SILVIA ROMANO

CLINICAL AND RESEARCH ACTIVITY
I have a broad background in hereditary neurological disorders with specific training and expertise in
clinical features and treatment of patients with spastic paraplegias, cerebellar ataxias, Huntington disease
and hereditary cerebrovascular disease such as in diagnosis and treatment of multiple sclerosis.
Specifically, my research focuses on clinical trial using repurposing approaches.
WORK EXPERIENCE
Jun 2025-Present Associate professor
Employer Role Sapienza University of Rome NESMOS Department
Research activities Neurogenetics outpatient clinic at SantAndrea Hospital,
Rome
2022-May 2025 Senior Researcher
Employer Role Sapienza University of Rome NESMOS Department
Research activities at the Multiple Sclerosis Center and Neurogenetics
outpatient clinic at SantAndrea Hospital, Rome
Aug 2020-Oct 2022 Neurologist
Pagina 1 - Curriculum vitae et studiorum
Dr.ssa Silvia Romano
Employer ASL RM2 – UOS Disabile Adulto Distretto 6
Role Clinical Neurologist
Jan 2021-Jul 2021 Research collaborator
Employer NESMOS Department, Sapienza University of Rome Faculty of Medicine and
Psychology
Role Research activity on neurodegenerative diseases
Mar 2019-Aug 2020 Research fellow
Employer NESMOS Department, Sapienza University of Rome Faculty of Medicine and
Psychology
Role Research activities within the project Demyelinating, Dysmyelinating and
Heredodegenerative Diseases
Jan 2014-Jan 2019 Researcher
Employer Sapienza University of Rome, Azienda Ospedaliera Sant’Andrea, Experimental
Therapies Center (CENTERS), Rome
Role Clinical and research activities at the Multiple Sclerosis Center and
Neurogenetics outpatient clinic, SantAndrea Hospital, Rome
2007-present Neurologist
Employer Role Italian Huntingtons Disease Association (AICH), Rome
Specialist neurological consultations for patients with Huntingtons Disease
May 2013-Jan 2014 Consultant neurologist
Employer Ferrovie dello Stato
Role Neurological assessments for occupational suitability
Dec 2012-Nov 2013 Research fellow
Employer Psychology
Role Patients
NESMOS Department, Sapienza University of Rome Faculty of Medicine and
Research project on Potential Immunomodulatory Drugs in Multiple Sclerosis
Nov 2012 – Apr 2013 Neurologist
Employer S.Andrea Hospital - Rome
Role Consultant and clinical neurologist for the project "Efficacy of riluzole in
hereditary cerebellar ataxia a randomized double-blind placebo-controlled trial
-FARM7KAJM7
Nov 2010 – Apr 2011 Employer Role Nov 2008 – Sep 2009 Employer Role Post-doc Research fellow
Prof.ssa Marina Frontali, Institute of Neurobiology and Molecular Medicine
(CNR-INMM), Rome
Diagnosis and treatment of CADASIL patients in the research project Effects of
tetrahydrobiopterin (6R-BH4) on flow-mediated dilatation in CADASIL patients:
a randomized controlled trial (EudraCT No. 2007-004370-55)
Co.co.pro
Dr. Ugo Nocentini - IRCCS Santa Lucia di Rome
Management of research protocols on cognitive and psychological aspects of
Multiple Sclerosis
Feb 2008 – Jun 2008 Neurologist
Pagina 2 - Curriculum vitae et studiorum
Dr.ssa Silvia Romano
Employer Role Jan 2010 – Apr 2012 Employer Role Dr. Caterina Mariotti, Biochemistry and Genetics Unit, Carlo Besta Neurological
Institute Foundation (IRCCS), Milan
Clinical data collection, patient evaluations and presentations within the
research project EUROSCA European Integrated Project on Spinocerebellar
Ataxias
Consultant neurologist
Dr. Caterina Mariotti, Biochemistry and Genetics Unit, Carlo Besta Neurological
Institute Foundation (IRCCS), Milan
Consultant for “EUROSCA-European Integrated Project on Spinocerebellar
Ataxias: Pathogenesis, Genetics, Animal model – CT 2003.503304 – RB13”
Education and training
2016-2017 Master’s in “Therapeutic Development Methodologies in Neurology”
Institution Sapienza University of Rome
Grade 70/70 with honors
2006-2010 PhD in Experimental and Clinical Neurosciences
Institution Sapienza University of Rome
Grade 70/70 with honors
2002-2006 Specialization in Neurology
Institution Sapienza University of Rome
Grade 70/70 with honors
1995-2000 MD in Medicine and Surgery
Institution Sapienza University of Rome
Grade 110/110 with honors
CERTIFICATIONS &
COURSES
2023 GCP for Clinical Trials
2025 UHDRS Motor Rater Training
2019 Neurostatus Level C
2002-2025 Numerous courses in neurology, neuroimmunology, and clinical trials
Teaching activity and Supervision of Students
2012-today Seminars, training, and supervision of undergraduate and graduate
students, residents in neurology, PhD students and post-doc fellows.
Faculty of Medicine and Psycology and Physiotherapy Degree Program,
NESMOS Department Sapienza University of Rome, Italy
Pagina 3 - Curriculum vitae et studiorum
Dr.ssa Silvia Romano
2016-today Member of PhD Faculty in Neurosensory Plasticity, Faculty of Medicine and
Psycology, NESMOS Department Sapienza University of Rome, Italy
2019 National Qualification as Associate Professor in MED26 – Neurology
2022-today Professor of Nervous System Diseases and Nursing Processes at Faculty of
Medicine and Psycology, NESMOS Department Sapienza University of Rome,
Italy
Reviewer activity Review Editor for Frontiers in Neurology
Associate Editor for Frontiers in Neurology.
Collaboration I have several national and international
collaborations. I here enclose only few examples:
- Prof.ssa Paola Giunti, UCL Queen Square
Institute of Neurology, Londra, UK
- Joana DAMÁSIO, Neurologist of Centro
Hospitalar do Porto, Porto
- Prof. Roberto Rodriguez Labrada, Centro de
Neurociencias de Cuba,
- Prof.ssa Theresa Zesiewicz, University of South
Florida, Tampa, USA
- Prof.ssa Gabriella Silvestri, Policlinico Gemelli,
Rome, IT
- Prof.ssa Agnese Suppiej, University of Ferrara,
IT
Publications
Book Chapters
1. Romano S, Colosimo C. Aggiornamento sulla malattia di Hallervorden-Spatz. Giornale di
Neuropsicofarmacologia 1999; :91-94.
2. Romano S, Colosimo C. La malattia di Hallervorden-Spatz. In: Trattato Italiano di neurologia, a
cura di P. Bergonzi e AR Massaro. Verduci, Roma 1999, pp 123.1-123.5.
3. Romano S, Colosimo C. Atetosi e sindromi atetosiche. In: Trattato Italiano di neurologia, a cura
di P. Bergonzi e AR Massaro. Verduci, Roma 1999, pp 121.1-121.4.
4. Strano S, Romano S. La diagnostica strumentale della sincope neuro mediata e degli stati
ipotensivi. In: Quaderni di Neurofisiopatologia n° 6, a cura di Milena De Marinis, I.P. Service
Editrice, Roma 2001, pp 11-23.
5. Coauthor “I disturbi neuropsichiatrici nella sclerosi multipla” a cura di Nocentini U, Caltagirone
C, Tedeschi G. Edizione Springer-Verlag 2011.
6. Coauthor “Affrontare il rischio genetico e proteggere la speranza. Storia e risultati di un modello
di collaborazione tra ricercatori, medici e famiglie con malattia di Huntington”. Mondadori
Electa, 2016.
7. Ferraldeschi M, Romano s, Buscarinu MC, Fornasiero A, Mechelli R, Mattei c, Stazi Ma,
Alimonti A, Salvetti M,Ristori G. “ Chemical Elements and Oxidative Status in
Neuroinflammation” In: White AR, Aschner M, Costa LG, Bush AI, eds., Biometals in
Neurodegenerative Diseases: Mechanisms and Therapeutics, San Diego: Academic Press,
2017: pp 67-82
8. Coauthor “Encefaliti” in Neurologia della Sapienza. Prima, seconda e terza edizione (2012,
2015, 2019). Casa Editrice Esculapio
9. Coautore del capitolo “Sclerosi Multipla” in Neurologia della Sapienza. Terza edizione, 2019,
casa editrice Esculapio.
Pagina 4 - Curriculum vitae et studiorum
Dr.ssa Silvia Romano
Peer-reviewed publications
1. Vanacore N., Bonifati V., Fabbrini G., Colosimo C., De Michele G., Marconi R., Nicholl D.,
Locuratolo N., Talarico G., Romano S., Stocchi F., Bonuccelli U., De Mari M., Vieregge P., Meco G., for
the ESGAP Consortium. Epidemiology of multiple system atrophy. Neurol Sci 2001; 22:97-99.
2. Vanacore N., Bonifati V., Colosimo C., Fabbrini G., De Michele G., Marconi R., Nicholl D.,
Locuratolo N., Romano S., Talarico G., Stocchi F., Bonuccelli U.,Lamberti P., Vieregge P., Meco G., for
the ESGAP Consortium. Epidemiology of progressive sopranuclear palsy. Neurol Sci 2001; 22:101-103.
3. Romano S, Colosimo C. Procerus sign in progressive supranuclear palsy. Neurology
2001;57(10):1928.
4. Pozzilli C., Romano S., Cannoni S. Epidemiology and current treatment of multiple sclerosis in
Europe today. Journal of Rehabilitation Research and Development 2002; 39:175-185.
5. Colosimo C, Chianese M, Romano S. Is hypertension associated with hemifacial spasm?
Neurology 2003;61(4):587.
6. Pozzilli C, Marinelli F, Romano S, Bagnato F. Corticosteroids treatment. J Neurol Sci 2004;
223(1):47- 51.
7. Greco A, Minghetti L, Puopolo M, Cannoni S, Romano S, Pozzilli C, Levi G. Cerebrospinal fluid
isoprostanes are not related to inflammatory activity in relapsing-remitting multiple sclerosis. J Neurol Sci
2004; 224(1-2):23-7
8. Salsano E, Ciano C, Romano S, Cornelio F, Di Donato S, Pareyson D. Propriospinal myoclonus
with life threatening tonic spasms as paraneoplastic presentation of breast cancer. J Neurol Neurosurg
Psychiatry 2006; 77(3):422-4.
9. Schmitz-Hubsch T, Tezenas du Montcel S, Baliko L, Boesch S, Bonato S, Fancellu R, Giunti P,
Globas C, Kang JS, Kremer B, Mariotti C, Melegh B, Rakowicz M, Rola R, Romano S, Schols L,
Szymanski S, van de Warrenburg BP, Zdzienicka E, Durr A, Klockgether T. Reliability and validity of the
International Cooperative Ataxia Rating Scale: a study in 156 spinocerebellar ataxia patients. Mov
Disord 2006; 21(5):699-704.
10. Annibali V, Ristori G, Cannoni S, Romano S, Visconti A, Ghazaryan A, Figa Talamanca L,
Salvetti M, Mechelli R. Multiple sclerosis: pharmacogenomics and personalised drug treatment. Neurol
Sci 2006;27 Suppl 5:S347-9.
11. Romano S, Salvetti M, Ceccherini I, De Simone T, Savoiardo M. Brainstem signs with
progressing atrophy of medulla oblongata and upper cervical spinal cord. Lancet Neurol 2007
Jun;6(6):562-70
12. Caroli F, Biancheri R, Seri M, Rossi A, Pessagno A, Bugiani M, Corsolini F, Savasta S, Romano
S, Antonelli C, Romano A, Pareyson D, Gambero P, Uziel G, Ravazzolo R, Ceccherini I, Filocamo M.
GFAP mutations and polymorphisms in 13 unrelated Italian patients affected by Alexander disease. Clin
Genet 2007 Sep 25
13. Farina L, Pareyson D, Minati L, Ceccherini I, Chiapparini L, Romano S, Gambero P, Fancellu R,
Savoiardo M. Can MR imaging diagnose adult-onset Alexander disease? AJNR Am J Neuroradiol
2008;29:1190-6.
14. Pareyson D, Fancellu R, Mariotti C, Romano S, Salmaggi A, Carella F, Girotti F, Gattellaro G,
Carriero MR, Farina L, Ceccherini I, Savoiardo M. Adult-onset Alexander disease: a series of eleven
unrelated cases with review of the literature. Brain. 2008 Sep;131(Pt 9):2321-31.
Pagina 5 - Curriculum vitae et studiorum
Dr.ssa Silvia Romano
15. O'Connor P, Comi G, Montalban X, Antel J, Radue EW, de Vera A, Pohlmann H, Kappos L;
FTY720 D2201 Study Group. Oral fingolimod (FTY720) in multiple sclerosis: two-year results of a phase
II extension study. Neurology 2009;72:73-9.
16. Aziz NA, Jurgens CK, Landwehrmeyer GB; EHDN Registry Study Group, van Roon-Mom WM,
van Ommen GJ, Stijnen T, Roos RA. Normal and mutant HTT interact to affect clinical severity and
progression in Huntington disease. Neurology 2009;73:1280-5.
17. Romano S, Ristori G, Visconti A, Cannoni S, Spadaro M, Frontali M, Pontieri FE, Vanacore N,
Salvetti M. Riluzole in cerebellar ataxia: a randomized, double-blind, placebo-controlled pilot trial.
Neurology 2010; 74:839-45.
18. Spanò B, Cercignani M, Basile B, Romano S, Mannu R, Centonze D, Caltagirone C, Bramanti P,
Nocentini U, Bozzali M. Multiparametric MR investigation of the motor pyramidal system in patients with
'truly benign' multiple sclerosis. Mult Scler 2010;16:178-88
19. Comi G, O'Connor P, Montalban X, Antel J, Radue EW, Karlsson G, Pohlmann H, Aradhye S,
Kappos L; FTY720 D2201 Study Group. Phase II study of oral fingolimod (FTY720) in multiple sclerosis:
3- year results. Mult Scler 2010;16:197-207.
20. Mantuano E, Romano S, Veneziano L, Gellera C, Castellotti B, Caimi S, Testa D, Estienne M,
Zorzi G, Bugiani M, Rajabally YA, Barcina MJ, Servidei S, Panico A, Frontali M, Mariotti C. Identification
of novel and recurrent CACNA1A gene mutations in fifteen patients with episodic ataxia type 2. J Neurol
Sci 2010;291:30-6.
21. Orth M; European Huntington's Disease Network, Handley OJ, Schwenke C, Dunnett SB,
Craufurd D, Ho A, Wild EJ, Tabrizi SJ. Observing Huntington's Disease: the European Huntington's
Disease Network's REGISTRY. PLoS Curr 2010 Sep 28;2.
22. Bachetti T, Di Zanni E, Lantieri F, Caroli F, Regis S, Filocamo M, Rainero I, Gallone S, Cilia R,
Romano S, Savoiardo M, Pareyson D, Biancheri R, Ravazzolo R, Ceccherini I. A novel polymorphic AP-
1 binding element of the GFAP promoter is associated with different allelic transcriptional activities. Ann
Hum Genet 2010;74:506-15.
23. Busse, Monica; Al-Madfai, Hasan; Kenkre, Joyce; Landwehrmeyer, G. Bernhard; Bentivoglio,
Annarita; Rosser, Anne; European, Huntington's Disease Network. Utilisation of healthcare and
associated services in Huntington's disease: A data mining study. Plos Currents 2010, 3: 1-14.
24. Annibali V, Ristori G, Angelini DF, Serafini B, Mechelli R, Cannoni S, Romano S, Paolillo A,
Abderrahim H, Diamantini A, Borsellino G, Aloisi F, Battistini L, Salvetti M. CD161(high)CD8+T cells
bear pathogenetic potential in multiple sclerosis. Brain 2011;134:542-54.
25. Cavallari M, Falco T, Frontali M, Romano S, Bagnato F, Orzi F. Fractal analysis reveals reduced
complexity of retinal vessels in CADASIL. PLoS One. 2011 Apr 27;6(4):e19150.
26. Rickards H, De Souza J, van Walsem M, van Duijn E, Simpson SA, Squitieri F, Landwehrmeyer
B; European Huntington’s Disease Network. Factor analysis of behavioural symptoms in Huntington’s
disease. J Neurol Neurosurg Psychiatry. 2011 Apr; 82(4):411-2.
27. López-Sendón JL, Royuela A, Trigo P, Orth M, Lange H, Reilmann R, Keylock J, Rickards H,
Piacentini S, Squitieri F, Landwehrmeyer B, Witjes-Ane MN, Jurgens CK, Roos RA, Abraira V, de
Yébenes JG; European HD Network. What is the impact of education on Huntington's disease? Mov
Disord. 2011 Jul;26(8):1489-95.
Pagina 6 - Curriculum vitae et studiorum
Dr.ssa Silvia Romano
28. Saft C, Epplen JT, Wieczorek S, Landwehrmeyer GB, Roos RA, de Yebenes JG,Dose M,
Tabrizi SJ, Craufurd D; REGISTRY Investigators of the European Huntington's Disease Network, Arning
L. NMDA receptor gene variations as modifiers in Huntington disease: a replication study. PLoS Curr.
2011 Oct 4;3:RRN1247.
29. Orth M; European Huntington's Disease Network, Handley OJ, Schwenke C, Dunnett S, Wild
EJ, Tabrizi SJ, Landwehrmeyer GB. Observing Huntington's disease: the European Huntington's
Disease Network's REGISTRY. J Neurol Neurosurg Psychiatry. 2011 Dec;82(12):1409-12.
30. Campolo J, De Maria R, Frontali M, Taroni F, Inzitari D, Federico A, Romano S, Puca E, Mariotti
C, Tomasello C, Pantoni L, Pescini F, Dotti MT, Stromillo ML, De Stefano N, Tavani A, Parodi O.
Impaired vasoreactivity in mildly disabled CADASIL patients. J Neurol Neurosurg Psychiatry. 2012
Mar;83(3):268-74.
31. Quarrell OW, Handley O, O'Donovan K, Dumoulin C, Ramos-Arroyo M, Biunno I, Bauer P, Kline
M, Landwehrmeyer GB; European Huntington’s Disease Network. Discrepancies in reporting the CAG
repeat lengths for Huntington's disease. Eur J Hum Genet. 2012 Jan;20(1):20-6.
32. Lee JM, Ramos EM, Lee JH, Gillis T, Mysore JS, Hayden MR, Warby SC, Morrison P, Nance M,
Ross CA, Margolis RL, Squitieri F, Orobello S, Di Donato S, Gomez-Tortosa E, Ayuso C, Suchowersky
O, Trent RJ, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire MH,
Hersch SM, Rosas HD, Lucente D, Harrison MB, Zanko A, Abramson RK, Marder K, Sequeiros J,
Paulsen JS; PREDICT-HD study of the Huntington Study Group (HSG), Landwehrmeyer GB;
REGISTRY study of the European Huntington's Disease Network, Myers RH; HD-MAPS Study Group,
MacDonald ME, Gusella JF; COHORT study of the HSG. CAG repeat expansion in Huntington disease
determines age at onset in a fully dominant fashion. Neurology. 2012 Mar 6;78(10):690-5.
33. Soyal SM, Felder TK, Auer S, Hahne P, Oberkofler H, Witting A, Paulmichl M, Landwehrmeyer
GB, Weydt P, Patsch W; European Huntington Disease Network. A greatly extended PPARGC1A
genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of
onset. Hum Mol Genet. 2012 Aug 1;21(15):3461-73.
34. Mechelli R, Umeton R, Policano C, Annibali V, Coarelli G, Ricigliano VA, Vittori D, Fornasiero A,
Buscarinu MC; International Multiple Sclerosis Genetics Consortium; Wellcome Trust Case Control
Consortium, Romano S, Salvetti M, Ristori G. A "candidate-interactome" aggregate analysis of genome-
wide association data in multiple sclerosis. PLoS One. 2013 May 16;8(5):e63300
35. Vittori A, Orth M, Roos RA, Outeiro TF, Giorgini F, Hollox EJ; Registry investigators of the
European Huntington's Disease Network. β-Defensin genomic copy number does not influence the age
of onset in Huntington's Disease. J Huntingtons Dis. 2013;2(1):107-24.
36. Metzger S, Walter C, Riess O, Roos RA, Nielsen JE, Craufurd D; REGISTRY Investigators of
the European Huntington’s Disease Network, Nguyen HP. The V471A polymorphism in autophagy-
related gene ATG7 modifies age at onset specifically in Italian Huntington disease patients. PLoS One.
2013 Jul 22;8(7):e68951.
37. Hart EP, Marinus J, Burgunder JM, Bentivoglio AR, Craufurd D, Reilmann R, Saft C, Roos RA;
REGISTRY Investigators of the European Huntington's Disease Network. Better global and cognitive
functioning in choreatic versus hypokinetic-rigid Huntington's disease. Mov Disord. 2013 Jul;28(8):1142-
5.
Pagina 7 - Curriculum vitae et studiorum
Dr.ssa Silvia Romano
38. 58.
Hubers AA, van Duijn E, Roos RA, Craufurd D, Rickards H, Bernhard Landwehrmeyer G, van
der Mast RC, Giltay EJ; REGISTRY investigators of the European Huntington's Disease Network.
Suicidal ideation in a European Huntington's disease population. J Affect Disord. 2013 Oct;151(1):248-
39. Ristori G, Romano S, Cannoni S, Visconti A, Tinelli E, Mendozzi L, Cecconi P, Lanzillo R,
Quarantelli M, Buttinelli C, Gasperini C, Frontoni M, Coarelli G, Caputo D, Bresciamorra V, Vanacore N,
Pozzilli C, Salvetti M. Effects of Bacille Calmette-Guerin after the first demyelinating event in the CNS.
Neurology. 2014 Jan 7;82(1):41-8.
40. Veneziano L, Mantuano E, Catalli C, Gellera C, Durr A, Romano S, Spadaro M, Frontali M,
Novelletto A. A shared haplotype for dentatorubropallidoluysian atrophy (DRPLA) in Italian families
testifies of the recent introduction of the mutation. J Hum Genet. 2014 Mar;59(3):153-7.
41. De Maria R, Campolo J, Frontali M, Taroni F, Federico A, Inzitari D, Tavani A, Romano S, Puca
E, Orzi F, Francia A, Mariotti C, Tomasello C, Dotti MT, Stromillo ML, Pantoni L, Pescini F, Valenti R,
Pelucchi C, Parolini M, Parodi O. Effects of sapropterin on endothelium-dependent vasodilation in
patients with CADASIL: a randomized controlled trial. Stroke. 2014 Oct;45(10):2959-66.
42. Ristori G, Romano S, Coarelli G, Buscarinu MC, Salvetti M. Author response. Neurology. 2014
Jul 22;83(4):381.
43. Ristori G, Romano S, Coarelli G, Buscarinu MC, Salvetti M. Author response. Neurology. 2014
Jul 15;83(3):293.
44. Argento O, Incerti CC, Pisani V, Magistrale G, Di Battista G, Romano S, Ferraro E, Caltagirone
C, Nocentini U. Domestic accidents and multiple sclerosis: an exploratory study of occurrence and
possible causes. Disabil Rehabil. 2014;36(26):2205-9.
45. Mechelli R, Vittori D, Coarelli G, Aimati L, De Luca O, Romano S, Ricigliano VA, Annibali V,
Policano C, Mattei C, Salvetti M, Ristori G. Screening for neurotropic viruses in cerebrospinal fluid of
patients with multiple sclerosis and other neurological diseases. Mult Scler. 2014 Apr;20(5):638,
46. Bertolotto A, Capobianco M, Amato MP, Capello E, Capra R, Centonze D, Di Ioia M, Gallo A,
Grimaldi L, Imberti L, Lugaresi A, Mancinelli C, Marrosu MG, Moiola L, Montanari E, Romano S, Musu L,
Paolicelli D, Patti F, Pozzilli C, Rossi S, Salvetti M, Tedeschi G, Tola MR, Trojano M, Zaffaroni M,
Malucchi S; Italian Multiple Sclerosis Study group. Guidelines on the clinical use for the detection of
neutralizing antibodies (NAbs) to IFN beta in multiple sclerosis therapy: report from the Italian Multiple
Sclerosis Study group. Neurol Sci. 2014 Feb;35(2):307-16.
47. Vittori A, Breda C, Repici M, Orth M, Roos RA, Outeiro TF, Giorgini F, Hollox EJ; REGISTRY
investigators of the European Huntington's Disease Network. Copy-number variation of the neuronal
glucose transporter gene SLC2A3 and age of onset in Huntington's disease. Hum Mol Genet. 2014 Jun
15;23(12):3129-37.
48. Mechelli R, Manzari C, Policano C, Annese A, Picardi E, Umeton R, Fornasiero A, D'Erchia AM,
Buscarinu MC, Agliardi C, Annibali V, Serafini B, Rosicarelli B, Romano S, Angelini DF, Ricigliano VA,
Buttari F, Battistini L, Centonze D, Guerini FR, D'Alfonso S, Pesole G, Salvetti M, Ristori G. Epstein-
Barr virus genetic variants are associated with multiple sclerosis. Neurology. 2015 Mar 4.
49. Annibali V, Mechelli R, Romano S, Buscarinu MC, Fornasiero A, Umeton R, Ricigliano VA, Orzi
F, Coccia EM, Salvetti M, Ristori G. IFN-β and multiple sclerosis: from etiology to therapy and back.
Cytokine Growth Factor Rev. 2015 Apr;26(2):221-8.
Pagina 8 - Curriculum vitae et studiorum
Dr.ssa Silvia Romano
50. 16.
Bečanović K, Nørremølle A, Neal SJ, Kay C, Collins JA, Arenillas D, Lilja T, Gaudenzi G,
Manoharan S, Doty CN, Beck J, Lahiri N, Portales-Casamar E, Warby SC, Connolly C, De Souza RA;
REGISTRY Investigators of the European Huntington's Disease Network, Tabrizi SJ, Hermanson O,
Langbehn DR, Hayden MR, Wasserman WW, Leavitt BR. A SNP in the HTT promoter alters NF-κB
binding and is a bidirectional genetic modifier of Huntington disease. Nat Neurosci. 2015 Jun;18(6):807-
51. Kuhle J, Disanto G, Dobson R, Adiutori R, Bianchi L, Topping J, Bestwick JP, Meier UC, Marta
M, Costa GD, Runia T, Evdoshenko E, Lazareva N, Thouvenot E, Iaffaldano P, Direnzo V, Khademi M,
Piehl F, Comabella M, Sombekke M, Killesten J, Hegen H, Rauch S, D'Alfonso S, Alvarez-Cermeño JC,
Kleinová P, Horáková D, Roesler R, Lauda F, Llufriu S, Avsar T, Uygunoglu U, Altintas A, Saip S,
Menge T, Rajda C, Bergamaschi R, Moll N, Khalil M, Marignier R, Dujmovic I, Larsson H, Malmestrom
C, Scarpini E, Fenoglio C, Wergeland S, Laroni A, Annibali V, Romano S, Martínez AD, Carra A, Salvetti
M, Uccelli A, Torkildsen Ø, Myhr KM, Galimberti D, Rejdak K, Lycke J, Frederiksen JL, Drulovic J,
Confavreux C, Brassat D, Enzinger C, Fuchs S, Bosca I, Pelletier J, Picard C, Colombo E, Franciotta D,
Derfuss T, Lindberg R, Yaldizli Ö, Vécsei L, Kieseier BC, Hartung HP, Villoslada P, Siva A, Saiz A,
Tumani H, Havrdová E, Villar LM, Leone M, Barizzone N, Deisenhammer F, Teunissen C, Montalban X,
Tintoré M, Olsson T, Trojano M, Lehmann S, Castelnovo G, Lapin S, Hintzen R, Kappos L, Furlong R,
Martinelli V, Comi G,Ramagopalan SV, Giovannoni G. Conversion from clinically isolated syndrome to
multiple sclerosis: A large multicentre study. Mult Scler. 2015 Jul;21(8):1013-24.
52. Valcárcel-Ocete L, Alkorta-Aranburu G, Iriondo M, Fullaondo A, García-Barcina M, Fernández-
García JM, Lezcano-García E, Losada-Domingo JM, Ruiz-Ojeda J, Álvarez de Arcaya A, Pérez-Ramos
JM, Roos RA, Nielsen JE, Saft C; REGISTRY investigators of the European Huntington's Disease
Network, Zubiaga AM, Aguirre A. Exploring Genetic Factors Involved in Huntington Disease Age of
Onset: E2F2 as a New Potential Modifier Gene. PLoS One. 2015 Jul 6;10(7):e0131573.
53. Vuono R, Winder-Rhodes S, de Silva R, Cisbani G, Drouin-Ouellet J; REGISTRY Investigators
of the European Huntington’s Disease Network, Spillantini MG, Cicchetti F, Barker RA. The role of tau in
the pathological process and clinical expression of Huntington's disease. Brain. 2015 Jul;138(Pt 7):1907-
18.
54. Romano S, Coarelli G, Marcotulli C, Leonardi L, Piccolo F, Spadaro M, Frontali M, Ferraldeschi
M, Vulpiani MC, Ponzelli F, Salvetti M, Orzi F, Petrucci A, Vanacore N, Casali C, Ristori G. Riluzole in
patients with hereditary cerebellar ataxia: a randomised, double-blind, placebo-controlled trial. Lancet
Neurol. 2015 Aug 25.
55. Severa M, Rizzo F, Giacomini E, Annibali V, Gafa V, Romano S, Buscarinu MC, Fornasiero A,
Salvetti M, Coccia EM. IFN-β Therapy Regulates TLR7-Mediated Response in Plasmacytoid Dendritic
Cells of Multiple Sclerosis Patients Influencing an Anti-Inflammatory Status. J Interferon Cytokine Res.
2015 Sep;35(9):668-81
56. Tedroff J, Waters S, Barker RA, Roos R, Squitieri F; EHDN Registry Study Group.
Antidopaminergic Medication is Associated with More Rapidly Progressive Huntington's Disease. J
Huntingtons Dis. 2015;4(2):131-40.
57. Faggianelli N, Puglisi R, Veneziano L, Romano S, Frontali M, Vannocci T, Fortuni S, Testi R,
Pastore A. Analyzing the Effects of a G137V Mutation in the FXN Gene. Front Mol Neurosci. 2015 Nov
25;8:66.
Pagina 9 - Curriculum vitae et studiorum
Dr.ssa Silvia Romano
58. Dale M, Maltby J, Martucci R, Shimozaki S; REGISTRY investigators of the European
Huntington's Disease Network. Factor analysis of the hospital anxiety and depression scale among a
Huntington's disease population. Mov Disord. 2015 Dec;30(14):1954-60.):789.
59. Dale M, Maltby J, Shimozaki S, Cramp R, Rickards H; REGISTRY Investigators of the European
Huntington's Disease Network. Disease stage, but not sex, predicts depression and psychological
distress in Huntington's disease: A European population study. J Psychosom Res. 2016 Jan;80:17-22.
60. Serafini G, Giordano G, Romano S, Raja M, Girardi P, Amore M, Pompili M. Huntington's
disease and suicidal behavior: The importance of lithium treatment. Clin Neurol Neurosurg. 2016
Jun;145:108-9.
61. Di Santo G, Adiutori R, Dobson R, Martinelli V, Dalla Costa G, Runia T, Evdoshenko E,
Thouvenot E, Trojano M, Norgren N, Teunissen C, Kappos L, Giovannoni G, Kuhle J; International
Clinically Isolated Syndrome Study Group. Serum neurofilament light chain levels are increased in
patients with a clinically isolated syndrome. J Neurol Neurosurg Psychiatry. 2016 Feb;87(2):126-9.
62. Romano S, Coarelli G, Vanacore N, Salvetti M, Ristori G. Riluzole in patients with hereditary
cerebellar ataxia - Authors' reply. Lancet Neurol. 2016 Jul;15(8):789.
63. Leonardi L, Marcotulli C, Storti E, Tessa A, Serrao M, Longobardi A, Romano S, Ristori G,
Santorelli FM, Pierelli F, Casali C. Spinocerebellar Ataxia Type 3 in Italy: Time to Change Mind.
Neuroepidemiology. 2016;46(4):268
64. Maltby J, Dale M, Underwood M, Rickards H, Callaghan J; REGISTRY Investigators of the
European Huntington’s Disease Network. Exploring the Structural Relationship Between Interviewer and
Self-Rated Affective Symptoms in Huntington's Disease. J Neuropsychiatry Clin Neurosci. 2016
Summer;28(3):236-8.
65. Jacobs M, Hart EP, van Zwet EW, Bentivoglio AR, Burgunder JM, Craufurd D, Reilmann R, Saft
C, Roos RA; REGISTRY investigators of the European Huntington’s Disease Network. Progression of
motor subtypes in Huntington's disease: a 6-year follow-up study. J Neurol. 2016 Jul 19.
66. Cubo E, Ramos-Arroyo MA, Martinez-Horta S, Martínez-Descalls A, Calvo S, Gil-Polo C;
European HD Network. Clinical manifestations of intermediate allele carriers in Huntington disease.
Neurology. 2016 Aug 9;87(6):571-8
67. Romano, S., Ferraldeschi, M., Buscarinu, M.C., Fornasiero, A., Mechelli, R., Cerasoli, B.,
Vanacore, N., Salvetti, M., Ristori, G. Vaccines in multiple sclerosis: the experience of BCG vaccination.
DRUGS OF THE FUTURE, Prous Science, 2016, Vol. 41, p. 293-300
68. Eleuteri C, Olla S, Veroni C, Umeton R, Mechelli R, Romano S, Buscarinu MC, Ferrari F, Calò
G, Ristori G, Salvetti M, Agresti C. A staged screening of registered drugs highlights remyelinating drug
candidates for clinical trials. Sci Rep. 2017 Apr 7;7:45780.
69. Buscarinu MC, Cerasoli B, Annibali V, Policano C, Lionetto L, Capi M, Mechelli R, Romano S,
Fornasiero A, Mattei G, Piras E, Angelini DF, Battistini L, Simmaco M, Umeton R, Salvetti M, Ristori G.
Altered intestinal permeability in patients with relapsing-remitting multiple sclerosis: A pilot study. Mult
Scler. 2017 Mar;23(3):442-446.
70. Olivito G, Cercignani M, Lupo M, Iacobacci C, Clausi S, Romano S, Masciullo M, Molinari M,
Bozzali M, Leggio M. Neural substrates of motor and cognitive dysfunctions in SCA2 patients: A network
based statistics analysis. Neuroimage Clin. 2017 Mar 25;14:719-725.
Pagina 10 - Curriculum vitae et studiorum
Dr.ssa Silvia Romano
71. Buscarinu MC, Fornasiero A, Romano S, Ferraldeschi M, Renié R, Trasimeni G, Salvetti M,
Ristori G. Coincident onset of multiple sclerosis and Herpes simplex virus 1 encephalitis: a case report.
Multiple Sclerosis and Demyelinating Disorders 2017 2:6 DOI: 10.1186/s40893-017-0023
72. Underwood M, Bonas S, Dale M, REGISTRY Investigators of the European Huntington’s
Disease Network. Huntington’s Disease: Prevalence and Psychological Indicators of Pain. Mov Dis Clin
Pract 2017 March/April 4(2):198-204.
73. Maltby J, Dale M, Underwood M, Simpson J and the REGISTRY investigators of the European
Huntington’s Disease Network. Irritability in Huntington’s Disease: Factor Analysis of Snaith’s Irritability
Scale. Mov Dis Clinical Practice. 2017 May/June 4(3):342–348
74. Moss DJH, Pardiñas AF, Langbehn D, Lo K, Leavitt BR, Roos R, Durr A, Mead S; TRACK-HD
investigators; REGISTRY investigators, Holmans P, Jones L, Tabrizi SJ. Identification of genetic variants
associated with Huntington's disease progression: a genome-wide association study. Lancet Neurol.
2017 Jun 20. pii: S1474 4422(17)30161-8.
75. Stuitje G, van Belzen MJ, Gardiner SL, van Roon-Mom WMC, Boogaard MW; REGISTRY
Investigators of the European Huntington Disease Network, Tabrizi SJ, Roos RAC, Aziz NA. Age of
onset in Huntington's disease is influenced by CAG repeat variations in other polyglutamine disease-
associated genes. Brain. 2017 Jul 1;140(7):e42.
76. Baake V, Reijntjes RHAM, Dumas EM, Thompson JC; REGISTRY Investigators of the European
Huntington's Disease Network, Roos RAC. Cognitive decline in Huntington's disease expansion gene
carriers. Cortex. 2017 Aug 3;95:51-62.
77. Rodrigues FB, Abreu D, Damásio J, Gonçalves N, Correia Guedes L, Coelho M, Ferreira JJ,
REGISTRY Investigators of the European Huntington’s Disease Network. Survival, Mortality, Causes
and Places of Death in a European Huntington’s Disease Prospective Cohort. Mov Dis Clinical Practice.
2017; September/October Volume 4 (5):737-742.
78. Buscarinu MC, Romano S, Mechelli R, Pizzolato Umeton R, Ferraldeschi M, Fornasiero A,
Reniè R, Cerasoli B, Morena E, Romano C, Loizzo ND, Umeton R, Salvetti M, Ristori G. Intestinal
Permeability in Relapsing-Remitting Multiple Sclerosis. Neurotherapeutics. 2017 Nov 8. doi:
10.1007/s13311-017-0582-3.
79. van Duijn E, Vrijmoeth EM, Giltay EJ, Bernhard Landwehrmeyer G; REGISTRY investigators of
the European Huntington's Disease Network. Suicidal ideation and suicidal behavior according to the C-
SSRS in a European cohort of Huntington's disease gene expansion carriers. J Affect Disord. 2017 Nov
15;228:194-204.
80. Olivito G, Lupo M, Iacobacci C, Clausi S, Romano S, Masciullo M, Molinari M, Cercignani M,
Bozzali M, Leggio M. Microstructural MRI Basis of the Cognitive Functions in Patients with
Spinocerebellar Ataxia Type 2. Neuroscience. 2017 Dec 16;366:44-53.
81. Tacchella A, Romano S, Ferraldeschi M, Salvetti M, Zaccaria A, Crisanti A, Grassi F.
Collaboration between a human group and artificial intelligence can improve prediction of multiple
sclerosis course: a proof-of-principle study. F1000Res. 2017 Dec 22;6:2172.
82. Olivito G, Lupo M, Iacobacci C, Clausi S, Romano S, Masciullo M, Molinari M, Cercignani M,
Bozzali M, Leggio M. Structural cerebellar correlates of cognitive functions in spinocerebellar ataxia type
2. J Neurol. 2018 Mar;265(3):597-606.
Pagina 11 - Curriculum vitae et studiorum
Dr.ssa Silvia Romano
83. Coarelli G, Romano S, Travaglini L, Ferraldeschi M, Nicita F, Spadaro M, Fornasiero A, Frontali
M, Salvetti M, Bertini E, Ristori G. Novel homozygous GBA2 mutation in a patient with complicated
spastic paraplegia. Clin Neurol Neurosurg. 2018 Mar 3;168:60-63.
84. Barkhuizen M, Rodrigues FB, Anderson DG, Winkens B; REGISTRY Investigators of the
European Huntington's Disease Network, Wild EJ, Kramer BW, Gavilanes AWD. Perinatal insults and
neurodevelopmental disorders may impact Huntington's disease age of diagnosis. Parkinsonism Relat
Disord 2018 May 18.
85. Valcárcel-Ocete L, Fullaondo A, Alkorta-Aranburu G, García-Barcina M, Roos RAC, Hjermind
LE, Saft C, Frontali M, Reilmann R, Rickards H; REGISTRY investigators of the European Huntington’s
Disease Network (EHDN), Zubiaga AM, Aguirre A. Does arterial hypertension influence the onset of
Huntington's disease? PLoS One. 2018 May 23;13(5):e0197975
86. Lupo M, Olivito G, Iacobacci C, Clausi S, Romano S, Masciullo M, Molinari M, Cercignani M,
Bozzali M, Leggio M. The cerebellar topography of attention sub-components in spinocerebellar ataxia
type 2. Cortex. 2018 Jul 31;108:35-49.
87. McNulty P, Pilcher R, Ramesh R, Necuiniate R, Hughes A, Farewell D, Holmans P, Jones L;
REGISTRY Investigators of the European Huntington's Disease Network. Reduced Cancer Incidence in
Huntington's Disease: Analysis in the Registry Study. J Huntingtons Dis. 2018;7(3):209-222.
88. Annibali V, Umeton R, Palermo A, Severa M, Etna MP, Giglio S, Romano S, Ferraldeschi M,
Buscarinu MC, Vecchione A, Annese A, Policano C, Mechelli R, Pizzolato Umeton R, Fornasiero A,
Angelini DF, Guerrera G, Battistini L, Coccia EM, Salvetti M, Ristori G. Analysis of coding and non-
coding transcriptome of peripheral B cells reveals an altered interferon response factor (IRF)-1 pathway
in multiple sclerosis patients. J Neuroimmunol 2018; 324(15): 165-171.
89. Oosterloo M, Bijlsma EK, van Kuijk SM, Minkels F, de Die-Smulders CE; REGISTRY
Investigators of the European Huntington's Disease Network; Registry Steering committee; Language
coordinators; EHDN's associate site in Singapore. Clinical and genetic characteristics of late-onset
Huntington's disease. Parkinsonism Relat Disord. 2018 Nov 29.
90. Ristori G, Faustman D, Matarese G, Romano S, Salvetti M. Bridging the gap between
vaccination with Bacille Calmette-Guérin (BCG) and immunological tolerance: the cases of type 1
diabetes and multiple sclerosis. Curr Opin Immunol. 2018 Dec;55:89-96.
91. Castaldo I, De Rosa M, Romano A, Zuchegna C, Squitieri F, Mechelli R, Peluso S, Borrelli C,
Del Mondo A, Salvatore E, Vescovi LA, Migliore S, De Michele G, Ristori G, Romano S, Avvedimento
EV, Porcellini A. DNA damage signatures in peripheral blood cells as biomarkers in prodromal
huntington disease. Ann Neurol. 2018 Dec 14.
92. Horton MC, Nopoulos P, Nance M, Landwehrmyer GB, Barker RA, Squitieri F; REGISTRY
Investigators of the European Huntington’s Disease Network, Burgunder JM, Quarrell O. Assessment of
the Performance of a Modified Motor Scale as Applied to Juvenile Onset Huntington's Disease. J
Huntingtons Dis. 2019;8(2):181-193. doi: 10.3233/JHD-180306. PMID: 30856116.
93. La Starza S, Ferraldeschi M, Buscarinu MC, Romano S, Fornasiero A, Mechelli R, Umeton R,
Ristori G, Salvetti M. Genome-Wide Multiple Sclerosis Association Data and Coagulation. Front Neurol.
2019 Feb 14;10:95.
94. Romano S, Ferraldeschi M, Bagnato F, Mechelli R, Morena E, Caldano M, Buscarinu MC,
Fornasiero A, Frontoni M, Nociti V, Mirabella M, Mayer F, Bertolotto A, Pozzilli C, Vanacore N, Salvetti
Pagina 12 - Curriculum vitae et studiorum
Dr.ssa Silvia Romano
M, Ristori G. Drug Holiday of Interferon Beta 1b in Multiple Sclerosis: A Pilot, Randomized, Single Blind
Study of Non-inferiority. Front Neurol. 2019 Jul 16;10:695.
95. Buscarinu MC, Fornasiero A, Romano S, Ferraldeschi M, Mechelli R, Reniè R, Morena E,
Romano C, Pellicciari G, Landi AC, Salvetti M, Ristori G. The Contribution of Gut Barrier Changes to
Multiple Sclerosis Pathophysiology. Front Immunol. 2019 Aug 28;10:1916. doi:
10.3389/fimmu.2019.01916. eCollection 2019.
96. Prosperini L, Cortese A, Lucchini M, Boffa L, Borriello G, Buscarinu MC, Capone F, Centonze D,
De Fino C, De Pascalis D, Fantozzi R, Ferraro E, Filippi M, Galgani S, Gasperini C, Haggiag S, Landi D,
Marfia G, Mataluni G, Millefiorini E, Mirabella M, Monteleone F, Nociti V, Pontecorvo S, Romano S,
Ruggieri S, Salvetti M, Tortorella C, Zannino S, Di Battista G. Exit strategies for "needle fatigue" in
multiple sclerosis: a propensity score-matched comparison study. J Neurol 2020; 267:694–702.
97. Mechelli R, Umeton R, Manfrè G, Romano S, Buscarinu MC, Rinaldi V, Bellucci G, Bigi R,
Ferraldeschi M, Salvetti M, Ristori G. Reworking GWAS Data to Understand the Role of Nongenetic
Factors in MS Etiopathogenesis. Genes (Basel). 2020 Jan 14;11(1):97.
98. Tiano F, Amati F, Cherubini F, Morini E, Vancheri C, Maletta S, Fortuni S, Serio D, Quatrana A,
Luffarelli R, Benini M, Alfedi G, Panarello L, Rufini A, Toschi N, Frontali M, Romano S, Marcotulli C,
Casali C, Gioiosa S, Mariotti C, Mongelli A, Fichera M, Condò I, Novelli G, Testi R, Malisan F. Frataxin
deficiency in Friedreich's ataxia is associated with reduced levels of HAX-1, a regulator of cardiomyocyte
death and survival. Hum Mol Genet. 2020 Feb 1;29(3):471-482.
99. Buscarinu MC, Fornasiero A, Ferraldeschi M, Romano S, Reniè R, Morena E, Romano C,
Pellicciari G, Landi AC, Fagnani C, Salvetti M, Ristori G. Disentangling the molecular mechanisms of
multiple sclerosis: The contribution of twin studies. Neurosci Biobehav Rev. 2020 Apr;111:194-198.
100. Olivito G, Siciliano L, Clausi S, Lupo M, Romano S, Masciullo M, Molinari M, Cercignani M,
Bozzali M, Leggio M. Functional Changes of Mentalizing Network in SCA2 Patients: Novel Insights into
Understanding the Social Cerebellum. Cerebellum 2020; Apr;19(2):235-242.
101. Chesi P, Marini MG, Mancardi GL, Patti F; SMART study project group, Alivernini L, Bisecco A,
Borriello G, Bucello S, Caleri F, Cavalla P, Cocco E, Cordioli C, Di Giuseppe M, Fantozzi R, Gattuso M,
Granella F, Liguori M, Locatelli L, Lugaresi A, Marangoni S, Moiola L, Mutta E, Neri W, Pastò L, Perini P,
Petruzzo M, Plewnia K, Repice AM, Rezzonico M, Romano S, Rovaris M, Sessa E, Tortorella C, Totaro
R, Valentino P. Listening to the neurological teams for multiple sclerosis: the SMART project. Neurol Sci.
2020 Mar 20
102. Vuono R, Kouli A, Legault EM, Chagnon L, Allinson KS, La Spada A; REGISTRY Investigators
of the European Huntington's Disease Network, Biunno I, Barker RA, Drouin-Ouellet J. Association
Between Toll-Like Receptor 4 (TLR4) and Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)
Genetic Variants and Clinical Progression of Huntington's Disease. Mov Disord. 2020 Mar;35(3):401-
408. doi: 10.1002/mds.27911. Epub 2019 Nov 14. PMID: 31724242; PMCID: PMC7154663.
103. Seccia R, Gammelli D, Dominici F, Romano S, Landi AC, Salvetti M, Tacchella A, Zaccaria A,
Crisanti A, Grassi F, Palagi L. Considering patient clinical history impacts performance of machine
learning models in predicting course of multiple sclerosis. PLoS One. 2020;15(3):e0230219.
104. Seccia R, Romano S, Salvetti M, Crisanti A, Palagi L, Grassi F. Machine Learning Use for
Prognostic Purposes in Multiple Sclerosis. Life (Basel). 2021 Feb 5;11(2):122. doi:
10.3390/life11020122. PMID: 33562572; PMCID: PMC7914671.
Pagina 13 - Curriculum vitae et studiorum
Dr.ssa Silvia Romano
105. Lepore V, Bosetti C, Santucci C, Iaffaldano P, Trojano M, Mosconi P; Italian Multiple Sclerosis
Register Centers Group, the Scientific Committee of Italian SM Register. Detection of disability
worsening in relapsing-remitting multiple sclerosis patients: a real-world roving Expanded Disability
Status Scale reference analysis from the Italian Multiple Sclerosis Register. Eur J Neurol. 2021
Feb;28(2):567-578. doi: 10.1111/ene.14589. PMID: 33058344.
106. Angeloni B, Bigi R, Bellucci G, Mechelli R, Ballerini C, Romano C, Morena E, Pellicciari G, Reniè
R, Rinaldi V, Buscarinu MC, Romano S, Ristori G, Salvetti M. A Case of Double Standard: Sex
Differences in Multiple Sclerosis Risk Factors. Int J Mol Sci. 2021 Apr 2;22(7):3696. doi:
10.3390/ijms22073696. PMID: 33918133; PMCID: PMC8037645.
107. Mechelli R, Romano S, Romano C, Morena E, Buscarinu MC, Bigi R, Bellucci G, Reniè R,
Pellicciari G, Salvetti M, Ristori G. MAIT Cells and Microbiota in Multiple Sclerosis and Other
Autoimmune Diseases. Microorganisms. 2021 May 24;9(6):1132. doi: 10.3390/microorganisms9061132.
PMID: 34074025; PMCID: PMC8225125.
108. Ferraldeschi M, Romano S, Giglio S, Romano C, Morena E, Mechelli R, Annibali V, Ubaldi M,
Buscarinu MC, Umeton R, Sani G, Vecchione A, Salvetti M, Ristori G. Circulating hsa-miR-323b-3p in
Huntington's Disease: A Pilot Study. Front Neurol. 2021 May 5;12:657973. doi:
10.3389/fneur.2021.657973. PMID: 34025560; PMCID: PMC8131841.
109. Nicita F, Ginevrino M, Travaglini L, D'Arrigo S, Zorzi G, Borgatti R, Terrone G, Catteruccia M,
Vasco G, Brankovic V, Siliquini S, Romano S, Veredice C, Pedemonte M, Armando M, Lettori D,
Stregapede F, Bosco L, Sferra A, Tessarollo V, Romaniello R, Ristori G, Bertini E, Valente EM, Zanni G.
Heterozygous KIF1A variants underlie a wide spectrum of neurodevelopmental and neurodegenerative
disorders. J Med Genet 2021 Jul;58(7):475-483.
110. Migliore S, D'Aurizio G, Maffi S, Ceccarelli C, Ristori G, Romano S, Castaldo A, Mariotti C,
Curcio G, Squitieri F. Cognitive and behavioral associated changes in manifest Huntington disease: A
retrospective cross-sectional study. Brain Behav 2021 Jul;11(7):e02151. doi: 10.1002/brb3.2151. PMID:
34110097.
111. Clausi S, Olivito G, Siciliano L, Lupo M, Bozzali M, Masciullo M, Molinari M, Romano S, Leggio
M. The neurobiological underpinning of the social cognition impairments in patients with spinocerebellar
ataxia type 2. Cortex 2021 May;138:101-112. doi: 10.1016/j.cortex.2020.12.027. PMID: 33677324.
112. McAllister B, Gusella JF, Landwehrmeyer GB, Lee JM, MacDonald ME, Orth M, Rosser AE,
Williams NM, Holmans P, Jones L, Massey TH; REGISTRY Investigators of the European Huntington's
Disease Network. Timing and Impact of Psychiatric, Cognitive, and Motor Abnormalities in Huntington
Disease. Neurology 2021 May 11;96(19):e2395-e2406. doi: 10.1212/WNL.0000000000011893. PMID:
33766994; PMCID: PMC8166441.
113. Buscarinu MC, Gargano F, Lionetto L, Capi M, Morena E, Fornasiero A, Reniè R, Landi AC,
Pellicciari G, Romano C, Mechelli R, Romano S, Borsellino G, Battistini L, Simmaco M, Fagnani C,
Salvetti M, Ristori G. Intestinal Permeability and Circulating CD161+CCR6+CD8+T Cells in Patients
With Relapsing-Remitting Multiple Sclerosis Treated With Dimethylfumarate. Front Neurol. 2021 Aug
26;12:683398. doi: 10.3389/fneur.2021.683398. PMID: 34512507; PMCID: PMC8426620.
114. Mechelli R, Romano C, Reniè R, Manfrè G, Buscarinu MC, Romano S, Marrone A, Bigi R,
Bellucci G, Ballerini C, Angeloni B, Rinaldi V, Salvetti M, Ristori G. Viruses and neuroinflammation in
Pagina 14 - Curriculum vitae et studiorum
Dr.ssa Silvia Romano
multiple sclerosis. Neuroimmunol Neuroinflammation 2021;8:269. http://dx.doi.org/10.20517/2347-
8659.2021.01
115. Romano S, Bacigalupo I, Marcotulli C, Cioffi E, Bertini ES, Vasco G, Perna A, Petrucci A, Massa
R, Frezza E, Romano C, Salvetti M, Ristori G, Silvestri G, Vanacore N, Casali C. A Clinical and
Epidemiological Prevalence Study on Friedreich's Ataxia in Latium, Italy. Neuroepidemiology.
2022;56(3):212-218. doi: 10.1159/000525159. PMID: 35636410.
116. Migliore S, D'Aurizio G, Scaricamazza E, Maffi S, Ceccarelli C, Ristori G, Romano S, Castaldo
A, Fichera M, Curcio G, Squitieri F. Cognitive Reserve in Early Manifest Huntington Disease Patients:
Leisure Time Is Associated with Lower Cognitive and Functional Impairment. J Pers Med. 2022 Jan
3;12(1):36. doi: 10.3390/jpm12010036. PMID: 35055351; PMCID: PMC8777615.
117. Langbehn DR; Registry Investigators of the European Huntington Disease Network. Longer
CAG repeat length is associated with shorter survival after disease onset in Huntington disease. Am J
Hum Genet. 2022 Jan 6;109(1):172-179. doi: 10.1016/j.ajhg.2021.12.002. PMID: 34942093; PMCID:
PMC8764269.
118. Ferraro D, Iaffaldano P, Guerra T, Inglese M, Capobianco M, Brescia Morra V, Zaffaroni M,
Mirabella M, Lus G, Patti F, Cavalla P, Cellerino M, Malucchi S, Pisano E, Vitetta F, Paolicelli D, Sola P,
Trojano M; Italian MS Register. Risk of multiple sclerosis relapses when switching from fingolimod to
cell-depleting agents: the role of washout duration. J Neurol. 2022 Mar;269(3):1463-1469. doi:
10.1007/s00415-021-10708-1. PMID: 34292396.
119. Rossi S, Rubegni A, Riso V, Barghigiani M, Bassi MT, Battini R, Bertini E, Cereda C, Cioffi E,
Criscuolo C, Dal Fabbro B, Dato C, D'Angelo MG, Di Muzio A, Diamanti L, Dotti MT, Filla A, Gioiosa V,
Liguori R, Martinuzzi A, Massa R, Mignarri A, Moroni R, Musumeci O, Nicita F, Orologio I, Orsi L,
Pegoraro E, Petrucci A, Plumari M, Ricca I, Rizzo G, Romano S, Rumore R, Sampaolo S, Scarlato M,
Seri M, Stefan C, Straccia G, Tessa A, Travaglini L, Trovato R, Ulgheri L, Vazza G, Orlacchio A, Silvestri
G, Santorelli FM, Melone MAB, Casali C. Clinical-Genetic Features Influencing Disability in Spastic
Paraplegia Type 4: A Cross-sectional Study by the Italian DAISY Network. Neurol Genet. 2022 Mar
30;8(2):e664. doi: 10.1212/NXG.0000000000000664. PMID: 35372684; PMCID: PMC8969300.
120. McAllister B, Donaldson J, Binda CS, Powell S, Chughtai U, Edwards G, Stone J, Lobanov S,
Elliston L, Schuhmacher LN, Rees E, Menzies G, Ciosi M, Maxwell A, Chao MJ, Hong EP, Lucente D,
Wheeler V, Lee JM, MacDonald ME, Long JD, Aylward EH, Landwehrmeyer GB, Rosser AE;
REGISTRY Investigators of the European Huntington’s disease network, Paulsen JS; PREDICT-HD
Investigators of the Huntington Study Group, Williams NM, Gusella JF, Monckton DG, Allen ND,
Holmans P, Jones L, Massey TH. Exome sequencing of individuals with Huntington's disease implicates
FAN1 nuclease activity in slowing CAG expansion and disease onset. Nat Neurosci. 2022
Apr;25(4):446-457. doi: 10.1038/s41593-022-01033-5. PMID: 35379994; PMCID: PMC8986535.
121. Umeton R, Bellucci G, Bigi R, Romano S, Buscarinu MC, Reniè R, Rinaldi V, Pizzolato Umeton
R, Morena E, Romano C, Mechelli R, Salvetti M, Ristori G. Multiple sclerosis genetic and non-genetic
factors interact through the transient transcriptome. Sci Rep. 2022 May 9;12(1):7536. doi:
10.1038/s41598-022-11444-w. PMID: 35534508; PMCID: PMC9085834.
122. Bergamaschi R, Beghi E, Bosetti C, Ponzio M, Santucci C, Lepore V, Mosconi P; Italian Multiple
Sclerosis and Related Disorders Register Centers Group and the Scientific Committee of Italian SM and
Related Disorders Register, Aguglia U, Amato MP, Ancona AL, Ardito B, Avolio C, Balgera R, Banfi P,
Pagina 15 - Curriculum vitae et studiorum
Dr.ssa Silvia Romano
Barcella V, Barone P, Bellantonio P, Berardinelli A, Bergamaschi R, Bertora P, Bianchi M, Bramanti P,
Morra VB, Brichetto G, Brioschi AM, Buccafusca M, Bucello S, Busillo V, Calchetti B, Cantello R,
Capobianco M, Capone F, Capone L, Cargnelutti D, Carrozzi M, Cartechini E, Cavaletti G, Cavalla P,
Celani MG, Clerici R, Clerico M, Cocco E, Confalonieri P, Coniglio MG, Conte A, Corea F, Cottone S,
Crociani P, D'Andrea F, Danni MC, De Luca G, de Pascalis D, De Riz M, De Robertis F, De Rosa G, De
Stefano N, Corte MD, Di Sapio A, Docimo R, Falcini M, Falcone N, Fermi S, Ferraro E, Ferrò MT,
Fortunato M, Foschi M, Gajofatto A, Gallo A, Gallo P, Gatto M, Gazzola P, Giordano A, Granella F,
Grasso MF, Grasso MG, Grimaldi LME, Iaffaldano P, Imperiale D, Inglese M, Iodice R, Leva S, Luezzi V,
Lugaresi A, Lus G, Maimone D, Mancinelli L, Maniscalco GT, Marfia GA, Marini B, Marson A, Mascoli N,
Massacesi L, Melani F, Merello M, Meucci G, Mirabella M, Montepietra S, Nasuelli D, Nicolao P,
Passantino F, Patti F, Peresson M, Pesci I, Piantadosi C, Piras ML, Pizzorno M, Plewnia K, Pozzilli C,
Protti A, Quatrale R, Realmuto S, Ribizzi G, Rinalduzzi S, Rini A, Romano S, Romeo M, Ronzoni M,
Rossi P, Rovaris M, Salemi G, Santangelo G, Santangelo M, Santuccio G, Sarchielli P, Sinisi L, Sola P,
Solaro C, Spitaleri D, Strumia S, Tassinari T, Tonietti S, Tortorella C, Totaro R, Tozzo A, Trivelli G,
Ulivelli M, Valentino P, Venturi S, Vianello M, Zaffaroni M, Zarbo R, Trojano M, Battaglia MA,
Capobianco M, Pugliatti M, Ulivelli M, Mosconi P, Gasperini C, Patti F, Amato MP, Bergamaschi R, Comi
G. Do patients' and referral centers' characteristics influence multiple sclerosis phenotypes? Results
from the Italian multiple sclerosis and related disorders register. Neurol Sci. 2022 Jun 7. doi:
10.1007/s10072-022-06169-7. PMID: 35672479.
123. Quatrana A, Morini E, Tiano F, Vancheri C, Panarello L, Romano S, Marcotulli C, Casali C,
Mariotti C, Mongelli A, Fichera M, Rufini A, Condò I, Novelli G, Testi R, Amati F, Malisan F. Hsa-miR223-
3p circulating level is upregulated in Friedreich's ataxia and inversely associated with HCLS1 associated
protein X-1, HAX-1. Hum Mol Genet. 2022 Jun 22;31(12):2010-2022. doi: 10.1093/hmg/ddac005. PMID:
35015850.
124. Romano S, Romano C, Peconi M, Fiore A, Bellucci G, Morena E, Troili F, Cipollini V, Annibali V,
Giglio S, Mechelli R, Ferraldeschi M, Veneziano L, Mantuano E, Sani G, Vecchione A, Umeton R,
Giubilei F, Salvetti M, Corbo RM, Scarabino D, Ristori G. Circulating U13 Small Nucleolar RNA as a
Potential Biomarker in Huntington's Disease: A Pilot Study. Int J Mol Sci. 2022 Oct 18;23(20):12440. doi:
10.3390/ijms232012440.
125. Morena E, Romano C, Marconi M, Diamant S, Buscarinu MC, Bellucci G, Romano S, Scarabino
D, Salvetti M, Ristori G. Peripheral Biomarkers in Manifest and Premanifest Huntington’s Disease. Int. J.
Mol. Sci. 2023, 24, 6051.
126. Boffa G, Signori A, Massacesi L, Mariottini A, Sbragia E, Cottone S, Amato MP, Gasperini C,
Moiola L, Meletti S, Repice AM, Brescia Morra V, Salemi G, Patti F, Filippi M, De Luca G, Lus G,
Zaffaroni M, Sola P, Conte A, Nistri R, Aguglia U, Granella F, Galgani S, Caniatti LM, Lugaresi A,
Romano S, Iaffaldano P, Cocco E, Saccardi R, Angelucci E, Trojano M, Mancardi GL, Sormani MP,
Inglese M; Italian BMT-MS Study Group and the Italian MS Register. Hematopoietic Stem Cell
Transplantation in People With Active Secondary Progressive Multiple Sclerosis. Neurology. 2023 Mar
14;100(11):e1109-e1122. doi: 10.1212/WNL.0000000000206750.
127. Cunha P, Petit E, Coutelier M, Coarelli G, Mariotti C, Faber J, Van Gaalen J, Damasio J, Fleszar
Z, Tosi M, Rocca C, De Michele G, Minnerop M, Ewenczyk C, Santorelli FM, Heinzmann A, Bird T,
Amprosi M, Indelicato E, Benussi A, Charles P, Stendel C, Romano S, Scarlato M, Le Ber I, Bassi MT,
Pagina 16 - Curriculum vitae et studiorum
Dr.ssa Silvia Romano
Serrano M, Schmitz-Hübsch T, Doss S, Van Velzen GAJ, Thomas Q, Trabacca A, Ortigoza-Escobar JD,
D'Arrigo S, Timmann D, Pantaleoni C, Martinuzzi A, Besse-Pinot E, Marsili L, Cioffi E, Nicita F, Giorgetti
A, Moroni I, Romaniello R, Casali C, Ponger P, Casari G, De Bot ST, Ristori G, Blumkin L, Borroni B,
Goizet C, Marelli C, Boesch S, Anheim M, Filla A, Houlden H, Bertini E, Klopstock T, Synofzik M, Riant
F, Zanni G, Magri S, Di Bella D, Nanetti L, Sequeiros J, Oliveira J, Van de Warrenburg B, Schöls L,
Taroni F, Brice A, Durr A. Extreme phenotypic heterogeneity in non-expansion spinocerebellar ataxias.
Am J Hum Genet. 2023 Jul 6;110(7):1098-1109. doi: 10.1016/j.ajhg.2023.05.009.
128. Zanghì A, Galgani S, Bellantonio P, Zaffaroni M, Borriello G, Inglese M, Romano S, Conte A,
Patti F, Trojano M, Avolio C, D'Amico E; Italian MS Registry. Relapse-associated worsening in a real-life
multiple sclerosis cohort: the role of age and pyramidal phenotype. Eur J Neurol. 2023 Sep;30(9):2736-
2744. doi: 10.1111/ene.15910.
129. Ciancimino C, Di Pippo M, Manco GA, Romano S, Ristori G, Scuderi G, Abdolrahimzadeh S.
Multimodal Ophthalmic Imaging in Spinocerebellar Ataxia Type 7. Life (Basel). 2023 Nov 6;13(11):2169.
doi: 10.3390/life13112169. PMID:38004309; PMCID: PMC10672172.
130. Iaffaldano P, Portaccio E, Lucisano G, Simone M, Manni A, Guerra T, Paolicelli D, Betti M, De
Meo E, Pastò L, Razzolini L, Rocca MA, Ferrè L, Brescia Morra V, Patti F, Zaffaroni M, Gasperini C, De
Luca G, Ferraro D, Granella F, Pozzilli C, Romano S, Gallo P, Bergamaschi R, Coniglio MG, Lus G,
Vianello M, Banfi P, Lugaresi A, Totaro R, Spitaleri D, Cocco E, Di Palma F, Maimone D, Valentino P,
Torri Clerici V, Protti A, Maniscalco GT, Salemi G, Pesci I, Aguglia U, Lepore V, Filippi M, Trojano M,
Amato MP; Italian Multiple Sclerosis Register. Multiple Sclerosis Progression and Relapse Activity in
Children. JAMA Neurol. 2024 Jan 1;81(1):50-58. doi: 10.1001/jamaneurol.2023.4455.
131. Iaffaldano P, Lucisano G, Guerra T, Patti F, Cocco E, De Luca G, Brescia Morra V, Pozzilli C,
Zaffaroni M, Ferraro D, Gasperini C, Salemi G, Bergamaschi R, Lus G, Inglese M, Romano S,
Bellantonio P, Di Monte E, Maniscalco GT, Conte A, Lugaresi A, Vianello M, Torri Clerici VLA, Di Sapio
A, Pesci I, Granella F, Totaro R, Marfia GA, Danni MC, Cavalla P, Valentino P, Aguglia U, Montepietra
S, Ferraro E, Protti A, Spitaleri D, Avolio C, De Riz M, Maimone D, Cavaletti G, Gazzola P, Tedeschi G,
Sessa M, Rovaris M, Di Palma F, Gatto M, Cargnelutti D, De Robertis F, Logullo FO, Rini A, Meucci G,
Ardito B, Banfi P, Nasuelli D, Paolicelli D, Rocca MA, Portaccio E, Chisari CG, Fenu G, Onofrj M,
Carotenuto A, Ruggieri S, Tortorella C, Ragonese P, Nica M, Amato MP, Filippi M, Trojano M; Italian MS
Register. Evaluation of drivers of treatment switch in relapsing multiple sclerosis: a study from the Italian
MS Registry. J Neurol. 2024 Mar;271(3):1150-1159. doi: 10.1007/s00415-023-12137-8.
132. Bellucci G, Buscarinu MC, Reniè R, Rinaldi V, Bigi R, Mechelli R, Romano S, Salvetti M, Ristori
G. Disentangling multiple sclerosis phenotypes through Mendelian disorders: A network approach. Mult
Scler. 2024 Mar;30(3):325-335. doi: 10.1177/13524585241227119.
133. Ruggieri S, Ianniello A, Copetti M, Altieri M, Buscarinu MC, Centonze D, Cortese A, De Giglio L,
Fantozzi R, Gasperini C, Grimaldi LME, Landi D, Marfia GA, Mirabella M, Nistri R, Nociti V, Oddo O,
Romano S, Salemi G, Tortorella C, Pozzilli C, Petracca M. Treatment modifiers across different
regimens of natalizumab treatment in MS: An Italian real-world experience. Neurotherapeutics. 2024
Apr;21(3):e00338. doi: 10.1016/j.neurot.2024.e00338.
134. Sharmin S, Roos I, Malpas CB, Iaffaldano P, Simone M, Filippi M, Kubala Havrdova E, Ozakbas
S, Brescia Morra V, Alroughani R, Zaffaroni M, Patti F, Eichau S, Salemi G, Di Sapio A, Inglese M,
Portaccio E, Trojano M, Amato MP, Kalincik T; Writing Group; Italian Multiple Sclerosis and Related
Pagina 17 - Curriculum vitae et studiorum
Dr.ssa Silvia Romano
Disorders Register and MSBase Study Group. Disease-modifying therapies in managing disability
worsening in paediatric-onset multiple sclerosis: a longitudinal analysis of global and national registries.
Lancet Child Adolesc Health. 2024 May;8(5):348- 357. doi: 10.1016/S2352-4642(24)00047-6.
135. Iaffaldano P, Lucisano G, Guerra T, Paolicelli D, Portaccio E, Inglese M, Foschi M, Patti F,
Granella F, Romano S, Cavalla P, De Luca G, Gallo P, Bellantonio P, Gallo A, Montepietra S, Di Sapio
A, Vianello M, Quatrale R, Spitaleri D, Clerici R, Torri Clerici V, Cocco E, Brescia Morra V, Marfia GA,
Boccia VD, Filippi M, Amato MP, Trojano M; Italian MS Register. A comparison of natalizumab and
ocrelizumab on disease progression in multiple sclerosis. Ann Clin Transl Neurol. 2024 Aug;11(8):2008-
2015. doi: 10.1002/acn3.52118.
136. Nasello M, Zancan V, Reniè R, Romano S, Buscarinu MC, Ristori G, Salvetti M, Bellucci G. Co-
existence of Myelin Oligodendrocyte Glycoprotien Antibody-associated Disease (MOGAD) and
Spinocerebellar Ataxia type 1 (SCA1): A case report. Neurol Sci. 2024 Aug;45(8):4067-4070. doi:
10.1007/s10072-024-07479-8.
137. Romano C, Morena E, Petrucci S, Diamant S, Marconi M, Travaglini L, Zanni G, Piane M,
Salvetti M, Romano S, Ristori G. Case report: A novel mutation of glial fibrillary acidic protein gene
causing juvenile-onset Alexander disease. Front Neurol. 2024 Mar 20;15:1362013. doi:
10.3389/fneur.2024.1362013. eCollection 2024.
138. Suppiej A, Ceccato C, Tzekov R, Cermakova I, Parmeggiani F, Bellucci G, Salvetti M, Zesiewicz
T, Ristori G, Romano S. Long-Term Follow-Up before and during Riluzole Treatment in Six Patients from
Two Families with Spinocerebellar Ataxia Type 7. Cerebellum. 2024 Jul 8. doi: 10.1007/s12311-024-
01714-w.
139. Simone M, Lucisano G, Guerra T, Paolicelli D, Rocca MA, Brescia Morra V, Patti F, Annovazzi
P, Gasperini C, De Luca G, Ferraro D, Margari L, Granella F, Pozzilli C, Romano S, Perini P,
Bergamaschi R, Coniglio MG, Lus G, Vianello M, Lugaresi A, Portaccio E, Filippi M, Amato MP,
Iaffaldano P; Italian Multiple Sclerosis Register. Disability trajectories by progression independent of
relapse activity status differ in pediatric, adult and late-onset multiple sclerosis. J Neurol. 2024
Oct;271(10):6782-6790. doi: 10.1007/s00415-024-12638-0. Epub 2024 Aug 23. PMID: 39179712;
PMCID: PMC11447039.
140. Ponzio M, Battaglia MA, Trojano M, Salivetto M, D'Ettorre A, Corrado D, Paletta P, Lepore V,
Mosconi P; Comitato Scientifico del Registro Italiano Sclerosi Multipla e Patologie Correlate; Rete dei
centri del Registro Italiano Sclerosi Multipla e Patologie Correlate; Rete degli assistenti di ricerca del
Registro Italiano Sclerosi Multipla e Patologie Correlate. Registers as central real world data source: the
experience of the Italian Multiple Sclerosis and Related Disorders Register. Epidemiol Prev. 2024 Jul-
Oct;48(4-5):In press. doi: 10.19191/EP24.4-5.A734.074.
141. Mechelli R, Umeton R, Bellucci G, Bigi R, Rinaldi V, Angelini DF, Guerrera G, Pignalosa FC, Ilari
S, Patrone M, Srinivasan S, Cerono G, Romano S, Buscarinu MC, Martire S, Malucchi S, Landi D,
Lorefice L, Pizzolato Umeton R, Anastasiadou E, Trivedi P, Fornasiero A, Ferraldeschi M; IMSGC
WTCCC2; Di Sapio A, Marfia G, Cocco E, Centonze D, Uccelli A, Di Silvestre D, Mauri P, de Candia P,
D'Alfonso S, Battistini L, Farina C, Magliozzi R, Reynolds R, Baranzini SE, Matarese G, Salvetti M,
Ristori G. A disease-specific convergence of host and Epstein-Barr virus genetics in multiple sclerosis.
Proc Natl Acad Sci U S A. 2025 Apr 8;122(14):e2418783122. doi: 10.1073/pnas.2418783122.
142.
Pagina 18 - Curriculum vitae et studiorum
Dr.ssa Silvia Romano
All From 2020
Citation 6190 3071
H index 38 30
i10-index 83 64
Google Scholar