Ritratto di giangaetano.tartaglia@uniroma1.it

Characterizing protein-RNA associations is key to unravel the complexity and functionality of mammalian genomes and could open up therapeutic avenues for the treatment of a broad range of neurodegenerative disorders.  My laboratory (and related teaching) deals with onassociations of non-coding RNAs, such as Xist, with proteins involved in transcriptional and translational regulation as well as neurodegenerative diseases (examples include Parkinson’s SNCA, FXTAS’ FMRP, ALS-related TDP-43 and FUS).  We aim to discover the involvement of RNA (coding, non-coding, viral) molecules in regulatory networks. More specifically, we are interested in understanding mechanisms whose alteration lead to aberrant accumulation of proteins.   One part of our research is dedicated to ribonucleoprotein granules and their implication for cell function.

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I graduated at the University Sapienza in the academic year 1999-2000 with a thesis on mathematical modeling of neurons (Physics department).

Between 2001 and 2005, I carried out my doctoral studies at the University of Zurich CH (Biochemistry department) focusing on the folding and misfolding of proteins associated with neurodegenerative disorders. As an associate researcher, I worked at the University of Cambridge UK (Chemistry and Genetics departments) under the supervision of Chris Dobson and Michele Vendruscolo.

In the period 2005-2010, I participated in several computational and experimental studies on amyloidosis. I am life member of the Clare Hall College in Cambridge UK since 2011.

Since 2010 I am a PI at the Centre for Genomic Regulation (CRG) in Barcelona. My group is composed of 5 post-doctoral researchers, 6 doctoral students and 2 technicians. The doctoral and post-doctoral researches hold competitive fellowships from Marie Curie, Ministry of Science and La Caixa bank. In 2013, I have been awarded an ERC starting grant for the studies on the role of coding and non-coding transcripts in regulation of amyloid genes.

Since 2014, I am tenured in Catalonia as ICREA professor of Life and Medical Sciences. In 2018, I became full professor in Biochemistry at Sapienza.