the study of somatosensory system (laser evoked potentials, contact heat evoked potentials, skin biopsy, quantitative sensory testing)
Pathophysiological mechanisms of pain Combination of neurophysiological and morphometric techniques for the study of pain mechanisms in patients with painful neuropathies
Treatment of neuropathic pain Investigation of biomarkes to predict the effect of pharmacological treatment
Investigators in multi center randomized controlled trials for the treatment of neuropathic pain (phase 2A, phase 3 and phase 4 studies).
- COMBO-DN study"--a multinational, randomized, double-blind, parallel-group study in patients with diabetic peripheral neuropathic pain.
- Double-blind, placebo-controlled, randomised withdrawal phase 2a trial with Nav1.7 selective sodium channel blocker in patients with trigeminal neuralgia.
- Multicentre, clinical and neurophysiological study with L-Acetyl-carnitine in Patients with Carpal Tunnel Syndrome.
- A double-blind placebo controlled randomized dose ranging trial to determine the safety and efficacy of EMA401 in reducing 24-hour average pain intensity score in patients with post-herpetic neuralgia (EMPHENE).
Trigeminal neuralgia Combination of neurophysiological and neuroimaging thechniques for the study of pain in patients with trigeminal neuralgia
Peripheral nervous system diseases Students supervisor, Department of Human Neuroscience, Sapienza University of Rome, Viale Università 30, 00185 Rome, Italy

Scientific collaborations and international society appointments

2021 Scientific collaboration: University of Liverpool (Prof. Turo Nurmikko), UCLH NHS Foundation Trust (Prof. Joanna Zakrzewska). Book contribution: Chapter 9 TREATMENT OF TRIGEMINAL NEURALGIA - pharmacological in Trigeminal Neuralgia and other Cranial Neuralgias: A Practical Personalised Holistic Approach (Oxford Pain Management Library Series) ahead-of-print
2022 Participation to the international Delphi survey and consensus meeting to define the core outcome set for trigeminal neuralgia clinical trials organized by University College London
2019 Scientific collaboration: University of Heidelberg (Referente Prof Rolf-Detlef Treede); Université catholique de Louvain (Referente Prof Andre Mouraux); Aarhus University (Referente: Prof Nanna Brix Finnerup). IMI-Pain Care, Horizon2020. Three relevant publications:
- Mouraux et al., IMI2-PainCare-BioPain-RCT3: a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by electroencephalography (EEG) . Trials 2021;
- Leone et al, How different experimental models of secondary hyperalgesia change the nociceptive flexion reflex . CLINPH 2021 ahead-of-print;
- Di Pietro et al, The N13 spinal component of somatosensory evoked potentials is modulated by heterotopic noxious conditioning stimulation: evidence for involvement of spinal wide-dynamic range neurons . CLINPH 2021 ahead-of-print.
2018 Scientific collaboration: Center for Neuroscience & Regeneration Research, Yale University School of Medicine. Referees: Prof. Sulayman D. Dib-Hajj, Prof Stephen G. Waxman. The collaboration focused on the genomic screen of the neuronal electrogenisome in patients with familial trigeminal neuralgia. Two relevant publications:
- Di Stefano et al., Familial trigeminal neuralgia - a systematic clinical study with a genomic screen of the neuronal electrogenisome . Cephalalgia, 2020;
- Gualdani et al., Trigeminal neuralgia TRPM8 mutation: Enhanced activation, basal [Ca2+]i and menthol response . Neurology Genetics, 2021
2016 Member of the International Expert Panel for the development of EAN guidelines on diagnosis and treatment of trigeminal neuralgia. One relevant publication:
- Bendtsen et al., European Academy of Neurology guideline on trigeminal neuralgia . Eur J Neurol, 2019
2016 Scientific collaboration: University of Copenhagen (Danish Headache Center, Department of Neurology, Faculty of Health Sciences). Collaboration aimed at the study of pathophysiological mechanisms undelying pain in trigeminale neuralgia. Three relevant publications:
- Di Stefano et al, Trigeminal neuralgia secondary to multiple sclerosis: From the clinical picture to the treatment options . J Headache and Pain 2019;
- Di Stefano et al, Triggering trigeminal neuralgia . Cephalalgia, 2018;
- Maarbjer et al, Trigeminal neuralgia - diagnosis and treatment . Cephalalgia, 2017.
2014 Scientific collaboration: Department of Neuroscience, Physiology and Pharmacology, University College of London. Supervisor: Prof. Giandomenico Iannetti. Three relevant publications:
- Moayedi et al. Nociceptive-Evoked Potentials Are Sensitive to Behaviorally Relevant Stimulus Displacements in Egocentric Coordinates , eNeuro. 2016;
- Bufacchi et al., Pain outside the body: Defensive peripersonal space deformation in trigeminal neuralgia , Sci Rep. 2017;
- Mancini et al., Characterizing the short-term habituation of event-related evoked potentials , eNeuro. 2018.

National and International Congresses

2011 Speaker at the 14th European Congress of Clinical Neurophysiology (Rome, 20 - 25
June, 2011). Title of the presentation: "Mechanisms of pain in distal symmetric polyneuropathy. A combined clinical and neurophysiological study".

2012 Speaker at the National Neurophysiology Meeting New Strategies ("Incontro Nazionale Neurofisiologia: Nuove Strategie"). Palermo, 29 - 30 November 2012.
2016 Speaker at the National Meeting on Pain of Elderly Patients ( Il dolore nel paziente anziano ) Alghero, 30 April, 2016. Title of the presentation: Fisiopatologia del dolore neuropatico .
2017 Speaker at the National Meeting on Neuropathic Pain ( Il dolore neuropatico ). Alghero, 29 April, 2017. Title of the presentation: Quando si parla di dolore neuropatico? Fisiopatologia del dolore neuropatico. Diagnosi clinica e strumentale del dolore neuropatico .
2017 Moderator and Speaker at the National Forum on Neuropathic Pain ( FORUM DEL DOLORE NEUROPATICO . San Giovanni Rotondo, 12 - 13 May, 2017.
2017 Speaker at the National Congress FederDolore SICD on Neuropathic Pain ("Congresso Nazionale FederDolore SCID: Il Dolore Neuropatico"). Cagliari, 28 - 30 June, 2017.
2017 Speaker at the 10th Congress of the European Pain Federation. Copenhagen, 6-9 September, 2017. Title of the presentation: Diagnostic accuracy of laser evoked potentials in diabetic neuropathy .
2017 Speaker at the XVII National Congress of the Italian Society for Neuroscience. Ischia, 1 - 4 October, 2017. Title of the presentation: Pathophysiological mechanisms of trigeminal neuralgia .
2018 Speaker at the XLIX SIN Congress. Title of the presentation: Neurophysiological and neuroimaging study of typical and atypical trigeminal neuralgia .
2018 Moderator of the Poster session Pain during the XLIX SIN Congress
2019 Moderator of the Poster session Headache and Pain during the 64° SINC Congress
2019 Promoter and moderator of the session study group Neurophysiology of Pain (Sessione Gruppo di Studio Neurofisiologia del dolore ) during the 64° SINC Congress.
2019 Speaker at the Laser and Pain Talks in Europe, 9th edition . Title of the presentation: N13-SEP as a possible biomarker for central sensitization . Lyon 23-25 May, 2019
2019 Participation to the 7th International Congress on Neuropathic Pain with an abstract titled: Neurophysiological and neuroimaging study of typical and atypical trigeminal neuralgia . London 8-11 May, 2019
2020 Speaker at the SIN Meeting with subject: The demand of neurological competences in the next future ( La richiesta di competenza neurologica nel prossimo futuro ). Title of the presentation: Voltage-Gated Na+ Channels variations in the pathogenesis of neuropathic pain . FADSIN Web Platform (www.fadsin.it), 12 - 14 June, 2020

2021 Speaker at the FAD Course on Neuropathic Pain: physiopathology, diagnosis and treatment ( Dolore Neuropatico: fisiopatologia, diagnosi e trattamento ). Title of the presentation: Il dolore neuropatico centrale: quando sospettarlo e come identificarlo
2021 Promoter and moderator of the session study group Neurophysiology of Pain (Sessione Gruppo di Studio Neurofisiologia del dolore ) during the 65° SINC Congress.
2022 Speaker at the GDS SIN on Neuropathic Pain. Title of the presentation: Il contributo della neurofisiologia clinica nella diagnosi di dolore neuropatico . WEBINAR 20 GENNAIO 2022
2022 Speaker at the SIN meeting La settimana del cervello: Le stagioni del cervello Title of the presentation: Cambia la percezione del dolore durante la nostra vita? 14 marzo 2022.
2022 Promoter and moderator of the session study group Neurophysiology of Pain (Sessione Gruppo di Studio Neurofisiologia del dolore ) during the 66° SINC Congress. Palermo, 18 Maggio 2022.
2022 Speaker at the SINC meeting RIUNIONE SINC MACRO AREA CENTRO SUD, NUOVE PROSPETTIVE DIAGNOSTICO TERAPEUTICHE IN NEUROFISIOLOGIA CLINICA. Session TECNICHE DI STUDIO DELLE VIE NOCICETTIVE , Title of the presentation: Tecniche non convenzionali . Webinar 18 Giugno 2022.
2022 Speaker at the 32nd International Congress of Clinical Neurophysiology (ICCN 2022) 4-8 September 2022. Title of the Course: Electrodiagnosis of Trigeminal and Facial Neuropathies .

Full list of Publications

1. De Stefano, G., Leone, C., Di Pietro, G., Truini, A., Di Stefano, G. Unravelling the role of unmyelinated nerve fibres in trigeminal neuralgia with concomitant continuous pain Clinical Neurophysiology, 2022, 142, pp. 52 58.
2. Galosi E, Leonardi L, Falco P, Di Pietro G, Fasolino A, Esposito N, Leone C, Di Stefano G, Inghilleri M, Luigetti M, Giovanni A, Truini A. Functional and morphometric assessment of small-fibre damage in late-onset hereditary transthyretin amyloidosis with polyneuropathy: the controversial relation between small-fibre-related symptoms and diagnostic test findings. Amyloid. 2022 Sep 12:1-8.
3. Gualdani R, Gailly P, Yuan JH, Yerna X, Di Stefano G, Truini A, Cruccu G, Dib-Hajj SD, Waxman SG. A TRPM7 mutation linked to familial trigeminal neuralgia: Omega current and hyperexcitability of trigeminal ganglion neurons. Proc Natl Acad Sci U S A 2022 Sep 20;119(38):e2119630119. DOI: 10.1073/pnas.2119630119.
4. Galosi E, Falco P, Di Pietro G, Leone C, Esposito N, De Stefano G, Di Stefano G, Truini A. The diagnostic accuracy of the Small Fiber Neuropathy Symptoms Inventory Questionnaire (SFN-SIQ) for identifying pure small fiber neuropathy. J Peripher Nerv Syst. 2022 Sep 29. doi: 10.1111/jns.12513
5. Galosi E, Truini A, Di Stefano G. A Systematic Review and Meta-Analysis of the Prevalence of Small Fibre Impairment in Patients with Fibromyalgia. Diagnostics 2022, 12(5), 1135; https://doi.org/10.3390/diagnostics12051135.
6. Dominguez M, Di Stefano G. Novel ways of approaching the pharmacologic treatment of trigeminal neuralgia. Headache. Headache. 2022 May;62(5):540-542.
doi: 10.1111/head.14316
7. Mouraux A, Bloms-Funke P, Boesl I, Caspani O, Chapman SC, Di Stefano G, Finnerup NB, Garcia-Larrea L, Goetz M, Kostenko A, Pelz B, Pogatzki-Zahn E, Schubart K, Stouffs A, Truini A, Tracey I, Troconiz IF, Van Niel J, Vela JM, Vincent K, Vollert J, Wanigasekera V, Wittayer M, Phillips KG, Treede RD. IMI2-PainCare-BioPain-RCT3: a randomized, double-blind, placebo-controlled, crossover, multi-center trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by electroencephalography (EEG). Trials. 2021 Jun 17;22(1):404.
8. Caterina Leone, Giulia Di Stefano, Giuseppe Di Pietro, Petra Bloms-Funke, Irmgard Boesl, Ombretta Caspani, Sonya C Chapman, Nanna Brix Finnerup, Luis Garcia-Larrea, Tom Li, Marcus Goetz, André Mouraux, Bernhard Pelz, Esther Pogatzki-Zahn, Andreas Schilder, Erik Schnetter, Karin Schubart, Irene Tracey, Inaki F Troconiz, Hans Van Niel, Jose Miguel Vela Hernandez, Katy Vincent, Jan Vollert, Vishvarani Wanigasekera, Matthias Wittayer, Keith G Phillips, Andrea Truini, Rolf-Detlef Treede. IMI2-PainCare-BioPain-RCT2 protocol: a randomized, double-blind, placebo-controlled, crossover, multicenter trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by non-invasive neurophysiological measurements of human spinal cord and brainstem activity. Trials, 2022, 23(1), 739
9. Leone C, Di Lionardo A, Di Pietro G, Di Stefano G, Falco P, Blockeel AJ, Caspani O, Garcia-Larrea L, Mouraux A, Phillips KG, Treede RD, Truini A, How different experimental models of secondary hyperalgesia change the nociceptive flexion reflex . CLINPH 2021 Dec;132(12):2989-2995;
10. Di Pietro G, Di Stefano G, Leone C, Di Lionardo A, Sgrò E, Blockeel AJ, Caspani O, Garcia-Larrea L, Mouraux A, Geoffrey Phillips K, Treede RD, Valeriani M, Truini A, The N13 spinal component of somatosensory evoked potentials is modulated by heterotopic noxious conditioning stimulation: evidence for involvement of spinal wide-dynamic range neurons . Neurophysiol Clin. 2021 Dec;51(6):517-523.
11. Di Lionardo et al. Modulation of the N13 component of the somatosensory evoked potentials in an experimental model of central sensitization in humans. Scientific Reports 2021 ahead-of-print.
12. Leandri M, Di Stefano G, Truini A, Marinelli L. Early nociceptive evoked potentials recorded from the scalp. Clin Neurophysiol. 2021 Jun 28:S1388-2457(21)00620-9.
13. Di Stefano G, Di Lionardo A, Di Pietro G, Cruccu G, Truini A. Pharmacotherapeutic Options for Managing Neuropathic Pain: A Systematic Review and Meta-Analysis. Pain Res Manag. 2021 Apr 26;2021:6656863.
14. Guerra A, Vicenzini E, Cioffi E, Colella D, Cannavacciuolo A, Pozzi S, Caccia B, Paparella G, Di Stefano G, Berardelli A, Bologna M. Effects of Transcranial Ultrasound Stimulation on Trigeminal Blink Reflex Excitability. 2021 Brain Sciences May 15;11(5):645.
15. G Di Stefano, G De Stefano, C Leone, A Di Lionardo, G Di Pietro, E Sgro, C Mollica, G Cruccu, A Truini. Real-world effectiveness and tolerability of carbamazepine and oxcarbazepine in 354 patients with trigeminal neuralgia. Eur J Pain. 2021 May;25(5):1064-1071.
16. Gualdani R, Yuan JH, Effraim P, Di Stefano G, Truini A, Cruccu G, Dib-hajj SD, Gailly P, and Waxman SG. Trigeminal neuralgia TRPM8 mutation: enhanced activation, basal [Ca2+]i and menthol response. Neurol Genet. 2021 Jan 11;7(1):e550.
17. Cruccu G, Di Stefano G, Truini A. Trigeminal Neuralgia. N Engl J Med. 2020 Aug 20;383(8):754-762.
18. Di Stefano G, Di Lionardo A, Di Pietro G, Truini A. Neuropathic Pain Related to Peripheral Neuropathies According to the IASP Grading System Criteria. Brain Sci. 2020 Dec 22;11(1):1.
19. Paparella G, Di Stefano G, Fasolino A, Di Pietro G, Colella D, Truini A, Cruccu G, Berardelli A, Bologna M. Painful stimulation increases spontaneous blink rate in healthy subjects. Sci Rep. 2020 Nov 17;10(1):20014.
20. Galosi E, Di Pietro G, La Cesa S, Di Stefano G, Leone C, Fasolino A; Di Lionardo A, Leonetti F, Buzzetti R, Mollica C, Cruccu G, Truini A. Differential involvement of myelinated and unmyelinated nerve fibers in painful diabetic polyneuropathy. Muscle Nerve. 2021 Jan;63(1):68-74.
21. Di Stefano G, De Stefano G, Leone C, Cruccu G, Fiorelli M, Truini A, Caramia F. Concomitant continuous pain in patients with trigeminal neuralgia is associated with trigeminal nerve root atrophy. Cephalalgia 2020 Nov;40(13):1502-1510.
22. Fasolino A, Di Stefano G, Leone C, Galosi E, Gioia C, Lucchino B, Terracciano A, Di Franco M, Cruccu G, Truini A. Small-fibre pathology has no impact on somatosensory system function in patients with fibromyalgia. Pain. 2020 Oct;161(10):2385-2393.
23. Leone C, Di Lionardo A, Diotallevi G, Mollica C, Di Pietro G, Di Stefano G, La Cesa S, Cruccu G, Truini A. Conduction velocity of the cold spinal pathway in healthy humans. Eur J Pain. 2020 Nov;24(10):1923-1931.
24. G Di Stefano, G De Stefano, A Di Lionardo, G Cruccu, A Truini. Pharmacotherapeutic Options for Managing Pain in Multiple Sclerosis. CNS Drugs. 2020 Jul;34(7):749-761.
25. Di Stefano G, Yuan JH, Cruccu G, Waxman SG, Dib-Hajj SD, Truini A. Familial trigeminal neuralgia - a systematic clinical study with a genomic screen of the neuronal electrogenisome. Cephalalgia. 2020 Jul;40(8):767-777.
26. Di Stefano G, Di Lionardo A, La Cesa S, Di Pietro G, Fasolino A, Galosi E, Leone C, Cruccu G, Marinelli L, Leandri M, Truini A. The new micropatterned interdigitated electrode for selective assessment of the nociceptive system. European Journal of Pain. 2020 May;24(5):956-966.
27. Bendtsen L, Zakrzewska JM, Abbott J, Braschinsky M, Di Stefano G, Donnet A, Eide PK, Leal PRL, Maarbjerg S, May A, Nurmikko T, Obermann M, Jensen TS, Cruccu G. European Academy of Neurology guideline on trigeminal neuralgia. Eur J Neurol. 2019 Jun;26(6):831-849.19.
28. Di Stefano G, Galosi E, Di Lionardo A, Truini A, Cruccu G. Acetyl-L-carnitine in painful peripheral neuropathy: a systematic review. J Pain Res. 2019 Apr 26;12:1341-1351
29. Di Stefano G, Maarbjerg S, Truini A. Trigeminal neuralgia secondary to multiple sclerosis: from the clinical picture to the treatment options. J Headache Pain. 2019 Feb 19;20(1):20.
30. Leone C, Dufour A, Di Stefano G, Fasolino A, Di Lionardo A, La Cesa S, Galosi E, Valeriani M, Nolano M, Cruccu G, Truini A. Cooling the skin for assessing small-fibre function. Pain. 2019 Sep;160(9):1967-1975.
31. Cruccu G, Di Stefano G, Marchettini P, Truini A. Micronized Palmitoylethanolamide: a Post-Hoc Analysis of a Controlled Study in Patients with Low Back Pain Sciatica. CNS Neurol Disord Drug Targets. 2019;18(6):491-495 23.
32. Di Stefano G, Maarbjerg S, Nurmikko T, Truini A, Cruccu G. Triggering trigeminal neuralgia. Cephalalgia. 2018 May;38(6):1049-1056.
33. Galosi E, La Cesa S, Di Stefano G, Karlsson P, Fasolino A, Leone C, Biasiotta A, Cruccu G, Truini A. A pain in the skin. Regenerating nerve sprouts are distinctly associated with ongoing burning pain in patients with diabetes. Eur J Pain. 2018 Nov;22(10):1727-1734.
34. Mancini F, Pepe A, Bernacchia a, Di Stefano G, Mouraux A, Iannetti GD. Characterising the short-term habituation of event-related evoked potentials. eNeuro. 2018 Sep 28;5(5):ENEURO.0014-18.2018.
35. Di Stefano G, Truini A, Cruccu G. Current and Innovative Pharmacological Options to Treat Typical and Atypical Trigeminal Neuralgia. Drugs. 2018 Sep;78(14):1433-1442.
36. Zakrzewska J, Palmer J, Bendtsen L, Di Stefano G, Ettlin D, Maarbjerg S, Obermann M, Morisset V, Steiner D, Tate S and Cruccu G. Challenges recruiting to a proof-of-concept pharmaceutical trial for a rare disease: the trigeminal neuralgia experience. Trials. 2018 Dec 27;19(1):704.
37. Maarbjerg S, Di Stefano G, Bendtsen L, Cruccu G. Trigeminal neuralgia - diagnosis and treatment. Cephalalgia. 2017 Jun;37(7):648-657.
38. Di Stefano G, La Cesa S, Leone C, Pepe A, Galosi E, Fiorelli M, Valeriani M, Lacerenza M, Pergolini M, Biasiotta A, Cruccu G, Truini A. Diagnostic accuracy of laser evoked potentials in diabetic neuropathyPain. 2017 Jun;158(6):1100-1107.
39. Di Stefano G, Limbucci N, Cruccu G, Truini A, Mangiafico S. Trigeminal neuralgia completely relieved after stent assisted coiling of a superior cerebellar artery aneurysm. World Neurosurg. 2017 May;101:812.e5-812.e9.
40. Stefano G, Tinelli E, Truini A. An unusual case of simultaneous bilateral trigeminal neuralgia due to multiple sclerosis. Di J Oral Facial Pain Headache. 2017 Fall;31(4):e4-e6.
41. Di Stefano G, Truini A. Pharmacological treatment of trigeminal neuralgia. Expert Rev Neurother. 2017 Oct;17(10):1003-1011.
42. La Cesa S, Di Stefano G, Leone C, Pepe A, Galosi E, Alu F, Fasolino A, Cruccu G, Valeriani M, Truini A.
Skin denervation does not alter cortical potentials to surface concentric electrode stimulation: a comparison with laser evoked potentials and contact heat evoked potentialsEur J Pain. 2018 Jan;22(1):161-169.
43. Bufacchi, R.J., Sambo, C.F., Di Stefano, G., Cruccu, G., Iannetti, G.D. Pain outside the body: Defensive peripersonal space deformation in trigeminal neuralgia. Sci Rep. 2017 Oct 2;7(1):12487.
44. Cruccu G, Di Stefano G, Fattaposta F, Jann S, Padua L, Schenone A, Truini A. L-Acetyl-carnitine in Patients with Carpal Tunnel Syndrome: Effects on Nerve Protection, Hand Function and Pain. CNS Drugs. 2017 Dec;31(12):1103-1111.
45. Di Stefano G, Celletti C, Baron R, Castori M, Di Franco M, La Cesa S, Leone C, Pepe A, Cruccu G, Truini A, Camerota F. Central sensitization as the mechanism underlying pain in joint hypermobility syndrome/Ehlers Danlos syndrome, hypermobility type. Eur J Pain. 2016 Sep;20(8):1319-25.
46. Leone C, Federico V, La Cesa S, Russo E, Di Stefano G, Finsinger P, Labriola R, Cruccu G, Petrucci MT, Truini A. An observational study assessing peripheral neuropathy related to multiple myeloma. Neurol Sci. 2016 Jul;37(7):1141-3.
47. Moayedi M, Di Stefano G, Stubbs MT, Djeugam B, Liang M, Iannetti GD. Nociceptive-Evoked Potentials Are Sensitive to Behaviorally Relevant Stimulus Displacements in Egocentric Coordinates. eNeuro. 2016 Jul 11;3(3).
48. Minichino A, Delle Chiaie R, Cruccu G, Piroso S, Di Stefano G, Francesconi M, Bersani FS, Biondi M, Truini A. Pain-processing abnormalities in bipolar I disorder, bipolar II disorder, and schizophrenia: A novel trait marker for psychosis proneness and functional outcome. Bipolar Disord. 2016 Nov;18(7):591-601.
49. Truini A, Biasiotta A, Onesti E, Di Stefano G, Ceccanti M, La Cesa S, Pepe A, Giordano C, Cruccu G, Inghilleri M. Small-fibre neuropathy related to bulbar and spinal-onset in patients with ALS. J Neurol. 2015;262(4):1014-8.
50. Truini A, Gerardi MC, Di Stefano G, La Cesa S, Iannuccelli C, Pepe A, Sarzi-Puttini P, Cruccu G, Di Franco M. Hyperexcitability in pain matrices in patients with fibromyalgia. Clin Exp Rheumatol. 2015 Jan-Feb;33(1 Suppl 88):S68-72.
51. Truini A, Piroso S, Pasquale E, Notartomaso S, Di Stefano G, Lattanzi R, Battaglia G, Nicoletti F, Cruccu G. N-acetyl-cysteine, a drug that enhances the endogenous activation of group-II metabotropic glutamate receptors, inhibits nociceptive transmission in humans. Mol Pain. 2015 Mar 20;11:14.
52. Lopergolo D, Isak B, Gabriele M, Onesti E, Ceccanti M, Capua G, Fionda L, Biasiotta A, Di Stefano G, La Cesa S, Frasca V, Inghilleri M. Cutaneous silent period recordings in demyelinating and axonal polyneuropathies. Clin Neurophysiol. 2015 Sep;126(9):1780-9.
53. Truini A, Biasiotta A, Di Stefano G, Leone C, La Cesa S, Galosi E, Piroso S, Pepe A, Giordano C, Cruccu G. Does the epidermal nerve fibre density measured by skin biopsy in patients with peripheral neuropathies correlate with neuropathic pain? Pain. 2014 Apr;155(4):828-32.
54. La Cesa S, Tinelli E, Toschi N, Di Stefano G, Collorone S, Aceti A, Francia A, Cruccu G, Truini A, Caramia F. fMRI pain activation in the periaqueductal gray in healthy volunteers during the cold pressor test. Magn Reson Imaging. 2014 Apr;32(3):236-40.
55. Biasiotta A, Casato M, La Cesa S, Colantuono S, Di Stefano G, Leone C, Carlesimo M, Piroso S, Cruccu G, Truini A. Clinical, neurophysiological, and skin biopsy findings in peripheral neuropathy associated with hepatitis C virus-related cryoglobulinemia. J Neurol. 2014 Apr;261(4):725-31.
56. Di Stefano G, La Cesa S, Truini A, Cruccu G. Natural history and outcome of 200 outpatients with classical trigeminal neuralgia treated with carbamazepine or oxcarbazepine in a tertiary centre for neuropathic pain. J Headache Pain. 2014 Jun 9;15(1):34.
57. Cruccu G, Pennisi EM, Antonini G, Biasiotta A, di Stefano G, La Cesa S, Leone C, Raffa S, Sommer C, Truini A. Trigeminal isolated sensory neuropathy (TISN) and FOSMN syndrome. Despite a dissimilar disease course do they share common pathophysiological mechanisms? BMC Neurol. 2014 Dec 19;14(1):248.
58. Truini A, Biasiotta A, Di Stefano G, La Cesa S, Leone C, Cartoni C, Leonetti F, Casato M, Pergolini M, Petrucci MT, Cruccu G. Peripheral nociceptor sensitization mediates allodynia in patients with distal symmetric polyneuropathy. J Neurol. 2013 Mar;260(3):761-6.
59. Onesti E, Gabriele M, Cambieri C, Ceccanti M, Raccah R, Di Stefano G, Biasiotta A, Truini A, Zangen A, Inghilleri M. H-coil repetitive transcranial magnetic stimulation for pain relief in patients with diabetic neuropathy. Eur J Pain. 2013 Oct;17(9):1347-56.7
60. Di Stefano G, La Cesa S, Biasiotta A, Leone C, Pepe A, Cruccu G, Truini A. Laboratory tools for assessing neuropathic pain. Neurol Sci. 2012 May; 33 Suppl 1:S5-7.
61. Truini A, Galeotti F, La Cesa S, Di Rezze S, Biasiotta A, Di Stefano G, Tinelli E, Millefiorini E, Gatti A, Cruccu G. Mechanisms of pain in multiple sclerosis: A combined clinical and neurophysiological study. Pain 2012 Oct;153(10):2048-54.
62. Truini A, Leone C, Di Stefano G, Biasiotta A, La Cesa S, Teofoli P, Padua L, Cruccu G. Topographical distribution of warmth, burning and itch sensations in healthy humans. Neurosci Lett. 2011 Apr 25;494(2):165-8.
63. Leone C, Biasiotta A, La Cesa S, Di Stefano G, Cruccu G, Truini A. Pathophysiological mechanisms of neuropathic pain. Future Neurology 2011, 6(4), pp. 497 509.
64. Truini A, Vergari M, Biasiotta A, La Cesa S, Gabriele M, Di Stefano G, Cambieri C, Cruccu G, Inghilleri M, Priori A. Transcutaneous spinal direct current stimulation inhibits nociceptive spinal pathway conduction and increases pain tolerance in humans. Eur J Pain. 2011 Nov;15(10):1023-7.
65. Truini A, Biasiotta A, Di Stefano G, La Cesa S, Leone C, Cartoni C, Federico V, Petrucci MT, Cruccu G. Palmitoylethanolamide restores myelinated-fibre function in patients with chemotherapy-induced painful neuropathy. CNS Neurol Disord Drug Targets. 2011 Dec;10(8):916-20.
66. Truini A, Biasiotta A, La Cesa S, Di Stefano G, Galeotti F, Petrucci MT, Inghilleri M, Cartoni C, Pergolini M, Cruccu G. Mechanism of pain in distal symmetric polyneuropathy: a combined clinical and neurophisiological study. Pain 2010 Sep; 150(3):516-21.

Textbook

1. Sistema Somatosensoriale . Di Stefano G, Truini A, Cruccu G. Capitolo II in La neurologia della Sapienza , Casa Editrice Esculapio, Ottobre 2012;

2. Malattie del Sistema Nervoso Periferico . Truini A, Di Stefano G, Cruccu G. Capitolo IXX in La neurologia della Sapienza , Casa Editrice Esculapio, Ottobre 2012.

3. Chapter 9 TREATMENT OF TRIGEMINAL NEURALGIA- pharmacological in Trigeminal Neuralgia and other Cranial Neuralgias: A Practical Personalised Holistic Approach (Oxford Pain Management Library Series) Edited by JOANNA ZAKRZEWSKA and TURO NURMIKKO.