SUSANNA SCARPA

Corsi di Patologia e Fisiopatologia Generale I e II nei corsi di laurea in Medicina e Chirurgia corso D, Medicina e Chirurgia corso B, III anno I-II semestre  

Scuola di Specializzazione in Farmacia Ospedaliera

Scuola di Specializzazione in Oncologia Medica

• 1981 Laurea in Scienze Biologiche presso l'Universita` degli Studi di Padova
• 1982/1984 Visiting Fellow presso il National Cancer Institute, National Institutes of Health,
Bethesda, Maryland, USA
• 1984 Abilitazione alla Professione di Biologo
• 1985 Consulting Expert presso il National Cancer Institute, National Institutes of Health, Bethesda,
USA
• 1985/1990 Specializzazione in Patologia Clinica presso l'Istituto di Patologia Generale,
Dipartimento di Medicina Sperimentale, Facolta` di Medicina e Chirurgia, Universita` degli Studi
La Sapienza, Roma
• 1987 Visiting Fellow presso il National Cancer Institute, National Institutes of Health, Bethesda,
USA
• 1990/1998 Ricercatore F04A, Dipartimento di Medicina Sperimentale e Patologia, Università degli
Studi La Sapienza, Roma
• 1991 Specialista in Patologia Clinica, Universita` degli Studi La Sapienza di Roma
• 1998/2001 Professore Associato di Patologia Generale F04A, Facoltà di Medicina e Chirurgia
“Agostino Gemelli” dell’Università Cattolica del Sacro Cuore
• dal 2001 Professore Ordinario di Patologia Generale, ssd MED/04, presso il Dipartimento di
Medicina Sperimentale, Facoltà di Medicina ed Odontoiatria, Università Sapienza, Roma

• Pubblicazioni
Modesti A, Kalebic T, Scarpa S, Togo S, Liotta L, Triche TJ: Type V collagen in human amnion is a 12 nm fibrillar
component of the pericellular interstitium. European Journal of Cell Biology 35: 246-255, 1984.
Verna R, Galli C, Pascale E, Pozzi D, D'Amore L, Scarpa S, Frati L, Modesti A: Prostaglandin-induced storage and
secretion of esteroproteases in the mouse submaxillary gland. Cytobios 46: 37-41, 1986.
Scarpa S, Modesti A, Triche TJ: Extracellular matrix synthesis by undifferentiated childhood neoplasia. American
Journal of Pathology 129: 74-85, 1987.
Scarpa S, D'Orazi G, Modesti M, Modesti A: Ewing's sarcoma lines synthesize laminin and fibronectin. Virchows
Archives A 410: 375-381, 1987.
Tsokos M, Scarpa S, Ross RA, Triche TJ: Differentation of human neuroblastoma recapitulates neural crest
development: study of morphology, neurotrasmitter enzymes and extracellular matrix proteins. American Journal of
Pathology 128: 484-496, 1987.
Santoni A, Scarpa S, Morrone S, Punturieri A, Gismondi A, D'Orazi G, Testi R, Piccoli M, Frati L, Modesti A:
Laminin production by Natural Killer Cells. Protides of Biological Fluids 35: 217-220, 1987.
Scarpa S, D'Orazi G, Modesti A, Valia S, Zucco F, Stammati A: Expression and synthesis of fibronectin and laminin
by an intestinal epithelial cell line. Tissue & Cell 20: 305-312, 1988.
Scarpa S, Morstyn G, Carney DN, Modesti A, Triche TJ: Small cell lung cancer pure and variant types can be
distinguished by their extracellular matrix synthesis in vitro. The European Respiratory Journal 1: 639-644, 1988.
Santoni A, Punturieri A, Morrone S, Scarpa S, Gismondi A, D'Orazi G, Piccoli M, Frati L, Modesti A: Laminin
expression by rat lymphoid cells. The Italian Journal of Biochemistry 37: 244A-246A, 1988.
Scarpa S, Dominici C, Grammatico P, Del Porto G, Raschella` G, Castello M, Forni G, Modesti A: Establishment
and characterization of a human neuroblastoma cell line. International Journal of Cancer, 43: 645-652, 1989.
Santoni A, Gismondi A, Morrone S, Procopio A, Modesti A, Scarpa S, D'Orazi G, Piccoli M, Frati L: Rat natural
Killer cells synthesize fibronectin: possible involvement in the cytotoxic function. The Journal of Immunology 143:
2415-2421, 1989.
Morrone S, Scarpa S, Punturieri A, Testi R, Gismondi A, Santoni G, Piccoli M, Frati L, Modesti A, Santoni A:
Laminin synthesis by NK cells and modulation of its expression by TPA. Experimental Cell Research 182: 543-549,
1989.
Scarpa S, Reddy MP, Bressani N, Mims S, Massari F, Triche TJ: A novel 500,000 Da, linear, single chain
extracellular protein synthesized by several childhood tumors. The Italian Journal of Biochemistry 38: 330-348,
1989.
Caretto P, Forni M, D'Orazi G, Scarpa S, Feraiorni P, Jemma C, Modesti A, Ferrarini M, Roncella S, Foa` R, Forni
G: Xenotransplantation in immunosuppressed nude mice of human solid tumors and acute leukemias directly from
patients or in vitro cell lines. Research in Clinic and Laboratory 19: 231-243, 1989.
Silvestroni L, Menditto A, Modesti A, Scarpa S: Zinc uptake in human seminal spermatozoa: characterization and
effects on cell membranes. Archives of Andrology 23: 97-103, 1989.
Carbonari M, Gaetano C, Cerchi M, Scarpa S, Modesti A, Fiorilli M: Expression of the natural killer antigen Leu
19/NKH-1 by human neural tumor cell lines. Journal of Immunological Research 1: 163-167, 1989.
Raschella` G, Negroni A, Giubilei C, Romeo A, Mauro F, Scarpa S, Castello M, Dominici C: Human neuroblastoma
as model for studing tumor heterogeneity at genomic and trascriptional level. Clinical Chemistry and Enzymology
Communications 2: 253-259, 1990.
Grammatico P, Lo Re ML, Scarpa S, Modesti A, Del Porto G: Human malignant melanoma: significance of
chromosomal aberrations. Cancer Genetics and Cytogenetics 48: 237-242, 1990.
Bosco MC, Giovarelli M, Forni M, Modesti A, Scarpa S, Masuelli L, Forni G: Low doses of IL-4 injected
perilymphatically in tumor-bearing mice inhibit the growth of poorly and apparently nonimmunogenic tumors and
induce a tumor specific immune memory. The Journal of Immunology 145: 3136-3143, 1990.
Negroni A, Scarpa S, Romeo A, Ferrari S, Modesti A, Raschella` G: Decrease of proliferation rate and induction of
differentiation by an MYCN antisense oligomer in a human neuroblastoma cell line. Cell Growth and Differentiation
2: 511-518, 1991.
Grammatico P, Scarpa S, Steindl K, Picardo M, Modesti A, Nazzaro-Porro M, Del Porto G: Effect of azelaic acid on
viability, ultrastructure and karyotype of melanoma cells in long term culture. The Cancer Journal 4: 39-43, 1991.
Grammatico P, Modesti A, Steindl K, Scarpa S, Heouaine A, Del Porto G: Lentigo maligna: cytogenetic,
ultrastructural and phenotypic characterization of a primary cell culture. Cancer Genetics and Cytogenetics 60: 141-
146, 1992.
Screpanti I, Meco D, Scarpa S, Morrone S, Frati L, Gulino A, Modesti A: Neuromodulatory loop mediated by nerve
growth factor and interleukin 6 in thymic stromal cell cultures. Proceedings National Academy Science USA 89:
3209-3212, 1992.
Scarpa S, D'Orazi G, Ragano-Caracciolo M, Cardelli P, Masuelli L, Modesti A: Modulation of laminin synthesis in
human neuroblastoma cells during retinoic acid induced differentiation. Cancer Letters 64: 31-37, 1992.
Gnessi L, Emidi A, Farini D, Scarpa S, Modesti A, Ciampani T, Silvestroni L, Spera G: Rat Leydig cells bind
platelet-derived growth factor through specific receptors and produce platelet-derived growth factor- like molecules.
Endocrinology 130: 2219-2224, 1992.
Gambella GR, Bellotti S, Cutolo M, Modesti A, Scarpa S, Novelli A, Ravera GB: Changes in fibronectin production
in rat liver during cirrhotic evolution due to treatment with CCl4 and steroid hormones: correlation with plasmatic
fibronectin. Pathologica 84: 343-361, 1992.
Modesti A, Masuelli L, Modica A, D'Orazi G, Scarpa S, Bosco M, Forni G: Ultrastructural evidence of the
mechanisms responsible for interleukin-4-activated rejection of a spontaneous murine adenocarcinoma.
International Journal of Cancer 53: 988-993, 1993.
Grammatico P, Scarpa S, Picardo M, Steindl K, Nazzaro-Porro M, Del Porto G: Karyotype modification in human
malignant melanoma cell cultures after treatment with azelaic acid. Mutation Research 300: 119-123, 1993.
Gnessi L, Emidi A, Scarpa S, Palleschi S, Ragano-Caracciolo M, Silvestroni L, Modesti A, Spera G: Platelet-
derived growth factors effects on purified testicular peritubular myoid cells: binding, cytosolic Ca++ increase,
mitogenic activity, and extracellular matrix production enhancement. Endocrinology 133: 1880-1890, 1993.
Manna A, Scarpa S, Reale MG, Oppido PA, Frati L: Human meningioma and neuron specific enolase expression.
The International Journal of Biological Markers 9: 146-147, 1994.
Grammatico P, Balus L, Scarpa S, Varesco L, Di Rosa C, Grammatico B, Del Porto G: Granulomatous Slack Skin:
cytogenetic and molecular analysis. Cancer Genetics and Cytogenetics 72: 96-100, 1994.
Scarpa S, Mincione G, Ragano-Caracciolo M, Modesti A, Colletta G: Transforming growth factor alpha modulates
replication and differentiation markers on a human neuroblastoma cell line. International Journal of Oncology 5:
547-552, 1994.
Meco D, Scarpa S, Napolitano M, Maroder M, Bellavia D, De Maria R, Ragano-Caracciolo M, Frati L, Modesti A,
Gulino A, Screpanti I: Modulation of fibronectin and thymic stromal cell-dependent thymocyte maturation by retinoic
acid. The Journal of Immunology 153: 73-83, 1994.
Gaetano C, Melchiori A, Albini A, Benelli R, Falcioni R, Modesti A, Modica A, Scarpa S, Sacchi A: Retinoic acid
negatively regulates beta4-integrin expression and suppresses the malignant phenotype in a Lewis lung carcinoma
cell line. Clinical Experimental Metastasis 12: 63-72, 1994.
Martinotti S, Toniato E, Colagrande A, Alesse E, Alleva C, Screpanti I, Morrone S, Scarpa S, Frati L, Hayday AC,
Piovella F, Gulino A: Heavy-metal modulation of the human intercellular adhesion molecule ICAM-I gene
expression. Biochimica et Biophysica Acta 1261: 107-114, 1995.
Screpanti I, Romani L, Musiani P, Modesti A, Fattori E, Lazzaro D, Sellitto C, Scarpa S, Bellavia D, Lattanzio G,
Bistoni F, Frati L, Cortese R, Gulino A, Ciliberto G, Costantini F, Poli V: Lymphoproliferative disorder and
imbalanced T-helper response in C/EBPbeta-deficent mice.
The EMBO Journal 14: 1932-1941, 1995.
Screpanti I, Scarpa S, Meco D, Bellavia D, Stuppia L, Frati L, Modesti A, Gulino A: Epidermal growth factor
promotes a neural phenotype in thymic epithelial cells and enhances neuropoietic cytokine expression. Journal of
Cell Biology 130: 183-192, 1995.
Maroder M, Scarpa S, Screpanti I, Stigliano A, Meco D, Vacca A, Stuppia L, Frati L, Modesti A, Gulino A: Human
immunodeficency virus type-1 tat protein modulates fibronectin expression in thymic epithelial cells and impairs in
vitro thymocyte development. Cellular Immunology 168: 49-58, 1996.
Gentile V, Modesti A, La Pera G, Vasaturo F, Modica A, Prigiotti G, Di Silverio F, Scarpa S: Ultrastructural and
immunohistochemical characterization of the tunica albuginea in Peyronie's disease and veno-occlusive
dysfunction. Journal of Andrology 17: 96-103, 1996.
Scarpa S, Coppa A, Ragano-Caracciolo M, Mincione G, Giuffrida A, Modesti A, Colletta G: Transforming growth
factor beta regulates differentiation and proliferation of human neuroblastoma. Experimental Cell Research 229:
147-154, 1996.
Scarpa S, Negroni A, Amendola R, Signorelli P, Calabretta B, Modesti A, Raschellà G: Phenotypic and
morphological characterization of neuroblastoma cells costitutively expressing B-myb. Journal of Neuro-oncology
31: 107-114, 1997.
Scarpa S, Giuffrida A, Palumbo C, Vasaturo F, Signorelli P, Forni G, Modesti M, Ferrantini M, Belardelli F,
Musiani P, Modesti A: Extracellular matrix remodelling in a murine mammary adenocarcinoma transfected with
the interferon alpha1 gene. J Pathol 181: 116-123, 1997.
Coppa A, Mincione G, Lazzareschi D, Ranieri A, Turco A, Lucignano B, Scarpa S, Ragano-Caracciolo M, Colletta
G: Restored expression of transforming growth factor beta type II receptor in k-ras-transformed thyroid cells,
TGFb-resistant, reverts their malignant phenotype. J Cell Physiol 172: 200-208, 1997.
Vasaturo F, Modesti A, Scarpa S: Interferon gamma modifies fibronectin and laminin synthesis in human
neuroblastoma cell lines. Int J Oncol 12: 895-898, 1998.
Savini F, Rucci C, Messina E, Quarantino CP, Scarpa S, Vasaturo F, Modesti A, Giacomello A: Differentiating and
biochemical effects of a reduction of intracellular GTP levels induced by mycophenolic acid in human
neuroblastoma cell lines. Adv Exp Med Biol 431: 443-446, 1998.
Scarpa S, Giuffrida A, Fazi M, Coletti A, Palumbo C, Pass HI, Procopio A, Modesti A: Migration of mesothelioma
cells correlates with histotype-specific synthesis of extracellular matrix. Int J Mol Med 4: 67-71, 1999.
Vacca A, Di Marcotullio L, Giannini G, Farina M, Scarpa S, Stopacciaro A, Calce A, Maroder M, Frati L, Screpanti
I, Gulino A: Thrombospondin-1 is a mediator of the neurotypic differentiation induced by EGF in thymic epithelial
cells. Exp Cell Res 248: 79-86, 1999.
Giannini G, Di Marcotullio L, Ristori E, Zani M, Crescenzi M, Scarpa S, Piaggio G, Vacca A, Peverali FA, Diana F,
Screpanti I, Frati L, Gulino A: HMGI(Y) and HMGI-C genes are expressed in neuroblastoma cell lines and tumors
and affect retinoic acid responsiveness. Cancer Res 59: 2484-2492, 1999.
Turco A, Scarpa S, Coppa A, Baccheschi G, Palumbo C, Leonetti C, Zupi G, Colletta G: Increased TGFbeta type
II receptor expression suppresses the malignant phenotype and induces differentiation of human neuroblastoma
cells. Exp Cell Res. 225: 77-85, 2000.
Scarpa S, Giuffrida A, Palumbo C, Coletti A, Cerrito MG, Vasaturo F, Sinibaldi P, Simonelli L, Procopio A, Modesti
A: Retinoic acid inhibits fibronectin and laminin synthesis and cell migration of human pleural mesothelioma in
vitro. Oncol Reports 9: 205-209, 2002.
Santini D, Vincenzi B, Tonini G, Scarpa S, Baldi A: Zoledronic acid exhibits inhibitory effects on osteoblastic and
osteolytic metastases of prostate cancer. Clin Cancer Res 9: 3215-3216, 2003.
Santini D, Vespasiani Gentilucci U, Vincenzi B, Picardi A, Vasaturo F, La Cesa A, Onori N, Scarpa S, Tonini G:
The antineoplastic role of biphosphonates: from basic research to clinical evidence. Ann Oncol 14: 1468-1476,
2003.
Gradilone A, Gazzaniga P, Ribuffo D, Scarpa S, Cigna E, Vasaturo F, Bottoni U, Innocenzi D, Calvieri S, Scuderi
N, Frati L, Aglianò AM: Survivin, bcl2, bax and bclX gene expression in sentinel lymph nodes from melanoma
patients. J Clin Oncol 21: 306-312, 2003.
Biondi-Zoccai GL, Abbate A, Vasaturo F, Scarpa S, Santini D, Leone AM, Parisi Q, de Giorgio F, Bussani R,
Silvestri F, Baldi F, Biasucci LM, Baldi A: Increased apoptosis in remote non-infarcted myocardium in multivessel
coronary disease. Int J Cardiol, 94: 105-110, 2004.
Baldi A, Santini D, Vasaturo F, Santini M, Vicidomini G, Di Marino M, Esposito V, Groeger AM, Vincenzi B, Tonini
G, Piccoli M, Baldi F, Scarpa S: Prognostic significance of cyclooxygenase-2 (COX-2) and cell cycle inhibitors p21
and p27 expression in human pleural malignant mesothelioma. Thorax 59: 428-433, 2004.
Salvioli R, Scarpa S, Ciaffoni F, Tatti M, Ramoni C, Vanier MT, Vaccaro AM: Glucosylceramidase mass and
subcellular localization are modulated by cholesterol in Niemann-Pick disease type C. J Biol Chem 279: 17674-
17680, 2004.
Vasaturo F, Malacrino C, Sallusti E, Coppotelli G, Birarelli P, Giuffrida A, Albonici L, Simonelli L, Modesti A,
Modesti M, Scarpa S: Role of extracellular matrix in regulation of staurosporine-induced apoptosis in breast
cancer cells. Oncol Report 13: 745-750, 2005.
Salvioli R, Tatti M, Scarpa S, Moavero SM, Ciaffoni F, Felicetti F, Kaneski CR, Brady RO, Vaccaro AM: The
N370S mutation affects the capacity of glucosylceramidase to interact with anionic phospholipid-containing
membranes and Saposin C. Biochem J 390: 95-103, 2005.
Vasaturo F, Sallusti E, Gradilone A, Malacrino C, Nardo T, Avagnano G, Aglianò AM, Granato T, Vincenzi B,
Coppotelli G, Marzullo A, Soda G, Modesti M, Scarpa S: Comparison of extracellular matrix and apoptotic
markers between benign lesions and carcinomas in human breast. Int J Oncol. 27: 1005-11, 2005.
Parisi Q, Biondi-Zoccai GG, Abbate A, Santini D, Vasaturo F, Scarpa S, Bussani R, Leone AM, Petrolini A,
Silvestri F, Biasucci LM, Baldi A. Hypoxia inducible factor-1 expression mediates myocardial response to
ischemia late after acute myocardial infarction. Int J Cardiol. 99: 337-339, 2005.
Abbate A, Bussani R, Biondi-Zoccai GG, Santini D, Vasaturo F, Scarpa S, Severino A, Biasucci LM, Baldi A.
Infarct related artery occlusion, tissue markers of ischemia and increased apoptosis in the peri-infarct viable
myocardium. Eur Heart J 26: 2039-2045, 2005.
Santini D, Vincenzi B, Tonini G, Scarpa S, Vasaturo F, Malacrino C, Vecchio F, Borzomati D, Valeri S, Coppola R,
Nuzzo G, Picciocchi A. Cyclooxygenase-2 overexpression is associated with a poor out come in resecate
ampullary cancer patients. Clin Cancer Res 11: 3784-3789, 2005.
Santini D, Caraglia M, Vincenzi B, Holen I, Scarpa S, Budillon A, Tonini G. Mechanisms of disease: preclinical
reports of antineoplastic synergistic action of bisphosphonates. Nature Clin Pract Oncol 3: 325-338, 2006.
Abbate A, Limana F, Capogrossi MC, Santini D, Biondi-Zoccai GG, Scarpa S, Germani A, Straino S, Severino A,
Vasaturo F, Campioni M, Liuzzo G, Crea F, Vetrovec GW, Biasucci LM, Baldi A: Cyclo-oxygenase 2 inhibition
reduces apoptosis in acute myocardial infarction. Apoptosis 11: 1061-3, 2006.
Abbate A, Scarpa S, Santini D, Palleiro J, Vasaturo F, Miller L, Morales C, Vetrovec GW, Baldi A: Myocardial
expression of servivi, an apoptosis inhibitor, in aging and heart failure. An experimental study in the
spontaneously hypertensive rat. Int J Cardiol 111: 371-376, 2006.
Abbate A, Morales C, De Falco M, Fedele V, Biondi Zoccai GG, Santini D, Palleriro J, Scarpa S, Vasaturo F,
Liuzzo G, Severino A, Baldi F, Crea F, Biasucci LM, Vetrovec GW, Gelpi RJ, Baldi A. Ischemia and apoptosis in
an animal model of permanent infarct-related artery occlusion. Int J Cardiol 121: 109-111, 2007.
Gradilone A, Gazzaniga P, Cigna E, Vasaturo F, Vincenzi B, Gandini O, Silvestri I, Ribuffo D, Scarpa S, Scuderi
N, Aglianò AM. Fibronectin and laminin expression in sentinel lymph nodes of patients with malignant melanoma.
Br J Dermatol.157: 398-401, 2007.
Gazzaniga P, Silvestri I, Gradilone A, Scarpa S, Morrone S, Gandini O, Gianni W, Frati L, Aglianò AM.
Gemcitabine-induced apoptosis in 5637 cell line: an in-vitro model for high-risk superficial bladder cancer. Anti-
cancer Drug 18: 179-85, 2007.
Salvioli R, Ricci-Titiani L, Tatti M, Scarpa S, De Maria R, Vaccaro AM: The secretion and maturation of
prosaposin and procathepsin D are blocked in embryonic progenitor cells. BBA 1783: 1480-1489, 2008.
Vaccaro AM, Motta M, Tatti M, Scarpa S, Masuelli L, Bhat M, Vanier MT, Salvioli R: Saposin C mutations in
Gaucher disease patients resulting in lisosoma lipid accumulation, saposin C deficency but normal prosaposin
processing and sorting. Hum Mol Genetics 19: 2987-2997, 2010.
Tatti M, Motta M, Di Bartolomeo S, Scarpa S, Cianfanelli V, Cecconi F, Salvioli R. Reduced chatepsins B and D
cause impaired autophagic degradation that can be almost completely restored by overexpression of these two
proteases in Sap C deficient fibroblasts. Hum Mol Genet 21: 6159-5173, 2012.
Vicinanza R, Coppotelli G, Malacrino C, Nardo T, Buchetti B, Lenti L, Celi F, Scarpa S. Oxidized-LDL impair
endothelial function by inhibiting non-genomic action of thyroid hormone-mediated nitric oxide production in
human endothelial cells. Thyroid 23: 231-238, 2013.
Silvestri I, Cattarino S, Aglianò A, Nicolazzo C, Scarpa S, Salciccia S, Frati L, Gentile V, Sciarra A. Effect of
Serenoa repens (Permixon®) on the expression of inflammation-related genes: analysis in primary cell cultures of
human prostate carcinoma. J Inflamm 10: 11. doi: 10.1186/1476-9255-10-11, 2013.
Vasaturo F, Solai F, Malacrino C, Nardo T, Vincenzi B, Modesti M, Scarpa S. Plasma levels of matrix
metalloproteinases 2 and 9 correlate with histological grade in breast cancer patients. Oncol Lett. 5: 316-320,
2013.
De Iuliis F, Amoroso L, Taglieri L, Vendittozzi S, Blasi L, Salerno G, Lanza R, Scarpa S. Chemotherapy of rare
skin adnexal tumors: a review of literature. Anticancer Res. 34: 5263-8, 2014.
De Iuliis F, Salerno G, Taglieri L, Vicinanza R, Lanza R, Scarpa S. Elderly woman with triple-negative metastatic
breast cancer successfully treated with metronomic capecitabine. Anticancer Res. 34: 4287-91, 2014.
Nardo T, Micalizzi G, Vicinanza R, De Iuliis F, Taglieri L, Scarpa S. Adhesion to type V collagen enhances
staurosporine-induced apoptosis of adrenocortical cancer cells. Tumour Biol. 35: 9949-55. doi: 10.1007/s13277-
014-2281-6, 2014.
De Iuliis F, Taglieri L, Amoroso L, Vendittozzi S, Blasi L, Salerno G, Lanza R, Scarpa S. Prevention of
osteonecrosis of the jaw in patients with bone metastases treated with bisphosphonates. Anticancer Res. 34:
2477-80, 2014.
De Iuliis F, Amoroso L, Blasi L, Vendittozzi S, Taglieri L, Salerno G, Buongiorno G, Bandiera G, Lanza R, Scarpa S.
Unexpected vocal cord paralysis and myasthenia gravis in a patient with squamous cell lung cancer. J Clin & Exp
Oncol. 3: 2-5, 2014.
Sini V, De Iuliis F, Graziano P, Mandolini PL, Cursano C, Menghi A, Taglieri L, Lanza R, Scarpa S. Single lung and
bone metastasis 30 years after thyroid cancer onset. Eur J Oncol 19: 185-189, 2014.
Bianchi E, Taurone S, Bardella L, Signore A, Pompili E, Sessa V, Chiappetta C, Fumagalli L, Di Gioia C, Pastore
FS, Scarpa S, Artico M. Involvement of pro-inflammatory cytokines and growth factors in the pathogenesis of
Dupuytren's contracture: a novel target for a possible future therapeutic strategy? Clin Sci 129: 711-20. doi:
10.1042/CS20150088, 2015.
De Iuliis F, Salerno G, Taglieri L, Scarpa S. Are pharmacogenomic biomarkers an effective tool to predict taxane
toxicity and outcome in breast cancer patients? Literature review. Cancer Chemother Pharmacol. 76: 679-90. doi:
10.1007/s00280-015-2818-4, 2015.
De Iuliis F, Taglieri L, Salerno G, Lanza R, Scarpa S. Taxane induced neuropathy in patients affected by breast
cancer: Literature review. Crit Rev Oncol Hematol. 96: 34-45. doi: 10.1016/j.critrevonc.2015.04.011, 2015.
Tatti M, Motta M, Scarpa S, Di Bartolomeo S, Cianfanelli V, Tartaglia M, Salvioli R. BCM-95 and (2-hydroxypropyl)-
β-cyclodextrin reverse autophagy dysfunction and deplete stored lipids in Sap C-deficient fibroblasts. Hum Mol
Genet. 24: 4198-211. doi: 10.1093/hmg/ddv153, 2015.
De Iuliis F, Salerno G, Taglieri L, Lanza R, Scarpa S. On and off metronomic oral vinorelbine in elderly women with
advanced breast cancer. Tumori 101: 30-5. doi: 10.5301/tj.5000207, 2015.
De Iuliis F, Lanza R, Scarpa S. Are we ready to change clinical practice after the 'soft and text' results? Future
Oncol. 11: 2857-2860, 2015.
De Monte C, Carradori S, Secci D, D’Ascenzio M, Guglielmi P, Mollica A, Morrone S, Scarpa S, Aglianò AM,
Giantulli S, Silvestri I. Synthesis and pharmacological screening of a large library of 1,3,4-thiadiazolines as
innovative therapeutic tools for the treatment of prostate cancer and melanoma. Europ J Med Chem 105: 245-62.
doi: 10.1016/j.ejmech.2015.10.023, 2015.
Amoroso L, De Iuliis F, Scarpa S. Molecular alterations chemoresistance-related in ovarian cancer patients and
related target therapies. Chapter 11 in Handbook on Ovarian Cancer, B.R. Collier editor, Nova Science Publishers
ISBN 9781634838740, 2015.
De Iuliis F, Amoroso L, Scarpa S. Elderly oravian cancer patients: treatment options. Chapter 14 in Handbook on
Ovarian Cancer, B.R. Collier editor, Nova Science Publishers ISBN 9781634838740, 2015.
De Iuliis F, Salerno G, Giuffrida A, Milana B, Taglieri L, Rubinacci G, Giantulli S, Terella F, Silvestri I, Scarpa S.
Breast cancer cells respond differently to docetaxel depending on their phenotype and on survivin upregulation.
Tumour Biol. 37: 2603-2611. doi: 10.1007/s13277-015-4075-X, 2016.
De Iuliis F, Salerno G, Taglieri L, De Biase L, Lanza R, Cardelli P, Scarpa S. Serum biomarkers evaluation to
predict chemotherapy-induced cardiotoxicity in breast cancer patients. Tumour Biol. 37: 3379-3387. doi:
10.1007/s13277-015-4183-7, 2016.
De Iuliis F, Taglieri L, Salerno G, Giuffrida A, Milana B, Giantulli S, Carradori S, Silvestri I, Scarpa S. The kinesin
Eg5 inhibitor K858 induces apoptosis but also survivin-related chemoresistance in breast cancer cells. Invest. New
Drugs 34: 399-406. doi: 10.1007/s10637-016-0345-8, 2016.
Corvino R, De Iuliis F, D’Aniello D, Cefalì K, Lanza R, Scarpa S. Novel schedule for treatment of inflammatory
breast cancer. Open J. Clin. Med. Case Reports. 2 (20): 1175. ISSN 2379-1039, 2016.
Corvino R, De Iuliis F, D’Aniello D, Cefalì K, Ferraro E, Lamazza A, Lanza R, Scarpa S. Long-lasting stent
placement in an elderly advanced ovarian cancer patient. Oncol Res Treat. 39: 146-8. doi: 10.1159/000444273,
2016.
De Iuliis F, Mandolini PL, Cursano MC, Menghi A, Salerno G, Taglieri L, Curatolo P, Lanza R, Scarpa S. Nodal and
cutaneous Kaposi’s sarcoma. G Ital Dermatol Venereol. 151: 215-216, 2016.
De Iuliis, Vendittozzi S, Taglieri L, Salerno G, Lanza R, Scarpa S. Metronomic chemotherapy preserves quality of
life ensuring efficacy in elderly advanced non-small cell lung cancer patients. Int J Cancer Clin Res. 3: 46. ISSN:
2378-3419, 2016.
De Iuliis F, Salerno G, Corvino R, D’Aniello D, Cefalì K, Taglieri L, Lanza R, Scarpa S. Anthracycline-free
neoadjuvant chemotherapy ensures higher rates of pathologic complete response in breast cancer. Clin Breast
Cancer 17: 34-40. doi: 10.1016/j.clbc.2016.06.010, 2017.
De Iuliis F, Salerno G, Taglieri L, Lanza R, Cardelli P, Scarpa S. Circulating neuregulin-1 and galectin-3 can be
prognostic markers in breast cancer. Int J Biol Markers 32: 333-336. doi: 10.5301/ijbm.5000262, 2017.
Taglieri L, De Iuliis F, Giuffrida A, Giantulli S, Silvestri I, Scarpa S. Resistance to the mTOR inhibitor everolimus
can be reversed by the downregulation of survivin in breast cancer cells. Oncol Lett. 14: 3832-3838. doi:
10.3892/ol.2017.6597, 2017.
Taglieri L, Nardo T, Vicinanza R, Ross JM, Scarpa S, Coppotelli G. Thyroid hormone regulates fibronectin
expression through the activation of the hypoxia inducible factor 1. Biochem Biophys Res Commun 493: 1304-
1310, doi: 10.1016/j.bbrc.2017.09.169, 2017.
Taglieri L, Rubinacci G, Giuffrida A, Carradori S, Scarpa S. The kinesin Eg5 inhibitor K858 induces apoptosis and
reverses the malignant invasive phenotype in human glioblastoma cells. Invest. New Drugs 36: 28-35. doi:
10.1007/s10637-017-0517-1, 2018.
Giantulli S, De Iuliis F, Taglieri L, Carradori S, Menichelli G, Morrone S, Scarpa S, Silvestri I. Growth arrest and
apoptosis induced by kinesin Eg5 inhibitor K858 and by its 1,3,4-thiadiazoline analogue in tumor cells. Anti-cancer
Drugs 29: 674-681. doi: 10.1097/CAD.0000000000000641, 2018.
Silvestri I, Tortorella E, Giantulli S, Scarpa S, Sciarra A. Immunotherapy in prostate cancer: Recent advances and
future directions. Europ. Medical Journal 7: 51-61, 2019.
Sciarra A, Gentilucci A, Silvestri I, Salciccia S, Scarpa S, Cattarino S, Gatto A, Frantellizzi V, Von Heland M,
Ricciuti GP, Del Giudice F, Maggi M. Androgen receptor variant 7 (AR-V7) in sequencing therapeutic agents for
castration resistant prostate cancer: a critical review. Medicine 98: 19 (e15608). doi:
10.1097/MD.0000000000015608, 2019.
Taurone S, Spoletini M, Chiappetta C, Di Gioia C, Carletti R, Greco A, Agostinelli E, Ralli M, Giangaspero F, Artico
M, Pastore MS, Scarpa S, Gobbi P, Di Liddo R. Brain gliomas and growth factors: immunohistochemical,
immunofluorescence, flow cytometry and RT-PCR profile in pediatric age. Journal of Biological regulators and
homeostatic agents 33: 1451-1463, 2019.
Domenici F, Capocefalo A, Brasili F, Bedini A, Giliberti C, Palomba R, Silvestri I, Scarpa S, Morrone S, Paradossi G,
Frogley M, Cinque G. Ultrasound delivery of surface enhanced InfraRed absorption active gold-nanoprobes into
fibroblast cells: a biological study via Synchrotron-based InfraRed microanalysis at single cell level. Scientific
Reports 9: 11845. doi: 10.1038/s41598-019-48292-0, 2019.
Stazi G, Taglieri L, Nicolai A, Romanelli A, Fioravanti R, Morrone S, Sabatino M, Ragno R, Taurone S, Nebbioso S,
Carletti R, Artico M, Valente S, Scarpa S, Mai A. Dissecting the role of novel EZH2 inhibitors in primary
glioblastoma cell cultures: effects on proliferation, epithelial-mesenchymal transition, migration, and on the pro-
inflammatory phenotype. Clinical Epigenetics 11: 173. doi: 10.1186/s13148-019-0763-5, 2019.
Taglieri L, Saccoliti F, Nicolai A, Peruzzi G, Madia VN, Tudino V, Messore A, Di Santo R, Artico M, Taurone S,
Salvati M, Costi R, Scarpa S. Discovery of a pyrimidine compound endowed with antitumor activity. Invest. New
Drugs 38: 39-49. doi: 10.1007/s10637-019-00762-y, 2020.
Sciarra A, Maggi M, Salciccia S, Nicolai A, Tortorella E, Giantulli S, Magliocca F, Silvestri I, Taglieri L, Cattarino S,
Scarpa S. Tissue expression of androgen receptor splice variant 7 at radical prostatectomy predicts risk of
progression in untreated non-metastatic prostate cancer. Oncology, doi: 10.1159/000512445, 2021.
Madia VM, Nicolai A, Messore A, De Leo A, Ialongo D, Tudino V, Saccoliti F, De Vita D, Scipione L, Artico M,
Taurone S, Taglieri L, Di Santo R, Scarpa S, Costi. Design, synthesis and biological evaluation of new pyrimidine
derivatives as anticancer agents. Molecules, 26, 771. doi: 10.3390/molecules26030771, 2021.
Nicolai A, Madia VM, Messore A, De Leo A, Ialongo D, Tudino V, Tortorella E, Scipione L, Taurone S, Pergolizzi T,
Artico M, Di Santo R, Costi R, Scarpa S. Anti-tumoral effects of a benzimidazolyl carbamate ester derivative on
head and neck squamous carcinoma cell lines. Pharmaceuticals 14: 564. doi: 10.3390/ph14060564, 2021.
Giantulli S, Tortorella E, Brasili F, Scarpa S, Cerroni B, Paradossi G, Bedini A, Morrone S, Silvestri I, Domenici F.
Effect of 1-MHz ultrasound on the proinflammatory interleukin-6 secretion in human keratiocytes. Scientific Reports
11: 19033, doi: 10.1038/s41598-021-98141-2, 2021.
Colafrancesco S, Barbati C, Priori R, Putro E, Giardina F, Gattamelata A, Monosi B, Colasanti T, Celia AI, Cerbelli
B, Giordano C, Scarpa S, Fusconi M, Berardicurti O, Gandolfo S, Nayar S, Barone F, Giacomelli R, De Vita S,
Alessandri C, Conti F. Maladaptive autophagy in the pathogenesis of autoimmune epithelitis in Sjogren’s
Syndrome. Arthritis Rheumatology, 74: 654-664, doi: 10.1002/art.42018, 2022.
Colasanti T, Spinelli FR, Barbati C, Ceccarelli F, Scarpa S, Vomero M, Alessandri C, Valesini G, Conti F.
Belimumab decreases autophagy and citrullination in peripheral blood mononuclear cells from patients with
Systemic Lupus Erythematosus. Cells, 11: 262, doi: 10.3390/cells11020262, 2022.
Taurone S, Ralli M, Artico M, Madia VN, Scarpa S, Nottola SA, maconi A, Betti M, Familiari P, Nebbioso M, Costi R,
Micera A. Oxidative stress and visual system: a review. EXCLI Journal, 21: 544-553, doi: 10.17179/excli2022-4663,
2022.
Nicolai A, Taurone S, Carradori S, Artico M, Greco A, Costi R, Scarpa S. The kinesin Eg5 inhibitor K858 exerts
antiproliferative and proapoptotic effects and attenuates the invasive potential of head and neck squamous
carcinoma cells. Investigational New Drugs, 40: 556-564, doi: 10.1007/s10637-022-01238-2, 2022.
Taurone S, De Ponte C, Rotili D, De Sanctis E, Mai A, Fiorentino F, Scarpa S, Artico M, Micera A. Biochemical
functions and clinical characterizations of the sirtuins in diabetes-induced retinal pathologies. International journal
of Molecular Sciences 23: 4048-4054, doi: 10.3390/ijms23074048, 2022.
Barbati C, Celia AI, Colasanti T, Vomero M, Speziali M, Putro E, Buoncuore G, Savino F, Ucci FM, Scarpa S,
Alessandri C, Conti F. Autophagy hijacking in PBMC from COVID-19 patients results in lymphopenia. Frontiers in
Immunology 13: 903498, doi: 10.3389/fimmu.2022.903498, 2022.
Ialongo D, Messore A, Madia VN, Tudino V, Nocentini A, Gratteri P, Giovannuzzi S, Supuran CT, Nicolai A, Scarpa
S, Taurone S, Camarda M, Artico M, Papa V, Saccoliti F, Luigi Scipione L, Di Santo R, Costi R. Pyrrolyl and indolyl
α-γ-diketo acid derivatives acting as selective inhibitors of human carbonic anhydrases IX and XII. Pharmaceuticals
16: 188, doi: 10.3390/ph16020188, 2023.