Ritratto di Emanuele.Cacci@uniroma1.it

Il docente riceve al termine delle lezioni oppure su appuntamento

Full Name: Emanuele Cacci
Current position: Assistant Professor
Current address: Sapienza, University of Rome Department of Biology and Biotechnology Charles Darwin , Piazzale Aldo Moro n. 5, 00185, Roma, Italia
Tel./Fax: +39 06 4991 2206/ +39 06 4991 2351
e-mail: emanuele.cacci@uniroma1.it

Education

- 2003 Ph.D. in Cell and Developmental Biology University of Rome La Sapienza
- 1999 B.Sc. in Biology cum laude University of Rome La Sapienza

Employment and research experience

1997 1999 undergraduate student Dept. Of Cell and Developmental Biology, University of Rome La Sapienza

1999-2003 graduate research student Dept. Of Cell and Developmental Biology, University of Rome La Sapienza

2003-2006 Post Doctoral position in the group headed by Professors Olle Lindvall and Zaal kokaia at University Hospital of Lund (Sweden) at Stem Cell Center.

July-August 2015: Visiting scientist at Stem Cell Center, hosted by Prof Zaal Kokaia, at Stem Cell Center, University hospital, Lund (Sweden)

June-July: Visiting scientist at Istitute of di Scienze e Technology (IST) of Klosterneuburg (Austria) hosted by Prof Gaia Novarino,

Present: permanent researcher (ricercatore) at Department of Biology and Biotechnology Charles Darwin , Sapienza, University of Rome.

Teaching experience

- 2007-2008/2008-2009 lecture in Methodologies to study the nervouse system
- 2012- present: lecturer in Stem cells in the nervouse system

Research field

Dr.Cacci research is mainly focused on studying: 1) the contribution of specific extrinsic and intrinsic factors controlling neural stem cell (NSCs) properties 2) the effects of neuroinflammation, mainly mediated by microglia and astrocytes, on neural stem cells (NSCs) maintenance, differentiation and neuronal survival 3) the properties of NSCs and their neurogenic potential in the brain of adult mice under pathological conditions (e.g. autism spectrum disorders) and during aging.

Selected publication (last 15 years)

1. Poiana G, Gioia R, Sineri S, Cardarelli S, Lupo G, Cacci E. Transcriptional regulation of adult neural stem/progenitor cells: tales from the subventricular zone. Neural Regen Res. 2020 Oct;15(10):1773-1783. doi: 10.4103/1673-5374.280301. Review.

2. Eleonora Stronati, Roberta Conti, Emanuele Cacci, Silvia Cardarelli, Stefano Biagioni, Giancarlo Poiana (2019). Exosome-induced differentiation of neural stem progenitor cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Jul 27;20(15). pii: E3691. doi: 10.3390/ijms20153691

3. Maria Antonietta Ajmone-Cat, Angela Onori, Camilla Toselli, Eleonora Stronati, Mariangela Morlando, Irene Bozzoni, Emanuela Monni, Zaal Kokaia, Giuseppe Lupo, Luisa Minghetti, Stefano Biagioni, Emanuele Cacci (2019). Increased FUS levels in astrocytes leads to astrocyte and microglia activation and neuronal death. SCIENTIFIC REPORTS, vol. 9, p. 1-15, ISSN: 2045-2322, doi: 10.1038/s41598-019-41040-4.

4. Giuseppe Lupo, Roberta Gioia, Paola Serena Nisi, Stefano Biagioni, Emanuele Cacci (2019). Molecular mechanisms of neurogenic aging in the adult mouse subventricular zone. JOURNAL OF EXPERIMENTAL NEUROSCIENCE, vol. 13, p. 1-10, ISSN: 1179-0695

5. Giuseppe Lupo, Silvana Gaetani, Emanuele Cacci, Stefano Biagioni, Rodolfo Negri (2019). Molecular signatures of the aging brain: finding the links between genes and phenotypes. NEUROTHERAPEUTICS, ISSN: 1933-7213, doi: 10.1007/s13311-019-00743-2.

6. Cera Arcangela Anna, Cacci Emanuele, Toselli Camilla, Cardarelli Silvia, Bernardi Alessandra, Gioia Roberta, Giorgi Mauro, Poiana Giancarlo, Biagioni Stefano (2018). Egr1 maintains NSC proliferation and its overexpression counteracts cell cycle exit triggered by the withdrawal of Epidermal Growth Factor. DEVELOPMENTAL NEUROSCIENCE, vol. 40, p. 223-233, ISSN: 0378-5866, doi: 10.1159/000489699.

7. Lupo Giuseppe, Nisi Paola S, Esteve Pilar, Paul Yu-Lee, Novo Clara Lopes, Sidders Ben, Khan, Muhammad A, Biagioni Stefano, Liu Hai-Kun, Bovolenta Paola, Cacci Emanuele*, Rugg-Gunn, Peter J (2018). Molecular profiling of aged neural progenitors identifies Dbx2 as a candidate regulator of age-associated neurogenic decline. AGING CELL, vol. 17, p. 1-15, ISSN: 1474-9718, doi: 10.1111/acel.12745. *corresponding author.

8. Roberto Sacco, Emanuele Cacci, Gaia Novarino (2018). Neural stem cells in neuropsychiatric disorders. CURRENT OPINION IN NEUROBIOLOGY, vol. 48, p. 131-138, ISSN: 0959-4388, doi: 10.1016/j.conb.2017.12.005.

9. Cacci Emanuele, Negri, Rodolfo, Biagioni, Stefano, Lupo, Giuseppe (2017). Histone methylation and microRNA-dependent regulation of epigenetic activities in neural progenitor self-renewal and differentiation. CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 17, p. 794-807, ISSN: 1568-0266, doi: 10.2174/1568026616666160414124456.

10. Guglielmi L, Nardella M, Musa C, Iannetti I, Arisi I, D'Onofrio M, Storti A, Valentini A, Cacci Emanuele, Biagioni, S, Augusti Tocco G, D'Agnano I, Felsani A. (2017). Lamin A/C Is Required for ChAT-Dependent Neuroblastoma Differentiation. MOLECULAR NEUROBIOLOGY, vol. 5, p. 3729-3744, ISSN: 0893-7648, doi: 10.1007/s12035-016-9902-6.

11. Guadagno Noemi Antonella, Moriconi Claudia, Licursi Valerio, D'acunto Emanuela, Nisi Paola Serena, Carucci, Nicoletta, De Jaco Antonella, Cacci Emanuele, Negri Rodolfo, Lupo Giuseppe, Miranda Banos Maria Elena (2017). Neuroserpin polymers cause oxidative stress in a neuronal model of the dementia FENIB. NEUROBIOLOGY OF DISEASE, vol. 103, p. 32-44, ISSN: 0969-9961, doi: 10.1016/j.nbd.2017.03.010.

12. Carucci Nicoletta, Cacci Emanuele, Nisi Paola Serena, Licursi Valerio, Paul, Yu Lee, Biagioni Stefano, Negri Rodolfo, Rugg Gunn, Peter J., Lupo, Giuseppe (2017). Transcriptional response of Hoxb genes to retinoid signalling is regionally restricted along the neural tube rostrocaudal axis. ROYAL SOCIETY OPEN SCIENCE, vol. 4, ISSN: 2054-5703, doi: 10.1098/rsos.160913.

13. Soldati C, Caramanica P, Burney MJ, Toselli C, Bithell A, Augusti Tocco G, Stanton LW, Biagioni, S, Buckley NJ, Cacci Emanuele (2015). RE1 silencing transcription factor/neuron-restrictive silencing factor regulates expansion of adult mouse subventricular zone-derived neural stem/progenitor cells in vitro. JOURNAL OF NEUROSCIENCE RESEARCH, vol. 8, p. 1203-1214, ISSN: 1097-4547, doi: 10.1002/jnr.23572.

14. Gioia Ubaldo, Valerio Di Carlo, Pasquale Caramanica, Camilla Toselli, Antonella Cinquino, Marcella Marchioni, Pietro Laneve, Stefano Biagioni, Irene Bozzoni, Emanuele Cacci*, Elisa Caffarelli (2014). miR-23a and miR-125b regulate neural stem/progenitor cell proliferation by targeting Musashi1. RNA BIOLOGY, vol. 11, p. 1105-1112, ISSN: 1547-6286, doi: 10.4161/rna.35508. *corresponding author.

15. Gabriele De Luca, Ilenia Ventura, Valentina Sanghez, Maria Teresa Russo, Maria Antonietta Ajmone Cat, Cacci, Emanuele, Alberto Martire, Patrizia Popoli, Germana Falcone, Flavia Michelini, Marco Crescenzi, Paolo Degan, Luisa Minghetti, Margherita Bignami, Gemma Calamandrei (2013). Prolonged lifespan with enhanced exploratory behavior in mice overexpressing the oxidized nucleoside triphosphatase hMTH1. AGING CELL, vol. 12, p. 695-705, ISSN: 1474-9718, doi: 10.1111/acel.12094.

16. Maddalena Sinno, Stefano Biagioni, Maria Antonietta Ajmone-Cat, Irene Pafumi, Pasquale Caramanica, Virginia Medda, Gaetana Tonti, Luisa Minghetti, Ferdinando Mannello, Emanuele Cacci (2013). The Matrix Metalloproteinase Inhibitor Marimastat Promotes Neural Progenitor Cell Differentiation into Neurons by Gelatinase-Independent TIMP-2-Dependent Mechanisms. STEM CELLS AND DEVELOPMENT, vol. 22, p. 345-358, ISSN: 1547-3287, doi: 10.1089/scd.2012.0299.

17. M.A. Ajmone-Cat, M.L. Salvatori, Roberta De Simone, Melissa Mancini, Stefano Biagioni, Antonietta Bernardo, Emanuele Cacci, Luisa Minghetti (2012). Docosahexaenoic acid modulates inflammatory and antineurogenic functions of activated microglial cells. JOURNAL OF NEUROSCIENCE RESEARCH, vol. 90, p. 575-587, ISSN: 0360-4012, doi: 10.1002/jnr.22783.

18. Chiara Soldati, Emanuele Cacci, Stefano Biagioni, Nicoletta Carucci, Giuseppe Lupo, Carla Perrone-Capano, Isabella Saggio, Gabriella Augusti-Tocco (2012). Restriction of Neural Precursor Ability to Respond to Nurr1 by Early Regional Specification. PLOS ONE, vol. 7, p. e51798-, ISSN: 1932-6203, doi: 10.1371/journal.pone.0051798.

19. Maria Antonietta Ajmone-Cat*, Emanuele Cacci*, Ylenia Ragazzoni, Luisa Minghetti, Stefano Biagioni (2010). Pro-gliogenic effect of IL-1 in the differentiation of embryonic neural precursor cells in vitro. JOURNAL OF NEUROCHEMISTRY, vol. 113, p. 1060-1072, ISSN: 0022-3042, doi: 10.1111/j.1471-4159.2010.06670.x. * gli autori hanno ugualmente contribuito al lavoro.

20. Maria Antonietta Ajmone-Cat, Emanuele Cacci, Luisa Minghetti (2010). Brain inflammation and the neuronal fate: from neurogenesis to neurodegeneration. In: Kenneth Maiese. Neurovascular Medicine: Pursuing Cellular Longevity for Healthy Aging. p. 319-344, Oxford University Press, ISBN: 978-019532669-7, doi: 10.1093/acprof:oso/9780195326697.003.0013

21. Emanuele Cacci, Biagioni Stefano (2009). Colture di cellule staminali neurali come modello per lo studio di patologie del sistema nervoso, studi farmacologici e di neurotossicitĂ . BIOCHIMICA CLINICA, vol. 33, p. 129-136, ISSN: 0393-0564

22. G. Martella, A. Tassone, G. Sciamanna, P. Platania, D. Cuomo, M.T. Viscomi, P. Bonsi, Emanuele Cacci, Stefano Biagioni, A. Usiello, G. Bernardi, N. Sharma, D.G. Standaert, A. Pisani (2009). Impairment of bidirectional synaptic plasticity in the striatum of a mouse model of DYT1 dystonia: role of endogenous acetylcholine. BRAIN, vol. 132, p. 2336-2349, ISSN: 0006-8950, doi: 10.1093/brain/awp194.

23. Gaetana A. Tonti, Ferdinando Mannello, Cacci Emanuele, Biagioni Stefano (2009). Neural stem cells at the crossroads: MMPs may tell the way. THE INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, vol. 53, p. 1-17, ISSN: 0214-6282, doi: 10.1387/ijdb.082573gt.

24. Emanuele Cacci, Maria Antonietta Ajmone-Cat, Tonino Anelli, Stefano Biagioni, Luisa Minghetti (2008). In vitro neuronal and glial differentiation from embryonic or adult neural precursor cells are differently affected by chronic or acute activation of microglia. GLIA, vol. 56, p. 412-425, ISSN: 0894-1491, doi: 10.1002/glia.20616.

25. Maria Ajmone-Cat, Emanuele Cacci, Luisa Minghetti (2008). Non steroidal anti-inflammatory drugs and neurogenesis in the adult mammalian brain. CURRENT PHARMACEUTICAL DESIGN, vol. 14, p. 1435-1442, ISSN: 1381-6128, doi: 10.2174/138161208784480199.

26. Emanuele Cacci, A. Villa, M. Parmar, M. Cavallaro, N. Mandahl, O. Lindvall, A. Martinez-Serrano, Z. Kokaia (2007). Generation of human cortical neurons from a new immortal fetal neural stem cell line. EXPERIMENTAL CELL RESEARCH, vol. 313, p. 588-601, ISSN: 0014-4827, doi: 10.1016/j.yexcr.2006.11.001.

27. Pär Thored, Andreas Arvidsson, Emanuele Cacci, H. Alhenius, Therese Kallur, K. Ekdal, Zaal Kokaia, Olle Lindvall (2006). Persistent production of neurons from adult brain stem cells during recovery after stroke. STEM CELLS, vol. 24, p. 739-747, ISSN: 1066-5099, doi: 10.1634/stemcells.2005-0281.

28. Emanuele Cacci, J.H. Claasen, K. Kokaia (2005). Microglia-derived tumor necrosis factor a exaggerates death of newborn hippocampal progenitor cells in vitro. JOURNAL OF NEUROSCIENCE RESEARCH, vol. 89, p. 789-797, ISSN: 0360-4012, doi: 10.1002/jnr.20531.

Publication metrics (source: Scopus; 2019)

ORCID ID 0000-003-0082-6999
- H-index: 14
- Total publication number: 30
- Total citations: 1291
- Average Citations per Product: 43

Insegnamento Codice Anno Corso - Frequentare
ANALISI BIOCHIMICO CLINICHE 1019007 2021/2022 Scienze Biologiche
CELLULE STAMINALI NELLO STUDIO DEL SISTEMA NERVOSO 1038203 2021/2022 Neurobiologia - Neurobiology
CELLULE STAMINALI NELLO STUDIO DEL SISTEMA NERVOSO 1038203 2020/2021 Neurobiologia - Neurobiology
CELLULE STAMINALI NELLO STUDIO DEL SISTEMA NERVOSO 1038203 2019/2020 Neurobiologia
CELLULE STAMINALI NELLO STUDIO DEL SISTEMA NERVOSO 1038203 2018/2019 Neurobiologia
CELLULE STAMINALI NELLO STUDIO DEL SISTEMA NERVOSO 1038203 2017/2018 Neurobiologia
CELLULE STAMINALI NELLO STUDIO DEL SISTEMA NERVOSO 1038203 2016/2017 Neurobiologia
Titolo Rivista Anno
Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development NATURE COMMUNICATIONS 2021
Transcriptional regulation of adult neural stem/progenitor cells: tales from the subventricular zone NEURAL REGENERATION RESEARCH 2020
X-ray irradiated cultures of mouse cortical neural stem/progenitor cells recover cell viability and proliferation with dose-dependent kinetics SCIENTIFIC REPORTS 2020
Molecular mechanisms of neurogenic aging in the adult mouse subventricular zone JOURNAL OF EXPERIMENTAL NEUROSCIENCE 2019
Increased FUS levels in astrocytes leads to astrocyte and microglia activation and neuronal death SCIENTIFIC REPORTS 2019
Molecular signatures of the aging brain: finding the links between genes and phenotypes NEUROTHERAPEUTICS 2019
Extracellular vesicle-induced differentiation of neural stem progenitor cells INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2019
Neural stem cells in neuropsychiatric disorders CURRENT OPINION IN NEUROBIOLOGY 2018
Molecular profiling of aged neural progenitors identifies Dbx2 as a candidate regulator of age-associated neurogenic decline AGING CELL 2018
Egr1 maintains NSC proliferation and its overexpression counteracts cell cycle exit triggered by the withdrawal of Epidermal Growth Factor DEVELOPMENTAL NEUROSCIENCE 2018
Histone methylation and microRNA-dependent regulation of epigenetic activities in neural progenitor self-renewal and differentiation CURRENT TOPICS IN MEDICINAL CHEMISTRY 2017
Lamin A/C Is Required for ChAT-Dependent Neuroblastoma Differentiation MOLECULAR NEUROBIOLOGY 2017
Transcriptional response of Hoxb genes to retinoid signalling is regionally restricted along the neural tube rostrocaudal axis ROYAL SOCIETY OPEN SCIENCE 2017
Neuroserpin polymers cause oxidative stress in a neuronal model of the dementia FENIB NEUROBIOLOGY OF DISEASE 2017
Exosome-induced differentiation of neural stem progenitor cells 2017
Glial phenotype induction of neural stem progenitor cells using astrocyte-derived exosomes 2017
Involvement of FUS in cell cycle regulation and ALS pathogenesis 2016
RE1 silencing transcription factor/neuron-restrictive silencing factor regulates expansion of adult mouse subventricular zone-derived neural stem/progenitor cells in vitro JOURNAL OF NEUROSCIENCE RESEARCH 2015
Dipartimento
BIOLOGIA E BIOTECNOLOGIE "CHARLES DARWIN"
SSD

BIO/12