ANGELA GISMONDI

Si comunica che per le lezioni in remoto del Corso di Immunologia Applicata per Farmacia (III anno I semestre) il link è: https://meet.google.com/fvi-vpvp-dtm.

Si comunica che per il corso integrato di Basi Fisiopatologiche delle Malattie per l’insegnamento di Immunologia e Immunopatologia e di Basi di Medicina di Laboratorio,  ho provveduto a creare il corso sulla piattaforma Google CLASSROOM (CODICE CORSO: kbcrhcr) per partecipare bisogna iscriversi con e-mail istituzionale a GOOGLE CLASSROOM INSERENDO IL CODICE DEL CORSO IL GIORNO STESSO DELLA LEZIONE. La lezione si terrà tramite videochiamata su MEET. Per l’orario io manterrei quello assegnatoci dalla segreteria didattica in modo da evitare sovrapposizioni con altre lezioni, pertanto se per voi va bene potremmo iniziare questo giovedì dalle 10,30 alle 13,30.

GISMONDI ANGELA, PHD
University of Rome “La Sapienza”
Department of Molecular Medicine,
Viale Regina Elena 291
00161-Rome
Italy
Telephone: +39 06 49255116
E-mail: angela.gismondi@uniroma1.it

Angela Gismondi graduated in Pharmacy at University of Rome “La Sapienza” in 1984 and in 1989 was Ph.D in Experimental Medicine at University of Rome “La Sapienza”. From 1990 to 2001 she was University Researcher at the Department of Experimental Medicine, University of Rome “La Sapienza”. From 2001 she is Full Professor, Chair of Immunology at the Medical School of University of Rome “La Sapienza”.
Dr. Gismondi’s research over the past two decades has focused on NK-cell biology, including their roles in pregnancy and in controlling pediatric hematological cancers. She has investigated signaling pathways activated by NK-cell receptors, showing that integrins act not only as adhesion molecules but also as signaling elements. More recently, her work has explored the mechanisms regulating NK-cell migration and tissue residency, the influence of the tissue microenvironment on NK-cell phenotype and function, and the involvement of NK cells in psoriasis.
The results obtained by Dr Gismondi has been published in highly qualified international journals and presented at many national and international scientific congresses.

Teaching Experience:

Teaching and student training in Immunology courses (Medical School CLMB, Pharmacy and Biomedical Laboratory Technicians) Faculty of Pharmacy and Medicine University of Rome “La Sapienza”.
Member of the teaching body for the evaluation of PhD students (PhD school in Immunological, Hematological and Rheumatological Sciences and since 2018 in “Innovation in immunomediated and hematological diseases”).

SCIENTIFIC ACTIVITY:
Author of 102 peer-reviewed papers with. H index 34 (by WOS).
ORCID: orcid.org/0000-0001-6731-6366

FUNDING:
She has been involved in several national and international research project in the past. She is presently involved in the following research project:

1. PI in the PRIN (Programmi di Ricerca Scientifica di Rilevante Interesse Nazionale): “Cell plasticity of tumor-associated immune infiltrate: molecular mechanisms and therapeutic options”. (Code 20174T7NXL_003). Timeline 2022-2026.

2. Partner in the Special Program Molecular Clinical Oncology 5 per mille (AIRC 5xmille): “Immunity in Cancer Spreading and Metastasis (ISM)” (Code 21147). Timeline 2018-2026.

3. Partner in the Investigator Grant from the Italian Association for Cancer Research: “Unraveling the role of mast cells in colorectal cancer”. (Code 24955). Timeline 2021-2026

LABORATORY SETTING:
On the basis of an institutional agreement, Angela Gismondi activities are performed in the Laboratory of Molecular Immunology and Immunopathology in the Department of Molecular Medicine, University of Rome “La Sapienza”. The laboratory is fully equipped for cellular and molecular biology activities and shares with other labs high-tech equipment and core facility (fluorimeter, spectrophotometer, flow cytometers and cell sorter, confocal microscopy, Luminex technology, BD Rhapsody Single-cell Analysis System a new approach to single-cell gene expression, ORBITRAP Fusion Tribid analyzer for metabolic and proteomic studies).

Selected Scientific Publications

1. Laffranchi M, Paraboschi EM, Bianchetto-Aguilera F, Tamassia N, Gasperini S, Gardiman E, Piserà A, Del Prete A, Invernizzi P, Gismondi A, Mantovani A, Cassatella MA, Asselta R, Sozzani S. Neutrophils restricted contribution of CCRL2 genetic variants to COVID-19 severity. Heliyon. 2025 Dec 17;11(1): e41267. doi: 10.1016/j.heliyon. 2024. e41267.
2. Passari M, Scutera S, Schioppa T, Tiberio L, Piantoni S, Tamassia N, Bugatti M, Vermi W, Angeli F, Caproli A, Salvi V, Sozio F, Gismondi A, Stabile H, Franceschini F, Bosisio D, Acquati F, Vermeren S, Sozzani S, Andreoli L, Del Prete A, Musso T. Regulation of neutrophil associated RNASET2 expression in rheumatoid arthritis. Sci Rep. 2024 Nov 5;14(1):26820. doi: 10.1038/s41598-024-77694-y.
3. Scarno G, Mazej J, Laffranchi M, Di Censo C, Mattiola I, Candelotti AM, Pietropaolo G, Stabile H, Fionda C, Peruzzi G, Brooks SR, Tsai WL, Mikami Y, Bernardini G, Gismondi A, Sozzani S, Di Santo JP, Vosshenrich CAJ, Diefenbach A, Gadina M, Santoni A, Sciumè G. Divergent roles for STAT4 in shaping differentiation of cytotoxic ILC1 and NK cells during gut inflammation. Proc Natl Acad Sci U S A. 2023 Oct 3;120(40): e2306761120. doi: 10.1073/pnas.2306761120. Epub 2023 Sep 27.
4. Sozio F, Schioppa T, Laffranchi M, Salvi V, Tamassia N, Bianchetto-Aguilera FM, Tiberio L, Bonecchi R, Bosisio D, Parmentier M, Bottazzi B, Leone R, Russo E, Bernardini G, Garofalo S, Limatola C, Gismondi A, Sciumè G, Mantovani A, Del Prete A, Sozzani S. CCRL2 Expression by Specialized Lung Capillary Endothelial Cells Controls NK-cell Homing in Lung Cancer. Cancer Immunol Res. 2023 Sep 1;11(9):1280-1295. doi: 10.1158/2326-6066.CIR-22-0951.
5. Cippitelli M, Stabile H, Kosta A, Petillo S, Lucantonio L, Gismondi A, Santoni A, Fionda C. Role of NF-kB Signaling in the Interplay between Multiple Myeloma and Mesenchymal Stromal Cells. Int J Mol Sci. 2023 Jan 17;24(3):1823. doi: 10.3390/ijms24031823.PMID: 36768145 Free PMC article. Review.
6. Fionda C, Ruggeri S, Sciumè G, Laffranchi M, Quinti I, Milito C, Palange P, Menichini I, Sozzani S, Frati L, Gismondi A, Santoni A, Stabile H. Age-dependent NK cell dysfunctions in severe COVID-19 patients. Front Immunol. 2022 Nov 17;13: 1039120. doi: 10.3389/fimmu.2022.1039120. eCollection 2022. PMID: 36466890 Free PMC article.
7. Milito ND, Zingoni A, Stabile H, Soriani A, Capuano C, Cippitelli M, Gismondi A, Santoni A, Paolini R, Molfetta R. NKG2D engagement on human NK cells leads to DNAM-1 hypo-responsiveness through different converging mechanisms. Eur J Immunol. 2023 Feb;53(2): e2250198. doi: 10.1002/eji.202250198. Epub 2022 Dec 8. PMID: 36440686
8. Kosta A, Mekhloufi A, Lucantonio L, Zingoni A, Soriani A, Cippitelli M, Gismondi A, Fazio F, Petrucci MT, Santoni A, Stabile H, Fionda C. GAS6/TAM signaling pathway controls MICA expression in multiple myeloma cells. Front Immunol. 2022 Jul 28; 13:942640. doi: 10.3389/fimmu.2022.942640. eCollection 2022. PMID: 35967396 Free PMC article.
9. Fionda C, Scarno G, Stabile H, Molfetta R, Di Censo C, Gismondi A, Paolini R, Sozzani S, Santoni A, Sciumè G. NK Cells and Other Cytotoxic Innate Lymphocytes in Colorectal Cancer Progression and Metastasis. Int J Mol Sci. 2022 Jul 16;23(14):7859. doi: 10.3390/ijms23147859. PMID: 35887206 Free PMC article. Review.
10. Grimaldi A, Pietropaolo G, Stabile H, Kosta A, Capuano C, Gismondi A, Santoni A, Sciumè G, Fionda C. The Regulatory Activity of Noncoding RNAs in ILCs. Cells. 2021 Oct 14;10(10):2742. doi: 10.3390/cells10102742.PMID: 34685721 Free PMC article. Review.
11. Fionda C, Stabile H, Molfetta R, Kosta A, Peruzzi G, Ruggeri S, Zingoni A, Capuano C, Soriani A, Paolini R, Gismondi A, Cippitelli M, Santoni A. Cereblon regulates NK cell cytotoxicity and migration via Rac1 activation. Eur J Immunol. 2021 Nov;51(11):2607-2617. doi: 10.1002/eji.202149269. Epub 2021 Sep 18. PMID: 34392531 Free PMC article.
12. Di Censo C, Marotel M, Mattiola I, Müller L, Scarno G, Pietropaolo G, Peruzzi G, Laffranchi M, Mazej J, Hasim MS, Asif S, Russo E, Tomaipitinca L, Stabile H, Lee SH, Vian L, Gadina M, Gismondi A, Shih HY, Mikami Y, Capuano C, Bernardini G, Bonelli M, Sozzani S, Diefenbach A, Ardolino M, Santoni A, Sciumè G. Granzyme A and CD160 expression delineates ILC1 with graded functions in the mouse liver. Eur J Immunol. 2021 Nov;51(11):2568-2575. doi: 10.1002/eji.202149209. Epub 2021 Aug 19. PMID: 34347289 Free PMC article.
13. Pietropaolo G, Scarno G, Stabile H, Grimaldi A, Gismondi A, Santoni A, Sciumè G. NK cell and ILC heterogeneity in colorectal cancer. New perspectives from high dimensional data. Mol Aspects Med. 2021 Aug; 80:100967. doi: 10.1016/j.mam.2021.100967. Epub 2021 May 1. PMID: 33941383 Review.
14. Cippitelli M, Stabile H, Kosta A, Petillo S, Gismondi A, Santoni A, Fionda C. Role of Aiolos and Ikaros in the Antitumor and Immunomodulatory Activity of IMiDs in Multiple Myeloma: Better to Lose Than to Find Them. Int J Mol Sci. 2021 Jan 22;22(3):1103. doi: 10.3390/ijms22031103. PMID: 33499314 Free PMC article. Review.
15. Del Prete A, Sozio F, Barbazza I, Salvi V, Tiberio L, Laffranchi M, Gismondi A, Bosisio D, Schioppa T, Sozzani S. Functional Role of Dendritic Cell Subsets in Cancer Progression and Clinical Implications. Int J Mol Sci. 2020 May 30;21(11):3930. doi: 10.3390/ijms21113930. PMID: 32486257 Free PMC article. Review.
16. Macchia I, La Sorsa V, Ruspantini I, Sanchez M, Tirelli V, Carollo M, Fedele G, Leone P, Schiavoni G, Buccione C, Rizza P, Nisticò P, Palermo B, Morrone S, Stabile H, Rughetti A, Nuti M, Zizzari IG, Fionda C, Maggio R, Capuano C, Quintarelli C, Sinibaldi M, Agrati C, Casetti R, Rozo Gonzalez A, Iacobone F, Gismondi A, Belardelli F, Biffoni M, Urbani F. Multicentre Harmonisation of a Six-Colour Flow Cytometry Panel for Naïve/Memory T Cell Immunomonitoring. J Immunol Res. 2020 Apr 12; 2020:1938704. doi: 10.1155/2020/1938704. eCollection 2020. PMID: 32322591 Free PMC article.
17. Molfetta R, Zitti B, Lecce M, Milito ND, Stabile H, Fionda C, Cippitelli M, Gismondi A, Santoni A, Paolini R. CD155: A Multi-Functional Molecule in Tumor Progression. Int J Mol Sci. 2020 Jan 30;21(3):922. doi: 10.3390/ijms21030922. PMID: 32019260 Free PMC article. Review.
18. Fionda C, Stabile H, Cerboni C, Soriani A, Gismondi A, Cippitelli M, Santoni A. Hitting More Birds with a Stone: Impact of TGF-β on ILC Activity in Cancer. J Clin Med. 2020 Jan 5;9(1):143. doi: 10.3390/jcm9010143. PMID: 31948072 Free PMC article. Review.
19. Mekhloufi A, Kosta A, Stabile H, Molfetta R, Zingoni A, Soriani A, Cippitelli M, Paolini R, Gismondi A, Ricciardi MR, Petrucci MT, Masuelli L, Caracciolo G, Palchetti S, Santoni A, Fionda C. (2020). Bone Marrow Stromal Cell-Derived IL-8 Upregulates PVR Expression on Multiple Myeloma Cells via NF-kB Transcription Factor. Cancers (Basel). Feb 13;12(2):440. doi: 10.3390/cancers12020440.PMID: 32069911
20. Stabile H, Fionda C, Santoni A, Gismondi A. (2018) Impact of bone marrow-derived signals on NK cell development and functional maturation Cytokine and Growth Factor Reviews, 42, pp. 13–19
21. Stabile H, Scarno G, Fionda C, Gismondi A, Santoni A, Gadina M, Sciumè G. (2018) JAK/STAT signaling in regulation of innate lymphoid cells: The gods before the guardians. Immunol Rev. Nov;286(1):148-159. doi: 10.1111/imr.12705. PMID: 30294965
22. Stabile H, Nisti P, Peruzzi G, Santoni A, Gismondi A. (2017) Reconstitution of multifunctional CD56lowCD16low natural killer cell subset in children with acute leukemia given α/β T cell-depleted HLA-haploidentical haematopoietic stem cell transplantation. OncoImmunology, 6(9), e1342024
23. Gismondi A, Stabile H, Nisti P, Santoni A. (2015). Effector Functions of Natural Killer Cell Subsets in the Control of Hematological Malignancies. Front Immunol.; 6:567. eCollection. Review.
24. Galli F, Rapisarda AS, Stabile H, Malviya G, Manni I, Bonanno E, Piaggio G, Gismondi A, Santoni A, Signore A. (2015). In Vivo Imaging of Natural Killer Cell Trafficking in Tumors. J Nucl Med. 56(10):1575-80. doi: 10.2967/jnumed.114.152918.
25. Stabile H, Nisti P, Morrone S, Pagliara D, Bertaina A, Locatelli F, Santoni A, Gismondi A. (2015). Multifunctional human CD56low CD16low natural killer cells are the prominent subset in bone marrow of both healthy pediatric donors and leukemic patients. Haematologica. 100(4):489-98. doi: 10.3324/haematol.2014.116053.
26. Morelli MB, Amantini C, Nabissi M, Liberati S, Cardinali C, Farfariello V, Tomassoni D, Quaglia W, Piergentili A, Bonifazi A, Del Bello F, Santoni M, Mammana G, Servi L, Filosa A, Gismondi A, Santoni G. (2014) Cross-talk between alpha1D-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation. BMC Cancer. 14:921. doi: 10.1186/1471-2407-14-921.
27. Seeger P, Bosisio D, Parolini S, Badolato R, Gismondi A, Santoni A, Sozzani S. (2014). Activin A as a Mediator of NK-Dendritic Cell Functional Interactions. J Immunol.; 192:1241-8. doi: 10.4049/jimmunol.1301487.
28. Bernardini G, Gismondi A, Santoni A. (2012). Chemokines and NK cells: Regulators of development, trafficking and functions. Immunology Letters, vol. 145, p. 39-46, ISSN: 0165-2478, doi: 10.1016/j.imlet. 2012.04.014.
29. Claudia Carlino, * Eleonora Trotta, * Helena Stabile, Stefania Morrone, Roberta Bulla, Alessandra Soriani, Maria Luisa Iannitto, Chiara Agostinis, Carlo Mocci, Massimo Minozzi, Cesare Aragona, Giorgia Perniola, Francesco Tedesco, Silvano Sozzani, Angela Santoni, and Angela Gismondi (2012). Chemerin Regulates NK Cell Accumulation and Endothelial Cell Morphogenesis in the Decidua during Early Pregnancy. The Journal of Clinical Endocrinology & Metabolism, vol. 97, p. 1-10, ISSN:1945-7197, doi: 10.1210/jc.2012-1102.
30. Caprodossi S, Amantini C, Nabissi M, Morelli Mb, Farfariello V, Santoni M, Gismondi A, Santoni G (2011). Capsaicin promotes a more aggressive gene expression phenotype and invasiveness in null-TRPV1 urothelial cancer cells. Carcinogenesis, vol. 32, p. 686-694, ISSN: 0143-3334, doi: 10.1093/carcin/bgr025.
31. Stabile H, Carlino C, Mazza C, Giliani S, S. Morrone, Notarangelo Ld, Notarangelo Ld, Santoni A, Gismondi A (2010). Impaired NK-cell migration in WAS/XLT patients: role of Cdc42/WASp pathway in the control of chemokine-induced beta2 integrin high-affinity state. Blood,vol. 115, p. 2818-2826, ISSN: 0006-4971, doi: 10.1182/Blood-2009-07-235804.
32. Agostinis C, Bulla R, Tripodo C, Gismondi A, Stabile H, Bossi F, Guarnotta C, Garlanda C, De Seta F,Spessotto P, Santoni A, Ghebrehiwet B, Girardi G, Tedesco F. (2010). An alternative role of C1q in cell migration and tissue remodeling: contribution to trophoblast invasion and placental development. Journal of Immunology, vol. 185, p. 4420-4429, ISSN: 0022-1767, doi: 10.4049/jimmunol.0903215.
33. Carlino C, Stabile H, Morrone S, Bulla R, Soriani A, Agostinis C, Bossi F, Mocci C,Sarazani F, Tedesco F, A. Santoni, Gismondi A (2008). Recruitment of circulating NK cells through decidual tissues: a possible mechanism controlling NK cell accumulation in the uterus during early pregnancy. Blood, vol. 111(6), p. 3108-3115, ISSN: 0006-4971, doi:10.1182/blood-2007-08-105965.
34. Santoni A, Carlino C, Stabile H, Gismondi A (2008). Mechanisms underlying recruitment and accumulation of decidual NK cells in uterus during pregnancy. American Journal Of Reproductive Immunology, vol. 59, p. 417-424, ISSN: 1046-7408, doi: 10.1111/j.1600-0897.2008.00598.
35. Santoni A, Carlino C, A Gismondi (2008). Uterine NK cell development, migration and function. Reproductive Biomedicine Online, vol. 16, p. 202-210, ISSN: 1472-6483, doi:10.1016/S1472-6483(10)60575-5.
36. Santoni A, Zingoni A, Cerboni C, A Gismondi (2007). Natural killer (NK) cells from killers to regulators: distinct features between peripheral blood and decidual NK cells. American Journal of Reproductive Immunology, vol. 58, p. 280-288, ISSN: 1046-7408, doi:10.1111/j.1600-0897.2007.00513.
37. Bernardini G, Kim JY, Gismondi A, Butcher EC, Santoni A (2005). Chemoattractant induces LFA-1 associated PI3K activity and cell migration that are dependent on Fyn signaling. Faseb J 19:1305-7.
38. Gismondi A, Cifaldi L, Mazza C, Giliani S, Parolini S, Morrone S, Jacobelli J, Bandiera E, Notarangelo L, Santoni A. (2004). Impaired natural and CD16-mediated NK cell cytotoxic function in WAS and XLT patients: ability of IL-2 to correct NK cell functional defect. Blood, vol. 104(2), p. 436-443, ISSN: 0006-4971, doi: 10.1182/blood-2003-07-2621.

Rome 11.20.2025