Ritratto di Andrea.Mele@uniroma1.it

CURRICULUM VITAE

Name and Surname: Andrea Mele
Place and date of birth: Roma, 01.08.1961
Author Scopus ID: 46062283200
IRIS ID: rp47347
ORCID 0000-0002-3155-5610
Address: Centro di Ricerca in Neurobiologia Daniel Bovet
Dipartimento di Biologia e Biotecnologie,
Università di Roma La Sapienza
P.le Aldo Moro, 5
00185, Roma
Tel.: 39 06 4991 2244
Fax.:39 06 4991 280
E-mail: andrea.mele@uniroma1.it

ACADEMIC QUALIFICATIONS AND HONORS
July 1986 Degree in Biological Sciences (Master equivalent), Sapienza University of Rome, Italy. Major: molecular biology. Master thesis: Opiate receptors and aggressive behavior.
Dec 1987 - Dec 1990 Fogarty fellowship, NIH, NIMH.
July 1989 Research associate, Dept. of Genetics and Molecular Biology, Sapienza University of Rome, Italy.
July 2001 Assistant Professor, Dept. of Genetics and Molecular Biology, Sapienza University of Rome, Italy.
July 2001 Associate Professor in Psychobiology, qualification
Sept 2019 Full Professor in Psychobiology

CAREER OUTLINE
2019- Full Professor, Faculty of Sciences, Sapienza Università di Roma
2005-2019 Associate Professor, Faculty of Sciences, Sapienza Università di Roma provided the first evidence of spatial learning induced plasticity in the striatal complex Ferretti et al, PNAS, 2010 (23 citations).
2001-2005 Assistant Professor, Dept. of Genetics and Molecular Biology, Sapienza Università di Roma addressed the problem of the striatal complex in cognitive functions Sargolini et al, 1999 (43 citations) and Sargolini et al, 2003 (54 citations).
1993 Visiting scientist, Biological Psychiatry Branch, Behavioral Pharmacology Section, National Institute of Mental Health, Bethesda MD demonstrated that NMDA antagonists effects on motor activity are independent on dopamine, Mele et al., 1997 (54 citations).
1990-2001 Research Associate, Dept. of Genetics and Molecular Biology, Sapienza Università di Roma demonstrated changes in brain dopamine levels after repeated psychostimulants administrations Imperato, Mele, Eur J Pharmacol, 1992 (74 citations) and their effects on cognitive functions, Mandillo et al, Behav Pharmacol 2004 (88 citations).
1987-1990 Postdoctoral fellow, Biological Psychiatry Branch, Behavioral Pharmacology Section, National Institute of Mental Health, Bethesda MD., A. Pert investigated the effects of drug of abuse on DA release - Rothman, Mele, Pharmacol Biochem Behav 1991 (129 citations).
1987 Pre-doctoral Fellow, I.P.P, C.N.R., Roma (A. Oliverio).
1987 Pre-doctoral Fellow, Institute of Pharmacology, Sapienza University of Rome, Italy
1986 Visiting student, Centre de Neurochemie CNRS, Strasbourg, France (P. Mandel).
1981-1985 Pre-doctoral Fellow, Dept. of Genetic e Molecular Biology, Sapienza University of Rome, Italy.

ACADEMIC APPOINTMENTS AND PROFESSIONAL MEMBERSHIP
2019 Associate Editor, Frontiers in Behavioral Neuroscience
2019 - Steering Committee, Dept. of Biology and Biotechnology, Sapienza University of Rome.
2018 - Scuola di Studi Superiori Avanzati Sapienza Università di Roma, Classe di Scienze della Vita, Junior Fellow.
2013 - 2017 Executive Committee, Faculty of Sciences, Sapienza University of Rome.
2013 - 2017 Executive Committee, Dept. of Biology and Biotechnology, Sapienza University of Rome.
2007 - Center for Research in Neurobiology, Sapienza University of Rome, member of the executive committee.
2013 - Master of Science Program in Neurobiology, Faculty of Sciences, Sapienza University of Rome, President.
2013 PhD program Psychobiology and Psychopharmacology, Sapienza Università di Roma, Chair
2004 - 2012 Coordinator, Master of Science Program in Neurobiology, Faculty of Sciences, Sapienza University of Rome.
2005 - 2010 Executive Committee, Dept. of Genetics and Molecular Biology, Sapienza University of Rome.

TEACHING ACTIVITY
2017-present University of Bordeaux - Erasmus Agreement, (promoter and teacher)
2016-present Neurobiology of memory, MSc Neurobiology, Sapienza University of Rome.
2014-present Universitat de Barcelona, invited teacher, course on Neural development and neurological or psychiatric disorders, Master in Genetics and Genomics
2004-present Psychopharmacology, MSc Neurobiology, Sapienza University of Rome.
2004-2006 Psychobiology of Mental Disorders, MSc Neurobiology, Sapienza University of Rome.
2002-2011 Neuropsychopharmacology Biotechnology, Sapienza University of Rome.
2000-2003 General Psychology, Psychology, University G.D Annunzio , Chieti.
1999-2001 Introductory Psychobiology, Psychology, Libera Università Maria Santissima Assunta, Roma.

INVITED LESSONS (selection)
2018 SynaNet, Lisboa
2016 University of Bordeaux, Bordeaux
2015 University of Sussex, Brighton,
2015 University of Barcelona, Barcelona
2015 EBRI Foundation, Rome
2011 The emotional brain from neurobiology to new therapeutic opportunities, Rome
2010 Master in Giornalismo Scientifico, Sapienza Università di Roma.
2008 Tigem Napoli.
2008 International Symposium on Learning, Memory and Cognitive Function, Valencia
2007 EBPS Meeting, Roma
2006 EMBL, Monterotondo
2006 Università dell Aquila, L Aquila.
2004 EBPS Workshop on Neurobehavioural Plasticity, Rome
2003 Scuola S. Normale, Pisa.
2002 NBI, Amsterdam.
2002 NIMH, NIH, Bethesda.
2000 Fens, Brighton.
1997 BPB, NIMH, NIH, Bethesda.
1997 EBBS General Meeting, Tutzing.

MEETING ORGANIZATION
2013-present EMBL-Sapienza Neuroseminars
2011 Meeting in honor of Alberto Oliverio, (Rome) Organizing committee.
2009 13th Biennial Meeting of EBPS (Rome) Organizing committee.
2007 EBPS Workshop on Neurobehavioural Plasticity, (Rome) Organizing committee.
2007 The Growth of Neuroscience since Daniel Bovet's Years (Roma) President of the scientific committee.

PEER REVIEW
Funding agencies: Human Frontiers Science Program (HFSP), Dutch Science Foundation (N.W.O.), MIUR (ANVUR), Agence Nationale Recherche (A.N.R., Fr), Università di Torino.
Journals: Neuroscience, Psychopharmacology, Pharmacology, Biochemistry and Behavior, Neural Plasticity, Neuropharmacology, Learning and Memory, PlosOne, Behavioral Brain Research, Neurobiology of Learning and Memory, Neuroscience & Biobehavioral Reviews etc.

CURRENT RESEARCH INTERESTS
Temporal dynamics of experience dependent plasticity
Neural circuits underlying memory stabilization

CURRENT AND PAST RESEARCH SUPPORT AS PRINCIPAL INVESTIGATOR
2019 Human Brain Project Infrastructure Voucher Programme Call 2018. Mapping Brain Circuits in Spatial Navigation (MAPS). P.I. Andrea Mele
2017 NARSAD (100K $) The Neurobiological basis of the Spacing effect as a tool to identify new pharmacological targets for cognitive deficits P.I. Andrea Mele
2013 CNR (90K ) AGESPAN. CoP.I. Andrea Mele
2009 Merz Pharmaceuticals (30K ) Animal models of visuo-spatial deficits following dopaminergic system degenerations. CoP.I. Andrea Mele
2007 ASI (120K ) Stress and Memory. P.I. Andrea Mele
2005 ASI (80K ) Effects of gravity on cognition: behavioral and molecular correlates. CoP.I Andrea Mele with Alberto Oliverio.
2005 MIUR (70K ) Chronic cannabinoids and cognitive deficits: critical periods and biological basis. P.I. Andrea Mele
2006 CRUI-Galileo (ITA-FRA Partnership) Aspetti motori e cognitivi del Morbo di Parkinson: nuovi approcci terapeutici. P.I. Andrea Mele
2004 CRUI-Galileo (ITA-FRA Partnership) Nuovi approcci terapeutici per il trattamento dei deficit motori e cognitivi in due modelli complementari di Morbo di Parkinson. P.I. Andrea Mele
1999 CNR. Neurobiologia delle Psicosi maggiori, sviluppo e validazione di un progetto per la validazione di un modello animale per lo studio delle basi neurobiologiche della schizofrenia. P.I. Andrea Mele
1996 CNR. Funzioni e sito di azione degli antagonisti dei recettori NMDA nel modulare l'attività motoria. P.I. Andrea Mele

SAPIENZA INTERNAL SUPPORT
2019 Sapienza Università di Roma (13.5K ). It s just a matter of times. P.I. Andrea Mele
2018 Sapienza Università di Roma (30K ). Role of oxytocin in pain-induced relapse into prescription opioid abuse. coP.I. Andrea Mele
2017 Sapienza Università di Roma (14K ). Molecular and anatomical bases of memory. P.I. Andrea Mele
2015 Sapienza Università di Roma (31K ). Molecular and anatomical bases of memory. P.I. Andrea Mele
2015 Sapienza Università di Roma (4K ). Neuroplasticità: dalle molecole al comportamento (Congressi). P.I. Andrea Mele
2014 Sapienza University of Rome (40K ). Fenotipizzazione comportamentale in modelli animali di patologie umane. P.I. Andrea Mele
2012 Sapienza University of Rome (40K ). Striatal plasticity associated with liability to compulsion. CoP.I. Andrea Mele
2011 Sapienza University of Rome (45K ). Mechanisms of neuroplasticity associated with normal learning and psychopathogenesis in the adult brain. CoP.I. Andrea Mele
2010 Sapienza University of Rome (50K ). Corticostriatal networks subserving habit learning, high motivational drives and stress adaptation: shared nodes. CoP.I. Andrea Mele

MAJOR CONTRIBUTIONS TO THE EARLY CAREERS OF EXCELLENT RESEARCHERS
Mentored pre- and post-doctoral fellows (present position; years at SAPIENZA, 1st author, total publication):
Pascal Roullet, Full Professor, Université Paul Sabatier, Toulouse: 1996; 4, 13.
Alessandro Usiello, Full professor, Seconda Università di Napoli: 1994; 1; 2.
Francesca Sargolini Maître de Conférences Laboratoire de Neurosciences Cognitives UMR 7291 Aix-Marseille Université-CNR; 1996-2002; 4; 11. first author on keynote paper 2014 Nobel prize to Ed and May Britt Moser.
Roberto Coccurello Senior fellow IBCN-C.N.R.; 1998-2001; 4; 6.
Pauline Lafenetre Maître de conférence, Université Bordeaux 1 & 2: 1998; 0, 1.
Elvira De Leonibus Senior fellow IIGB-C.N.R.; 1997-2002; 2004-2007; 8; 14.
Arianna Rinaldi Assistant professor, Dipartimento di Biologia e Biotecnologie, Sapienza Università di Roma; 2002-2007; 4; 9.
Valentina Ferretti: Postdoctoral fellow IIT; 2002-2008; 3; 4.
Fabrizio Capitano Postdoctoral fellow University of Nice Sophia Antipolis; 2009-2015; 3; 5

PUBBLICATIONS
Total Citations: 2492 (Scopus), 3195 (Google Scholar).
H index: 32 (Scopus), 35 (Google Scholar).

Top-7 senior author publications (of 29 senior author publications)
1. Roullet, P., Sargolini, F., Oliverio, A., & Mele, A. (2001). NMDA and AMPA antagonist infusions into the ventral striatum impair different steps of spatial information processing in a nonassociative task in mice. The Journal of Neuroscience 21(6), 2143 9 - first systematic description of the differential role of AMPA and NMDA receptors in long-term memory formation (66 citations).
2. Rinaldi, A., Mandillo, S., Oliverio, A., & Mele, A. (2007). D1 and D2 receptor antagonist injections in the prefrontal cortex selectively impair spatial learning in mice. Neuropsychopharmacology, 32(2), 309 19 (46 citations).
3. Rinaldi, A., Vincenti, S., De Vito, F., Bozzoni, I., Oliverio, A., Presutti, C., Fragapane, P., & Mele, A.. (2010). Stress induces region specific alterations in microRNAs expression in mice. Behavioural Brain Research, 208(1), 265 9 first in vivo demonstration of brain region dependent stress induced modulation of miRNAs expression (100 citations).
4. Ferretti, V., Roullet, P., Sargolini, F., Rinaldi, A., Perri, V., Del Fabbro, M., Costantini, V. J. A., Annese, V., Scesaa, G., De Stefano, M.E., Oliverio, A. & Mele, A. (2010). Ventral striatal plasticity and spatial memory. Proceedings of the National Academy of Sciences of the United States of America, 107(17), 7945 50 - [Reviewed in: Bermudez-Rattoni (2010) Is memory consolidation a multiple-circuit system? PNAS (107): 8051-52] first evidence that successful consolidation of spatial information requires protein synthesis in the ventral striatum. (26 citations).
5. Coccurello, R., Oliverio, A., & Mele, A. (2012). Dopamine-Glutamate Interplay in the Ventral Striatum Modulates Spatial Learning in a Receptor Subtype-Dependent Manner. Neuropsychopharmacology : 37(5), 1122 1133 - first time demonstration of a selective dopamine/glutamate receptors interactions and their role in shaping behavior (15 citations).
6. De Leonibus, E., Managò, F., Giordani, F., Petrosino, F., Lopez, S., Oliverio, A., Amalric, M., & Mele, A. (2009). Metabotropic glutamate receptors 5 blockade reverses spatial memory deficits in a mouse model of Parkinson s disease. Neuropsychopharmacology 34(3), 729 38 first demonstration, in a mouse model of Parkinson Disease, that systemic pharmacological treatments with drugs with potential therapeutic efficacy on motor symptoms can also reverse the cognitive deficits (47 citations).
7. Ferretti V., Perri V., Cristofoli A., Vetere G., Fragapane P., Oliverio A., Ammassari Teule M., Mele A. (2015) AMPA receptor phosphorylation within the ventral striatum is required for long term spatial memory and plasticity. Brain Structure and Function. Doi 10.1007/s00429-014-0816-7 - first in vivo demonstration that AMPA receptors phosphorylation acts as an essential starting signal for long-term memory stabilization (11 citations).

Peer reviewed papers
Andrea Mele
Research articles: 72 (3 submitted)
Book chapters: 3
Indici Biobliometrici:
Total Citations: 2455 (Scopus)
H index: 32 (Scopus)

1. Puglisi-Allegra, S., Mele, A., & Cabib, S. (1984). Involvement of endogenous opioid systems in social behavior of individually-housed mice. Progress in clinical and biological research, 167, 209 25.
2. Mele, A, Cabib, S., Oliverio, A., Melchiorri, P., & Puglisi-Allegra, S. (1987). Effects of corticotropin releasing factor and sauvagine on social behavior of isolated mice. Peptides, 8(5), 935 8.
3. Cabib, S, Kempf, E., Schleef, C., Mele, A., & Puglisi-Allegra, S. (1988). Different effects of acute and chronic stress on two dopamine-mediated behaviors in the mouse. Physiology & behavior, 43(2), 223 7.
4. Rothman, R. B., Mele, A., Reid, A A, Akunne, H., Greig, N., Thurkauf, A., Rice, K. C., & Pert, A.l. (1989). Tight binding dopamine reuptake inhibitors as cocaine antagonists. A strategy for drug development. FEBS letters, 257(2), 341 4.
5. Rothman, R. B., Mele, A., Reid, A. A., Akunne, H., Grieg, N., Thurkauf, A., DeCosta, B. R., Rice, K C, & Pert, A. (1990). Preliminary evidence that the high affinity dopamine reuptake inhibitor, GBR12909, antagonizes the ability of cocaine to elevate extracellular levels of dopamine. NIDA research monograph, 105, 359 60.
6. Glue, P., Costello, M. J., Pert, A., Mele, A., & Nutt, D. J. (1990). Regional neurotransmitter responses after acute and chronic electroconvulsive shock. Psychopharmacology, 100(1), 60 5.
7. Castellano, C., Mele, A. & Oliverio, A. Glutamatergic-cholinergic interaction on memory consolidation in mice. Psychobiology 24, 57 61 (1996).
8. Wozniak, K. M., Pert, A., Mele, A., & Linnoila, M. (1991). Focal application of alcohols elevates extracellular dopamine in rat brain: a microdialysis study. Brain research, 540(1-2), 31 40.
9. Rothman, R. B., Mele, A., Reid, A. A., Akunne, H. C., Greig, N., Thurkauf, A., de Costa, B. R., Rice, K C, & Pert, A. (1991). GBR12909 antagonizes the ability of cocaine to elevate extracellular levels of dopamine. Pharmacology, biochemistry, and behavior, 40(2), 387 97.
10. Hamilton, M. E., Mele, A., & Pert, A. (1992). Striatal extracellular dopamine in conscious vs. anesthetized rats: effects of chloral hydrate anesthetic on responses to drugs of different classes. Brain research, 597(1), 1 7.
11. Imperato, A., Mele, A., Scrocco, M. G., & Puglisi-Allegra, S. (1992). Chronic cocaine alters limbic extracellular dopamine. Neurochemical basis for addiction. European journal of pharmacology, 212(2-3), 299 300.
12. Mele, A, Battaglia, M., & Sansone, M. (1994). Reversal of chlorpromazine-induced avoidance depression by the N-methyl-D-aspartate antagonist, dizocilpine, in mice. The Journal of pharmacy and pharmacology, 46(5), 390 2.
13. Mele, A, Cabib, S., & Oliverio, A. (1995). Effects of the NMDA-antagonist, MK-801, on stress-induced alterations of dopamine dependent behavior. Psychopharmacology, 117(3), 313 7.
14. Mele, A., Castellano, C., Cestari, V., & Oliverio, A. (1995). Interaction between the NMDA competitive antagonist CPP and the dopaminergic system in one-trial inhibitory avoidance in C57BL/6 mice. Neurobiology of learning and memory, 63(2), 143 8.
15. Mele, A., Castellano, C., & Oliverio, A. (1995). Chronic treatment with MK-801 affects the behavioral response to both D1 and D2 dopamine agonist in the one-trial inhibitory avoidance. Psychopharmacology, 121(3), 401 5.
16. Roullet, P., Mele, A., & Ammassari-Teule, M. (1996). Involvement of glutamatergic and dopaminergic systems in the reactivity of mice to spatial and non-spatial change. Psychopharmacology, 126(1), 55 61.
17. Cestari, V., Mele, A., Oliverio, A., & Castellano, C. (1996). Amygdala lesions block the effect of cocaine on memory in mice. Brain Research, 713(1-2), 286 9.
18. Mele, A., Castellano, C., Felici, A., Cabib, S., Caccia, S., & Oliverio, A. (1996). Dopamine-N-methyl-D-aspartate interactions in the modulation of locomotor activity and memory consolidation in mice. European journal of pharmacology, 308(1), 1 12.
19. Mele, Andrea, Fontana, D., & Pert, A. (1997). Alterations in striatal dopamine overflow during rotational behavior induced by amphetamine, phencyclidine, and MK-801. Synapse (New York, N.Y.), 26(3), 218 24.
20. Roullet, P., Mele, A., & Ammassari-Teule, M. (1997). Ibotenic lesions of the nucleus accumbens promote reactivity to spatial novelty in nonreactive DBA mice: implications for neural mechanisms subserving spatial information encoding. Behavioral neuroscience, 111(5), 976 84.
21. Adriani, W., Felici, A., Sargolini, F., Roullet, P., Usiello, A., Oliverio, A., & Mele, A. (1998). N-methyl-D-aspartate and dopamine receptor involvement in the modulation of locomotor activity and memory processes. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale, 123(1-2), 52 9.
22. Cabib, S., Giardino, L., Calzá, L., Zanni, M., Mele, A., & Puglisi-Allegra, S. (1998). Stress promotes major changes in dopamine receptor densities within the mesoaccumbens and nigrostriatal systems. Neuroscience, 84(1), 193 200.
23. Mele, A., Thomas, D. N., & Pert, A. (1998). Different neural mechanisms underlie dizocilpine maleate- and dopamine agonist-induced locomotor activity. Neuroscience, 82(1), 43 58.
24. Mele, A., Wozniak, K. M., Hall, F. S., & Pert, A. (1998). The role of striatal dopaminergic mechanisms in rotational behavior induced by phencyclidine and phencyclidine-like drugs. Psychopharmacology, 135(2), 107 18.
25. Usiello, A., Sargolini, F., Roullet, P., Ammassari-Teule, M., Passino, E., Oliverio, A., & Mele, A. (1998). N-methyl-D-aspartate receptors in the nucleus accumbens are involved in detection of spatial novelty in mice. Psychopharmacology, 137(2), 175 83.
26. Sargolini, F., Roullet, P., Oliverio, A., & Mele, A. (1999). Effects of lesions to the glutamatergic afferents to the nucleus accumbens in the modulation of reactivity to spatial and non-spatial novelty in mice. Neuroscience, 93(3), 855 867.
27. Adriani, W., Sargolini, F., Coccurello, R., Oliverio, A., & Mele, A. (2000). Role of dopaminergic system in reactivity to spatial and non-spatial changes in mice. Psychopharmacology, 150(1), 67 76.
28. Coccurello, R., Adriani, W., Oliverio, A., & Mele, A. (2000). Effect of intra-accumbens dopamine receptor agents on reactivity to spatial and non-spatial changes in mice. Psychopharmacology, 152(2), 189 99.
29. De Leonibus, E., Mele, A., Oliverio, A., & Pert, A. (2001). Locomotor activity induced by the non-competitive N-methyl-D-aspartate antagonist, MK-801: role of nucleus accumbens efferent pathways. Neuroscience, 104(1), 105 16.
30. Roullet, P., Sargolini, F., Oliverio, A., & Mele, A. (2001). NMDA and AMPA antagonist infusions into the ventral striatum impair different steps of spatial information processing in a nonassociative task in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience, 21(6), 2143 9.
31. Coccurello, R., Castellano, C., Paggi, P., Mele, A., & Oliverio, A. (2002). Genetically dystrophic mdx/mdx mice exhibit decreased response to nicotine in passive avoidance. Neuroreport, 13(9), 1219 22.
32. De Leonibus, E., Mele, A., Oliverio, A., & Pert, A. (2002). Distinct pattern of c-fos mRNA expression after systemic and intra-accumbens amphetamine and MK-801. Neuroscience, 115(1), 67 78.
33. De Leonibus, E., Costantini, V. J. A., Castellano, C., Ferretti, V., Oliverio, A., & Mele, A. (2003). Distinct roles of the different ionotropic glutamate receptors within the nucleus accumbens in passive-avoidance learning and memory in mice. European Journal of Neuroscience, 18(8), 2365 2373.
34. De Leonibus, E., Lafenetre, P., Oliverio, A., & Mele, A. (2003). Pharmacological evidence of the role of dorsal striatum in spatial memory consolidation in mice. Behavioral Neuroscience, 117(4), 685 694.
35. Mandillo, S., Del Signore, A., Paggi, P., Francia, N., Santucci, D., Mele, A., & Oliverio, A. (2003). Effects of acute and repeated daily exposure to hypergravity on spatial learning in mice. Neuroscience Letters, 336(3), 147 150.
36. Mandillo, S., Rinaldi, A., Oliverio, A., & Mele, A. (2003). Repeated administration of phencyclidine, amphetamine and MK-801 selectively impairs spatial learning in mice: a possible model of psychotomimetic drug-induced cognitive deficits. Behavioural pharmacology, 14(7), 533 44.
37. Sargolini, F., Florian, C., Oliverio, A., Mele, A., & Roullet, P. (2003). Differential involvement of NMDA and AMPA receptors within the nucleus accumbens in consolidation of information necessary for place navigation and guidance strategy of mice. Learning & memory (Cold Spring Harbor, N.Y.), 10(4), 285 92.
38. Sargolini, F., Roullet, P., Oliverio, A., & Mele, A. (2003). Effects of intra-accumbens focal administrations of glutamate antagonists on object recognition memory in mice. Behavioural brain research, 138(2), 153 63.
39. Del Signore, A., Mandillo, S., Rizzo, A., Di Mauro, E., Mele, A., Negri, R., Oliverio, A., & Paggi, P. (2004). Hippocampal gene expression is modulated by hypergravity. The European journal of neuroscience, 19(3), 667 77.
40. Mele, A., Avena, M., Roullet, P., De Leonibus, E., Mandillo, S., Sargolini, F., Coccurello, R., & Oliverio, A. (2004). Nucleus accumbens dopamine receptors in the consolidation of spatial memory. Behavioural pharmacology, 15(5-6), 423 31.
41. De Leonibus, E., Oliverio, A., & Mele, A. (2005). A study on the role of the dorsal striatum and the nucleus accumbens in allocentric and egocentric spatial memory consolidation. Learning & memory (Cold Spring Harbor, N.Y.), 12(5), 491 503. doi:10.1101/lm.94805
42. Ferretti, V., Florian, C., Costantini, V. J. A., Roullet, P., Rinaldi, A., De Leonibus, E., Oliverio, A., & Mele, A. (2005). Co-activation of glutamate and dopamine receptors within the nucleus accumbens is required for spatial memory consolidation in mice. Psychopharmacology, 179, 108 116.
43. De Leonibus, E., Verheij, M. M. M., Mele, A., & Cools, A. (2006). Distinct kinds of novelty processing differentially increase extracellular dopamine in different brain regions. The European journal of neuroscience, 23(5), 1332 40.
44. De Leonibus, E., Pascucci, T., Lopez, S., Oliverio, A., Amalric, M., & Mele, A. (2007). Spatial deficits in a mouse model of Parkinson disease. Psychopharmacology, 194(4), 517 25.
45. Ferretti, V., Sargolini, F., Oliverio, A., Mele, A., & Roullet, P. (2007). Effects of intra-accumbens NMDA and AMPA receptor antagonists on short-term spatial learning in the Morris water maze task. Behavioural brain research, 179(1), 43 9.
46. Lopez, S., Turle-Lorenzo, N., Acher, F., De Leonibus, E., Mele, A., & Amalric, M. (2007). Targeting group III metabotropic glutamate receptors produces complex behavioral effects in rodent models of Parkinson s disease. The Journal of neuroscience : the official journal of the Society for Neuroscience, 27(25), 6701 11.
47. Pilo Boyl, P., Di Nardo, A., Mulle, C., Sassoè-Pognetto, M., Panzanelli, P., Mele, A., Kneussel, M., Costantini, V. J., Perlas, E. Massimi, M., Vara, H., Giustetto, M. and Witke, W. (2007). Profilin2 contributes to synaptic vesicle exocytosis, neuronal excitability, and novelty-seeking behavior. The EMBO journal, 26(12), 2991 3002.
48. Rinaldi, A., Mandillo, S., Oliverio, A., & Mele, A. (2007). D1 and D2 receptor antagonist injections in the prefrontal cortex selectively impair spatial learning in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 32(2), 309 19.
49. De Leonibus, E., Managò, F., Giordani, F., Petrosino, F., Lopez, S., Oliverio, A., Amalric, M., & Mele, A. (2009). Metabotropic glutamate receptors 5 blockade reverses spatial memory deficits in a mouse model of Parkinson s disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 34(3), 729 38.
50. Managò, F., Castellano, C., Oliverio, A., Mele, A., & De Leonibus, E. (2009). Role of dopamine receptors subtypes, D1-like and D2-like, within the nucleus accumbens subregions, core and shell, on memory consolidation in the one-trial inhibitory avoidance task. Learning & memory (Cold Spring Harbor, N.Y.), 16(1), 46 52.
51. Ferretti, V., Roullet, P., Sargolini, F., Rinaldi, A., Perri, V., Del Fabbro, M., Costantini, V. J. A., Annese, V., Gianluigi Scesa, G., De Stefano, M.E., Alberto Oliverio, A. & Mele, A. (2010). Ventral striatal plasticity and spatial memory. Proceedings of the National Academy of Sciences of the United States of America, 107(17), 7945 50.
52. Rinaldi, A., Romeo, S., Agustín-Pavón, C., Oliverio, A., & Mele, A. (2010). Distinct patterns of Fos immunoreactivity in striatum and hippocampus induced by different kinds of novelty in mice. Neurobiology of learning and memory, 94(3), 373 81.
53. Rinaldi, A., Vincenti, S., De Vito, F., Bozzoni, I., Oliverio, A., Presutti, C., Fragapane, P., & Mele, A.. (2010). Stress induces region specific alterations in microRNAs expression in mice. Behavioural brain research, 208(1), 265 9.
54. Tomassy, G. S., De Leonibus, E., Jabaudon, D., Lodato, S., Alfano, C., Mele, A., Macklis, J. D., & Studer, M. (2010). Area-specific temporal control of corticospinal motor neuron differentiation by COUP-TFI. Proceedings of the National Academy of Sciences of the United States of America, 107(8), 3576 81.
55. De Leonibus, E., Costantini, V. J. A., Massaro, A., Mandolesi, G., Vanni, V., Luvisetto, S., Pavone, F., Oliverio, A., & Mele, A. (2011). Cognitive and neural determinants of response strategy in the dual-solution plus-maze task. Learning & memory (Cold Spring Harbor, N.Y.), 18(4), 241 4.
56. Coccurello, R., Oliverio, A., & Mele, A. (2012). Dopamine-Glutamate Interplay in the Ventral Striatum Modulates Spatial Learning in a Receptor Subtype-Dependent Manner. Neuropsychopharmacology : 37(5), 1122 1133.
57. Rinaldi, A., Oliverio, A., & Mele, A. (2012). Spatial memory, plasticity and nucleus accumbens. Reviews in the neurosciences 23(5-6), 527-41. doi: 10.1515/revneuro-2012-0070
58. Manago, F., Lopez, S., Oliverio, A., Amalric, M., Mele A. & De Leonibus, E. (2013) Interaction between the mGlu receptors 5 antagonist, MPEP, and amphetamine on memory and motor functions. Psychopharmacology 226(3), 541-50. doi: 10.1007/s00213-012-2925-4.
59. Coccurello, R., Oliverio, A. & Mele, A. (2013) Impairing effect of amphetamine and concomitant ionotropic glutamate receptors blockade in the ventral striatum on spatial learning in mice. Psychopharmacology 227(4):651-60. Doi, 10.1007/s00213-013-2989-9
60. Mannironi C., Camon J., De Vito F., Biundo A., De Stefano M.E., Persiconi I., Bozzoni I., Fragapane P., Mele A., Presutti C., (2013) Acute stress alters amygdala microRNA miR-135a and miR-124 expression: inferences for corticosteroid dependent stress response PlosOne 2013 Sep 4;8(9):e73385. doi: 10.1371/journal.pone.0073385.
61. Gaglio, D., Capitano, F., Mastrodonato, A., Minicocci, E., Deiana, C., Fragapane, P., Mele, A. (2014). Learning induced epigenetic modifications in the ventral striatum are necessary for long-term memory. Behavioural Brain Research, 265, 61 8. http://doi.org/10.1016/j.bbr.2014.02.006
62. Ferretti, V., Perri, V., Cristofoli, A., Vetere, G., Fragapane, P., Oliverio, A., Mele, A. (2015). Phosphorylation of S845 GluA1 AMPA receptors modulates spatial memory and structural plasticity in the ventral striatum. Brain Structure & Function, 220(5), 2653 61. http://doi.org/10.1007/s00429-014-0816-7
63. Olivito, L., Saccone, P., Perri, V., Bachman, J. L., Fragapane, P., Mele, A., De Leonibus, E. (2016). Phosphorylation of the AMPA receptor GluA1 subunit regulates memory load capacity. Brain Structure & Function, 221(1), 591 603. http://doi.org/10.1007/s00429-014-0927-1
64. Capitano, F., Camon, J., Ferretti, V., Licursi, V., De Vito, F, Rinadi, A., Vincenti, S., Mannironi, C., Fragapane, P., Bozzoni, I., Oliverio, A., Negri, R., Presutti, C., Mele, A. (2016) micro-RNAs modulate spatial memory in the hippocampus and in the ventral striatum in a region specific manner. Molecular Neurobiology, 53(7), 4618-4630 Doi 10.1007/s12035-015-9398-5
65. Capitano, F., Gargiuli, C., Angerilli, A., Maccaroni, K., Pelliccia, F., Mele, A., & Camilloni, G. (2016). RNA polymerase I transcription is modulated by spatial learning in different brain regions. Journal of Neurochemistry, 136(4), 706 716. http://doi.org/10.1111/jnc.13504
66. Mannironi, C., Biundo, A., Rajendran, S., De Vito, F., Saba, L., Caioli, S., Mele, A., Presutti, C. (2017). miR-135a Regulates Synaptic Transmission and Anxiety-Like Behavior in Amygdala. Molecular Neurobiology. http://doi.org/10.1007/s12035-017-0564-9
67. Capitano, F., Camon, J., Licursi, V., Ferretti, V., Maggi, L., Scianni, M., Mele, A. (2017). MicroRNA-335-5p modulates spatial memory and hippocampal synaptic plasticity. Neurobiology of Learning and Memory, 139, 63 68. http://doi.org/10.1016/j.nlm.2016.12.019 (I.F.5y: 2.168)
68. Cappucci, U., Torromino, G., Casale, A.M., Camon, J., Capitano, F., Berloco, M., Mele, A., Pimpinelli, A., Rinaldi, A., Piacentini, L. (2018) Stress-induced strain and brain region specific activation of LINE-1 transposons in adult mice. Stress, 21(6), 575-579. http://doi.org/10.1080/10253890.2018.1485647 (I.F.5y: 2.168)
69. Torromino, G, Autore, L., Khalil, V., Mastrorilli, V., Centofante, E., Biasini, G.M., Pignataro, A. Griguoli, M., De Turris,V., Ammassari-Teule, M., Rinaldi, M., and Mele, A. (2019) Ventral subiculum-ventral striatum communication is required for spatial memory consolidation Nature Communications, 10, 5721, https://doi.org/10.1038/s41467-019-13703-3 (I.F.5y: 13.81)
70. De Risi, M., Torromino, G., Tufano, M., Moriceau, S., Rivagorda, M., Pignataro, A., Ammassari-Teule, M., Gardoni, F., Middei, S., Mele, A., Oury, F. and De Leonibus E. Spermidine restores memory-induced post-translational modifications of AMPA receptors in middle-aged mice: role of autophagy. (submitted for publication).
71. Flati, T., Gioiosa, S., Chillemi, G., Mele, A., Oliverio, A., Mannironi, C., Rinaldi, A. and Castriglianò, T. Stress mice portal: a trascriptomic data web resource and gene expression atlas for different kinds of stress. (submitted for publication).
72. Rinaldi, A., De Leonibus, E., Cifra, A., Torromino, G., Minicocci, E., Oliverio, A. and Mele, A. Differential effect of novelty on the neural networks activated during allocentric and egocentric spatial memory retrieval. (submitted for publication).

Book chapters
1. Puglisi-Allegra S., Mele A. and Cabib S. Involvement of endogenous opiods system in social behavior of individually housed mice. In: "Ethopharmacological Aggression Research" (K.A. Miczeck, M. Kruk and B. Olivier eds.), 209-225. Alan R. Liss Inc., New York, 1984.
2. Rothman R.B., Mele A., Reid A.A., Akunne H.C., Greig N., Thurkauf A., de Costa B.R., Rice K.C. and Pert A. Preliminary evidence that the high affinity dopamine reuptake inhibitor, GBR12909, antagonizes the ability of to elevate extracellular levels of dopamine. NIDA Research Monographs 105: 359-360, 1991.
3. Roullet P., Mele A. and Ammassari-Teule M. Reactivity of mice to spatial and non spatial change: effect of haloperidol and MK-801 treatments. In "Macromolecular Interplay in Brain Associative Mechanisms" (Anna Neugebauer ed.), pp 117-122, World Scientific Press, Singapore, New York, London, Hong Kong, 1998.

Insegnamento Codice Anno Corso - Frequentare
PSYCHOBIOLOGY WITH ELEMENTS OF PSYCHOPHARMACOLOGY 10592805 2021/2022 Neurobiologia - Neurobiology
NEUROBIOLOGY OF MEMORY 1055713 2021/2022 Neurobiologia - Neurobiology
PSYCHOBIOLOGY WITH ELEMENTS OF PSYCHOPHARMACOLOGY 10592805 2021/2022 Genetica e Biologia Molecolare - Genetics and Molecular Biology
PSYCHOBIOLOGY WITH ELEMENTS OF PSYCHOPHARMACOLOGY 10592805 2020/2021 Neurobiologia - Neurobiology
NEUROBIOLOGY OF MEMORY 1055713 2020/2021 Neurobiologia - Neurobiology
PSYCHOBIOLOGY WITH ELEMENTS OF PSYCHOPHARMACOLOGY 10592805 2020/2021 Genetica e Biologia Molecolare - Genetics and Molecular Biology
NEUROBIOLOGY OF MEMORY 1055713 2019/2020 Neurobiologia
PSYCHOBIOLOGY WITH ELEMENTS OF PSYCHOPHARMACOLOGY 10592805 2019/2020 Neurobiologia
PSYCHOBIOLOGY WITH ELEMENTS OF PSYCHOPHARMACOLOGY 10592805 2019/2020 Genetica e Biologia Molecolare
TIROCINIO AAF1041 2018/2019 Neurobiologia
PSYCHOPHARMACOLOGY 1051928 2018/2019 Neurobiologia
NEUROBIOLOGY OF MEMORY 1055713 2018/2019 Neurobiologia
PSYCHOBIOLOGY 1052230 2018/2019 Neurobiologia
PSYCHOBIOLOGY 1052230 2018/2019 Genetica e Biologia Molecolare
TIROCINIO AAF1041 2017/2018 Neurobiologia
NEUROBIOLOGY OF MEMORY 1055713 2017/2018 Neurobiologia
PSYCHOPHARMACOLOGY 1051928 2017/2018 Neurobiologia
NEUROBIOLOGIA DELLA MEMORIA 1052235 2017/2018 Neurobiologia
PSYCHOBIOLOGY 1052230 2017/2018 Neurobiologia
PSYCHOBIOLOGY 1052230 2017/2018 Genetica e Biologia Molecolare
TIROCINIO AAF1041 2016/2017 Neurobiologia
PSYCHOPHARMACOLOGY 1051928 2016/2017 Neurobiologia
NEUROBIOLOGIA DELLA MEMORIA 1052235 2016/2017 Neurobiologia
PSYCHOBIOLOGY 1052230 2016/2017 Neurobiologia
Titolo Rivista Anno
Flexible use of allocentric and egocentric spatial memories activates differential neural networks in mice SCIENTIFIC REPORTS 2020
A gene expression atlas for different kinds of stress in the mouse brain SCIENTIFIC DATA 2020
Mechanisms by which autophagy regulates memory capacity in ageing AGING CELL 2020
Offline ventral subiculum-ventral striatum serial communication is required for spatial memory consolidation NATURE COMMUNICATIONS 2019
miR-135a Regulates Synaptic Transmission and Anxiety-Like Behavior in Amygdala MOLECULAR NEUROBIOLOGY 2018
Stress-induced strain and brain region-specific activation of LINE-1 transposons in adult mice STRESS 2018
MicroRNA-335-5p modulates spatial memory and hippocampal synaptic plasticity NEUROBIOLOGY OF LEARNING AND MEMORY 2017
microRNAs Modulate Spatial Memory in the Hippocampus and in the Ventral Striatum in a Region-Specific Manner MOLECULAR NEUROBIOLOGY 2016
RNA polymerase i transcription is modulated by spatial learning in different brain regions JOURNAL OF NEUROCHEMISTRY 2016
Facoltà
Scienze Matematiche, Fisiche e Naturali
Dipartimento
BIOLOGIA E BIOTECNOLOGIE "CHARLES DARWIN"
SSD

M-PSI/02