SILVIA ROMANO

CLINICAL AND RESEARCH ACTIVITY
I have a broad background in hereditary neurological disorders with specific training and expertise in clinical features and treatment of patients with spastic paraplegias, cerebellar ataxias, Huntington disease and hereditary cerebrovascular disease such as in diagnosis and treatment of multiple sclerosis. Specifically, my research focuses on clinical trial using repurposing approaches.

WORK EXPERIENCE
Jun 2025-Present Associate professor
Employer Sapienza University of Rome NESMOS Department
Role Research activities Neurogenetics outpatient clinic at SantAndrea Hospital, Rome

2022-May 2025 Senior Researcher
Employer Sapienza University of Rome NESMOS Department
Role Research activities at the Multiple Sclerosis Center and Neurogenetics outpatient clinic at SantAndrea Hospital, Rome

Aug 2020-Oct 2022 Neurologist
Employer ASL RM2 – UOS Disabile Adulto Distretto 6
Role Clinical Neurologist

Jan 2021-Jul 2021 Research collaborator
Employer NESMOS Department, Sapienza University of Rome Faculty of Medicine and Psychology
Role Research activity on neurodegenerative diseases

Mar 2019-Aug 2020 Research fellow
Employer NESMOS Department, Sapienza University of Rome Faculty of Medicine and Psychology
Role Research activities within the project Demyelinating, Dysmyelinating and Heredodegenerative Diseases

Jan 2014-Jan 2019 Researcher
Employer Sapienza University of Rome, Azienda Ospedaliera Sant’Andrea, Experimental Therapies Center (CENTERS), Rome
Role Clinical and research activities at the Multiple Sclerosis Center and Neurogenetics outpatient clinic, SantAndrea Hospital, Rome

2007-present Neurologist
Employer Italian Huntingtons Disease Association (AICH), Rome
Role Specialist neurological consultations for patients with Huntingtons Disease

May 2013-Jan 2014 Consultant neurologist
Employer Ferrovie dello Stato
Role Neurological assessments for occupational suitability

Dec 2012-Nov 2013 Research fellow
Employer NESMOS Department, Sapienza University of Rome Faculty of Medicine and Psychology
Role Consultant anh clinical neurologist for the Research project on Potential Immunomodulatory Drugs in Multiple Sclerosis

Nov 2012 – Apr 2013 Neurologist
Employer S.Andrea Hospital - Rome
Role Consultant and clinical neurologist for the project "Efficacy of riluzole in hereditary cerebellar ataxia a randomized double-blind placebo-controlled trial -FARM7KAJM7

Nov 2010 – Apr 2011
Employer Prof.ssa Marina Frontali, Institute of Neurobiology and Molecular Medicine (CNR-INMM), Rome
Role Post-doc Research fellow
Consutant neurologist for the project Diagnosis and treatment of CADASIL patients in the research project Effects of tetrahydrobiopterin (6R-BH4) on flow-mediated dilatation in CADASIL patients: a randomized controlled trial (EudraCT No. 2007-004370-55)

Nov 2008 – Sep 2009
Employer IRCCS Santa Lucia Roma
Role Co.co.pro, research fellow, consultant neurologist for the project on neurocognitive pattern of Multiple Sclerosis patients

Feb 2008 – Jun 2008
Employer Dr. Caterina Mariotti, Biochemistry and Genetics Unit, Carlo Besta Neurological Institute Foundation (IRCCS), Milan
Role Neurologist, Clinical data collection, patient evaluations and presentations within the research project EUROSCA European Integrated Project on Spinocerebellar Ataxias “EUROSCA-European Integrated Project on Spinocerebellar Ataxias: Pathogenesis, Genetics, Animal model – CT 2003.503304 – RB13”

Education and training

2016-2017 Master’s in “Therapeutic Development Methodologies in NeurologyInstitution Sapienza University of Rome
Grade 70/70 with honors

2006-2010 PhD in Experimental and Clinical Neurosciences
Institution Sapienza University of Rome
Grade 70/70 with honors

2002-2006 Specialization in Neurology
Institution Sapienza University of Rome
Grade 70/70 with honors

1995-2000 MD in Medicine and Surgery
Institution Sapienza University of Rome
Grade 110/110 with honors

Teaching activity and Supervision of Students

2012-today Seminars, training, and supervision of undergraduate and graduate students, residents in neurology, PhD students and post-doc fellows.
Faculty of Medicine and Psycology and Physiotherapy Degree Program, NESMOS Department Sapienza University of Rome, Italy

2016-today Member of PhD Faculty in Neurosensory Plasticity, Faculty of Medicine and Psycology, NESMOS Department Sapienza University of Rome, Italy

2022-today Professor of Nervous System Diseases and Nursing Processes at Faculty of Medicine and Psycology, NESMOS Department Sapienza University of Rome, Italy

Reviewer activity
Review Editor for Frontiers in Neurology
Associate Editor for Frontiers in Neurology.

Collaboration
I have several national and international collaborations.
- Prof.ssa Paola Giunti, UCL Queen Square Institute of Neurology, Londra, UK
- Joana DAMÁSIO, Neurologist of Centro Hospitalar do Porto, Porto
- Prof. Roberto Rodriguez Labrada, Centro de Neurociencias de Cuba,
- Prof.ssa Theresa Zesiewicz, University of South Florida, Tampa, USA
- Prof.ssa Gabriella Silvestri, Policlinico Gemelli, Rome, IT
- Prof.ssa Agnese Suppiej, University of Ferrara, IT

Publications
Book Chapters
1. Romano S, Colosimo C. Aggiornamento sulla malattia di Hallervorden-Spatz. Giornale di Neuropsicofarmacologia 1999; :91-94.
2. Romano S, Colosimo C. La malattia di Hallervorden-Spatz. In: Trattato Italiano di neurologia, a cura di P. Bergonzi e AR Massaro. Verduci, Roma 1999, pp 123.1-123.5.
3. Romano S, Colosimo C. Atetosi e sindromi atetosiche. In: Trattato Italiano di neurologia, a cura di P. Bergonzi e AR Massaro. Verduci, Roma 1999, pp 121.1-121.4.
4. Strano S, Romano S. La diagnostica strumentale della sincope neuro mediata e degli stati ipotensivi. In: Quaderni di Neurofisiopatologia n° 6, a cura di Milena De Marinis, I.P. Service Editrice, Roma 2001, pp 11-23.
5. Coauthor “I disturbi neuropsichiatrici nella sclerosi multipla” a cura di Nocentini U, Caltagirone C, Tedeschi G. Edizione Springer-Verlag 2011.
6. Coauthor “Affrontare il rischio genetico e proteggere la speranza. Storia e risultati di un modello di collaborazione tra ricercatori, medici e famiglie con malattia di Huntington”. Mondadori Electa, 2016.
7. Ferraldeschi M, Romano s, Buscarinu MC, Fornasiero A, Mechelli R, Mattei c, Stazi Ma, Alimonti A, Salvetti M,Ristori G. “ Chemical Elements and Oxidative Status in Neuroinflammation” In: White AR, Aschner M, Costa LG, Bush AI, eds., Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics, San Diego: Academic Press, 2017: pp 67-82
8. Coauthor “Encefaliti” in Neurologia della Sapienza. Prima, seconda e terza edizione (2012, 2015, 2019). Casa Editrice Esculapio
9. Coautore del capitolo “Sclerosi Multipla” in Neurologia della Sapienza. Terza edizione, 2019, casa editrice Esculapio.

Peer-reviewed publications
1. Vanacore N., Bonifati V., Fabbrini G., Colosimo C., De Michele G., Marconi R., Nicholl D., Locuratolo N., Talarico G., Romano S., Stocchi F., Bonuccelli U., De Mari M., Vieregge P., Meco G., for the ESGAP Consortium. Epidemiology of multiple system atrophy. Neurol Sci 2001; 22:97-99.
2. Vanacore N., Bonifati V., Colosimo C., Fabbrini G., De Michele G., Marconi R., Nicholl D., Locuratolo N., Romano S., Talarico G., Stocchi F., Bonuccelli U.,Lamberti P., Vieregge P., Meco G., for the ESGAP Consortium. Epidemiology of progressive sopranuclear palsy. Neurol Sci 2001; 22:101-103.
3. Romano S, Colosimo C. Procerus sign in progressive supranuclear palsy. Neurology 2001;57(10):1928.
4. Pozzilli C., Romano S., Cannoni S. Epidemiology and current treatment of multiple sclerosis in Europe today. Journal of Rehabilitation Research and Development 2002; 39:175-185.
5. Colosimo C, Chianese M, Romano S. Is hypertension associated with hemifacial spasm? Neurology 2003;61(4):587.
6. Pozzilli C, Marinelli F, Romano S, Bagnato F. Corticosteroids treatment. J Neurol Sci 2004; 223(1):47- 51.
7. Greco A, Minghetti L, Puopolo M, Cannoni S, Romano S, Pozzilli C, Levi G. Cerebrospinal fluid isoprostanes are not related to inflammatory activity in relapsing-remitting multiple sclerosis. J Neurol Sci 2004; 224(1-2):23-7
8. Salsano E, Ciano C, Romano S, Cornelio F, Di Donato S, Pareyson D. Propriospinal myoclonus with life threatening tonic spasms as paraneoplastic presentation of breast cancer. J Neurol Neurosurg Psychiatry 2006; 77(3):422-4.
9. Schmitz-Hubsch T, Tezenas du Montcel S, Baliko L, Boesch S, Bonato S, Fancellu R, Giunti P, Globas C, Kang JS, Kremer B, Mariotti C, Melegh B, Rakowicz M, Rola R, Romano S, Schols L, Szymanski S, van de Warrenburg BP, Zdzienicka E, Durr A, Klockgether T. Reliability and validity of the International Cooperative Ataxia Rating Scale: a study in 156 spinocerebellar ataxia patients. Mov Disord 2006; 21(5):699-704.
10. Annibali V, Ristori G, Cannoni S, Romano S, Visconti A, Ghazaryan A, Figa Talamanca L, Salvetti M, Mechelli R. Multiple sclerosis: pharmacogenomics and personalised drug treatment. Neurol Sci 2006;27 Suppl 5:S347-9.
11. Romano S, Salvetti M, Ceccherini I, De Simone T, Savoiardo M. Brainstem signs with progressing atrophy of medulla oblongata and upper cervical spinal cord. Lancet Neurol 2007 Jun;6(6):562-70
12. Caroli F, Biancheri R, Seri M, Rossi A, Pessagno A, Bugiani M, Corsolini F, Savasta S, Romano S, Antonelli C, Romano A, Pareyson D, Gambero P, Uziel G, Ravazzolo R, Ceccherini I, Filocamo M. GFAP mutations and polymorphisms in 13 unrelated Italian patients affected by Alexander disease. Clin Genet 2007 Sep 25
13. Farina L, Pareyson D, Minati L, Ceccherini I, Chiapparini L, Romano S, Gambero P, Fancellu R, Savoiardo M. Can MR imaging diagnose adult-onset Alexander disease? AJNR Am J Neuroradiol 2008;29:1190-6.
14. Pareyson D, Fancellu R, Mariotti C, Romano S, Salmaggi A, Carella F, Girotti F, Gattellaro G, Carriero MR, Farina L, Ceccherini I, Savoiardo M. Adult-onset Alexander disease: a series of eleven unrelated cases with review of the literature. Brain. 2008 Sep;131(Pt 9):2321-31.
15. O'Connor P, Comi G, Montalban X, Antel J, Radue EW, de Vera A, Pohlmann H, Kappos L; FTY720 D2201 Study Group. Oral fingolimod (FTY720) in multiple sclerosis: two-year results of a phase II extension study. Neurology 2009;72:73-9.
16. Aziz NA, Jurgens CK, Landwehrmeyer GB; EHDN Registry Study Group, van Roon-Mom WM, van Ommen GJ, Stijnen T, Roos RA. Normal and mutant HTT interact to affect clinical severity and progression in Huntington disease. Neurology 2009;73:1280-5.
17. Romano S, Ristori G, Visconti A, Cannoni S, Spadaro M, Frontali M, Pontieri FE, Vanacore N, Salvetti M. Riluzole in cerebellar ataxia: a randomized, double-blind, placebo-controlled pilot trial. Neurology 2010; 74:839-45.
18. Spanò B, Cercignani M, Basile B, Romano S, Mannu R, Centonze D, Caltagirone C, Bramanti P, Nocentini U, Bozzali M. Multiparametric MR investigation of the motor pyramidal system in patients with 'truly benign' multiple sclerosis. Mult Scler 2010;16:178-88
19. Comi G, O'Connor P, Montalban X, Antel J, Radue EW, Karlsson G, Pohlmann H, Aradhye S, Kappos L; FTY720 D2201 Study Group. Phase II study of oral fingolimod (FTY720) in multiple sclerosis: 3- year results. Mult Scler 2010;16:197-207.
20. Mantuano E, Romano S, Veneziano L, Gellera C, Castellotti B, Caimi S, Testa D, Estienne M, Zorzi G, Bugiani M, Rajabally YA, Barcina MJ, Servidei S, Panico A, Frontali M, Mariotti C. Identification of novel and recurrent CACNA1A gene mutations in fifteen patients with episodic ataxia type 2. J Neurol Sci 2010;291:30-6.
21. Orth M; European Huntington's Disease Network, Handley OJ, Schwenke C, Dunnett SB, Craufurd D, Ho A, Wild EJ, Tabrizi SJ. Observing Huntington's Disease: the European Huntington's Disease Network's REGISTRY. PLoS Curr 2010 Sep 28;2.
22. Bachetti T, Di Zanni E, Lantieri F, Caroli F, Regis S, Filocamo M, Rainero I, Gallone S, Cilia R, Romano S, Savoiardo M, Pareyson D, Biancheri R, Ravazzolo R, Ceccherini I. A novel polymorphic AP-1 binding element of the GFAP promoter is associated with different allelic transcriptional activities. Ann Hum Genet 2010;74:506-15.
23. Busse, Monica; Al-Madfai, Hasan; Kenkre, Joyce; Landwehrmeyer, G. Bernhard; Bentivoglio, Annarita; Rosser, Anne; European, Huntington's Disease Network. Utilisation of healthcare and associated services in Huntington's disease: A data mining study. Plos Currents 2010, 3: 1-14.
24. Annibali V, Ristori G, Angelini DF, Serafini B, Mechelli R, Cannoni S, Romano S, Paolillo A, Abderrahim H, Diamantini A, Borsellino G, Aloisi F, Battistini L, Salvetti M. CD161(high)CD8+T cells bear pathogenetic potential in multiple sclerosis. Brain 2011;134:542-54.
25. Cavallari M, Falco T, Frontali M, Romano S, Bagnato F, Orzi F. Fractal analysis reveals reduced complexity of retinal vessels in CADASIL. PLoS One. 2011 Apr 27;6(4):e19150.
26. Rickards H, De Souza J, van Walsem M, van Duijn E, Simpson SA, Squitieri F, Landwehrmeyer B; European Huntington’s Disease Network. Factor analysis of behavioural symptoms in Huntington’s disease. J Neurol Neurosurg Psychiatry. 2011 Apr; 82(4):411-2.
27. López-Sendón JL, Royuela A, Trigo P, Orth M, Lange H, Reilmann R, Keylock J, Rickards H, Piacentini S, Squitieri F, Landwehrmeyer B, Witjes-Ane MN, Jurgens CK, Roos RA, Abraira V, de Yébenes JG; European HD Network. What is the impact of education on Huntington's disease? Mov Disord. 2011 Jul;26(8):1489-95.
28. Saft C, Epplen JT, Wieczorek S, Landwehrmeyer GB, Roos RA, de Yebenes JG,Dose M, Tabrizi SJ, Craufurd D; REGISTRY Investigators of the European Huntington's Disease Network, Arning L. NMDA receptor gene variations as modifiers in Huntington disease: a replication study. PLoS Curr. 2011 Oct 4;3:RRN1247.
29. Orth M; European Huntington's Disease Network, Handley OJ, Schwenke C, Dunnett S, Wild EJ, Tabrizi SJ, Landwehrmeyer GB. Observing Huntington's disease: the European Huntington's Disease Network's REGISTRY. J Neurol Neurosurg Psychiatry. 2011 Dec;82(12):1409-12.
30. Campolo J, De Maria R, Frontali M, Taroni F, Inzitari D, Federico A, Romano S, Puca E, Mariotti C, Tomasello C, Pantoni L, Pescini F, Dotti MT, Stromillo ML, De Stefano N, Tavani A, Parodi O. Impaired vasoreactivity in mildly disabled CADASIL patients. J Neurol Neurosurg Psychiatry. 2012 Mar;83(3):268-74.
31. Quarrell OW, Handley O, O'Donovan K, Dumoulin C, Ramos-Arroyo M, Biunno I, Bauer P, Kline M, Landwehrmeyer GB; European Huntington’s Disease Network. Discrepancies in reporting the CAG repeat lengths for Huntington's disease. Eur J Hum Genet. 2012 Jan;20(1):20-6.
32. Lee JM, Ramos EM, Lee JH, Gillis T, Mysore JS, Hayden MR, Warby SC, Morrison P, Nance M, Ross CA, Margolis RL, Squitieri F, Orobello S, Di Donato S, Gomez-Tortosa E, Ayuso C, Suchowersky O, Trent RJ, McCusker E, Novelletto A, Frontali M, Jones R, Ashizawa T, Frank S, Saint-Hilaire MH, Hersch SM, Rosas HD, Lucente D, Harrison MB, Zanko A, Abramson RK, Marder K, Sequeiros J, Paulsen JS; PREDICT-HD study of the Huntington Study Group (HSG), Landwehrmeyer GB; REGISTRY study of the European Huntington's Disease Network, Myers RH; HD-MAPS Study Group, MacDonald ME, Gusella JF; COHORT study of the HSG. CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion. Neurology. 2012 Mar 6;78(10):690-5.
33. Soyal SM, Felder TK, Auer S, Hahne P, Oberkofler H, Witting A, Paulmichl M, Landwehrmeyer GB, Weydt P, Patsch W; European Huntington Disease Network. A greatly extended PPARGC1A genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of onset. Hum Mol Genet. 2012 Aug 1;21(15):3461-73.
34. Mechelli R, Umeton R, Policano C, Annibali V, Coarelli G, Ricigliano VA, Vittori D, Fornasiero A, Buscarinu MC; International Multiple Sclerosis Genetics Consortium; Wellcome Trust Case Control Consortium, Romano S, Salvetti M, Ristori G. A "candidate-interactome" aggregate analysis of genome-wide association data in multiple sclerosis. PLoS One. 2013 May 16;8(5):e63300
35. Vittori A, Orth M, Roos RA, Outeiro TF, Giorgini F, Hollox EJ; Registry investigators of the European Huntington's Disease Network. β-Defensin genomic copy number does not influence the age of onset in Huntington's Disease. J Huntingtons Dis. 2013;2(1):107-24.
36. Metzger S, Walter C, Riess O, Roos RA, Nielsen JE, Craufurd D; REGISTRY Investigators of the European Huntington’s Disease Network, Nguyen HP. The V471A polymorphism in autophagy-related gene ATG7 modifies ge at onset specifically in Italian Huntington disease patients. PLoS One. 2013 Jul 22;8(7):e68951.
37. Hart EP, Marinus J, Burgunder JM, Bentivoglio AR, Craufurd D, Reilmann R, Saft C, Roos RA; REGISTRY Investigators of the European Huntington's Disease Network. Better global and cognitive functioning in choreatic versus hypokinetic-rigid Huntington's disease. Mov Disord. 2013 Jul;28(8):1142-5.
38. Hubers AA, van Duijn E, Roos RA, Craufurd D, Rickards H, Bernhard Landwehrmeyer G, van der Mast RC, Giltay EJ; REGISTRY investigators of the European Huntington's Disease Network. Suicidal ideation in a European Huntington's disease population. J Affect Disord. 2013 Oct;151(1):248-39.
39. Ristori G, Romano S, Cannoni S, Visconti A, Tinelli E, Mendozzi L, Cecconi P, Lanzillo R, Quarantelli M, Buttinelli C, Gasperini C, Frontoni M, Coarelli G, Caputo D, Bresciamorra V, Vanacore N, Pozzilli C, Salvetti M. Effects of Bacille Calmette-Guerin after the first demyelinating event in the CNS. Neurology. 2014 Jan 7;82(1):41-8.
40. Veneziano L, Mantuano E, Catalli C, Gellera C, Durr A, Romano S, Spadaro M, Frontali M, Novelletto A. A shared haplotype for dentatorubropallidoluysian atrophy (DRPLA) in Italian families testifies of the recent introduction of the mutation. J Hum Genet. 2014 Mar;59(3):153-7.
41. De Maria R, Campolo J, Frontali M, Taroni F, Federico A, Inzitari D, Tavani A, Romano S, Puca E, Orzi F, Francia A, Mariotti C, Tomasello C, Dotti MT, Stromillo ML, Pantoni L, Pescini F, Valenti R, Pelucchi C, Parolini M, Parodi O. Effects of sapropterin on endothelium-dependent vasodilation in patients with CADASIL: a randomized controlled trial. Stroke. 2014 Oct;45(10):2959-66.
42. Ristori G, Romano S, Coarelli G, Buscarinu MC, Salvetti M. Author response. Neurology. 2014 Jul 22;83(4):381.
43. Ristori G, Romano S, Coarelli G, Buscarinu MC, Salvetti M. Author response. Neurology. 2014 Jul 15;83(3):293.
44. Argento O, Incerti CC, Pisani V, Magistrale G, Di Battista G, Romano S, Ferraro E, Caltagirone C, Nocentini U. Domestic accidents and multiple sclerosis: an exploratory study of occurrence and possible causes. Disabil Rehabil. 2014;36(26):2205-9.
45. Mechelli R, Vittori D, Coarelli G, Aimati L, De Luca O, Romano S, Ricigliano VA, Annibali V, Policano C, Mattei C, Salvetti M, Ristori G. Screening for neurotropic viruses in cerebrospinal fluid of patients with multiple sclerosis and other neurological diseases. Mult Scler. 2014 Apr;20(5):638,
46. Bertolotto A, Capobianco M, Amato MP, Capello E, Capra R, Centonze D, Di Ioia M, Gallo A, Grimaldi L, Imberti L, Lugaresi A, Mancinelli C, Marrosu MG, Moiola L, Montanari E, Romano S, Musu L, Paolicelli D, Patti F, Pozzilli C, Rossi S, Salvetti M, Tedeschi G, Tola MR, Trojano M, Zaffaroni M, Malucchi S; Italian Multiple Sclerosis Study group. Guidelines on the clinical use for the detection of neutralizing antibodies (NAbs) to IFN beta in multiple sclerosis therapy: report from the Italian Multiple Sclerosis Study group. Neurol Sci. 2014 Feb;35(2):307-16.
47. Vittori A, Breda C, Repici M, Orth M, Roos RA, Outeiro TF, Giorgini F, Hollox EJ; REGISTRY investigators of the European Huntington's Disease Network. Copy-number variation of the neuronal glucose transporter gene SLC2A3 and age of onset in Huntington's disease. Hum Mol Genet. 2014 Jun 15;23(12):3129-37.
48. Mechelli R, Manzari C, Policano C, Annese A, Picardi E, Umeton R, Fornasiero A, D'Erchia AM, Buscarinu MC, Agliardi C, Annibali V, Serafini B, Rosicarelli B, Romano S, Angelini DF, Ricigliano VA, Buttari F, Battistini L, Centonze D, Guerini FR, D'Alfonso S, Pesole G, Salvetti M, Ristori G. Epstein-Barr virus genetic variants are associated with multiple sclerosis. Neurology. 2015 Mar 4.
49. Annibali V, Mechelli R, Romano S, Buscarinu MC, Fornasiero A, Umeton R, Ricigliano VA, Orzi F, Coccia EM, Salvetti M, Ristori G. IFN-β and multiple sclerosis: from etiology to therapy and back. Cytokine Growth Factor Rev. 2015 Apr;26(2):221-8.
50. Bečanović K, Nørremølle A, Neal SJ, Kay C, Collins JA, Arenillas D, Lilja T, Gaudenzi G, Manoharan S, Doty CN, Beck J, Lahiri N, Portales-Casamar E, Warby SC, Connolly C, De Souza RA; REGISTRY Investigators of the European Huntington's Disease Network, Tabrizi SJ, Hermanson O, Langbehn DR, Hayden MR, Wasserman WW, Leavitt BR. A SNP in the HTT promoter alters NF-κB binding and is a bidirectional genetic modifier of Huntington disease. Nat Neurosci. 2015 Jun;18(6):807.
51. Kuhle J, Disanto G, Dobson R, Adiutori R, Bianchi L, Topping J, Bestwick JP, Meier UC, Marta M, Costa GD, Runia T, Evdoshenko E, Lazareva N, Thouvenot E, Iaffaldano P, Direnzo V, Khademi M, Piehl F, Comabella M, Sombekke M, Killesten J, Hegen H, Rauch S, D'Alfonso S, Alvarez-Cermeño JC, Kleinová P, Horáková D, Roesler R, Lauda F, Llufriu S, Avsar T, Uygunoglu U, Altintas A, Saip S, Menge T, Rajda C, Bergamaschi R, Moll N, Khalil M, Marignier R, Dujmovic I, Larsson H, Malmestrom C, Scarpini E, Fenoglio C, Wergeland S, Laroni A, Annibali V, Romano S, Martínez AD, Carra A, Salvetti M, Uccelli A, Torkildsen Ø, Myhr KM, Galimberti D, Rejdak K, Lycke J, Frederiksen JL, Drulovic J, Confavreux C, Brassat D, Enzinger C, Fuchs S, Bosca I, Pelletier J, Picard C, Colombo E, Franciotta D, Derfuss T, Lindberg R, Yaldizli Ö, Vécsei L, Kieseier BC, Hartung HP, Villoslada P, Siva A, Saiz A, Tumani H, Havrdová E, Villar LM, Leone M, Barizzone N, Deisenhammer F, Teunissen C, Montalban X, Tintoré M, Olsson T, Trojano M, Lehmann S, Castelnovo G, Lapin S, Hintzen R, Kappos L, Furlong R, Martinelli V, Comi G,Ramagopalan SV, Giovannoni G. Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study. Mult Scler. 2015 Jul;21(8):1013-24.
52. Valcárcel-Ocete L, Alkorta-Aranburu G, Iriondo M, Fullaondo A, García-Barcina M, Fernández-García JM, Lezcano-García E, Losada-Domingo JM, Ruiz-Ojeda J, Álvarez de Arcaya A, Pérez-Ramos JM, Roos RA, Nielsen JE, Saft C; REGISTRY investigators of the European Huntington's Disease Network, Zubiaga AM, Aguirre A. Exploring Genetic Factors Involved in Huntington Disease Age of Onset: E2F2 as a New Potential Modifier Gene. PLoS One. 2015 Jul 6;10(7):e0131573.
53. Vuono R, Winder-Rhodes S, de Silva R, Cisbani G, Drouin-Ouellet J; REGISTRY Investigators of the European Huntington’s Disease Network, Spillantini MG, Cicchetti F, Barker RA. The role of tau in the pathological process and clinical expression of Huntington's disease. Brain. 2015 Jul;138(Pt 7):1907-18.
54. Romano S, Coarelli G, Marcotulli C, Leonardi L, Piccolo F, Spadaro M, Frontali M, Ferraldeschi M, Vulpiani MC, Ponzelli F, Salvetti M, Orzi F, Petrucci A, Vanacore N, Casali C, Ristori G. Riluzole in patients with hereditary cerebellar ataxia: a randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2015 Aug 25.
55. Severa M, Rizzo F, Giacomini E, Annibali V, Gafa V, Romano S, Buscarinu MC, Fornasiero A, Salvetti M, Coccia EM. IFN-β Therapy Regulates TLR7-Mediated Response in Plasmacytoid Dendritic Cells of Multiple Sclerosis Patients Influencing an Anti-Inflammatory Status. J Interferon Cytokine Res.2015 Sep;35(9):668-81
56. Tedroff J, Waters S, Barker RA, Roos R, Squitieri F; EHDN Registry Study Group. Antidopaminergic Medication is Associated with More Rapidly Progressive Huntington's Disease. J Huntingtons Dis. 2015;4(2):131-40.
57. Faggianelli N, Puglisi R, Veneziano L, Romano S, Frontali M, Vannocci T, Fortuni S, Testi R, Pastore A. Analyzing the Effects of a G137V Mutation in the FXN Gene. Front Mol Neurosci. 2015 Nov 25;8:66.
58. Dale M, Maltby J, Martucci R, Shimozaki S; REGISTRY investigators of the European Huntington's Disease Network. Factor analysis of the hospital anxiety and depression scale among a Huntington's disease population. Mov Disord. 2015 Dec;30(14):1954-60.):789.
59. Dale M, Maltby J, Shimozaki S, Cramp R, Rickards H; REGISTRY Investigators of the European Huntington's Disease Network. Disease stage, but not sex, predicts depression and psychological distress in Huntington's disease: A European population study. J Psychosom Res. 2016 Jan;80:17-22.
60. Serafini G, Giordano G, Romano S, Raja M, Girardi P, Amore M, Pompili M. Huntington's disease and suicidal behavior: The importance of lithium treatment. Clin Neurol Neurosurg. 2016 Jun;145:108-9.
61. Di Santo G, Adiutori R, Dobson R, Martinelli V, Dalla Costa G, Runia T, Evdoshenko E, Thouvenot E, Trojano M, Norgren N, Teunissen C, Kappos L, Giovannoni G, Kuhle J; International Clinically Isolated Syndrome Study Group. Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome. J Neurol Neurosurg Psychiatry. 2016 Feb;87(2):126-9.
62. Romano S, Coarelli G, Vanacore N, Salvetti M, Ristori G. Riluzole in patients with hereditary cerebellar ataxia - Authors' reply. Lancet Neurol. 2016 Jul;15(8):789.
63. Leonardi L, Marcotulli C, Storti E, Tessa A, Serrao M, Longobardi A, Romano S, Ristori G, Santorelli FM, Pierelli F, Casali C. Spinocerebellar Ataxia Type 3 in Italy: Time to Change Mind. Neuroepidemiology. 2016;46(4):268
64. Maltby J, Dale M, Underwood M, Rickards H, Callaghan J; REGISTRY Investigators of the European Huntington’s Disease Network. Exploring the Structural Relationship Between Interviewer and Self-Rated Affective Symptoms in Huntington's Disease. J Neuropsychiatry Clin Neurosci. 2016 Summer;28(3):236-8.
65. Jacobs M, Hart EP, van Zwet EW, Bentivoglio AR, Burgunder JM, Craufurd D, Reilmann R, Saft C, Roos RA; REGISTRY investigators of the European Huntington’s Disease Network. Progression of motor subtypes in Huntington's disease: a 6-year follow-up study. J Neurol. 2016 Jul 19.
66. Cubo E, Ramos-Arroyo MA, Martinez-Horta S, Martínez-Descalls A, Calvo S, Gil-Polo C; European HD Network. Clinical manifestations of intermediate allele carriers in Huntington disease. Neurology. 2016 Aug 9;87(6):571-8
67. Romano, S., Ferraldeschi, M., Buscarinu, M.C., Fornasiero, A., Mechelli, R., Cerasoli, B., Vanacore, N., Salvetti, M., Ristori, G. Vaccines in multiple sclerosis: the experience of BCG vaccination. DRUGS OF THE FUTURE, Prous Science, 2016, Vol. 41, p. 293-300
68. Eleuteri C, Olla S, Veroni C, Umeton R, Mechelli R, Romano S, Buscarinu MC, Ferrari F, Calò G, Ristori G, Salvetti M, Agresti C. A staged screening of registered drugs highlights remyelinating drug candidates for clinical trials. Sci Rep. 2017 Apr 7;7:45780.
69. Buscarinu MC, Cerasoli B, Annibali V, Policano C, Lionetto L, Capi M, Mechelli R, Romano S, Fornasiero A, Mattei G, Piras E, Angelini DF, Battistini L, Simmaco M, Umeton R, Salvetti M, Ristori G. Altered intestinal permeability in patients with relapsing-remitting multiple sclerosis: A pilot study. Mult Scler. 2017 Mar;23(3):442-446.
70. Olivito G, Cercignani M, Lupo M, Iacobacci C, Clausi S, Romano S, Masciullo M, Molinari M, Bozzali M, Leggio M. Neural substrates of motor and cognitive dysfunctions in SCA2 patients: A network based statistics analysis. Neuroimage Clin. 2017 Mar 25;14:719-725.
71. Buscarinu MC, Fornasiero A, Romano S, Ferraldeschi M, Renié R, Trasimeni G, Salvetti M, Ristori G. Coincident onset of multiple sclerosis and Herpes simplex virus 1 encephalitis: a case report. Multiple Sclerosis and Demyelinating Disorders 2017 2:6 DOI: 10.1186/s40893-017-0023
72. Underwood M, Bonas S, Dale M, REGISTRY Investigators of the European Huntington’s Disease Network. Huntington’s Disease: Prevalence and Psychological Indicators of Pain. Mov Dis Clin Pract 2017 March/April 4(2):198-204.
73. Maltby J, Dale M, Underwood M, Simpson J and the REGISTRY investigators of the European Huntington’s Disease Network. Irritability in Huntington’s Disease: Factor Analysis of Snaith’s Irritability Scale. Mov Dis Clinical Practice. 2017 May/June 4(3):342–348
74. Moss DJH, Pardiñas AF, Langbehn D, Lo K, Leavitt BR, Roos R, Durr A, Mead S; TRACK-HD investigators; REGISTRY investigators, Holmans P, Jones L, Tabrizi SJ. Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study. Lancet Neurol. 2017 Jun 20. pii: S1474 4422(17)30161-8.
75. Stuitje G, van Belzen MJ, Gardiner SL, van Roon-Mom WMC, Boogaard MW; REGISTRY Investigators of the European Huntington Disease Network, Tabrizi SJ, Roos RAC, Aziz NA. Age of onset in Huntington's disease is influenced by CAG repeat variations in other polyglutamine disease-associated genes. Brain. 2017 Jul 1;140(7):e42.
76. Baake V, Reijntjes RHAM, Dumas EM, Thompson JC; REGISTRY Investigators of the European Huntington's Disease Network, Roos RAC. Cognitive decline in Huntington's disease expansion gene carriers. Cortex. 2017 Aug 3;95:51-62.
77. Rodrigues FB, Abreu D, Damásio J, Gonçalves N, Correia Guedes L, Coelho M, Ferreira JJ, REGISTRY Investigators of the European Huntington’s Disease Network. Survival, Mortality, Causes and Places of Death in a European Huntington’s Disease Prospective Cohort. Mov Dis Clinical Practice. 2017; September/October Volume 4 (5):737-742.
78. Buscarinu MC, Romano S, Mechelli R, Pizzolato Umeton R, Ferraldeschi M, Fornasiero A, Reniè R, Cerasoli B, Morena E, Romano C, Loizzo ND, Umeton R, Salvetti M, Ristori G. Intestinal Permeability in Relapsing-Remitting Multiple Sclerosis. Neurotherapeutics. 2017 Nov 8. doi: 10.1007/s13311-017-0582-3.
79. van Duijn E, Vrijmoeth EM, Giltay EJ, Bernhard Landwehrmeyer G; REGISTRY investigators of the European Huntington's Disease Network. Suicidal ideation and suicidal behavior according to the C-SSRS in a European cohort of Huntington's disease gene expansion carriers. J Affect Disord. 2017 Nov 15;228:194-204.
80. Olivito G, Lupo M, Iacobacci C, Clausi S, Romano S, Masciullo M, Molinari M, Cercignani M, Bozzali M, Leggio M. Microstructural MRI Basis of the Cognitive Functions in Patients with Spinocerebellar Ataxia Type 2. Neuroscience. 2017 Dec 16;366:44-53.
81. Tacchella A, Romano S, Ferraldeschi M, Salvetti M, Zaccaria A, Crisanti A, Grassi F. Collaboration between a human group and artificial intelligence can improve prediction of multiple sclerosis course: a proof-of-principle study. F1000Res. 2017 Dec 22;6:2172.
82. Olivito G, Lupo M, Iacobacci C, Clausi S, Romano S, Masciullo M, Molinari M, Cercignani M, Bozzali M, Leggio M. Structural cerebellar correlates of cognitive functions in spinocerebellar ataxia type 2. J Neurol. 2018 Mar;265(3):597-606.
83. Coarelli G, Romano S, Travaglini L, Ferraldeschi M, Nicita F, Spadaro M, Fornasiero A, Frontali M, Salvetti M, Bertini E, Ristori G. Novel homozygous GBA2 mutation in a patient with complicated spastic paraplegia. Clin Neurol Neurosurg. 2018 Mar 3;168:60-63.
84. Barkhuizen M, Rodrigues FB, Anderson DG, Winkens B; REGISTRY Investigators of the European Huntington's Disease Network, Wild EJ, Kramer BW, Gavilanes AWD. Perinatal insults and neurodevelopmental disorders may impact Huntington's disease age of diagnosis. Parkinsonism Relat Disord 2018 May 18.
85. Valcárcel-Ocete L, Fullaondo A, Alkorta-Aranburu G, García-Barcina M, Roos RAC, Hjermind LE, Saft C, Frontali M, Reilmann R, Rickards H; REGISTRY investigators of the European Huntington’s Disease Network (EHDN), Zubiaga AM, Aguirre A. Does arterial hypertension influence the onset of Huntington's disease? PLoS One. 2018 May 23;13(5):e0197975
86. Lupo M, Olivito G, Iacobacci C, Clausi S, Romano S, Masciullo M, Molinari M, Cercignani M, Bozzali M, Leggio M. The cerebellar topography of attention sub-components in spinocerebellar ataxia type 2. Cortex. 2018 Jul 31;108:35-49.
87. McNulty P, Pilcher R, Ramesh R, Necuiniate R, Hughes A, Farewell D, Holmans P, Jones L; REGISTRY Investigators of the European Huntington's Disease Network. Reduced Cancer Incidence in Huntington's Disease: Analysis in the Registry Study. J Huntingtons Dis. 2018;7(3):209-222.
88. Annibali V, Umeton R, Palermo A, Severa M, Etna MP, Giglio S, Romano S, Ferraldeschi M, Buscarinu MC, Vecchione A, Annese A, Policano C, Mechelli R, Pizzolato Umeton R, Fornasiero A, Angelini DF, Guerrera G, Battistini L, Coccia EM, Salvetti M, Ristori G. Analysis of coding and non-coding transcriptome of peripheral B cells reveals an altered interferon response factor (IRF)-1 pathway in multiple sclerosis patients. J Neuroimmunol 2018; 324(15): 165-171.
89. Oosterloo M, Bijlsma EK, van Kuijk SM, Minkels F, de Die-Smulders CE; REGISTRY Investigators of the European Huntington's Disease Network; Registry Steering committee; Language coordinators; EHDN's associate site in Singapore. Clinical and genetic characteristics of late-onset Huntington's disease. Parkinsonism Relat Disord. 2018 Nov 29.
90. Ristori G, Faustman D, Matarese G, Romano S, Salvetti M. Bridging the gap between vaccination with Bacille Calmette-Guérin (BCG) and immunological tolerance: the cases of type 1 diabetes and multiple sclerosis. Curr Opin Immunol. 2018 Dec;55:89-96.
91. Castaldo I, De Rosa M, Romano A, Zuchegna C, Squitieri F, Mechelli R, Peluso S, Borrelli C, Del Mondo A, Salvatore E, Vescovi LA, Migliore S, De Michele G, Ristori G, Romano S, Avvedimento EV, Porcellini A. DNA damage signatures in peripheral blood cells as biomarkers in prodromal huntington disease. Ann Neurol. 2018 Dec 14.
92. Horton MC, Nopoulos P, Nance M, Landwehrmyer GB, Barker RA, Squitieri F; REGISTRY Investigators of the European Huntington’s Disease Network, Burgunder JM, Quarrell O. Assessment of the Performance of a Modified Motor Scale as Applied to Juvenile Onset Huntington's Disease. J Huntingtons Dis. 2019;8(2):181-193. doi: 10.3233/JHD-180306. PMID: 30856116.
93. La Starza S, Ferraldeschi M, Buscarinu MC, Romano S, Fornasiero A, Mechelli R, Umeton R, Ristori G, Salvetti M. Genome-Wide Multiple Sclerosis Association Data and Coagulation. Front Neurol. 2019 Feb 14;10:95.
94. Romano S, Ferraldeschi M, Bagnato F, Mechelli R, Morena E, Caldano M, Buscarinu MC, Fornasiero A, Frontoni M, Nociti V, Mirabella M, Mayer F, Bertolotto A, Pozzilli C, Vanacore N, Salvetti M, Ristori G. Drug Holiday of Interferon Beta 1b in Multiple Sclerosis: A Pilot, Randomized, Single Blind Study of Non-inferiority. Front Neurol. 2019 Jul 16;10:695.
95. Buscarinu MC, Fornasiero A, Romano S, Ferraldeschi M, Mechelli R, Reniè R, Morena E, Romano C, Pellicciari G, Landi AC, Salvetti M, Ristori G. The Contribution of Gut Barrier Changes to Multiple Sclerosis Pathophysiology. Front Immunol. 2019 Aug 28;10:1916. doi: 10.3389/fimmu.2019.01916. eCollection 2019.
96. Prosperini L, Cortese A, Lucchini M, Boffa L, Borriello G, Buscarinu MC, Capone F, Centonze D, De Fino C, De Pascalis D, Fantozzi R, Ferraro E, Filippi M, Galgani S, Gasperini C, Haggiag S, Landi D, Marfia G, Mataluni G, Millefiorini E, Mirabella M, Monteleone F, Nociti V, Pontecorvo S, Romano S, Ruggieri S, Salvetti M, Tortorella C, Zannino S, Di Battista G. Exit strategies for "needle fatigue" in multiple sclerosis: a propensity score-matched comparison study. J Neurol 2020; 267:694–702.
97. Mechelli R, Umeton R, Manfrè G, Romano S, Buscarinu MC, Rinaldi V, Bellucci G, Bigi R, Ferraldeschi M, Salvetti M, Ristori G. Reworking GWAS Data to Understand the Role of Nongenetic Factors in MS Etiopathogenesis. Genes (Basel). 2020 Jan 14;11(1):97.
98. Tiano F, Amati F, Cherubini F, Morini E, Vancheri C, Maletta S, Fortuni S, Serio D, Quatrana A, Luffarelli R, Benini M, Alfedi G, Panarello L, Rufini A, Toschi N, Frontali M, Romano S, Marcotulli C, Casali C, Gioiosa S, Mariotti C, Mongelli A, Fichera M, Condò I, Novelli G, Testi R, Malisan F. Frataxin deficiency in Friedreich's ataxia is associated with reduced levels of HAX-1, a regulator of cardiomyocyte death and survival. Hum Mol Genet. 2020 Feb 1;29(3):471-482.
99. Buscarinu MC, Fornasiero A, Ferraldeschi M, Romano S, Reniè R, Morena E, Romano C, Pellicciari G, Landi AC, Fagnani C, Salvetti M, Ristori G. Disentangling the molecular mechanisms of multiple sclerosis: The contribution of twin studies. Neurosci Biobehav Rev. 2020 Apr;111:194-198.
100. Olivito G, Siciliano L, Clausi S, Lupo M, Romano S, Masciullo M, Molinari M, Cercignani M, Bozzali M, Leggio M. Functional Changes of Mentalizing Network in SCA2 Patients: Novel Insights into Understanding the Social Cerebellum. Cerebellum 2020; Apr;19(2):235-242.
101. Chesi P, Marini MG, Mancardi GL, Patti F; SMART study project group, Alivernini L, Bisecco A, Borriello G, Bucello S, Caleri F, Cavalla P, Cocco E, Cordioli C, Di Giuseppe M, Fantozzi R, Gattuso M, Granella F, Liguori M, Locatelli L, Lugaresi A, Marangoni S, Moiola L, Mutta E, Neri W, Pastò L, Perini P, Petruzzo M, Plewnia K, Repice AM, Rezzonico M, Romano S, Rovaris M, Sessa E, Tortorella C, Totaro R, Valentino P. Listening to the neurological teams for multiple sclerosis: the SMART project. Neurol Sci. 2020 Mar 20
102. Vuono R, Kouli A, Legault EM, Chagnon L, Allinson KS, La Spada A; REGISTRY Investigators of the European Huntington's Disease Network, Biunno I, Barker RA, Drouin-Ouellet J. Association Between Toll-Like Receptor 4 (TLR4) and Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Genetic Variants and Clinical Progression of Huntington's Disease. Mov Disord. 2020 Mar;35(3):401-408. doi: 10.1002/mds.27911.
103. Seccia R, Gammelli D, Dominici F, Romano S, Landi AC, Salvetti M, Tacchella A, Zaccaria A, Crisanti A, Grassi F, Palagi L. Considering patient clinical history impacts performance of machine learning models in predicting course of multiple sclerosis. PLoS One. 2020;15(3):e0230219.
104. Seccia R, Romano S, Salvetti M, Crisanti A, Palagi L, Grassi F. Machine Learning Use for Prognostic Purposes in Multiple Sclerosis. Life (Basel). 2021 Feb 5;11(2):122. doi:10.3390/life11020122.
105. Lepore V, Bosetti C, Santucci C, Iaffaldano P, Trojano M, Mosconi P; Italian Multiple Sclerosis Register Centers Group, the Scientific Committee of Italian SM Register. Detection of disability worsening in relapsing-remitting multiple sclerosis patients: a real-world roving Expanded Disability Status Scale reference analysis from the Italian Multiple Sclerosis Register. Eur J Neurol. 2021 Feb;28(2):567-578. doi: 10.1111/ene.14589.
106. Angeloni B, Bigi R, Bellucci G, Mechelli R, Ballerini C, Romano C, Morena E, Pellicciari G, Reniè R, Rinaldi V, Buscarinu MC, Romano S, Ristori G, Salvetti M. A Case of Double Standard: Sex Differences in Multiple Sclerosis Risk Factors. Int J Mol Sci. 2021 Apr 2;22(7):3696.
107. Mechelli R, Romano S, Romano C, Morena E, Buscarinu MC, Bigi R, Bellucci G, Reniè R, Pellicciari G, Salvetti M, Ristori G. MAIT Cells and Microbiota in Multiple Sclerosis and Other Autoimmune Diseases. Microorganisms. 2021 May 24;9(6):1132. doi: 10.3390/microorganisms9061132.
108. Ferraldeschi M, Romano S, Giglio S, Romano C, Morena E, Mechelli R, Annibali V, Ubaldi M, Buscarinu MC, Umeton R, Sani G, Vecchione A, Salvetti M, Ristori G. Circulating hsa-miR-323b-3p in Huntington's Disease: A Pilot Study. Front Neurol. 2021 May 5;12:657973. doi:10.3389/fneur.2021.657973. PMID: 34025560; PMCID: PMC8131841.
109. Nicita F, Ginevrino M, Travaglini L, D'Arrigo S, Zorzi G, Borgatti R, Terrone G, Catteruccia M, Vasco G, Brankovic V, Siliquini S, Romano S, Veredice C, Pedemonte M, Armando M, Lettori D, Stregapede F, Bosco L, Sferra A, Tessarollo V, Romaniello R, Ristori G, Bertini E, Valente EM, Zanni G. Heterozygous KIF1A variants underlie a wide spectrum of neurodevelopmental and neurodegenerative disorders. J Med Genet 2021 Jul;58(7):475-483.
110. Migliore S, D'Aurizio G, Maffi S, Ceccarelli C, Ristori G, Romano S, Castaldo A, Mariotti C, Curcio G, Squitieri F. Cognitive and behavioral associated changes in manifest Huntington disease: A retrospective cross-sectional study. Brain Behav 2021 Jul;11(7):e02151. doi: 10.1002/brb3.2151. PMID:34110097.
111. Clausi S, Olivito G, Siciliano L, Lupo M, Bozzali M, Masciullo M, Molinari M, Romano S, Leggio M. The neurobiological underpinning of the social cognition impairments in patients with spinocerebellar
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112. McAllister B, Gusella JF, Landwehrmeyer GB, Lee JM, MacDonald ME, Orth M, Rosser AE, Williams NM, Holmans P, Jones L, Massey TH; REGISTRY Investigators of the European Huntington's Disease Network. Timing and Impact of Psychiatric, Cognitive, and Motor Abnormalities in Huntington Disease. Neurology 2021 May 11;96(19):e2395-e2406. doi: 10.1212/WNL.0000000000011893. PMID:33766994; PMCID: PMC8166441.
113. Buscarinu MC, Gargano F, Lionetto L, Capi M, Morena E, Fornasiero A, Reniè R, Landi AC, Pellicciari G, Romano C, Mechelli R, Romano S, Borsellino G, Battistini L, Simmaco M, Fagnani C, Salvetti M, Ristori G. Intestinal Permeability and Circulating CD161+CCR6+CD8+T Cells in Patients With Relapsing-Remitting Multiple Sclerosis Treated With Dimethylfumarate. Front Neurol. 2021 Aug 26;12:683398.
114. Mechelli R, Romano C, Reniè R, Manfrè G, Buscarinu MC, Romano S, Marrone A, Bigi R, Bellucci G, Ballerini C, Angeloni B, Rinaldi V, Salvetti M, Ristori G. Viruses and neuroinflammation in multiple sclerosis. Neuroimmunol Neuroinflammation 2021;8:269. http://dx.doi.org/10.20517/2347-8659.2021.01
115. Romano S, Bacigalupo I, Marcotulli C, Cioffi E, Bertini ES, Vasco G, Perna A, Petrucci A, Massa R, Frezza E, Romano C, Salvetti M, Ristori G, Silvestri G, Vanacore N, Casali C. A Clinical and Epidemiological Prevalence Study on Friedreich's Ataxia in Latium, Italy. Neuroepidemiology. 2022;56(3):212-218. doi: 10.1159/000525159. PMID: 35636410.
116. Migliore S, D'Aurizio G, Scaricamazza E, Maffi S, Ceccarelli C, Ristori G, Romano S, Castaldo A, Fichera M, Curcio G, Squitieri F. Cognitive Reserve in Early Manifest Huntington Disease Patients: Leisure Time Is Associated with Lower Cognitive and Functional Impairment. J Pers Med. 2022 Jan 3;12(1):36. doi: 10.3390/jpm12010036. PMID: 35055351; PMCID: PMC8777615.
117. Langbehn DR; Registry Investigators of the European Huntington Disease Network. Longer CAG repeat length is associated with shorter survival after disease onset in Huntington disease. Am J Hum Genet. 2022 Jan 6;109(1):172-179. doi: 10.1016/j.ajhg.2021.12.002. PMID: 34942093; PMCID:PMC8764269.
118. Ferraro D, Iaffaldano P, Guerra T, Inglese M, Capobianco M, Brescia Morra V, Zaffaroni M, Mirabella M, Lus G, Patti F, Cavalla P, Cellerino M, Malucchi S, Pisano E, Vitetta F, Paolicelli D, Sola P, Trojano M; Italian MS Register. Risk of multiple sclerosis relapses when switching from fingolimod to cell-depleting agents: the role of washout duration. J Neurol. 2022 Mar;269(3):1463-1469. doi:10.1007/s00415-021-10708-1. PMID: 34292396.
119. Rossi S, Rubegni A, Riso V, Barghigiani M, Bassi MT, Battini R, Bertini E, Cereda C, Cioffi E, Criscuolo C, Dal Fabbro B, Dato C, D'Angelo MG, Di Muzio A, Diamanti L, Dotti MT, Filla A, Gioiosa V, Liguori R, Martinuzzi A, Massa R, Mignarri A, Moroni R, Musumeci O, Nicita F, Orologio I, Orsi L, Pegoraro E, Petrucci A, Plumari M, Ricca I, Rizzo G, Romano S, Rumore R, Sampaolo S, Scarlato M, Seri M, Stefan C, Straccia G, Tessa A, Travaglini L, Trovato R, Ulgheri L, Vazza G, Orlacchio A, Silvestri G, Santorelli FM, Melone MAB, Casali C. Clinical-Genetic Features Influencing Disability in Spastic Paraplegia Type 4: A Cross-sectional Study by the Italian DAISY Network. Neurol Genet. 2022 Mar 30;8(2):e664. doi: 10.1212/NXG.0000000000000664. PMID: 35372684; PMCID: PMC8969300.
120. McAllister B, Donaldson J, Binda CS, Powell S, Chughtai U, Edwards G, Stone J, Lobanov S, Elliston L, Schuhmacher LN, Rees E, Menzies G, Ciosi M, Maxwell A, Chao MJ, Hong EP, Lucente D, Wheeler V, Lee JM, MacDonald ME, Long JD, Aylward EH, Landwehrmeyer GB, Rosser AE; REGISTRY Investigators of the European Huntington’s disease network, Paulsen JS; PREDICT-HD Investigators of the Huntington Study Group, Williams NM, Gusella JF, Monckton DG, Allen ND, Holmans P, Jones L, Massey TH. Exome sequencing of individuals with Huntington's disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset. Nat Neurosci. 2022 Apr;25(4):446-457. doi: 10.1038/s41593-022-01033-5. PMID: 35379994; PMCID: PMC8986535.
121. Umeton R, Bellucci G, Bigi R, Romano S, Buscarinu MC, Reniè R, Rinaldi V, Pizzolato Umeton R, Morena E, Romano C, Mechelli R, Salvetti M, Ristori G. Multiple sclerosis genetic and non-genetic factors interact through the transient transcriptome. Sci Rep. 2022 May 9;12(1):7536. doi:10.1038/s41598-022-11444-w. PMID: 35534508; PMCID: PMC9085834.
122. Bergamaschi R, Beghi E, Bosetti C, Ponzio M, Santucci C, Lepore V, Mosconi P; Italian Multiple Sclerosis and Related Disorders Register Centers Group and the Scientific Committee of Italian SM and Related Disorders Register, Aguglia U, Amato MP, Ancona AL, Ardito B, Avolio C, Balgera R, Banfi P, Barcella V, Barone P, Bellantonio P, Berardinelli A, Bergamaschi R, Bertora P, Bianchi M, Bramanti P, Morra VB, Brichetto G, Brioschi AM, Buccafusca M, Bucello S, Busillo V, Calchetti B, Cantello R, Capobianco M, Capone F, Capone L, Cargnelutti D, Carrozzi M, Cartechini E, Cavaletti G, Cavalla P, Celani MG, Clerici R, Clerico M, Cocco E, Confalonieri P, Coniglio MG, Conte A, Corea F, Cottone S, Crociani P, D'Andrea F, Danni MC, De Luca G, de Pascalis D, De Riz M, De Robertis F, De Rosa G, De Stefano N, Corte MD, Di Sapio A, Docimo R, Falcini M, Falcone N, Fermi S, Ferraro E, Ferrò MT, Fortunato M, Foschi M, Gajofatto A, Gallo A, Gallo P, Gatto M, Gazzola P, Giordano A, Granella F, Grasso MF, Grasso MG, Grimaldi LME, Iaffaldano P, Imperiale D, Inglese M, Iodice R, Leva S, Luezzi V,
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123. Quatrana A, Morini E, Tiano F, Vancheri C, Panarello L, Romano S, Marcotulli C, Casali C, Mariotti C, Mongelli A, Fichera M, Rufini A, Condò I, Novelli G, Testi R, Amati F, Malisan F. Hsa-miR223-3p circulating level is upregulated in Friedreich's ataxia and inversely associated with HCLS1 associated protein X-1, HAX-1. Hum Mol Genet. 2022 Jun 22;31(12):2010-2022. doi: 10.1093/hmg/ddac005. PMID:35015850.
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