Ritratto di helena.stabile@uniroma1.it

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Insegnamento Codice Anno Corso - Frequentare Bacheca
ADE AAF1433 2023/2024
PATOLOGIA GENERALE 1019206 2023/2024
IMMUNOLOGIA ED IMMUNOPATOLOGIA 1030914 2023/2024
IMMUNOLOGIA ED IMMUNOPATOLOGIA - PATOLOGIA MOLECOLARE E CELLULARE 10596057 2023/2024
CORSO INTERDISCIPLINARE II 1036295 2023/2024
ADE AAF1433 2022/2023
PATOLOGIA GENERALE 1019206 2022/2023
CORSO INTERDISCIPLINARE II 1036295 2022/2023
IMMUNOLOGIA ED IMMUNOPATOLOGIA - PATOLOGIA MOLECOLARE E CELLULARE 10596057 2022/2023
IMMUNOLOGIA ED IMMUNOPATOLOGIA 1030914 2022/2023
ADE AAF1433 2021/2022
PATOLOGIA GENERALE 1019206 2021/2022
CORSO INTERDISCIPLINARE II 1036295 2021/2022
IMMUNOLOGIA ED IMMUNOPATOLOGIA 1030914 2021/2022
IMMUNOLOGIA ED IMMUNOPATOLOGIA - PATOLOGIA MOLECOLARE E CELLULARE 10596057 2021/2022
ADE AAF1433 2020/2021
CORSO INTERDISCIPLINARE II 1036295 2020/2021
PATOLOGIA GENERALE 1019206 2020/2021
IMMUNOLOGIA ED IMMUNOPATOLOGIA 1030914 2020/2021
IMMUNOLOGIA ED IMMUNOPATOLOGIA - PATOLOGIA MOLECOLARE E CELLULARE 10596057 2020/2021
IMMUNOLOGIA ED IMMUNOPATOLOGIA 1030914 2020/2021
PATOLOGIA GENERALE 1019206 2019/2020
IMMUNOLOGIA ED IMMUNOPATOLOGIA - PATOLOGIA MOLECOLARE E CELLULARE 1055794 2019/2020
PATOLOGIA GENERALE 1019206 2018/2019
IMMUNOLOGIA ED IMMUNOPATOLOGIA - PATOLOGIA MOLECOLARE E CELLULARE 1055794 2018/2019
PATOLOGIA GENERALE 1019206 2017/2018
IMMUNOLOGIA ED IMMUNOPATOLOGIA - PATOLOGIA MOLECOLARE E CELLULARE 1055794 2017/2018
IMMUNOLOGIA ED IMMUNOPATOLOGIA - PATOLOGIA MOLECOLARE E CELLULARE 1044591 2016/2017

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Curriculum Vitae

Name: Maria Helena Stabile
Natinality: Italian
Work address: Department of Molecular Medicine, Policlinico Umberto I
University of Rome Sapienza , Viale Regina Elena 324, 00161 Rome, Italy.
e-mail: helena.stabile@uniroma1.it
Education

Type Year Institution

University graduation 1998 University of Milan, Degree in Biological Sciences (Summa cum Laude).
Pre-doctorate training 1999-2000 University of Brescia, School of Medicine. Research fellow at the Department
Research fellow at the Department of Molecular and Translational Medicine.
Licensure 2001 University of Milan, Licensure in Biology (180/180).
PhD 2005 University of Brescia, School of Medicine.
PhD in Cellular and Molecular Biotechnologies (excellent).
ASN 2018 National academic qualification as associate professor.
Abilitazione Scientifica Nazionale Fascia II SC 06/N1 SSD MED/46.

Accademic Appointments

2011-2020 Researcher Assistant Professor at La Sapienza University of Rome.
2020-present Associate Professor at La Sapienza University of Rome.

Teaching Experience:

2012-present Teaching in Immunology and Immunopathology at University of Rome La Sapienza .

Professional interests

Tumor immunology Phenotypical and functional characterization of innate lymphoid cells (ILCs) in human patients affected by solid and haematological tumors.

NK cell biology Analysis of biochemical events triggered by chemokine receptors in human NK cells.
Receptor-triggered signals leading to activation of NK cell migration and functions.
Study of the relationship between circulating and tissue resident NK cells, and the role played by specific tissue microenvironments in the modulation of NK cell phenotypic and functional profile

Tumor Angiogenesis Purification and characterization of angiogenic factors involved in tumor angiogienesis. Setting of in vivo and in vitro models of angiogenesis.

Enzymology Functional and structural characterization of enzymes by cinetic and spetroscopics techniques.

Laboratory experience

Intimate knowledge of modern scientific methodologies that deals with the culture of eukaryotic cells, microbiology, biochemistry, and molecular biology.
In details: Techniques of cellular biology for in vitro studies; Biochemical techniques for protein analysis; Molecular biology techniques; Techniques for the in vivo study of potentially angiogenic and tumorigenic substances; Flow cytometry.
Editorial Position

2016-present Member of the Editorial board for Frontiers in Immunology-Session: Cytokine and Soluble Mediators in Immunity.
2017 Guest Editor: Special issue for AIMS Allergy Immunology on Novel insight on NK cell receptors and their ligands in health and disease .
2019 Guest Editor: Special Issue for Journal of Clinical Medicine on "Development and Function of Natural Killer Cells and their Importance in Immunotherapy".

Pubblications

Reale R, Peruzzi G, Ghoreishi M, Stabile H, Ruocco G, Leonetti M. A low-cost, label-free microfluidic scanning flow cytometer for high-accuracy quantification of size and refractive index of particles.
Lab Chip. 2023 Apr 12;23(8):2039-2047. doi: 10.1039/d2lc01179d.
PMID: 36897350

Cippitelli M, Stabile H, Kosta A, Petillo S, Lucantonio L, Gismondi A, Santoni A, Fionda C. Role of NF- B Signaling in the Interplay between Multiple Myeloma and Mesenchymal Stromal Cells.
Int J Mol Sci. 2023 Jan 17;24(3):1823. doi: 10.3390/ijms24031823.
PMID: 36768145

Fionda C, Ruggeri S, Sciumè G, Laffranchi M, Quinti I, Milito C, Palange P, Menichini I, Sozzani S, Frati L, Gismondi A, Santoni A, Stabile H.
Front Immunol. 2022 Nov 17;13:1039120. doi: 10.3389/fimmu.2022.1039120. eCollection 2022. Age-dependent NK cell dysfunctions in severe COVID-19 patients.
PMID: 36466890

Milito ND, Zingoni A, Stabile H, Soriani A, Capuano C, Cippitelli M, Gismondi A, Santoni A, Paolini R, Molfetta R. NKG2D engagement on human NK cells leads to DNAM-1 hypo-responsiveness through different converging mechanisms.
Eur J Immunol. 2023 Feb;53(2):e2250198. doi: 10.1002/eji.202250198. Epub 2022 Dec 8.
PMID: 36440686

Kosta A, Mekhloufi A, Lucantonio L, Zingoni A, Soriani A, Cippitelli M, Gismondi A, Fazio F, Petrucci MT, Santoni A, Stabile H, Fionda C. GAS6/TAM signaling pathway controls MICA expression in multiple myeloma cells.
Front Immunol. 2022 Jul 28;13:942640. doi: 10.3389/fimmu.2022.942640. eCollection 2022.
PMID: 35967396

Fionda C, Scarno G, Stabile H, Molfetta R, Di Censo C, Gismondi A, Paolini R, Sozzani S, Santoni A, Sciumè G. NK Cells and Other Cytotoxic Innate Lymphocytes in Colorectal Cancer Progression and Metastasis.
Int J Mol Sci. 2022 Jul 16;23(14):7859. doi: 10.3390/ijms23147859.
PMID: 35887206

Grimaldi A, Pietropaolo G, Stabile H, Kosta A, Capuano C, Gismondi A, Santoni A, Sciumè G, Fionda C. The Regulatory Activity of Noncoding RNAs in ILCs. Cells. 2021 Oct 14;10(10):2742. doi: 10.3390/cells10102742.
PMID: 34685721

Fionda C, Stabile H, Molfetta R, Kosta A, Peruzzi G, Ruggeri S, Zingoni A, Capuano C, Soriani A, Paolini R, Gismondi A, Cippitelli M, Santoni A. Cereblon regulates NK cell cytotoxicity and migration via Rac1 activation.
Eur J Immunol. 2021 Nov;51(11):2607-2617. doi: 10.1002/eji.202149269. Epub 2021 Sep 18.
PMID: 34392531

Di Censo C, Marotel M, Mattiola I, Müller L, Scarno G, Pietropaolo G, Peruzzi G, Laffranchi M, Mazej J, Hasim MS, Asif S, Russo E, Tomaipitinca L, Stabile H, Lee SH, Vian L, Gadina M, Gismondi A, Shih HY, Mikami Y, Capuano C, Bernardini G, Bonelli M, Sozzani S, Diefenbach A, Ardolino M, Santoni A, Sciumè G. Granzyme A and CD160 expression delineates ILC1 with graded functions in the mouse liver.
Eur J Immunol. 2021 Nov;51(11):2568-2575. doi: 10.1002/eji.202149209. Epub 2021 Aug 19.
PMID: 34347289

Grimaldi A, Pietropaolo G, Stabile H, Kosta A, Capuano C, Gismondi A, Santoni A, Sciumè G, Fionda C.
Cells. 2021 Oct 14;10(10):2742. doi: 10.3390/cells10102742. The Regulatory Activity of Noncoding RNAs in ILCs.
PMID: 34685721 Free PMC article. Review.

Pietropaolo G, Scarno G, Stabile H, Grimaldi A, Gismondi A, Santoni A, Sciumè G.
NK cell and ILC heterogeneity in colorectal cancer. New perspectives from high dimensional data.
Mol Aspects Med. 2021 Apr 30:100967. doi: 10.1016/j.mam.2021.100967. Online ahead of print.
PMID: 33941383

Cippitelli M, Stabile H, Kosta A, Petillo S, Gismondi A, Santoni A, Fionda C.
Role of Aiolos and Ikaros in the Antitumor and Immunomodulatory Activity of IMiDs in Multiple Myeloma: Better to Lose Than to Find Them.
Int J Mol Sci. 2021 Jan 22;22(3):1103. doi: 10.3390/ijms22031103.
PMID: 33499314 Free PMC article. Review.

Macchia I, La Sorsa V, Ruspantini I, Sanchez M, Tirelli V, Carollo M, Fedele G, Leone P, Schiavoni G, Buccione C, Rizza P, Nisticò P, Palermo B, Morrone S, Stabile H, Rughetti A, Nuti M, Zizzari IG, Fionda C, Maggio R, Capuano C, Quintarelli C, Sinibaldi M, Agrati C, Casetti R, Rozo Gonzalez A, Iacobone F, Gismondi A, Belardelli F, Biffoni M, Urbani F.
"Multicentre Harmonisation of a Six-Colour Flow Cytometry Panel for Naïve/Memory T Cell Immunomonitoring".
J Immunol Res. 2020 Aug 10;2020:2698258. doi: 10.1155/2020/2698258. eCollection 2020.
PMID: 32851098 Free PMC article.

Mekhloufi A, Kosta A, Stabile H, Molfetta R, Zingoni A, Soriani A, Cippitelli M, Paolini R, Gismondi A, Ricciardi MR, Petrucci MT, Masuelli L, Caracciolo G, Palchetti S, Santoni A, Fionda C. Bone Marrow Stromal Cell-Derived IL-8 Upregulates PVR Expression on Multiple Myeloma Cells via NF-kB Transcription Factor. Cancers (Basel). 2020 Feb 13;12(2). pii: E440. doi: 10.3390/cancers12020440.

Molfetta R, Zitti B, Lecce M, Milito ND, Stabile H, Fionda C, Cippitelli M, Gismondi A, Santoni A, Paolini R. CD155: A Multi-Functional Molecule in Tumor Progression. Int J Mol Sci. 2020 Jan 30;21(3). pii: E922. doi: 10.3390/ijms21030922. Review.

Fionda C*, Stabile H*, Cerboni C, Soriani A, Gismondi A, Cippitelli M, Santoni A.
Hitting More Birds with a Stone: Impact of TGF- on ILC Activity in Cancer. J Clin Med. 2020 Jan 5;9(1). pii: E143. doi: 10.3390/jcm9010143. Review. *Authors equally contributed

Stabile H, Nisti P, Fionda C, Pagliara D, Gaspari S, Locatelli F, Santoni A, Gismondi A.
NK Cell Reconstitution in Paediatric Leukemic Patients after T-Cell-Depleted HLA-Haploidentical Haematopoietic Stem Cell Transplantation Followed by the Reinfusion of iCasp9-Modified Donor T Cells. J Clin Med. 2019 Nov 7;8(11). pii: E1904. doi: 10.3390/jcm8111904.

Fionda C, Di Bona D, Kosta A, Stabile H, Santoni A, Cippitelli M.
The POU-Domain Transcription Factor Oct-6/POU3F1 as a Regulator of Cellular Response to Genotoxic Stress. Cancers (Basel). 2019 Jun 11;11(6). pii: E810. doi: 10.3390/cancers11060810. Published by MDPI AG, Basel, Switzerland.

Sciumè G, Fionda C, Stabile H, Gismondi A, Santoni A.
Negative regulation of innate lymphoid cell responses in inflammation and cancer. Immunol Lett. 2019 Jan 31. pii: S0165-2478(18)30610-2. doi: 10.1016/j.imlet.2019.01.011. Published by Elsevier

Carlino C, Rippo MR, Lazzarini R, Monsurrò V, Morrone S, Angelini S, Trotta E, Stabile H, Bastianelli C, Albertini MC, Olivieri F, Procopio A, Santoni A, Gismondi A.
Differential microRNA expression between decidual and peripheral blood natural killer cells in early pregnancy. Hum Reprod. 2018 Dec 1;33(12):2184-2195. doi: 10.1093/humrep/dey323. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology.

Vulpis E*, Stabile H*, Soriani A, Fionda C, Petrucci MT, Mariggio' E, Ricciardi MR, Cippitelli M, Gismondi A, Santoni A, Zingoni A. Key Role of the CD56lowCD16low Natural Killer Cell Subset in the Recognition and Killing of Multiple Myeloma Cells. Cancers (Basel). 2018 Nov 29;10(12). pii: E473. doi: 10.3390/cancers10120473. *Authors equally contributed Published by MDPI AG, Basel, Switzerland.

Fionda C, Stabile H, Molfetta R, Soriani A, Bernardini G, Zingoni A, Gismondi A, Paolini R, Cippitelli M, Santoni A.
Translating the anti-myeloma activity of Natural Killer cells into clinical application. Cancer Treat Rev. 2018 Nov;70:255-264. doi: 10.1016/j.ctrv.2018.10.005. Epub 2018 Oct 10. Review. Published by Elsevier B.V.

Stabile H, Scarno G, Fionda C, Gismondi A, Santoni A, Gadina M, Sciumè G.
JAK/STAT signaling in regulation of innate lymphoid cells: The gods before the guardians Immunol Rev. 2018 Nov;286(1):148-159. doi: 10.1111/imr.12705. Review. Published by John Wiley & Sons Ltd

Stabile H , Fionda C, Santoni A, Gismondi A.
Impact of bone marrow-derived signals on NK cell development and functional maturation. Cytokine Growth Factor Rev. 2018 Aug;42:13-19. doi: 10.1016/j.cytogfr.2018.03.008. Epub 2018 Mar 27. Review. Corresponding author. Published by Elsevier Ltd.

Soriani A, Stabile H, Gismondi A, Santoni A, Bernardini G.
Chemokine regulation of innate lymphoid cell tissue distribution and function. Cytokine Growth Factor Rev. 2018 Aug;42:47-55. doi: 10.1016/j.cytogfr.2018.02.003. Epub 2018 Feb 14. Review. Published by Elsevier Ltd.

Bernardini G, Vulpis E, Bonanni V, Stabile H, Ricciardi MR, Petrucci MT, Gismondi A, Santoni A, Zingoni A.
High expression levels of IP10/CXCL10 are associated with modulation of the natural killer cell compartment in multiple myeloma. Leuk Lymphoma. 2017 Oct;58(10):2493-2496. doi: 10.1080/10428194.2017.1295144. Epub 2017 Feb 28. Published by Tailor & Francis group

Stabile H, Nisti P, Peruzzi G, Fionda C, Pagliara D, Pomonia BL, Merli P, Locatelli F, Santoni A and Gismondi A.
Reconstitution of multifunctional CD56lowCD16low Natural Killer cell subset in children with acute leukemia given T cell-depleted HLA-haploidentical hematopoietic stem cell transplantation. Oncoimmunology, 2017. 16; 6 (10) doi: 10.1080/2162402X.2017 Published by Taylor & Francis.

Zitti B, Molfetta R, Fionda C, Quatrini L, Stabile H, de Turris V, Petrucci MT, Ricciardi MR, Cippitelli M, Gismondi A, Angela Santoni A, Paolini R.
Innate immune activating ligand SUMOylation affects tumor cell recognition by NK cells. Sci Rep. 2017 Sep 5;7(1):10445. doi: 10.1038/s41598-017-10403-0. Published by Nature group

Del Prete A, Schioppa T, Tiberio L, Stabile H, Sozzani S.
Leukocyte trafficking in tumor microenvironment. Curr Opin Pharmacol, 2017. 31;35:40-47. doi: 10.1016/j.coph.2017.05.004. Review. Published by Elsevier Ltd.

Stabile H*, Fionda C*, Gismondi A and Santoni A.
Role of Distinct natural Killer Cell Subsets in Anticancer Response. 2017. Front Immunol, 2017. 16;8:293. doi: 10.3389/fimmu.2017.00293. Review. *Authors equally contributed

Bernardini G, Vulpis E, Bonanni V, Stabile H, Ricciardi MR, Petrucci MT, Gismondi A, Santoni A, Zingoni A.
High expression levels of IP10/CXCL10 are associated with modulation of the natural killer cell compartment in multiple myeloma. Leuk Lymphoma, 2017. 28:1-4. doi: 10.1080/10428194.2017.1295144.

Franzese O, Palermo B, Di Donna C, Sperduti I, Ferraresi V, Stabile H, Gismondi A, Santoni A, Nisticò P.
Polyfunctional Melan-A-specific tumor-reactive CD8(+) T cells elicited by dacarbazine treatment before peptide-vaccination depends on AKT activation sustained by ICOS. Oncoimmunology, 2016. 1;5(5):e1114203. doi: 10.1080/2162402X.2015.1114203.

Gismondi A, Stabile H, Nisti P, Santoni A.
Effector Functions of Natural Killer Cell Subsets in the Control of Hematological Malignancies. Front Immunol, 2015. 5;6:567. doi: 10.3389/fimmu.2015.00567. Review.

Stabile H, Nisti P, Pagliara D, Locatelli F, Santoni A, Gismondi A.
Response to comment on Multifunctional human CD56low CD16low NK cells are the prominent subset in bone marrow of both pediatric healthy donors and leukemic patients. Haematologica, 2015.100(8):e332-3. doi: 10.3324/haematol.2015.130831.

Galli F, Rapisarda AS, Stabile H, Manni I, Bonanno E, Piaggio G. Gismondi A, Santoni A, Signore A.
In vivo imaging of NK cell trafficking in tumors. J Nucl Med, 2015. 56(10):1575-80. doi: 10.2967/jnumed.114.152918.

Stabile H, Nisti P, Morrone S, Pagliara D, Bertaina A, Locatelli F, Santoni A, Gismondi A.
Multifunctional human CD56low CD16low natural killer cells are the prominent subset in bone marrow of both pediatric healthy donors and leukemic patients. Haematologica, 2015. Haematologica. 2015 Apr;100(4):489-98. doi: 10.3324/haematol.2014.116053. Epub 2015 Jan 16. Published by Ferrata Storti Fundation.

Carlino C, Trotta E, Stabile H, Morrone S, Bulla R, Soriani A, Iannitto ML, Agostinis C, Mocci C, Minozzi M, Aragona C, Perniola G, Tedesco F, Sozzani S, Santoni A, Gismondi A.
Chemerin regulates NK cell accumulation and endothelial cell morphogenesis in the decidua during early pregnancy. J Clin Endocrinol Metab, 2012. 97(10):3603-12.

Agostinis C, Bulla R, Tripodo C, Gismondi A, Stabile H, Bossi F, Guarnotta C, Garlanda C, De Seta, Spessotto P, Santoni A, Ghebrehiwet B, Ghirardi G, Tedesco F.
An alternative Role of C1q in Cell Migration and Tissue Remodeling: Contribution to Trophoblast Invasion and Placental Developement. J Immunol, 2010. 1;185(7):4420-9. doi: 10.4049/jimmunol. 0903215.

Stabile H, Carlino C, Mazza C, Giliani S, Morrone S, Notarangelo L, Notarangelo L.D, Santoni A, Gismondi A.
Impaired NK cell migration in WAS/XLT patients: role of Cdc42/WASp in the control of chemokine-induced integrin high-affinity state. Blood, 2010. 8; 115(14):2818-26.

Mellone M, Rinaldi C, Massimi I, Petroni M, Veschi V, Talora C, Truffa S, Stabile H., Frati L, Screpanti I, Gulino A, Giannini G.
Human Papilloma Virus-Dependent HMGA1 Expression Is a Relevant Step in Cervical Carcinogenesis. Neoplasia, 2008. 10(8):773-81.

Santoni A, Carlino C, Stabile H, Gismondi A.
Mechanisms underlying the recruitment and accumulation of decidual NK cells in the uterus during pregnancy. Am J Reprod Immunol. 2008. 59:417-424.

Carlino C, Stabile H., Morrone S, Bulla R, Soriani A, Agostinis C, Bossi F, Mocci C, Sarzani F, Tedesco F, Santoni A, Gismondi A.
Recruitment of circulating NK cells through decidual tissues: a possible meachanism controlling NK cell accumulation in the uterus during early pregnancy. Blood 2008. 15; 111:3108-15.

Stabile H, Mitola S, Moroni E, Belleri M, Nicoli S, Coltrini D, Peri F, Pessi A, Orsatti L, Talamo F, Castronovo V, Waltregny D, Cotelli F, Ribatti D, Presta M.
Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor. Blood. 2007. 1; 109:1834-40.

Presta M, Oreste P, Zoppetti G, Belleri M, Tanghetti E, Leali D, Urbinati C, Bugatti A, Ronca R, Nicoli S, Moroni E, Stabile H, Camozzi M, Hernandez GA, Mitola S, Dell Era P, Rusnati M. Ribatti D.
Antiangiogenetic Activity of Semisynthetic Biotechnological Heparins. Low-Molecular-Weight-Sulfated Escherichia coli K5 Polysaccharide Derivatives a Fibroblast Growth Factor Antagonists. Arteriosclerosis Thrombosis and Vascular Biology. 2005; 25:71-76.

Conti P, Roda G, Stabile H, Vanoni M.A, Curti B, De Amici M.
Syntesis and biological evaluation of new amino acids structurally related to antitumor agent acivicin. Farmaco, 2003. 58: 683-90.

Leali D, Dell Era P, Stabile H, Sennino B, Chambers A.F, Naldini A, Sozzani S, B. Nico B, Ribatti D, Presta M.
Osteopontin (Eta-1) and Fibroblast Growth Factor-2 Cross-Talk in Angiogenesis. J Immunol, 2003. 15; 171: 1085-93.

Presta M, Leali D, Stabile H, Ronca R, Camozzi M, Coco L, Moroni E, Liekens S, Rusnati M. Heparin derivatives as angiogenesis inhibitors Curr. Pharma. Design, 2003. 9: 553-566.

Dell Era P. Belleri M. Stabile H. Massardi M.L. Ribatti D. Presta M.
Paracrine and autocrine effects of fibroblast growth factor-4 in endothelial cells. Oncogene 2001, 10; 2655-2663.

Stabile, H. Curti, B. Vanoni M.A.
Functional properties of recombinant Azospirillum brasilense glutamate synthase, a complex iron-sulfur flavoprotein. Eur.J. Biochem. 2000, 267:2720-2730.

Rome, 19-04-2023

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