Biochemistry

ANTONIO COLUCCIA

General skills

At the end of the course, the student will have acquired the main basic notions regarding medicinal chemistry by a biochemical approach. In particular, he will know the physical and chemical principles of the action of drugs, the classes of receptors on which the drugs act and the action of the main classes of drugs on their receptors.


Specific skills

a) knowledge and understanding
- knowledge of the main classes of receptors involved in the action of drugs
- knowledge of the chemical structure of drugs


b) applying knowledge and understanding
- explain the mechanism of action of drugs by a biochemical approach
- explain the binding of the drugs on their receptors


c) making judgments
- identify the biochemical mechanisms of the drug action
- suggest the potential action of drugs on different receptors


d) communication skills
- draw the chemical structures of drugs
- describe the interaction of drugs on their receptors by a biochemical approach


e) learning skills
- acquisition of the basics of medicinal chemistry to carry out in-depth study of the subject
- apply the knowledge acquired in medicinal chemistry working conditions

This course will provide an in-depth look at how novel pharmacologically active molecules are designed to treat human diseases.

An overview of medicinal chemistry, from first principles of drug action to design and development of potential therapeutics, will be presented.

The action and behavior of pharmaceutical compounds and the relationship between their structure and their chemical and therapeutic properties, and therefore, the chemical considerations in drug design will be explored.
Structure activity relationships will be explored through case studies.

Methods of drug discovery will be investigated, including the development of drugs from natural products, computer modeling and rational drug design.

there are not prerequisite

-Introduction to medicinal chemistry
Drug discovery
The pathological process approach
Let’s talk about drugs

The slide of the course will be available any drug discovery book is fine to reach the mandatory knowledge about medicinal chemistry

Lesson will held in presence in class

Attendance is recommended but not mandatory.

The exam is held in person. Students will be required to present and discuss a scientific article in the field of pharmaceutical chemistry, emphasizing the state of the art and the design rationale.

Describe the SAR of the studied compounds

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  • Books: -