Industrial Chemistry

Fundamentals of Nuclear Magnetic Resonance. Magnetic properties of nuclei, protons, neutrons, electrons. Classical treatment of Larmor's precession. Resonance conditions. Interactions of nuclei with their surroundings. Phenomelogical equations of Bloch. Simple quantum treatmentTheoretical aspects and practical applications of NMR spectral parameters: chemical shift. Multiplicity of signals and coupling constant. Signal area. Relaxation mechanisms and T1 and T2 relaxation times. Overhauser nuclear effect. Applications of NMR parameters to macromolecular systems.Instrumental aspects. Electromagnets and superconducting magnets. Checking the homogeneity of the static magnetic field. Analog-to-digital converter. Transmitter and Receiver. Fourier transform NMR. Pulse method. Phase cycles. Signal processing. Types of window functions. Product operator theory.Methods of carrying out the experiments: one-dimensional sequences (sequences with decoupling from the proton, INEPT, DEPT, INADEQUATE, measurement of relaxation times); two-dimensional homonuclear sequences (COZY, TOCSY, NOESY, ROESY); two-dimensional heteronuclear sequences (HETCOR, HSQC, HMQC, HMBC); sequences for the measurement of diffusion coefficients (DOSY).Microstructure of polymers: composition, constitution, configuration and conformation. Nuclei used in the study of polymeric materials. Studies of homopolymers and synthetic copolymers. Spectral information on polymer synthesis mechanisms and information on catalytic mechanisms. Direction of addition of monomers. Type, length and location of branches and cross-links. Tacticity. Determinations in terms of the number of monometric units (triads, tetrodes, etc.). biocompatible polymers of natural and semi-synthetic origin. Gel and hydrogel.Differences between solution and solid state NMR spectroscopy. Solid state high resolution NMR. Causes of broadening of the NMR signal. Sensitivity problems. Magic angle spectroscopy. Hartmann-Hann effect and cross polarization. Examples of applications to solids of different nature. Two-dimensional spectroscopy in solids.

Knowledge of basic quantum mechanics and of the interaction between radiation and matter.

A.E. Tonelli: NMR spectroscopy and polymer microstructure. The conformational connectionK. Matsuzaki, T. Uryu, T. Asakura: NMR spectroscopy and stereoregularity of polymers

Attendance is not mandatory

The exam will be oral

The course will be held in presence