Chemistry

The course is divided into two parts. In the first part (31 hours) many of the general concepts related to physical organic chemistry will be presented with the aim to enable the student to manage the matter of organic reactivity. It includes elements of phenomenological chemical kinetics, theoretical chemical kinetics (Eyring theory, Hammond and Leffler-Hammond postulates, Reactivity-selectivity rules, Curtin-Hammett rule, etc.), Kinetic Isotope Effects, free energy relationships (Hammett, Okamoto-Brown, Yukawa-Tsuno, Broensted, Winstein-Grunwald, Swain-Schott, Schleyer, Hansch), General/Specific Acid/Base catalysis, Non-perfect synchronization, Salt effects. In the second part the reaction mechanisms of the main organic reactions will be presented (nucleophilic substitutions at the aliphatic carbon, eliminations, nucleophilic substitutions at the aromatic carbon, electrophilic substitutions at the aromatic carbon, examples of nucleophilic addition to the carbonyl carbon (ester hydrolysis, imine formation, acetal formation), aldol condensations, intramolecular reactions (effective molarity concept). The notion of catalysis by complexation as a consequence of recognition of the transition state (Pauling and Schowen) with related examples will be given to the students. An optional argument related to the mechanisms of polymerization is also presented in the last part of the program. Additional information concerning the teaching is available in the web link: https://www.chem.uniroma1.it/didattica/offerta-formativa/insegnamenti/chimica-organica-iv

The student should have an appropriate knowledge of the fundamental notions of Organic Chemistry, Physical Chemistry, Analytical Chemistry, Mathematics and Physics, which are taught in the basis teachings of the Bachelor in Chemistry (three years program). Essential Requirement. The student should have an appropriate knowledge of the English language since the adopted text book is written in English and the original papers from which many of the topics discussed in the classroom are taken from, are written in English. Important Requirement. The student should use electronic devices such as PC or Smartphone with the aim at having access to the course teaching material available in the web. Useful Requirement.

Modern Physical Organic Chemistry, Anslyn-Dougherty, University Science Books, Sausalito, CA (USA), 2006

2 h Frontal Lessons with a 15 min break. The lessons can have theoretical or training character. In order to follow the lessons from home the google meet address is:

2 consecutive lectures (45 minute duration) for 3 times a week

Questioning for a duration of 30 min (more or less)

Additional information and teaching material is available in the following web link: https://www.chem.uniroma1.it/didattica/offerta-formativa/insegnamenti/chimica-organica-iv

lectures in classroom (45 minutes duration)

The course is divided into two parts. In the first part (31 hours) many of the general concepts related to physical organic chemistry will be presented with the aim to enable the student to manage the matter of organic reactivity. It includes elements of phenomenological chemical kinetics, theoretical chemical kinetics (Eyring theory, Hammond and Leffler-Hammond postulates, Reactivity-selectivity rules, Curtin-Hammett rule, etc.), Kinetic Isotope Effects, free energy relationships (Hammett, Okamoto-Brown, Yukawa-Tsuno, Broensted, Winstein-Grunwald, Swain-Schott, Schleyer, Hansch), General/Specific Acid/Base catalysis, Non-perfect synchronization, Salt effects. In the second part the reaction mechanisms of the main organic reactions will be presented (nucleophilic substitutions at the aliphatic carbon, eliminations, nucleophilic substitutions at the aromatic carbon, electrophilic substitutions at the aromatic carbon, examples of nucleophilic addition to the carbonyl carbon (ester hydrolysis, imine formation, acetal formation), aldol condensations, intramolecular reactions (effective molarity concept). The notion of catalysis by complexation as a consequence of recognition of the transition state (Pauling and Schowen) with related examples will be given to the students. An optional argument related to the mechanisms of polymerization is also presented in the last part of the program. Additional information concerning the teaching is available in the web link: https://www.chem.uniroma1.it/didattica/offerta-formativa/insegnamenti/chimica-organica-iv

The student should have an appropriate knowledge of the fundamental notions of Organic Chemistry, Physical Chemistry, Analytical Chemistry, Mathematics and Physics, which are taught in the basis teachings of the Bachelor in Chemistry (three years program). Essential Requirement. The student should have an appropriate knowledge of the English language since the adopted text book is written in English and the original papers from which many of the topics discussed in the classroom are taken from, are written in English. Important Requirement. The student should use electronic devices such as PC or Smartphone with the aim at having access to the course teaching material available in the web. Useful Requirement.

Modern Physical Organic Chemistry, Anslyn-Dougherty, University Science Books, Sausalito, CA (USA), 2006

2 consecutive lectures (45 minute duration) for 3 times a week

Questioning for a duration of 30 min (more or less)

lectures in classroom (45 minutes duration)