Dentistry and Dental Prosthodontics

INTRODUCTION Evidence-based medicine. Placebo effect. Introduction to Pharmacology. PHARMACODYNAMICS Mechanisms of drug action. Drug targets: G-protein coupled receptors, catalytic receptors, ligand-gated ion channels, other ion channels, nuclear receptors, transporters, enzymes. Drug sensitization and tolerance. Binding curves: definition of orthosteric and allosteric binding sites and ligands. Graduated concentration-response curves: definition of agonist, partial agonist, inverse agonists, antagonist. PHARMACOKINETICS Routes of administration. Absorption. Distribution. Biotransformation. Renal and extrarenal excretion of drugs. Pharmacokinetics parameters: bioavailability, compartments, volume of distribution, plasma half-life, clearance. CLINICAL PHARMACOLOGY Mechanisms of drug interaction mechanisms. Individual differences in pharmacology. Quantal dose-response curves. PHYSIO-PHARMACOLOGY OF NEURAL TRANSMISSION NEUROPHARMACOLOGY OF PAIN Definition of pain. Pain receptors and pain pathways. Opioid and non opioid analgesics. Definition of anesthesia. General anesthetics. Local anesthetics. NEUROPHARMACOLOGY OF NEURODEGENERATIVE DISORDERS Dopaminergic system. Parkinson's Disease. NEUROPSYCHOPHARMACOLOGY Antipsychotics. Antidepressants. Anxiolytics. Substances of abuse: psychostimulants, opioids, alcohol, tobacco, cannabis, hallucinogenic drugs. Drug reward. Drug harm (including drug addiction). Drug addiction treatment.

Goodman and Gilman's The Pharmacological Basis of Therapeutics, 14th Edition. Laurence Brunton, Bjorn Knollmann (Ed.) McGraw Hill (29 Mar. 2023) or Katzung's Basic and Clinical Pharmacology, 16th Edition. Todd W. Vanderah (Ed.). McGraw Hill (19 Jan. 2024)

Mandatory attendance of lectures.

Oral examination.

Standard class lectures