Chemistry

Enzymes as catalysts. Mechanism of enzyme catalysis. Proton coupled electron transfer reactions. Enzymatic reactions: reduction and oxidation; monooxygenaation and dioxygenation; substitutions; carboxylation and decarboxylation; isomerizations; eliminations and additions; aldol and Claisen reactions and retroreactions; rearrangements

Good knowledges of stucture and physical-chemical properties of monofunctional organic compounds and reaction mechanisms

- R. B. Silverman “The Organic Chemistry of Enzyme-Catalyzed Reactions”, Academic press, Elsevier, 2000 - T.D.H. Bugg “Introduction to enzyme and coenzyme chemistry” , Wiley, third edition 2012 - H. Dugas - "Bioorganic Chemistry. A chemical Approach to Enzyme Action", Springer, third edition - Articles provided by the teacher

Not mandatory

It will consist of an oral examination of the course topics To pass the exam the student must obtain a grade of not less than 18/30. The student must demonstrate to have acquired a basic knowledge of all the subjects covered in class and to be able to expose them in a coherent manner and with an appropriate scientific language. To achieve a score of 30/30 cum laude, the student must instead demonstrate that he/she has acquired excellent knowledge of all the topics covered during the course, being able to link them in a logical and consistent way

Concepts will be illustrated with slides and molecular models. Students will be invitated to partecipate with questions and observations. Exercises will be developed with the contribution of students

Enzymes as catalysts. Mechanism of enzyme catalysis. Proton coupled electron transfer reactions. Enzymatic reactions: reduction and oxidation; monooxygenaation and dioxygenation; substitutions; carboxylation and decarboxylation; isomerizations; eliminations and additions; aldol and Claisen reactions and retroreactions; rearrangements

Good knowledges of stucture and physical-chemical properties of monofunctional organic compounds and reaction mechanisms

- R. B. Silverman “The Organic Chemistry of Enzyme-Catalyzed Reactions”, Academic press, Elsevier, 2000 - T.D.H. Bugg “Introduction to enzyme and coenzyme chemistry” , Wiley, third edition 2012 - H. Dugas - "Bioorganic Chemistry. A chemical Approach to Enzyme Action", Springer, third edition - Articles provided by the teacher

Not mandatory

It will consist of an oral examination of the course topics To pass the exam the student must obtain a grade of not less than 18/30. The student must demonstrate to have acquired a basic knowledge of all the subjects covered in class and to be able to expose them in a coherent manner and with an appropriate scientific language. To achieve a score of 30/30 cum laude, the student must instead demonstrate that he/she has acquired excellent knowledge of all the topics covered during the course, being able to link them in a logical and consistent way

Concepts will be illustrated with slides and molecular models. Students will be invitated to partecipate with questions and observations. Exercises will be developed with the contribution of students