Ritratto di giuseppe.sciume@uniroma1.it

Tutti giorni, previo appuntamento tramite email
Viale Regina Elena 291,
Laboratorio Immunologia e Immunopatologia
Piano 3

Titoli di Studio:

- 2010 Dottorato in Scienze Immunologiche PhD
Titolo della tesi: Differential chemokine receptor expression regulates trafficking of mouse bone marrow NK cell subsets.
Sapienza Universita di Roma.

- 2006 Laureato con lode in Biotecnologie (Laurea specialistica)
Sapienza Universita di Roma.
Titolo della tesi: Analysis of CX3CR1/CX3CL1 receptor/ligand pair expression and function in human glioma cell lines: Regulation by TGF-beta .

- 2004 Laureato con lode in Biotecnologie (Laurea Specialistica)
Sapienza Universita di Roma.

Esperienze di Ricerca

- Da Dic 2019 Ricercatore a tempo determinato di tipo B (RTDB)
Dipartimento di Medicina Molecolare
Sapienza Universita di Roma.

- Feb 2017- Dic 2019 Assegnista di Ricerca
Dipartimento di Medicina Molecolare
Sapienza Universita di Roma.
Supervisore: Dr Angela Santoni

- Ott 2015- Nov 2016 Guest Research Fellow
Molecular Immunology and Inflammation Branch, Lymphocyte cell Biology Section, NIAMS, NIH.
Supervisore: Dr. John J. O Shea

- Ott 2015- Nov 2016 Research Fellow
Molecular Immunology and Inflammation Branch, Lymphocyte cell Biology Section, NIAMS, NIH.
Supervisore: Dr. John J. O Shea

- Ott 2012- Set 2015 Visiting Fellow
Molecular Immunology and Inflammation Branch, Lymphocyte cell Biology Section, NIAMS, NIH.
Supervisore: Dr. John J. O Shea

- Ott 2010- Set 2012 Supplemental Visiting Fellow
Molecular Immunology and Inflammation Branch, Lymphocyte cell Biology Section, NIAMS, NIH.
Supervisore: Dr. John J. O Shea
Borsa di Studio: Pasteur Institute-Cenci Bolognetti

- Ott 2006- Ott 2010 Studente di dottorato:
Laboratorio di Immunologia, Dipartimento di Medicina Sperimentale, Policlinico Umberto I, Sapienza Universita di Roma.
Supervisor: Prof. Angela Santoni

- Abilitazione nazionale valida dal 31/10/2018 al 31/10/2024

SETTORE CONCORSUALE 06/A2; PATOLOGIA GENERALE E PATOLOGIA CLINICA.

Finanziamenti

2019-2023: My First AIRC Grant MFAG 2018. Dissecting roles for NCR+ innate lymphoid cells in colorectal cancer. PI; Overall: 500,000 Euros.

2018-2019: Programmes Transversaux de Recherche - PTR 2017 (Pasteur Institute, Paris, France). Dissecting roles for diverse innate lymphoid cell subsets in colitis-induced colorectal cancer. Co-PI; Overall: 150,000 Euros.

Pubblicazioni Scientifiche

Profilo Google Scholar: http://scholar.google.com/citations?user=71JN5qsAAAAJ
H-index (Scopus): 19
Numero di citazioni: > 1400

31: Scarno G, Pietropaolo G, Di Censo C, Peruzzi G, Sciumè G.
Assessing Phosphorylation of STAT Transcription Factors in Mouse Innate Lymphoid Cells.
Methods Mol Biol. 2020.

30: Vian L, Le MT, Gazaniga N, Kieltyka J, Liu C, Pietropaolo G, Dell'Orso S, Brooks SR, Furumoto Y, Thomas CJ, O'Shea JJ, Sciumè G*, Gadina M*.
JAK Inhibition Differentially Affects NK Cell and ILC1 Homeostasis.
Front Immunol. 2019.
*Co-ultimo autore e corrispondente.

29: Scarno G, Pietropaolo G, Di Censo C, Gadina M, Santoni A, Sciumè G.
Transcriptional, Epigenetic and Pharmacological Control of JAK/STAT Pathway in NK Cells.
Front Immunol. 2019.

28: Bonanni V, Sciumè G, Santoni A, Bernardini G.
Bone Marrow NK Cells: Origin, Distinctive Features, and Requirements for Tissue Localization.
Front Immunol. 2019.

27: Sciumè G, Fionda C, Stabile H, Gismondi A, Santoni A.
Negative regulation of innate lymphoid cell responses in inflammation and cancer.
Immunol Lett. 2019

26: Stabile H, Scarno G, Fionda C, Gismondi A, Santoni A, Gadina M, Sciumè G.
JAK/STAT signaling in regulation of innate lymphoid cells: The gods before the guardians.
Immunol Rev. 2018.

25: Sciumè G.
Guest editorial: Innate lymphocytes: Development, homeostasis, and disease.
Cytokine Growth Factor Rev. 2018.

24: Mikami Y, Scarno G, Zitti B, Shih HY, Kanno Y, Santoni A, O'Shea JJ, Sciumè G.
NCR(+) ILC3 maintain larger STAT4 reservoir via T-BET to regulate type 1 features upon IL-23 stimulation in mice.
Eur J Immunol. 2018.

23: Sciumè G, Shih HY, Mikami Y, O'Shea JJ.
Epigenomic Views of Innate Lymphoid Cells.
Front Immunol. 2017.

22: Antonangeli F, Soriani A, Cerboni C, Sciumè G, Santoni A.
How Mucosal Epithelia Deal with Stress: Role of NKG2D/NKG2D Ligands during Inflammation.
Front Immunol. 2017.

21: Villarino AV*, Sciumè G*, Davis FP, Iwata S, Zitti B, Robinson GW, Hennighausen L, Kanno Y, O'Shea JJ.
Subset- and tissue-defined STAT5 thresholds control homeostasis and function of innate lymphoid cells.
J Exp Med. 2017.
*Co-primo autore.

20: Cassani B, Castriconi R, Mazzoni A, Piconese S, Sciumè G.
The SIICA School of Immunology 2017: a gathering for NGS (next generation scientists).
Eur J Immunol. 2017.

19. Sciumè G, Le M, Gadina M.
HiJAKing Innate lymphoid cells?
Front Immunol. 2017.

18: Furumoto Y, Smith CK, Blanco L, Zhao W, Brooks SR, Thacker SG, Zarzour A, Sciumè G, Tsai WL, Trier AM, Nunez L, Mast L, Hoffmann V, Remaley AT, O'Shea JJ, Kaplan MJ, Gadina M.
Tofacitinib ameliorates murine lupus and its associated vascular dysfunction.
Arthritis Rheumatol. 2017.

17: Shih HY*, Sciumè G*, Mikami Y*, Guo L, Sun HW, Brooks SR, Urban JF Jr, Davis FP, Kanno Y, O'Shea JJ.
Developmental Acquisition of Regulomes Underlies Innate Lymphoid Cell Functionality.
Cell. 2016.
*Co-primo autore.

16: Ponzetta A, Benigni G, Antonangeli F, Sciumè G, Sanseviero E, Zingoni A, Ricciardi MR, Petrucci MT, Santoni A, Bernardini G.
Multiple Myeloma Impairs Bone Marrow Localization of Effector Natural Killer Cells by Altering the Chemokine Microenvironment.
Cancer Res. 2015.

15: Yang XP, Jiang K, Hirahara K, Vahedi G, Afzali B, Sciume G, Bonelli M, Sun HW, Jankovic D, Kanno Y, Sartorelli V, O'Shea JJ, Laurence A.
EZH2 is crucial for both differentiation of regulatory T cells and T effector cell expansion.
Sci Rep. 2015.

14: Hirahara K, Onodera A, Villarino AV, Bonelli M, Sciumè G, Laurence A, Sun HW, Brooks SR, Vahedi G, Shih HY, Gutierrez-Cruz G, Iwata S, Suzuki R, Mikami Y, Okamoto Y, Nakayama T, Holland SM, Hunter CA, Kanno Y, O'Shea JJ.
Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity.
Immunity. 2015.

13: Han-Yu S, Sciumè G, Poholek AC, Vahedi G, Hirahara K, Villarino AV, Bonelli M, Bosselut R, Kanno Y, Muljo SA, O Shea JJ.
Transcriptional and epigenetic networks of helper T and innate lymphoid cells.
Immunological Reviews. 2014.

12: Steward-Tharp SM, Laurence A, Kanno Y, Kotlyar A, Villarino AV, Sciume G, Kuchen S, Resch W, Wohlfert EA, Jiang K, Hirahara K, Vahedi G, Sun HW, Feigenbaum L, Milner JD, Holland SM, Casellas R, Powrie F, O'Shea JJ.
A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3.
Blood. 2014.

11: Meylan F, Hawley ET , Barron L , Barlow JL, Penumetcha P, Pelletier M, Sciumè G , Richard AC , Hayes ET, Gomez-Rodriguez J, Chen X, Paul WE, Wynn TA , McKenzie ANJ and Siegel RM.
The TNF-family cytokine TL1A promotes allergic immunopathology through group 2 innate lymphoid cells.
Mucosal Immunol. 2014.

10: Ponzetta A, Sciumè G, Benigni G, Antonangeli F, Morrone S, Santoni A, Bernardini G.
CX3CR1 Regulates the Maintenance of KLRG1+ NK Cells into the Bone Marrow by Promoting Their Entry into Circulation.
J Immunol. 2013.

9: Roychoudhuri R, Hirahara K, Mousavi K, Clever D, Klebanoff AC, Bonelli M, Sciume G, Zare H, Vahedi G, Dema B, Yu Z, Liu H, Takahashi H, Rao M, Muranski P, Crompton JG, Punkosdy G, Bedognetti D, Wang E, Hoffmann V, Rivera J, Marincola FM, Nakamura A, Sartorelli V, Kanno Y, Gattinoni L, Muto A, Igarashi K, O Shea JJ, Restifo NP.
Bach2 represses effector programmes to stabilize Treg-mediated immune homeostasis.
Nature. 2013.

8: Bernardini G, Sciumè G, Santoni A.
Differential chemotactic receptor requirments for NK cell subset trafficking into bone marrow.
Frontier in Immunology. 2013.

7: Sciumè G, Hirahara K, Takahashi H, Laurence A, Villarino AV, Singleton KL, Spencer SP,
Wilhelm C, Poholek AC, Vahedi G, Kanno Y, Belkaid Y, O Shea JJ.
Distinct requirements for T-bet in gut innate lymphoid cells.
J Exp Med. 2012.
Comment in: Innate-like lymphocytes: Will the real ILC1 please stand up? [Nat Rev Immunol. 2013]

6: Hirahara K, Ghoreschi K, Yang XP, Takahashi H, Laurence A, Vahedi G, Sciumè G, O Hara Hall A, Dupont C, Francisco LM, Chen Q, Tanaka M, Kanno Y, Sun HW, Sharpe AH, Hunter CA, O Shea JJ.
IL-27 priming of T cells controls IL-17-production in trans via induction of PD-L1.
Immunity. 2012.

5: Takahashi H, Kanno T, Nakayamada S, Hirahara K, Sciumè G, Muljo SA, Kuchen S, Casellas R, Wei L, Kanno Y, O'Shea JJ.
TGF- and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells.
Nat Immunol. 2012.

4: Bernardini G, Sciumè G, Bosisio D, Morrone S, Sozzani S, Santoni A.
CCL3 and CXCL12 regulate trafficking of mouse bone marrow NK cell subsets.
Blood. 2008.

3: Sciumè G, Soriani A, Piccoli M, Frati L, Santoni A, Bernardini G.
CX3CR1/CX3CL1 axis negatively controls glioma cell invasion and is modulated by transforming growth factor- 1.
Neuro Oncol. 2010.

2: Sciumè G, Santoni A, Bernardini G.
Chemokines and glioma: invasion and more.
J Neuroimmunol. 2010.

1: Sciumè G, De Angelis G, Benigni G, Ponzetta A, Morrone S, Santoni A, Bernardini G.
CX3CR1 expression defines 2 KLRG1+ mouse NK-cell subsets with distinct functional properties and positioning in the bone marrow.
Blood. 2011; 117:4467-75.

Esperienze di insegnamento

2020; Immunologia e Immunopatologia (Sapienza Universita di Roma, sede Venafro, Tecnico Sanitario di Laboratorio)

2020; Patologia Generale (Sapienza Universita di Roma, sede Bracciano, Fisioterapia)

2012; Immunologia. The Catholic University of America 620 Michigan Ave., N.E. Washington, DC 20064

Partecipazione a Congressi come Relatore

WISC 2018: XXXI Congresso Nazionale SIAAIC Joint Meeting SIAAIC/WAO. Personalised Medicine in Allergy: Biologics and Immunotherapy. Firenze, Italia, 2018.
ILC1 in allergy and clinical immunology.
Invited speaker

5th European Congress of Immunology (ECI). Amsterdam, the Netherlands, 2018.
NCR+ ILC3 maintain larger STAT4 reservoir via T-BET to regulate type 1 features upon IL-23 stimulation in mice.

11th National Conference SIICA, Italian Society of Immunology, Clinical Immunology and Allergology. Bari, Italia, 2017.
Epigenetic regulation of Innate Lymphoid Cell Functionality.
Invited speaker

Giornata Romana di Immunologia, Consiglio Nazionale delle Ricerche, Roma, Italia, 2017.
JAK/STAT signals underlying innate lymphoid cell homeostasis and activation.
Invited speaker

Pasteur Institute Seminar Series, organizzato dall Istituto Pasteur-Fondazione Cenci-Bolognetti, Roma, Italia, 2017.
Transcriptional and Epigenetic regulation of Innate lymphoid cell biology.
Invited speaker

16th Annual Meeting of the Society for Natural Immunity. Taormina, Italy, 2016.
Developmental Acquisition of Regulomes Underlies Innate Lymphoid Cell Functionality.
Invited speaker

Barrier Immunity and Repair, NIH, Bethesda, MD, 2013.
Roles of STAT5 and STAT4 in innate lymphoid cells homeostasis and function.
Invited speaker

Receptors and Cytokines in Innate Immunity, NIH, Bethesda, MD, 2013.
Distinct requirements for T-bet in gut innate lymphoid cells.
Invited speaker

7th National Conference SIICA, Italian Society of Immunology, Clinical Immunology and Allergology. Bari, 2010.
CX3CR1 expression defines a KLRG1+ NK cell subset with impaired effector functions.

6th National Conference SIICA, Italian Society of Immunology, Clinical Immunology and Allergology. Rome, 2008.
Membrane-bound CX3CL1 expression inhibits glioma cell invasiveness. Regulation by TGF-beta.

Titolo Rivista Anno
MicroRNA-221 and -222 modulate intestinal inflammatory Th17 cell response as negative feedback regulators downstream of interleukin-23 IMMUNITY 2021
Multi-Dimensional Gene Regulation in Innate and Adaptive Lymphocytes: A View From Regulomes FRONTIERS IN IMMUNOLOGY 2021
Granzyme A and CD160 expression delineates ILC1 with graded functions in the mouse liver EUROPEAN JOURNAL OF IMMUNOLOGY 2021
Assessing Phosphorylation of STAT Transcription Factors in Mouse Innate Lymphoid Cells 2020
Immunometabolism pathways as the basis for innovative anti-viral strategies (INITIATE): A Marie Sklodowska-Curie innovative training network VIRUS RESEARCH 2020
Rapid Enhancer Remodeling and Transcription Factor Repurposing Enable High Magnitude Gene Induction upon Acute Activation of NK Cells IMMUNITY 2020
Negative regulation of innate lymphoid cell responses in inflammation and cancer IMMUNOLOGY LETTERS 2019
JAK inhibition differentially affects NK cell and ILC1 homeostasis FRONTIERS IN IMMUNOLOGY 2019
Transcriptional, epigenetic and pharmacological control of JAK/STAT pathway in NK cells FRONTIERS IN IMMUNOLOGY 2019
Bone Marrow NK Cells: Origin, Distinctive Features, and Requirements for Tissue Localization FRONTIERS IN IMMUNOLOGY 2019
NCR+ ILC3 maintain larger STAT4 reservoir via T-BET to regulate type 1 features upon IL-23 stimulation in mice EUROPEAN JOURNAL OF IMMUNOLOGY 2018
JAK/STAT signaling in regulation of innate lymphoid cells: The gods before the guardians IMMUNOLOGICAL REVIEWS 2018
Guest editorial: Innate lymphocytes: Development, homeostasis, and disease CYTOKINE & GROWTH FACTOR REVIEWS 2018
HiJAKing innate lymphoid cells? FRONTIERS IN IMMUNOLOGY 2017
How mucosal epithelia deal with stress: Role of NKG2D/NKG2D ligands during inflammation FRONTIERS IN IMMUNOLOGY 2017
Epigenomic views of innate lymphoid cells FRONTIERS IN IMMUNOLOGY 2017
Subset- and tissue-defined STAT5 thresholds control homeostasis and function of innate lymphoid cells JOURNAL OF EXPERIMENTAL MEDICINE 2017
The SIICA school of Immunology 2017. a gathering for NGS (next generation scientists EUROPEAN JOURNAL OF IMMUNOLOGY 2017
Developmental Acquisition of Regulomes Underlies Innate Lymphoid Cell Functionality CELL 2016
Multiple Myeloma Impairs Bone Marrow Localization of Effector Natural Killer Cells by Altering the Chemokine Microenvironment. CANCER RESEARCH 2015
Dipartimento
MEDICINA MOLECOLARE
SSD

MED/04