Ritratto di Gianni.Cenci@uniroma1.it

Modalità per l’erogazione di didattica (corsi di Genetica), secondo semestra AA 2020-2021

 

 

Si avvisano gli studenti che la didattica relativa agli insegnamenti di Genetica per Scienze Biologiche (codice corso 1011788) e di Genetica per Biotecnologie Interfacoltà (codice corso 1051488) verrà erogata “in presenza al 50%” secondo quanto previsto dalla delibera del Senato Accademico del 2 febbraio 2021. A tale proposito si fa presente che:

 

  1. Il sistema di prenotazione sarà PRODIGIT e rimarrà l’alternanza delle matricole [00-49,50-99]. Si rende noto che è stato implementato un meccanismo di token che il docente può emettere lezione per lezione e comunicarlo agli studenti presenti perché registrino la loro presenza. Seguiranno dettagli tecnici e istruzioni precise su questa pagina e sui siti e-learning dei corsi
  2. Le lezioni in aula sono svolte nel rispetto delle regole anti-Covid. Le lezioni saranno proiettate attraverso la piattaforma Google Meet. Gli orari sono esattamente gli stessi come da programmazione del corso "I anno II semestre". Per accedere alle lezioni da remoto, gli studenti dovranno collegarsi al link Hangouts Meet che il docente indicherà sulla pagina e-learning del corso. Il link sarà lo stesso per tutte le lezioni.
  3. Le lezioni saranno registrate e rese disponibili agli studenti assenti previa richiesta giustificata.
  4. Durante la lezione gli studenti collegati da remoto sono invitati a mantenere sia il microfono che la webcam del proprio dispositivo spenti, fatta eccezione per richieste esplicite del docente. In questa fase, gli studenti potranno comunicare con il docente mediante la Chat associata al Google Meet.
  5. Gli studenti sono invitati a registrarsi alle pagine Google Classroom degli insegnamenti di appartenenza che sono indicati con i seguenti codici
    • x65gvcg (Genetica per Scienze Biologiche, codice corso 1011788)
    • sdl2t2q (Genetica per Biotecnologie Interfacoltà, codice corso 1051488)

Lunedì ore 10.30-12.00

Curriculum Vitae
Giovanni Cenci

ORCID.ORG/0000-0002-9628-1411
https://scholar.google.co.uk/citations?user=7B7vx3kAAAAJ&hl=en&oi=ao

General Information

Full Name Giovanni Cenci
Citizenship Italian
e-mail giovanni.cenci@uniroma1.it
Spoken Languages Italian, English, French

Education
Type Year Institution Notes (Degrees, Experience...)
University Degree 1990 University "La Sapienza", Rome (Italy) Summa cum laude, Field: Genetics
PhD 1997 University of Bari, (BA), Italy Genetics and Molecular Evolution
Specialty 1997 University "La Sapienza", Rome (Italy) Specialization in Applied Genetics

Appointments
Academic Appointments
Start End Institution Position
1993 1995 Cornell University- Ithaca (NY) Visiting Fellow (two year fellowship - Cenci Bolognetti Foundation (Rome)
1998 1999 University "La Sapienza", Rome (Italy) Post Doctoral Fellowship -Cenci-Bolognetti Foundation (Rome)
1999 2000 University "Roma Tre", Rome (Italy) Post Doctoral Fellowship (Assegno di Ricerca)
2000 2007 University of Salento, Lecce (Italy) University Researcher/Assistant Professor of Genetics
2007 2007 Cornell University- Ithaca (NY) Visiting Faculty- EMBO Short Term Fellowship
2007 2012 University of L'Aquila, L'Aquila (Italy) University Researcher/Assistant Professor of Genetics
2011 2016 Temple University, Philadelphia (PA) Adjunct Associate Professor
Dec
2012 to date SAPIENZA University of Rome, (RM) Italy Associate Professor of Genetics
Dec 2014 ASN, National Scientific Habilitation Full Professor of Genetics (Qualification)

Teaching Experience
Year Institution Lecture/Course
2000-2001 University of Salento, Lecce (Italy) Genetics- FACULTY OF ENVIRONMENTAL SCIENCES
2001-2004 University of Salento, Lecce (Italy) Advanced Genetics- FACULTY OF SCIENCES
2004-2007 University of Salento, Lecce (Italy) Advanced Genetics; Techniques of Genetic Analysis; Evolutionary Genetics- FACULTY OF SCIENCES
2007-2010 University of L'Aquila, L'Aquila (Italy) Cytogenetics; FACULTY OF SCIENCES; FACULTY OF BIOTECHNOLOGY
2009-2013 University of L'Aquila, L'Aquila (IT) Introduction to Human Genetics; Human Molecular Genetics; Fundamental Genomics; Techniques of Molecular Genetics- FACULTY OF BIOTECHNOLOGY
2013-to date SAPIENZA University of Rome (IT) Genetics- FACULTY OF PHARMACY AND MEDICINE AND FACULTY OF MATHEMATIC, PHYSIC AND NATURAL SCIENCES
2016-to date SAPIENZA University of Rome (IT) Methods in Human Genetics- FACULTY OF MATHEMATIC, PHYSIC AND NATURAL SCIENCES

Scientific Society Activities
Year Title
Since 1995 Member of Genetics Society of America (GSA)
Since 1998
Since 2016 Member of Italian Association of Genetics (AGI)
Associate Scientist-FERMI Institute for Multidisciplinary Studies (Italy)
Since 2017
Executive Member of Italian Association of Genetics (AGI)

Award and Honors
Year Title
1998 AGI Award for the best PhD Thesis
2004 Colleferro Rotary Club Award for Distinguished Contribution to Research

Funding Information
Year Title, Function Funding Agency/Program
2005-2007 Telomere protection and cell cycle checkpoints in Drosophila (Prot. 2005050884_002) (53k )
Role: PI MIUR (Italian Ministry of University and Research
2007-2009 Telomere protection and checkpoint mechanisms: molecular cross-talks contributing to preserve genome integrity- (Prot. 20078TXBJY) (70k )
Role: PI and National Coordinator MIUR (Italian Ministry of University and Research
2009-2012 The role of mitochondrial citrate transport in the maintenance of chromosome integrity (Investigator Grant IG N. 8589) (150k )
Role: PI AIRC (Italian Association for Cancer Research)
2009-2011 Molecular Mechanisms preventing chromosome end fusions in eukaryotes (Prot. 2009ZWNBPC_002) (84k )
Role: PI MIUR (Italian Ministry of University and Research
2012-2015 Separase has a conserved role in chromosome stability
(Investigator Grant IG N. 12749) (150k )
Role: PI AIRC (Italian Association for Cancer Research)
2013-2016 Identification of new factors required for telomere capping in Drosophila (60k )
Role: PI Fondazione Cenci-Bolognetti-Pasteur Institute (Italy)
2014
Chromosome metabolism and cell cycle analysis by means of Thermo Scientific Multiskan GO (53k ) SAPIENZA Ateneo Medie Attrezzature
Role: Role: Coordinator and PI
2018-2020 Conserved mechanisms for the epigenetic regulation of telomere maintenance SAPIENZA Ateneo
Research Grant
Role: Coordinator and PI (64k )

2016-2018 FLYINGLOW: effects of protracted low radiation doses on Drosophila metabolism
Role: coPI (75k ) FERMI Institute for Multidisciplinary Studies (Italy)
2018-2020 Role of HP1/Cbx protein ubiquitination in chromatin organization
Role: Coordinator and PI (300k )(HPUCO-PTR 24-2017) Programmes Transversaux de Recherche (PTR), Pasteur Institute (France)
2018-2020 Functional analysis of separase-dependent lamins regulation in AD-EDMD (100k )
Role: Coordinator and PI (N. 21566) The French Muscular Dystrophy Association (AFM-Telethon)-France
2018-2021 Characterization of the role of Separase in the regulation of Lamins and Rad50
Role: PI (60k ) Fondazione Cenci-Bolognetti-Pasteur Institute (Italy)

Research Activities
Keywords Short Description
1. Drosophila Our lab is interested on the comprehension of molecular mechanisms underlying the maintenance of chromosome integrity in the model organism, Drosophila melanogaster. The specific aims of our research deal with three major issues: a) the genetic and molecular regulation of telomere capping. In particular, we are addressing the role of ubiquitination at chromosome ends and unraveling unanticipated functions of centromeric factors in telomere homeostasis; b) the involvement of intra-cellular metabolism in the maintenance of genome stability. More specifically, we are investigating how the mitochondrial-mediated flux of metabolites controls cell proliferation and chromosome integrity; c) the biological effects of low dose radiation/low dose rate on Drosophila genome stability. In particular we are studying the genetic and molecular bases that underlie the radioadaptive response using fruit flies as an in vivo model. Owing the high level of protein homology between Drosophila and humans, these studies will be instrumental for the identification of new players and pathways in human chromosome stability. Our research is currently supported by Fondazione Cenci Bolognetti, FERMI Institute, Pasteur Institute (France) and The French Muscular Dystrophy Association (AFM-Telethon)

Research Keywords
1. Drosophila
2. Telomeres
3. Chromosome Structure
4. Genetics
5. Cell Cycle
6. DNA Repair
7. Cell Metabolism

Peer Review
Journals Journal of Cell Science, Nature Genetics, Chromosoma, Genetics, Mechanisms of Aging and Development, Frontiers in Genetics, Journal of Cellular Physiology, Developmental Dynamics, RNA Biology, Insect Biochemistry and Molecular Biology, Fly

Funding Agencies MIUR, The Wellcome Trust

2013 Lead Guest Editor for "Special Issue on Telomere Functions in Cell Division" in BioMed Research International.

PhD Program Scientific Board Activity
2008-2012 Experimental Medicine (University of L'Aquila)
2013-to date Life Science (University of Rome, Pasteur Institute)

Organization of Conferences
2014 Italian Conference of Drosophila Genetics (Anagni, FR-Italy)
2018 Course in Molecular Cytogenetics and Cytogenomics-School of Genetics, AGI (Cortona, AR-Italy)

Activities of Public Engagement
Since 2016 G. Cenci has been engaged at several local activities of science divulgation
(http://bbcd.bio.uniroma1.it/bbcd/attivit-di-educazione-e-divulgazione-sc...)

Publications (2015-2020)

Articles in Journals (with Journal IFs)
1. Vernì F., Cenci G** 2015. The Drosophila histone variant H2A.V works in concert with HP1 to promote kinetochore-driven microtubule formation. Cell Cycle 14(4): 577-88. doi: 10.4161/15384101.2014.991176.
2. Cenci G*, Ciapponi L, Marzullo M, Raffa GD, Morciano P, Raimondo D, Burla R, Saggio I, Gatti G. 2015. The analysis of pendolino (peo) mutants reveals differences in the fusigenic potential among Drosophila telomeres. PLOS Genetics 11(6): e1005260
3. Burla R , Carcuro M , Raffa GD, Galati A, Raimondo D , Rizzo A, La Torre M, Micheli M, Ciapponi L, Cenci G, Cundari E, Musio A, Biroccio A, Cacchione S, Gatti M, Saggio I. 2015. AKTIP/Ft1, a new shelterin-interacting factor required for telomere maintenance. PLOS Genetics 11(6): e1005167
4. Cipressa F, Morciano P, Bosso S, Mannini L, Galati A, Raffa GD, Cacchione S, Musio A, Cenci G (2016). A role for Separase in telomere protection. Nat Comm, 7:10405 doi: 10.1038/ncomms10405)
5. Cicconi A, Micheli E, Vernì F, Jackson A, Gradilla A, Cipressa F, Raimondo D Bosso G, Wakefield J, Ciapponi L, Cenci G, Gatti M, Cacchione S, Raffa G. (2017) The Drosophila telomere-capping protein Verrocchio binds single-stranded DNA and protects telomeres from DNA damage response. Nucleic Acids Res. 2017 45:3068-3085. doi: 10.1093/nar/gkw1244.
6. Morciano P, Iorio R, Iovino D, Cipressa F, Esposito G, Porrazzo A, Satta L, Alesse E, Tabocchini MA, Cenci G. (2017) Effects of reduced natural background radiation on Drosophila melanogaster growth and development as revealed by the FLYINGLOW program. J Cell Physiol. doi: 10.1002/jcp.25889
7. Graziadio L, Palumbo V, Cipressa F, Williams BC, Cenci G, Gatti M, Goldberg ML, Bonaccorsi S. (2018) Phenotypic characterization of diamond (dind), a Drosophila gene required for multiple aspects of cell division. Chromosoma. 4: 489-504
8. Morciano P, Cipressa F, Porrazzo A, Esposito G, Tabocchini MA, Cenci G. (2018) Fruit Flies Provide New Insights in Low-Radiation Background Biology at the INFN Underground Gran Sasso National Laboratory (LNGS). Radiat Res. 190:217-225.
9. Morciano, P, Di Giorgio ML, Porrazzo A, Licursi V, Negri R, Rong Y, Cenci G. (2019) Depletion of ATP-Citrate Lyase (ATPCL) Affects Chromosome Integrity Without Altering Histone Acetylation in Drosophila Mitotic Cells. Front Physiol 10: 383,
10. Bosso G, Cipressa F, Moroni ML, Pennisi R, Albanesi J, Brandi V, Cugusi S, Renda F, Ciapponi L, Polticelli F,, Antoccia A,, di Masi A. , Cenci G** (2019). NBS1 interacts with HP1 to ensure genome integrity. Cell Death and Disease 10:951
11. Di Giorgio ML, Morciano P, Bucciarelli E, Porrazzo A, Cipressa F, Saraniero S, Manzi D, Rong YS, Cenci G. (2020) The Drosophila Citrate Lyase Is Required for Cell Division during Spermatogenesis. Cells. 9. pii: E206.

Articles in Books
1. Raffa, GD and Cenci G** (Mar 2015) Telomere. In: eLS. John Wiley & Sons Ltd, Chichester. http://www.els.net [doi: 10.1002/9780470015902.a0005787.pub3]

Insegnamento Codice Anno Corso - Frequentare
METHODS IN HUMAN GENETICS 1051860 2021/2022 Genetica e Biologia Molecolare - Genetics and Molecular Biology
GENETICA 1051488 2021/2022 Biotecnologie
GENETICA 1011788 2021/2022 Scienze Biologiche
GENETICA 1011788 2020/2021 Scienze Biologiche
METHODS IN HUMAN GENETICS 1051860 2020/2021 Genetica e Biologia Molecolare - Genetics and Molecular Biology
GENETICA 1051488 2020/2021 Biotecnologie
GENETICA 1011788 2019/2020 Scienze Biologiche
METHODS IN HUMAN GENETICS 1051860 2019/2020 Genetica e Biologia Molecolare
GENETICA 1051488 2019/2020 Biotecnologie
METHODS IN HUMAN GENETICS 1051860 2018/2019 Genetica e Biologia Molecolare
GENETICA 1011788 2018/2019 Scienze Biologiche
GENETICA 1051488 2018/2019 Biotecnologie
GENETICA 1011788 2017/2018 Scienze Biologiche
METHODS IN HUMAN GENETICS 1051860 2017/2018 Genetica e Biologia Molecolare
GENETICA 1051488 2017/2018 Biotecnologie
GENETICA 1011788 2016/2017 Scienze Biologiche
METHODS IN HUMAN GENETICS 1051860 2016/2017 Genetica e Biologia Molecolare
GENETICA 1051488 2016/2017 Biotecnologie
Titolo Rivista Anno
Reduced RNA turnover as a driver of cellular senescence LIFE SCIENCE ALLIANCE 2021
The organization of the Golgi structures during drosophila male meiosis requires the citrate lyase ATPCL INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2021
The Drosophila Citrate Lyase Is Required for Cell Division during Spermatogenesis CELLS 2020
Intimate functional interactions between TGS1 and the Smn complex revealed by an analysis of the Drosophila eye development PLOS GENETICS 2020
Silence at the End: How Drosophila Regulates Expression and Transposition of Telomeric Retroelements JOURNAL OF MOLECULAR BIOLOGY 2020
Underground Radiobiology: A Perspective at Gran Sasso National Laboratory FRONTIERS IN PUBLIC HEALTH 2020
Depletion of ATP-citrate lyase (ATPCL) affects chromosome integrity without altering histone acetylation in Drosophila mitotic cells FRONTIERS IN PHYSIOLOGY 2019
NBS1 interacts with HP1 to ensure genome integrity CELL DEATH & DISEASE 2019
Phenotypic characterization of diamond (dind), a Drosophila gene required for multiple aspects of cell division CHROMOSOMA 2018
Fruit Flies Provide New Insights in Low-Radiation Background Biology at the INFN Underground Gran Sasso National Laboratory (LNGS) RADIATION RESEARCH 2018
The Drosophila telomere-capping protein Verrocchio binds single-stranded DNA and protects telomeres from DNA damage response NUCLEIC ACIDS RESEARCH 2017
Effects of Reduced Natural Background Radiation on Drosophila melanogaster Growth and Development as Revealed by the FLYINGLOW Program JOURNAL OF CELLULAR PHYSIOLOGY 2017
A role for Separase in telomere protection NATURE COMMUNICATIONS 2016
The Drosophila histone variant H2A.V works in concert with HP1 to promote kinetochore-driven microtubule formation CELL CYCLE 2015
AKTIP/Ft1, a new shelterin-interacting factor required for telomere maintenance PLOS GENETICS 2015
The analysis of pendolino (peo) mutants reveals differences in the fusigenic potential among Drosophila telomeres PLOS GENETICS 2015