Ritratto di paola.bezzi@uniroma1.it

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CURRENT POSITION Associate Professor, Department of Physiology and Pharmacology Vittorio Erspamer , La Sapienza University

DEGREES, TITLES

1988 Maturité B, Bac Gymnase, Vigevano
1993 M. Sc. Biology, University of Pavia (Italy)
1998 Ph. D. Pharmacology, University of Milan (Italy)

UNIVERSITY TRAINING

1989-93 Biology, University of Pavia (Italy)
1993-98 PhD Pharmacology, University of Milan (Italy)

POST-GRADUATE COURSES
2004 « Imaging structure and function in the nervous system » (organized by: Karel Svoboda, Janelia Farm, USA and Frijtof Helmchen, ETH Zurich, Switzerland), Cold Spring Harbour Lab, NY, USA

PROFESSIONAL POSITIONS:
1998-2001 Postgraduate Research Neuroscientist, Department Pharmacological Sciences, University of Milan, Italy
2001-2005 Postgraduate Research Neuroscientist, Department of Cell Biology and Morphology, University of Lausanne, Switzerland
2005- Junior Group Leader, Department of Cell Biology and Morphology, University of Lausanne, Switzerland
2009- Maitre d Enseignement et de Recherche 1 (PI/Senior Researcher), Department of Fundamental Neurosciences, University of Lausanne
2019- Associate Professor, La Sapienza University, Rome, Italy

AWARDS AND PROFESSIONNAL ACTIVITIES:

1994-1998 Dean s Fellowship for PhD students, University of Milan
1998 Best presentation price, Italian Society of Neuroscience
2014 Best teacher first year of Medicine (LMT awards; FBM, UNIL)

Original reports last 5 years

1. Mitochondrial biogenesis in developing astrocytes regulates astrocyte maturation and synapse formation.
T Zehnder, F Petrelli, J Romanos, ECDO Figueiredo, TL Lewis Jr, N Déglon, F Polleux, M Santello, P Bezzi
Cell Reports, 2021

2. Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer's disease.
Richetin K, Steullet P, Pachoud M, Perbet R, Parietti E, Maheswaran M, Eddarkaoui S, Bégard S, Pythoud C, Rey M, Caillierez R, Q Do K, Halliez S, Bezzi P, Buée L, Leuba G, Colin M, Toni N, Déglon N.
Nature Neurosci., 2020

3. Insights into the release mechanism of astrocytic glutamate evoking in neurons NMDA receptor-mediated slow depolarizing inward currents.
Gómez-Gonzalo M, Zehnder T, Requie LM, Bezzi P, Carmignoto G.
Glia, 2018

4. Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments.
Petrelli F, Dallérac G, Pucci L, Calì C, Zehnder T, Sultan S, Lecca S, Chicca A, Ivanov A, Asensio CS, Gundersen V, Toni N, Knott GW, Magara F, Gertsch J, Kirchhoff F, Déglon N, Giros B, Edwards RH, Mothet JP, Bezzi P.
Mol Psychiatry., 2020 (Cover)

5. SHANK3 controls maturation of social reward circuits in the VTA.
Bariselli S, Tzanoulinou S, Glangetas C, Prévost-Solié C, Pucci L, Viguié J, Bezzi P, O'Connor EC, Georges F, Lüscher C, Bellone C.
Nature Neurosci., 2016

6. Homer1 Scaffold Proteins Govern Ca2+ Dynamics in Normal and Reactive Astrocytes.
Buscemi L, Ginet V, Lopatar J, Montana V, Pucci L, Spagnuolo P, Zehnder T, Grubi i V, Truttman A, Sala C, Hirt L, Parpura V, Puyal J, Bezzi P.
Cereb Cortex, 2017

7. Synaptic Integration of Adult-Born Hippocampal Neurons Is Locally Controlled by Astrocytes.
Sultan S, Li L, Moss J, Petrelli F, Cassé F, Gebara E, Lopatar J, Pfrieger FW, Bezzi P, Bischofberger J, Toni N.
Neuron, 2016

8. G-protein coupled receptor-evoked glutamate exocytosis from astrocytes: role of prostaglandins.
Cali C, Lopatar J, Petrelli F, Pucci L, Bezzi P.
Neural Plast., 2014

1. Reviews last 5 years

1. mGlu5-mediated signalling in developing astrocyte and the pathogenesis of autism spectrum disorders.
Petrelli F, Bezzi P.
Curr Opin Neurobiol., 2018

2. Astrocytes and Microglia and Their Potential Link with Autism Spectrum Disorders.
Petrelli F, Pucci L, Bezzi P.
Front Cell Neurosci., 2016

3. Novel insights into gliotransmitters.
Petrelli F, Bezzi P.
Curr Opin Pharmacol., 2016

4. Understanding the multifaceted role of inflammatory mediators in ischemic stroke
Amantea D, Tassorelli C, Petrelli F, Certo M, Bezzi P, Micieli G, Corasaniti MT, Bagetta G. Curr Med Chem., 2013

Titolo Rivista Anno
Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments MOLECULAR PSYCHIATRY 2020
Spatio-temporal overview of neuroinflammation in an experimental mouse stroke model SCIENTIFIC REPORTS 2019
mGlu5-mediated signalling in developing astrocyte and the pathogenesis of autism spectrum disorders 2018
Insights into the release mechanism of astrocytic glutamate evoking in neurons NMDA receptor-mediated slow depolarizing inward currents GLIA 2018
Homer1 scaffold proteins govern Ca2+ dynamics in normal and reactive astrocytes CEREBRAL CORTEX 2017
SHANK3 controls maturation of social reward circuits in the VTA NATURE NEUROSCIENCE 2016
Astrocytes and microglia and their potential link with autism spectrum disorders FRONTIERS IN CELLULAR NEUROSCIENCE 2016
Novel insights into gliotransmitters CURRENT OPINION IN PHARMACOLOGY 2016
Synaptic Integration of Adult-Born Hippocampal Neurons Is Locally Controlled by Astrocytes NEURON 2015
Dipartimento
FISIOLOGIA E FARMACOLOGIA "VITTORIO ERSPAMER"
SSD

BIO/09