Cardiocirculatory and Cardiovascular Perfusion techniques

1. EVIDENCE BASED MEDICINE (EBM) 1.1. Definition and Overview 1.2. Methodology 1.3. Formulating a well-built clinical question: the P.I.C.O. model 1.4. Resources: First- and second-level databases 1.4.1. Literature search using PubMed 1.4.2. Literature search using Embase 2. HIERARCHY OF EVIDENCE: The evidence pyramid 3. CLINICAL STUDY 3.1. Types of studies 3.1.1. Experimental studies: clinical trials, field intervention trials, community trials 3.1.2. Observational studies: Descriptive studies, Analytical studies (Cohort studies, Cross- sectional studies, Case-control studies) 3.2. Assessment of clinical study results 3.2.1. Measures of association 3.2.1.1. Frequency measures: number, ratio, proportion, rate 3.2.1.2. Measures of health outcome: incidence and prevalence 3.2.1.3. Measures of efficacy: absolute risk and odds 3.2.2. Risk comparison between groups 3.2.2.1. Absolute risk reduction, Relative risk, odds ratio 3.2.2.2. Relative risk reduction, Number Needed to Treat, Number Needed to Harm 4. SYSTEMATIC REVIEWS AND META-ANALYSIS 5. GUIDELINES FOR A COMPLETE REPORTING OF STUDY RESEARCH 5.1. Introduction to guidelines 5.2. Consolidated Standards of Reporting Trials: The CONSORT Statement 5.2.1. Checklist 5.2.2. Flow Diagram 5.3. Strengthening the Reporting of Observational studies in Epidemiology (STROBE) Statement : checklist of items that should be included in reports of observational studies 5.4. Preferred Reporting Items for Systematic reviews and Meta-Analyses: The PRISMA Statement 5.4.1. Checklist 5.4.2. Flow Diagram 6. ASSESSMENT OF THE VALIDITY OF SCIENTIFIC EVIDENCE

Educational material is available free of charge at the following web sites: 1. http://www.cebm.net/category/ebm-resources/tools/ 2. http://www.ema.europa.eu/ema/index.jsp?curl=pages/regulation/general/general_content_000429.jsp 3. http://www.cdc.gov/ophss/csels/dsepd/ss1978/ 4. Higgins JPT, Gree n S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org 5. http://www.consort-statement.org/ 6. http://www.strobe-statement.org/ 7. http://www.prisma-statement.org/statement.htm 8. https://clinicaltrials.gov/. “ClinicalTrials.gov is a registry and results database of publicly and privately supported clinical studies of human participants conducted around the world.”

The course will take place with traditional and / or distance lessons.

The attendance is mandatory.

The Assessment will consist of an oral interview.

Classroom lessons