INDUSTRIAL BIOTRANSFORMATION

Course objectives

The teaching of Industrial Biotransformation aims to provide the student with fundamental specialist knowledge related to the production, separation and purification of products of industrial biotechnological interest using innovative methodologies and strategies of biotechnological synthesis highlighting problems and advantages from industrial point of view. The main objective of the course will be therefore to provide the tools to fully understand the concepts of sustainable development and industrial sustainability and the role of biotechnology in the sustainability of industrial processes. Lectures are developed starting from the study of the market of industrial enzymes and its characteristics, the new tools for obtaining new enzymatic activities, up to the analysis of some examples of biotechnological applications of industrial production with isolated enzymes (detergent industry, starch, bioethanol, textile industry, food industry (animal and human nutrition) and fine chemicals, followed by topics typical of industrial bioproductions (the cell as a cellular factory) up to the production of proteins and metabolites of industrial interest. The knowledge acquired in this teaching constitutes a framework of reference for subsequent competences, understood in their broadest meaning. Students who have passed the exam will be able to know and understand (acquired knowledge) - The structure-performance relationships of biological catalysts and their main technological applications. - the main biotechnological transformations and their importance from an industrial point of view. - the main bioseparation and purification techniques of biotechnological products - the most recent literature developments in the field of industrial biotechnology - aspects related to the study of the main and current applications of isolated (or immobilized) enzymes and of whole cells in industrial production Students who have passed the exam will be able to (skills and skills acquired): - critically interpret the influence of the reaction conditions on the structure and activity (enantio and regioselectivity) of biological catalysts - understand the connection with the other cultural areas of the CdS, in particular the aspects of analytical chemistry, inorganic chemistry, organic chemistry and physical chemistry. - develop the ability to communicate what has been learned, through oral examination tests. - ability to develop independent study through the indication of accessible sources of updating.

Channel 1
CLEOFE PALOCCI Lecturers' profile

Program - Frequency - Exams

Course program
Introduction (2 CFU) • Sustainable development and industrial sustainability; sustainable industrial processes; role of biotechnology in the sustainability of industrial processes • Foundations and guiding criteria of industrial bioproduction and bioconversion Industrial bioconversions (3CFU) • New Tools for obtaining enzymatic activities: molecular evolution (DNA shuffling), rational design; • Bioprocess engineering (dynamic kinetic resolution) • Biocatalysis in supercritical fluids: methodologies and industrial applications • Extremophile enzymes: biotechnological applications • Mesophilic enzymes in biotransformation: some examples of applications (detergent industry, starch, bioethanol, textile industry, food industry (animal and human nutrition), fine chemicals • Bioconversions for greater sustainability of certain large industrial productions (leather, gelatin, paper) • Future perspectives Bioproductions (4CFU) • The cell as a cell factory; production of proteins and metabolites of industrial interest • Bioproduction of organic acids: Ethanol, Citric acid. • Bioproduction of Antibiotics; amino acids; vitamins. • Bioplastics: biodegradability and compostability. The biorefinery • Bioproduction of polysaccharides: polysaccharide gums (case of xanthan), bacterial cellulose, • Biosynthesis of Polyesters (polyhydroxyalkanoates). Applications of 3-hydroxy methyl alkanoates as biofuels • The case of PLA (polylactic acid). Polyamino acids • Biopolymers from transgenic plants
Books
Non verrà adottato alcun testo in lingua inglese, ma gli studenti riceveranno copie di lavori scientifici su riviste ad alto impatto su alcuni argomenti trattati a lezione
Frequency
The course includes 6 hours of frontal teaching per week
Exam mode
The evaluation of the knowledge acquired will be carried out through the formulation of specific questions relating to the contents of the programme
Lesson mode
The lessons of frontal teaching will be carried out in the classroom, with the aid of video projection which will allow the visualization of the contents of the lessons through power point presentations. During the lessons time is dedicated to the discussion of the topics covered in class and to the questions asked by the students regarding clarifications and/or insights
  • Lesson code1022453
  • Academic year2024/2025
  • CourseIndustrial Chemistry
  • CurriculumOrganico Biotecnologico (OB)
  • Year2nd year
  • Semester1st semester
  • SSDCHIM/04
  • CFU9
  • Subject areaDiscipline chimiche ambientali, biotecnologiche, industriali, tecniche ed economiche