Notizie
METODI DI NEUROSCIENZE COMPORTAMENTALI
(Laurea magistrale in Neurobiologia)
Orario: Martedì e Giovedì 11.00-13.00,
Aula Tecce (B), Ed. Fisiologia Generale (CU026)
Inizio lezioni: Martedì 4 Marzo 2025
Per accedere al materiale delle lezioni su e-learning è necessario iscriversi utilizzando l'apposita chiave di accesso che sarà comunicata nella prima lezione.
Durante la prima lezione verrà descritto il corso e verranno fornite tutte le informazioni riguardanti le esercitazioni e la prova di esame. Si raccomanda la presenza alla prima lezione anche agli studenti non-frequentanti.
INTRODUZIONE ALLE NEUROSCIENZE
(Laurea triennale in Scienze Biologiche)
Orario: Lunedì 11.00-13.00, Aula Pasquini, Ed. Zoologia (Viale dell'Università, 32)
Venerdi 14.00-16.00, Aula Rasetti, Ed. Fisica "G. Marconi" (CU013, piano 2)
Inizio lezioni: Venerdì 28 Febbraio 2025
Per accedere al materiale delle lezioni su e-learning è necessario iscriversi utilizzando l'apposita chiave di accesso che sarà comunicata nella prima lezione.
Durante la prima lezione verrà descritto il corso e verranno fornite tutte le informazioni riguardanti la prova di esame. Si raccomanda la presenza alla prima lezione anche agli studenti non-frequentanti.
FONDAMENTI DI NEUROSCIENZE
(Laurea triennale in Scienze Matematiche per l'Intelligenza Artificiale)
Orario: Giovedì 8.00-10.00 e Venerdì 9.00-11.00, Aula IV, Ed. Matematica "Guido Castelnuovo" (CU006)
Inizio lezioni: Giovedì 27 Febbraio 2025
Per accedere al materiale delle lezioni su e-learning è necessario iscriversi utilizzando l'apposita chiave di accesso che sarà comunicata nelle prime lezioni.
Durante la prima lezione verrà descritto il corso e verranno fornite tutte le informazioni riguardanti la prova di esame. Si raccomanda la presenza alla prima lezione anche agli studenti non-frequentanti.
Orari di ricevimento
Si riceve su appuntamento.
Scrivere a: arianna.rinaldi@uniroma1.it
Curriculum
ADDRESS
Sapienza University of Rome
Department of Biology and Biotechnology "C. Darwin"
Center for Research in Neurobiology "D. Bovet"
P.le Aldo Moro 5, 00185 Rome, Italy
Tel. +39 (0)6 4991 2088
arianna.rinaldi@uniroma1.it
ORCID: 0000-0002-5167-7420
EDUCATION
2007 Ph.D. in Psychobiology e Psychopharmacology, Sapienza University of Rome, Italy.
2004 Degree in Biological Sciences (master equivalent), 110/110 cum laude, Sapienza University of Rome, Italy.
CURRENT POSITION
04/2022-present Associate Professor (SSD PSIC-01/B, ex-M-PSI/02). Dept. of Biology and Biotechnology C.Darwin, Sapienza University of Rome.
PREVIOUS POSITIONS
12/2011-03/2022 Assistant Professor (Ricercatore Universitario - SSD M-PSI/02). Dept. of Biology and Biotechnology C.Darwin and Centre for Research in Neurobiology D.Bovet, Sapienza University of Rome.
01/2012-03/2018 Research Associate. Institute of Cell Biology and Neurobiology (IBCN), CNR.
01/2008-08/2012 Postdoctoral research fellow. Laboratory of Dr. M.F. Nolan (Marie Curie Excellence Team, Wellcome Trust Project Grant), Centre for
Integrative Physiology, University of Edinburgh.
10/2004–12/2007 Ph.D. student. Laboratory of Psychobiology, Dept. of Genetics and Molecular Biology, Sapienza University of Rome. Supervisor: Prof. A. Mele.
03-04/2004 Visiting student. Laboratory of Dr. A. Mulder, Swammerdam Institute for Life Sciences, University of Amsterdam.
01/2002–07/2004 Undergraduate student. Laboratory of Psychobiology, Dept. of Genetics and Molecular Biology, Sapienza University of Rome. Supervisor: Prof. A. Oliverio.
TEACHING
From AA 2022-23 to present "Fundamental to neuroscience”, SSD M-PSI/02, Module 2, 3 CFU, Bachelor in Mathematical sciences for artificial intelligence, Sapienza University of Rome.
from AA 2019-20 to present "Introduction to neuroscience”, SSD M-PSI/02, 6 CFU, Bachelor in Biology, Sapienza University of Rome.
from AA 2019-20 to present "Methods in Behavioural Neuroscience", SSD M-PSI/02, 6 CFU, LM in Neurobiology, Sapienza University of Rome.
From AA.2012-13 to AA.2019-19 "Methods in Behavioural Neuroscience", SSD M-PSI/02, Module 1, 3 CFU, LM in Neurobiology, Sapienza University of Rome.
2023-present Faculty Member, Ph.D. Program in Behavioural Neuroscience, Curriculum Psychobiology and Psychopharmacology, Sapienza University of Rome
2022-present Faculty Member, Bachelor in Mathematical sciences for artificial intelligence, Sapienza University of Rome.
2019-present Faculty Member, Bachelor in Biology, Sapienza University of Rome.
2012-present Faculty Member, LM in Neurobiology, Sapienza University of Rome.
2012-present Faculty Member, Ph.D. Program in Behavioral Neuroscience (curriculum of Psychobiology and Psychopharmacology), Sapienza University of Rome.
2005-present Supervision of undergraduate, master and PhD students, Sapienza University of Rome and University of Edinburgh.
2005-2007 Laboratory teaching, Plant biology, Sapienza University of Rome.
PEER-REVIEWED PUBLICATIONS
1. S.Mandillo, A.Rinaldi, A.Oliverio, A.Mele (2003). Repeated administration of phencyclidine, amphetamine and MK-801 selectively impairs spatial learning in mice: a possible model of psychotomimetic drug-induced cognitive deficits. Behavioural Pharmacology, 14: 533-544.
2. V.Ferretti, C.Florian, V.J.A.Costantini, P.Roullet, A.Rinaldi, E. De Leonibus, A. Oliverio, A. Mele (2005). Co-activation of glutamate and dopamine receptors within the nucleus accumbens is required for spatial memory consolidation in mice. Psychopharmacology, 179: 108-116.
3. A.Rinaldi, S.Mandillo, A.Oliverio, A.Mele (2007). D1 and D2 antagonist injections in the prefrontal cortex selectively impair spatial learning in mice. Neuropsychopharmacology, 32: 309-319.
4. A.Rinaldi, S.Vincenti, F.De Vito, I.Bozzoni, A.Oliverio, C.Presutti, P.Fragapane, A.Mele (2010). Stress induces region specific alterations in microRNAs expression in mice. Behavioural Brain Research, 208: 265-269.
5. V.Ferretti, P.Roullet, F.Sargolini, A.Rinaldi, V.Perri, M.Del Fabbro, V.Costantini, V.Annese, G.Scesa, M.E.De Stefano, A.Oliverio, A.Mele (2010). Ventral striatal plasticity and spatial memory. PNAS, 107: 7945-7950.
6. A.Rinaldi, S.Romeo, C.Agustìn-Pavòn, A.Oliverio, A.Mele (2010). Different patterns of Fos immunoreactivity in striatum and hippocampus induced by different kinds of novelty in mice. Neurobiology of Learning and Memory, 94: 373-381.
7. B.Zonta, A.Desmazieres, A.Rinaldi, S.Tait, D.L.Sherman, M.F.Nolan, P.J.Brophy (2011). Selective disruption due to loss of neurofascin reveals a role for the axon initial segment in regulating action potentials. Neuron, 69: 945-956.
8. A.Rinaldi, A.Oliverio, A.Mele (2012). Spatial memory, plasticity and nucleus accumbens. Reviews in the Neurosciences, 23: 527-541.
9. A.Rinaldi, C.Defterali, A.Mialot, D.L.F.Garden, M.Beraneck, M.F.Nolan (2013). Specific contribution of HCN1 channels in Purkinje cells to motor learning and synaptic integration. Journal of Physiology, 591: 5691-5709.
10. F.Capitano, J.Camon, V.Ferretti, V.Licursi, F.De Vito, A.Rinaldi, S.Vincenti, C.Mannironi, P.Fragapane, I.Bozzoni, A.Oliverio, R.Negri, C.Presutti, A.Mele (2015). micro-RNAs modulate spatial memory in the hippocampus and in the ventral striatum in a region specific manner. Molecular Neurobiology, 53:4618-4630.
11. M.Jelitai, P.Puggioni, T.Ishikawa, A.Rinaldi, I.Duguid (2016). Dendritic excitation-inhibition balance shapes cerebellar output during motor behaviour. Nature Communications, 7: 13722. IF(5years)=13.81
12. D.L.F.Garden, A.Rinaldi, M.F.Nolan (2017). Active integration of glutamatergic input to the inferior olive generates bidirectional postsynaptic potentials. Journal of Physiology, 595:1239-1251. IF(5years)=4.94
13. F.Capitano, J.Camon, V.Licursi, V.Ferretti, L.Maggi, M.Scianni, G.Del Vecchio, A.Rinaldi, C.Mannironi, C.Limatola, C.Presutti, A.Mele (2017). MicroRNA-335-5p modulates spatial memory and hippocampal synaptic plasticity. Neurobiology of Learning and Memory, 139:63-68.
14. C.Mannironi, A.Biundo, S.Rajendran, F.De Vito, S.Caioli, C.Zona, T.Ciotti, S.Caristi, E.Perlas, I.Bozzoni, A.Rinaldi, A.Mele, C.Presutti (2017). miR-135a regulates synaptic activity and anxiety-like behavior in amygdala. Molecular Neurobiology, 55:3301-3315.
15. M.Oostland, D.L.F.Garden, M.Jelitai, A.Rinaldi, I.Duguid, M.F.Nolan (2018). Inferior olive HCN1 channels coordinate synaptic integration, complex spike timing and motor learning. Cell Reports, 22:1722-1733.
16. U.Cappucci, G.Torromino, A.M.Casale, J.Camon, F.Capitano, M.Berloco, A.Mele, S.Pimpinelli, A.Rinaldi* and L.Piacentini* (2018). Stress-induced strain and brain region specific activation of LINE-1 transposons in adult mice. Stress, 21: 575-579 (*Corresponding author).
17. K.Hair, M.R.Macleod, E.S.Sena, The IICARus Collaboration (A.Rinaldi)* (2019). A randomised controlled trial of an Intervention to Improve Compliance with the ARRIVE guidelines (IICARus). BMC Research Integrity and Peer Review, 4:12 (*Member of the collaboration group).
18. G.Torromino, L.Autore, V.Khalil, V.Mastrorilli, M.Griguoli, A.Pignataro, E.Centofante, G.M.Biasini, V.De Turris, M.Ammassari-Teule, A.Rinaldi, A.Mele (2019). Ventral subiculum-ventral striatum communication is required for spatial memory consolidation. Nature Communications, 10:5721.
19. S.Gasparini, G.Del Vecchio, S.Gioiosa, T.Flati, T.Castrignanoò, I.Legnini, V.Licursi, L.Ricceri, M.L.Scattoni, A.Rinaldi, C.Presutti, C.Mannironi. Differential expression of hippocampal circular RNAs in the BTBR mouse model for autism spectrum disorder. Molecular Neurobiology, 57:2301-2313.
20. A.Rinaldi*, E.De Leonibus, A.Cifra, E.Minicocci, E. De Sanctis, R. Lopez Pedrajas, A.Oliverio, A.Mele (2020). Flexible use of allocentric and egocentric spatial memories activates differential neural networks in mice. Scientific Reports, 10, 11338.
21. T.Flati, S.Gioiosa,G.Chillemi, A.Mele, A.Oliverio, C.Mannironi, A.Rinaldi*,T.Castrignanò* (2020). Stress Mice Portal: a transcriptomic data web resource and gene expression atlas for different kinds of stress. Scientific Data 7, 437.
22. V.Mastrorilli, E.Centofante, F.Antonelli, A.Rinaldi, A.Mele (2022). The neural substrate of spatial memory stabilization depends on the distribution of the training sessions. PNAS, 119:e2120717119.
23. R.Gioia, T.Seri, T.Diamanti, S.Fimmanò, M.Vitale, H.Ahlenius, Z.Kokaia, F.Tirone, L.Micheli, S.Biagioni, G.Lupo, A.Rinaldi, A.De Jaco, E.Cacci (2023). Adult hippocampal neurogenesis and social behavioural deficits in the R451C Neuroligin3 mouse model of autism are reverted by the antidepressant Fluoxetine. Journal of Neurochemistry, 165:318–333.
24. E.Centofante, L. Fralleoni, C.A.Lupascu, A.Rinaldi, A.Mele, A (2023). Specific patterns of neural activity in the hippocampus after massed or distributed spatial training. Scientific Reports, 13:13357.
25. F.Stabile, G.Torromino, S.Rajendran, G.Del Vecchio, C.Presutti, C.Mannironi, E.De Leonibus, A. Mele, A.Rinaldi* (2024). Short-term memory deficit associates with miR-153-3p upregulation in the hippocampus of middle-aged mice. Mol Neurobiol, 61: 3031–3041.
26. S.Gioiosa, S.Gasparini, C.Presutti, A.Rinaldi, T.Castrignanò, C.Mannironi (2025). Integrated gene expression and alternative splicing analysis in human and mouse models of Rett Syndrome. Sci Rep, 15:2778.
(*Corresponding author)