ANTONIA MANDUCA

PERSONAL INFORMATION
Family name, First name: MANDUCA, ANTONIA
ORCID: 0000-0001-9730-2467; Scopus ID: 54983543900; Research ID: Z-3737-2019
e-mail: antonia.manduca@uniroma1.it

PRESENT POSITION
Associate Professor in Pharmacology, Dept. of Physiology and Pharmacology «V. Erspamer», Faculty of Pharmacy and Medicine, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.

PROFESSIONAL EXPERIENCE
• Tenure-track assistant professor (Ricercatore a tempo determinato tipologia B, RTDB), Dept. of Physiology and Pharmacology «V. Erspamer», Faculty of Pharmacy and Medicine, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy (10/10/2022 – 09/10/2025).
• Postdoctoral Fellow, laboratory of Dr. Viviana Trezza, Dept. of Science, Roma Tre University, Rome, Italy (01/01/2019 – 30/09/2022).
• Postdoctoral Fellow, laboratory of Dr. Olivier Manzoni, Institut de Neurobiologie de la Mediterranèe (INMED), Marseille, France (01/04/2014 – 17/11/2018).
• PhD student, laboratory of Dr. Viviana Trezza, Dept. of Science, Roma Tre University, Rome, Italy (01/01/2011 – 25/02/2014).
• Research Assistant, laboratory of Prof. Maura Palmery, Dept. of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy (01/01/2010 – 31/12/2010).
• Undergraduate internship, laboratory of Prof. Maura Palmery, Dept. of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy (01/11/2007 – 21/07/2009).
• Undergraduate internship, laboratory of Cell and Plant Physiology, Faculty of Pharmacy, University of Granada, Granada, Spain (01/09/2006 – 01/03/2007).

EDUCATION
• Ph.D. in Biology Applied to the Human Health, Dept. of Science, Roma Tre University, Rome, Italy (25/02/2014). Supervisor: Dr. Viviana Trezza. Thesis title: Role of the endocannabinoid system in the modulation of emotions and cognition.
• M.Sc. in Pharmacy, Faculty of Pharmacy, Sapienza University of Rome, Rome, Italy (21/07/2009).
• B.Sc. in Scientific Studies, Liceo Scientifico “Carlo Pisacane”, Padula, Italy (01/07/2003).

NATIONAL SCIENTIFIC ABILITATION
National Scientific Habilitation for Associate Professor (ASN 2018-2020) in the Academic Recruiting Field of “Pharmacology, Clinical Pharmacology and Pharmacognosy (05/G1)” from 31/05/2021 to 31/05/2032.

PUBLICATIONS
1. Di Trapano M., Buzzelli V., Rizzi B., Mottarlini F., Schiavi S., Ciccocioppo R., Fattore L., Romualdi P., Fumagalli F., Trezza V., Caffino L., Manduca A. Early Life Social Isolation Dysregulates Social Reward Processing, BDNF Signaling, and Intracellular Vesicular Sorting in the Nucleus Accumbens of Male and Female Rats. J Neurochem. 2025;169(8):e70181.
2. Miele R., Fullone M.R., Casella I., Maftei D., Prosperi G., Manduca A., Lattanzi R. Physical TRPV1-PKR2 interaction modulates PKR2 localization, activation and β-arrestin-2 recruitment. Cellular Signaling. 2025; 131:111761.
3. Prosperi G., Manduca A. New insights into the neural consequences of synthetic cannabinoids during adolescence: the critical role of Reelin at prefrontal synapses. Biol Psychiatry Glob Open Sci. 2025; 5(2):100456.
4. Manzoni O.J., Manduca A., Trezza V. Therapeutic Potential of Cannabidiol Polypharmacology in Neuropsychiatric Disorders. Trends in Pharmacological Sciences. 2025; 46(2):145-162.
5. Rava A., Buzzelli V., Feo A., Ascone F., Di Trapano M., Schiavi S., Carbone E., Pasquadibisceglie A., Polticelli F., Manduca A., Trezza V. Role of peroxisome proliferator-activated receptors α and γ in mediating the beneficial effects of β-caryophyllene in a rat model of fragile X syndrome. Prog Neuropsychopharmacol Biol Psychiatry. 2024; 136:111234.
6. Manduca A.*, Buzzelli V., Rava A., Feo A., Carbone E., Schiavi S., Peruzzi B., D'Oria V., Pezzullo M., Pasquadibisceglie A., Polticelli F., Micale V., Kuchar M., Trezza V. Cannabidiol and positive effects on object recognition memory in an in vivo model of Fragile X Syndrome: Obligatory role of hippocampal GPR55 receptors. Pharmacol Res. 2024; 203:107176. doi: 10.1016/j.phrs.2024.107176 (*: corresponding author).
7. Bernabeu A., Bara A., Green M.N.M., Manduca A.*, Wager-Miller J., Borsoi M., Lassalle O., Pelissier-Alicot A.L., Chavis P., Mackie K., Manzoni O.J. Sexually dimorphic adolescent trajectories of prefrontal endocannabinoid synaptic plasticity equalize in adulthood, reflected by endocannabinoid system gene expression. Cannabis Cannabinoid Res. 2023; 8(5):749-767 (*: second authorship).
8. Schiavi S.*, Manduca A.*, Carbone E., Buzzelli V., Rava A., Feo A., Ascone F., Morena M., Campolongo P., Hill M.N., Trezza V. Anandamide and 2-arachidonoylglycerol differentially modulate autistic-like traits in a genetic model of autism based on FMR1 deletion in rats. Neuropsychopharmacology. 2023; 48(6):897-907 (*: co-first authorship).
9. Carbone E., Buzzelli V., Manduca A.*, Leone S., Rava A., Trezza V. Maternal immune activation induced by prenatal lipopolysaccharide exposure leads to long-lasting autistic-like social, cognitive and immune alterations in male Wistar rats. Int J Mol Sci. 2023; 24(4), 3920 (*: second authorship).
10. Buzzelli V., Carbone E., Manduca A.*, Schiavi S., Feo A., Perederiy J.V., Ambert K.H., Hausman M., Viviana Trezza. Psilocybin mitigates the cognitive deficits observed in a rat model of Fragile X syndrome. Psychopharmacology. 2023;240(1):137-147. (*: second authorship).
11. D’Elia A., Schiavi S., Manduca A., Rava A., Buzzelli V., Ascone F., Orsini T., Putti S., Soluri A., Galli F., Soluri A., Mattei M., Cicconi R., Massari R., Trezza V. FMR1 deletion in rats induces hyperactivity with no changes in striatal dopamine transporter availability. Sci Rep. 2022; 12, 22535.
12. Schiavi S., Carbone E., Melancia F., Buzzelli V., Manduca A., Campolongo P., Pallottini V., Trezza V. Perinatal supplementation with omega-3 fatty acids corrects the aberrant social and cognitive traits observed in a genetic model of autism based on FMR1 deletion in rats. Nutr Neurosci. 2022; 25(5):898-911.
13. Manduca A.*, Carbone E., Schiavi S., Cacchione C., Buzzelli V., Campolongo P., Trezza V. The neurochemistry of social reward during development: what have we learned from rodent models?. J Neurochem. 2021;157(5):1408–1435. (*: corresponding author).
14. Carbone E.*, Manduca A.*, Cacchione C., Vicari S., Trezza V. Healing autism spectrum disorder with cannabinoids: a neuroinflammatory story. Neurosci Biobehav Rev. 2021;121:128-143. (*: co-first authorship).
15. Schiavi S., Melancia F., Carbone E., Buzzelli V., Manduca A., Jiménez Peinado P., Zwergel C., Mai A., Campolongo P., Vanderschuren L.J.M.J., Trezza V. Detrimental effects of the ‘bath salt’ Methylenedioxypyrovalerone on social play behavior in male rats. Neuropsychopharmacology. 2020;45(12):2012-2019.
16. Manduca A.*, Servadio M., Melancia F., Schiavi S., Manzoni O.J., Trezza V. Sex-specific behavioral deficits induced at early life by prenatal exposure to the cannabinoid receptor agonist WIN 55,212-2 depend on mGlu5 receptor signaling. Br J Pharmacol. 2020;177(2):449-463. (*: corresponding author).
17. Schiavi S., Iezzi D., Manduca A., Leone S., Melancia F., Carbone C., Petrella M., Mannaioni G., Masi A., Trezza V. Reward-Related Behavioral, Neurochemical and Electrophysiological Changes in a Rat Model of Autism Based on Prenatal Exposure to Valproic Acid. Front Cell Neurosci. 2019;13:479.
18. Schiavi S.*, Manduca A.*, Segatto M., Campolongo P., Pallottini V., Vanderschuren L.J.M.J., Trezza V. Unidirectional opioid-cannabinoid cross-tolerance in the modulation of social play behavior in rats. Psychopharmacology (Berl). 2019; 236(9):2557-2568. (*: co-first authorship).
19. Borsoi M., Manduca A., Bara A., Lassalle O., Pelissier-Alicot A.L., Manzoni O.J. Sex Differences in the Behavioral and Synaptic Consequences of a Single in vivo Exposure to the Synthetic Cannabimimetic WIN55,212-2 at Puberty and Adulthood. Front Behav Neurosci. 2019 Mar 5;13:23. eCollection 2019.
20. Bara A.*, Manduca A.*, Bernabeu A., Borsoi M., Servadio M., Lassalle O., Murphy M., Wager-Miller J., Mackie K., Pelissier-Alicot A.L., Trezza V., Manzoni O.J. Sex-dependent effects of in utero cannabinoid exposure on cortical function. Elife. 2018 Sep 11;7. (*: co-first authorship).
21. Servadio M., Manduca A., Melancia F., Leboffe L., Schiavi S., Campolongo P., Palmery M., Ascenzi P., di Masi A., Trezza V. Impaired repair of DNA damage is associated with autistic-like traits in rats prenatally exposed to valproic acid. Eur Neuropsychopharmacol. 2018 Jan;28(1):85-96.
22. Manduca A., Bara A., Larrieu T., Lassalle O., Joffre C., Layé S., Manzoni O.J. Amplification of mGlu5-Endocannabinoid Signaling Rescues Behavioral and Synaptic Deficits in a Mouse Model of Adolescent and Adult Dietary Polyunsaturated Fatty Acid Imbalance. J Neurosci. 2017 Jul 19;37(29):6851-6868.
23. Manduca A., Lassalle O., Sepers M., Campolongo P., Cuomo V., Marsicano G., Kieffer B., Vanderschuren L.J., Trezza V., Manzoni O.J. Interacting Cannabinoid and Opioid Receptors in the Nucleus Accumbens Core Control Adolescent Social Play. Front Behav Neurosci. 2016 Nov 16;10:211. eCollection 2016.
24. Servadio M., Melancia F., Manduca A., di Masi A., Schiavi S., Cartocci V., Pallottini V., Campolongo P., Ascenzi P., Trezza V. Targeting anandamide metabolism rescues core and associated autistic-like symptoms in rats prenatally exposed to valproic acid. Transl Psychiatry. 2016 Sep 27;6(9):e902.
25. Manduca A., Servadio M., Damsteegt R., Campolongo P., Vanderschuren L.J., Trezza V. Dopaminergic Neurotransmission in the Nucleus Accumbens Modulates Social Play Behavior in Rats. Neuropsychopharmacology. 2016 Aug;41(9):2215-23.
26. Janecka M., Manduca A., Servadio M., Trezza V., Smith R., Mill J., Schalkwyk L.C., Reichenberg A., Fernandes C. Effects of advanced paternal age on trajectories of social behavior in offspring. Genes Brain Behav. 2015 Jul;14(6):443-53.
27. Manduca A., Morena M., Campolongo P., Servadio M., Palmery M., Trabace L., Hill M.N., Vanderschuren L.J., Cuomo V., Trezza V. Distinct roles of the endocannabinoids anandamide and 2-arachidonoylglycerol in social behavior and emotionality at different developmental ages in rats. Eur Neuropsychopharmacology. 2015 Aug;25(8):1362-74.
28. Manduca A., Servadio M., Campolongo P., Palmery M., Trabace L., Vanderschuren L.J., Cuomo V., Trezza V. Strain- and context-dependent effects of the anandamide hydrolysis inhibitor URB597 on social behavior in rats. Eur Neuropsychopharmacol. 2014 Aug;24(8):1337-48.
29. Manduca A., Campolongo P., Palmery M., Vanderschuren L.J., Cuomo V., Trezza V. Social play behavior, ultrasonic vocalizations and their modulation by morphine and amphetamine in Wistar and Sprague-Dawley rats. Psychopharmacology (Berl). 2014 Apr;231(8):1661-73.
30. Segatto M., Manduca A., Lecis C., Rosso P., Jozwiak A., Swiezewska E., Moreno S., Trezza V., Pallottini V. Simvastatin treatment highlights a new role for the isoprenoid/cholesterol biosynthetic pathway in the modulation of emotional reactivity and cognitive performance in rats. Neuropsychopharmacology. 2014 Mar;39(4):841-54.
31. Manduca A., Campolongo P., Trezza V.. Cannabinoid modulation of mother-infant interaction: is it just about milk? Rev Neurosci. 2012;23(5-6):707-22.
32. Trezza V., Damsteegt R.*, Manduca A.*, Petrosino S., Van Kerkhof L.W., Pasterkamp R.J., Zhou Y., Campolongo P., Cuomo V., Di Marzo V., Vanderschuren L.J. Endocannabinoids in amygdala and nucleus accumbens mediate social play reward in adolescent rats. J Neurosci. 2012 Oct 24;32(43):14899-908. (*: equal contribution).
33. Campolongo P., Ratano P., Manduca A., Scattoni M.L., Palmery M., Trezza V., Cuomo V. The endocannabinoid transport inhibitor AM404 differentially modulates recognition memory in rats depending on environmental aversiveness. Front Behav Neurosci. 2012 Mar 20;6:11. eCollection 2012.
34. Trezza V., Campolongo P., Manduca A., Morena M., Palmery M., Vanderschuren L.J., Cuomo V. Altering endocannabinoid neurotransmission at critical developmental ages: impact on rodent emotionality and cognitive performance. Front Behav Neurosci. 2012 Jan 24;6:2. eCollection 2012.

BOOK CHAPTERS
1) Manduca A., Vanderschuren L.J.M.J., Trezza V. Cannabinoid modulation of rodent ultrasonic vocalizations in a social context: communicative and rewarding properties. In Cannabinoid Modulation of Emotion, Memory and Motivation. Springer. 2015; Chapter 10; 225-244.
2) Manduca A., Trezza V. Microbiota e autismo. In Atti del XLVI Seminario sulla Evoluzione biologica e i grandi problemi della Biologia. Il microbiota, il secondo genoma degli eucarioti. 2020.
3) Manduca A., Trezza V. Behavioral consequences of pre/peri-natal cannabis exposure. In Cannabis and the Developing Brain. Elsevier. 2022; Chapter 5; 79-89.
4) Schiavi S.*, Manduca A.*, Carbone E., Buzzelli V., Trezza V. Assessing Dyadic Social Interactions in Rodent Models of Neurodevelopmental Disorders. In Translational Research Methods in Neurodevelopmental Disorders. Neuromethods. 2022; Vol. 185, Chapter 10; 193-216. (*: equal contribution).

GRANTS AS PI-PRINCIPAL INVESTIGATOR and CO-INVESTIGATOR
• Istituto Pasteur Italia Fondazione Cenci Bolognetti (40.000 €) for research project in neuroscience. Title: Mother’s mood matters: deconstructing the neurobehavioral signature of peripartum depression (2025 – 2027). Role: PI
• Sapienza Progetti di Ateneo Medi 2023 (10.602,63 €) for multidisciplinary research project. Title: Dissecting the mechanisms underlying the impact of maternal environmental risk factors on offspring mental health (2024 – 2026). Role: PI.
• PRIN 2022 PNRR (230.792 €) for research project of national relevance. Title: Deprivation matters: exploring sex-dependent vulnerability to alcohol use and anorexia nervosa following social impoverishment during early adolescence (2023 – 2025). Role: co-PI and Responsible of Research Unit (under 40).
• PRIN 2022 (186.904 €) for research project of national relevance. Title: “Evaluation of Castanea sativa by-products as a source of bioactive molecules against Helicobacter pylori-induced inflammation: a novel sustainable strategy (2023 – 2025). Role: co-PI and Responsible of Research Unit (under 40).
• Sapienza University of Rome SEED PNR 2022 (10.000 €) for the most promising multidisciplinary research project. Title: Dissecting the mechanisms underlying the detrimental effects of maternal Cannabis on offspring: focus on sex-specific therapeutic strategies (2023 – 2024). Role: PI.
• Fondazione Zardi Gori Postdoctoral Fellowship (54.000 €) for the most promising research in drugs of abuse and addiction. Title: Detrimental effects of maternal Cannabis use: exploring emerging strategies for treating sex-dependent behavioral and neurobiological consequences in the offspring (2022 – 2023). Role: PI.
• Autism Speaks Postdoctoral Fellowship (135.000 $) for the most promising research on autism. Title: New Insights on the role of cannabidiol in autism spectrum disorder: from synapse to behavior (2020 – 2021). Role: PI.
• L'Oreal-UNESCO for Women in Science (FWIS) Postdoctoral Fellowship (20.000 €) for the most promising young female researchers. Title: Cannabis and dietary imbalance during breast-feeding: what are the consequences for the fetus? (2018 – 2019). Role: PI.
• PV/MM/MS-14.449, Ville de Marseille Postdoctoral Fellowship for a 1-year period in the laboratory of Dr. Olivier Manzoni, INMED, Marseille, France (2.000 €). Title: Omega-3 Fatty Acids and Depression (2014). Role: PI.
• Sapienza University of Rome Postgraduate Fellowship for a 6-month research period in the laboratory of Dr. Olivier Manzoni, INMED, France (7.740 €). Title: Corticolimbic brain regions underlying social behavior: focus on the interaction between the endocannabinoid and opioid systems (2014). Role: PI.
• Italian Ministry of Education, Universities and Research (MIUR) (40.000 €) for a 3-year PhD project in the laboratory of Dr. Viviana Trezza, Department of Science, Roma Tre University, Rome, Italy. Title: Role of the endocannabinoid system in the modulation of emotions and cognition (2011 – 2013).
• Fondazione Enrico ed Enrica Sovena Research Fellowship (10.000 €) for a 1-year period in the laboratory of Prof. Maura Palmery, Sapienza University of Rome, Rome, Italy. Title: Modulatory effect of adenosine receptors in the opioid dependence in the guinea pig ileum (2010). Role: PI.
• ERASMUS Scholarships, Sapienza University of Rome (1.800 €) for a 6-month period abroad, University of Granada, Spain (2006).

GRANTS AS I-INVESTIGATOR
• Bando di Terza Missione, Sapienza University of Rome (20.000 €). Title: Respira Sapienza! Scienze in sinergia e comunità attiva contro l’epidemia del vaping e del fumo di tabacco per la tutela della salute pubblica, la sostenibilità dell'ambiente e il benessere futuro (2025-2027). Role: Participant. PI: A. Di Sotto
• Bando di Ateneo per Medie Attrezzature Scientifiche, Sapienza University of Rome (60.000 €). Title: Behavioral Analysis Toolbox (BAT)-a toolkit for computer classification of complex behaviors in experimental animals (2024-2026). Role: Participant. PI: G. Esposito
• PNRR: M6/C2_CALL 2023 (239.700 €) for collaborative research project in chronic non-communicable diseases with a high impact on health and social care systems. Title: Interactions between type-1 trace amine receptors and metabotropic glutamate receptors in the pathophysiology and treatment of stress-related disorders and neurodevelopmental disorders (2024 – 2026). Role: Principal Collaborator of Research Unit (Fondazione Santa Lucia, Rome, Italy). PI: F. Nicoletti
• Regione Lazio Progetti di Gruppi di Ricerca 2020, Italy (149.893 €). Title: Endocannabinoids and phytocannabinoids in autism spectrum disorder: from new biomarkers to innovative nutraceutics (2020-2021). Role: Participant. PI: V. Trezza
• Ricerca Finalizzata 2019 Giovani Ricercatori, Italian Ministry of Health, Italy (449.980 €). Title: Integrating cannabinoids into the treatment of Posttraumatic Stress Disorder: exploring mechanisms of amygdala-hippocampal communication during information contextualization (2021-2023). Role: Participant. PI: M. Morena
• National Institut on Drug Abuse (NIDA) and National Institute of Health (NIH) USA (311.445 $). Title: Sex-specific critical periods determine the effects of cannabinoids on the mesocorticolimbic system (2017-2018). Role: Participant. PI: O. Manzoni
• INSERM Fondation Recherche Medical (FRM) Equipe 2021, France (399.500 €). Title: Multi scale study of in utero Cannabis exposure (2015 – 2018). Role: Participant.
• Agence Nationale de la Recherche (ANR), France (449.981 €). Title: Depression and Nutrition (2014 – 2016). Role: Participant. PI: O. Manzoni

PRIZES AND AWARDS
• Regione Lazio Fondo Sociale Europeo Plus (FSE+ 2021-2027) research award (2.000 €) sponsored by Regione Lazio to strengthen the professional experience of young researchers working in Regione Lazio research system (Rome, Italy, 20 September 2022).
• Travel grant (150 €) sponsored by the Italian Society of Neuroscience (SINS) to attend the FENS 2020 Virtual Forum (Glasgow, United Kingdom 11 – 17 July 2020).
• Travel grant (350 €) sponsored by the Italian Society of Pharmacology (SIF) to attend the International Conference "Addiction 2020: Enlightening the addicted brain: cells, circuits and therapies” (Villasimius, Italy 20 – 23 September 2020).
• Travel grant (350 €) sponsored by the Italian Society of Pharmacology (SIF) to attend the International Conference "Perinatal Origins of Neuropsychiatric Disorders: from Molecular Mechanisms to Therapeutic Perspectives" (Palermo, Italy 29 – 31 May 2019).
• Best Poster Presentation Award sponsored by Springer/Nature at the 6th Conference of the Mediterranean Society of Neuroscience (MNS), Mediterranean Neuroscience Society (MNS) (St. Julian’s, Malta, 12 – 15 June 2017).
• SIF-Farmindustria-2016 Prize for Young Scientist in Pharmacology (5.000 €) sponsored by the Italian Society of Pharmacology (SIF) (Rimini, Italy, 19 September 2016).
• Travel grant (500 €) sponsored by the Mediterranean Neuroscience Society (MNS) to attend the 5th MSN Conference (Santa Margherita di Pula, Italy, 12 – 15 June 2015).
• Best Post-Doctoral Presentation Award (150 $) sponsored by the International Cannabinoid Research Society (ICRS) at the 24th Annual ICRS Conference (Baveno, Italy, 28 June – 3 July 2014).
• Travel grant (500 $) sponsored by the International Cannabinoid Research Society (ICRS) to attend the 24th Annual ICRS Conference (Baveno, Italy, 28 June – 3 July 2014).
• Travel grant (750 €) sponsored by the European Behavioural Pharmacology Society (EBPS) to attend the 15th Biennial Meeting of EBPS (La Rochelle, France, 6 – 9 September 2013).
• Long-term fellowship for joining a foreign laboratory (1500 €) sponsored by the Italian Society of Pharmacology (April 2014 – March 2015).
• Best Poster Presentation Award (500 €) sponsored by the Italian Society of Pharmacology (SIF) at the 35th National Congress of SIF (Bologna, Italia, 14 – 17 September 2011).

INVITED PRESENTATIONS AT NATIONAL AND INTERNATIONAL CONFERENCES AS SPEAKER
1. 21th SINS National Congress (Pisa, Italy, 10-13 September 2025). Title: Neuroplastic mechanisms underlying social reward deficits following early life isolation.
2. 10th Mediterranean Neuroscience Society (MNS) Conference (Crete, Greece, 7-11 June 2025). Title: Sex-dependent vulnerability to social reward deficits following early life social isolation.
3. Center for Behavioral Sciences and Mental Health, Italian National Institute of Health (ISS) (Rome, Italy, 26 June 2023). Title: Developmental vulnerability to neuropsychiatric disorders: focus on the endocannabinoid system.
4. International School of Advanced Studies, PhD Programme in Theoretical and Applied Neuroscience (Camerino, Italy, 22 June 2023). Title: Behavioral phenotyping in rodent models of neuropsychiatric disorders.
5. Highlighting the Research Activity of the Sapienza Faculty of Pharmacy and Medicine (Rome, Italy, 22-23 February 2023). Title: Cannabis and the developing brain: consequences of prenatal exposure to cannabinoids.
6. 41th Congress of the Italian Society of Pharmacology (SIF) (Rome, Italy, 16 – 19 November 2022). Title: Sex-dependent impact of prenatal valproate on neurodevelopmental disorder: possible strategies for intervention.
7. Addiction 2022 (Villasimius, Italy, 25 – 28 September 2022). Title: Detrimental effects of maternal cannabis use: exploring emerging strategies for treating sex-dependent behavioral and neurobiological consequences in the offspring.
8. 8th MNS Conference (Dubrovnik, Croatia, 29 May – 2 June 2022). Title: The endocannabinoid system as a novel target for autism spectrum disorder.
9. EBPS Biennial Meeting 2021 (Online, 13 – 16 July 2021). Title: Role of the endocannabinoid system in genetic and environmental preclinical models of ASD.
10. JNC/ISN Reward Seeking Mini-Symposium (Online, 7 July 2021). Title: Neurobiology of Social Reward: from Physiology to Pathophysiology.
11. 40th Congress of the Italian Society of Pharmacology (SIF) (Digital Edition, 9 – 13 March 2021). Title: Sex-dependent behavioral deficits induced at early life by in utero cannabinoid exposure depend on mGlu5 receptor signaling.
12. 7th MNS Conference (Marrakech, Morocco, 23 – 27 June 2019). Title: Sex-dependent consequences of prenatal cannabinoid exposure.
13. Perinatal Origins of Neuropsychiatric Disorders: from molecular mechanisms to therapeutic perspectives (Palermo, Italy, 29 – 31 May 2019). Title: Sex-dependent effects of in utero cannabinoid exposure on behavioral and cortical function.
14. 38th Congress of the Italian Society of Pharmacology (SIF) (Rimini, Italy, 25 – 28 October 2017). Title: Nutritional omega-3 deficiency starting at adolescence impairs synaptic plasticity and emotional behavior at adulthood: implication of the metabotropic glutamate receptor 5 (mGluR5)-endocannabinoid signaling complex.
15. National Congress of the Italian Neuroscience Society (SINS) (Ischia, Italy, 1 – 4 October 2017). Title: Amplification of mGlu5-endocannabinoid signaling rescues behavioral and synaptic deficits induced by a dietary polyunsaturated fatty acids imbalance starting at adolescence.
16. Valentina De Castro memorial symposium, Sapienza University of Rome (Rome, Italy, 2 December 2015). Title: Food for the brain: the importance of nutrition in proper brain development.
17. Journées INMED 2015 (Marseille, France, 16 – 18 September 2015). Title: Nutrition gets cognition.
18. 5th MNS Conference (Santa Margherita di Pula, Italy, 12 – 15 June 2015). Title: CB1 and Mu opioid receptors interplay in the nucleus accumbens core underlies social reward in adolescent rats.
19. Cellular Biology of Addiction Summer Course, Partnered with the Cold Spring Harbor Laboratory (CSHL) (Barcelona, Spain, 13 – 20 July 2014). Title: Social reward is mediated by interaction opioid and CB1 cannabinoid receptors in the nucleus accumbens core in adolescent rats.
20. 24th Annual International Cannabinoid Research Society Symposium on the Cannabinoids (ICRS) (Baveno, Italy, 28 June – 3 July 2014). Title: Social reward is mediated by interaction opioid and CB1 cannabinoid receptors in the nucleus accumbens core in adolescent rats.
21. 36th Congress of the Italian Society of Pharmacology (SIF) (Torino, Italy, 23 – 26 October 2013). Title: Dopaminergic neurotransmission in the NAc mediates social play behavior in rats.
22. 15th Biennial Meeting of the European Behavioural Pharmacology Society (EBPS) (La Rochelle, France, 6 – 9 September 2013). Title: Dopaminergic neurotransmission in nucleus accumbens mediates social play behavior in adolescent rats.
23. 16th National Meeting of PhD student and Postdoctoral scholar in Pharmacological studies (Rimini, Italy, 16 – 19 September 2012). Title: Role of the amygdala and nucleus accumbens in endocannabinoid modulation of social play behavior in adolescent rats.

POSTER PRESENTATIONS AT NATIONAL AND INTERNATIONAL CONFERENCES
• Morphine-induced mechanical hypersensitivity in mice requires prokineticin receptors. Prosperi G., Maftei D., Manduca A., Miele R., Lattanzi R. INRC 2025 - International Narcotics Research Conference. Bologna, Italy, 8-11 July 2025.
• Developmental phytocannabinoid exposure: relevance for autism spectrum disorder. Rava A., Buzzelli V., Feo A., Ascone F., Manduca A., Di Trapano M., Trezza V. 21th SINS National Congress. Pisa, Italy, 10-13 September 2025.
• Psilocybin mitigates the cognitive deficits observed in a rat model of fragile X syndrome. Buzzelli V., Carbone E., Manduca A., Schiavi S., Feo A., Perederiy J.V., Ambert K.H., Hausman M., Trezza V. ISN-APSN 2022 Meeting, Kyoto, 28 August – 1 September 2022
• Cannabidiol rescues autistic-like symptoms in a genetic model of autism based on FMR1 deletion in rats. Manduca A., Buzzelli V., Carbone E., Rava A., Schiavi S., Micale V., Kuchar M., Trezza V. FENS 2022, Paris, France, 9-13 July 2022.
• Role of the endocannabinoid system in a genetic model of autism based on FMR1 deletion in rats. Carbone E., Buzzelli V., Manduca A., Schiavi S., Trezza V. FENS 2022, Paris, France, 9-13 July 2022.
• Role of the endocannabinoid system in a preclinical model of Fragile X Syndrome. Schiavi S., Carbone E., Manduca A., Buzzelli V., Trezza V. Jacques Monod Conference "Genetics, environment, signalling & synaptic plasticity in developmental brain disorders: from bench to bedside”, Roscoff, France, 11‐15 April 2022.
• Prenatal exposure to the cannabinoid receptor agonist WIN55,212-2 induces sex-specific deficits at early ages depending on mGlu5 receptor signalling. Manduca A., Schiavi S., Manzoni O.J., Trezza V. FENS 2020 Virtual Forum, Glasgow, UK, 11-15 July 2020.
• Effects of cannabinoid drugs in preclinical models of autism spectrum disorder. Carbone E., Manduca A., Schiavi S., Buzzelli V., Trezza V. Giornata della Ricerca, Rome, Italy, 22 January 2020.
• Role of the endocannabinoid system in a preclinical model of Fragile X syndrome. Schiavi S., Carbone E., Manduca A., Buzzelli V., Trezza V. Society for Neuroscience (SfN) Conference, Chicago, IL, USA, 21 – 23 October 2019.
• Effects of cannabinoid drugs in preclinical models of autism spectrum disorder. Schiavi S., Manduca A., Trezza V. Society for Neuroscience (SfN) Conference, Chicago, IL, USA, 21 – 23 October 2019.
• Reward-related behavioral, and neurochemical changes in a rat model of autism based on prenatal exposure to valproic acid. Schiavi S., Manduca A., Leone S., Melancia F., Trezza V. 48th Meeting of the European Brain and Behaviour Society (EBBS), Prague, Czech Republic, 21 – 24 September 2019.
• Sexual dimorphic effects of in utero cannabinoid exposure. Manduca A., Bara A., Lassalle O., Trezza V., Manzoni OJ. Journées INMED 2018, Institut de Neurobiologie de la Méditerranée (INMED), Marseille, France, 4 – 5 October 2018.
• Amplification of mGlu5-endocannabinoid signaling rescues behavioral and synaptic deficits induced by a dietary polyunsaturated fatty acids imbalance. Manduca A., Bara A., Larrieu T., Lassalle O., Joffre C., Layé S., Manzoni O.J. 6th MNS Conference, Saint Julian’s, Malta, 12 – 15 June 2017.
• WIN55,212-2 acute administration induces behavioural and synaptic changes in a sex- and age-dependent manner. Borsoi M., Manduca A., Bara A., Lassalle O., Pelissier-Alicot A.L., Manzoni OJ. 6th MNS Conference, Saint Julian’s, Malta, 12 – 15 June 2017.
• Ultrasonic vocalization and homing behavior in the valproic acid rat model of autism spectrum disorders: role of the endocannabinoid system. Servadio M., Manduca A., Montebello L., Dore R., de Castro V., Trezza V. ECNP Workshop on Neuropsychopharmacology for Junior Scientists in Europe, Nice, France, 12 – 15 March 2015.
• Effects of advanced paternal age on trajectories of social behaviour and motor development in offspring. Janecka M., Manduca A., Servadio M., Smith R., Schalkwyk L., Mill J., Trezza V., .Reichenberg V., Fernandes C. BNA Festival of Neuroscience, Edinburgh, United Kingdom, 12 – 15 April 2015.
• Nutritional omega-3 deficiency in adulthood impairs accumbens synaptic plasticity and anxiety-related behaviour in mice. Bara A., Larrieu T., Manduca A., Lassalle O., Layé S., Manzoni O. 12e Colloque de la Société des Neurosciences (SN), Montpellier, France, 12 – 15 May 2015.
• Role of the endocannabinoid system in the behavioral alterations observed in the rat valproic acid model of autism. Servadio M., Melancia F., Manduca A., Trezza V. 5th MNS Conference, Santa Margherita di Pula, Italy, 12 – 15 June 2015.
• Pharmacological insights into social play behavior: the role of nucleus accumbens dopamine. Servadio M.*, Manduca A.*, Damsteegt R., Campolongo P., Dore R., Vanderschuren L.J.M.J., Trezza V. 5th MNS Conference, Santa Margherita di Pula, Italy, 12 – 15 June 2015. (*: equal contribution).
• Role of the endocannabinoid system in the behavioral alterations observed in the rat valproic acid model of autism. Servadio M., Melancia F., Manduca A., Trezza V. 28th ECNP Congress, Amsterdam, The Netherland, 29 August –1 September 2015.
• Developmental trajectory and parental behaviour contribution to the advanced paternal age effects on autism-related phenotypes in mice. Janecka M., Manduca A., Smith R., Schalkwyk L., Mill J., Trezza V., Reichenberg A., Fernandes C. International Meeting for Autism Research (IMFAR), Atlanta, Georgia, USA, 14 –17 May 2014.
• Dual Fatty Acid Amide Hydrolase and Monoacylglicerol Lipase inhibition affects socio-emotional responses in rats. Manduca A., Morena M., Servadio M., Montebello L., Dore R., Campolongo P., Trezza V. 24th Annual International Cannabinoid Research Society (ICRS) Symposium on the Cannabinoids, Baveno, Italy, 28 June –3 July 2014.
• Nucleus accumbens dopaminergic neurotransmission mediates social play behavior in rats. Servadio M*, Manduca A.*, Damsteegt R., Montebello L., Vanderschuren L.J.M.J., Trezza V. The Social Brain, FENS. Copenhagen, Denmark, 5 – 8 October 2014 (*: equal contribution).
• Le 2-AG: cible thérapeutique dans le traitement des déficits de la plasticité endocannabinoide et des troubles de l’humeur induits par un déséquilibre alimentaire en acides gras polyinsaturés. Bara A., Lassalle O., Manduca A., Larrieu T., Layè S., Manzoni OJ. Journées de l’Institut de Neurobiologie de la Méditerranée (INMED), Point Royal en Provence, France, 8 – 10 October 2014.
• Role of nucleus accumbens dopamine in social play behavior in adolescent rats. Manduca A., Damsteegt R., Campolongo P., Cuomo V., Vanderschuren L.J.M.J., Trezza V. Dopamine 2013, Alghero, Italy, 24 – 28 May 2013.
• Dopaminergic neurotransmission in nucleus accumbens mediates social play behavior in adolescent rats. Manduca A., Damsteegt R., Campolongo P., Cuomo V., Vanderschuren L.J.M.J., Trezza V. 15th Biennial Meeting of EBPS, La Rochelle, France, 6 – 9 September 2013.
• Mevalonate pathway is crucial for the regulation of memory performance in rodents. Segatto M., Manduca A., Lecis C., Trezza V., Pallottini V. XV Congress of the Italian Society of Neuroscience (S.I.N.S.), Rome, Italy 3 – 5 October 2013.
• Effect of morphine and amphetamine on social play behavior and ultrasonic vocalization in rats: a strain comparison. Manduca A., Campolongo P., Palmery M., Vanderschuren L.J.M.J., Cuomo V., Trezza V. XV Congress of the Italian Society of Neuroscience (S.I.N.S.), Rome, Italy 3 – 5 October 2013.
• Effects of the dual FAAH-MAGL inhibitor JZL195 on emotional reactivity in rats. Manduca A., Morena M., Campolongo P., Bedetta M.C., Pasquale A., Palmery M., Cuomo V., Vanderschuren L.J.M.J., Trezza V. FENS-IBRO Workshop “Drugs and the Brain: an update in Psychopharmacology”, Braga, Portugal, 15 – 20 April 2012.
• The regulation of emotional aspects of behaviour: a new role for cholesterol biosynthetic pathway in the central nervous system. Segatto M., Trapani L., Manduca A., Trezza V., Acconcia F., Marino M., Pallottini V. 6th Meeting of the Young Researchers in Physiology, Fondazione MediaTerraneo, Sestri Levante, Genova, Italy, 30 May –1 June 2012.
• Strain differences in social play behavior and ultrasonic vocalizations in adolescent rats. Manduca A., Campolongo P., Bedetta M.C., Pasquale A., Cuomo V., Vanderschuren L.J.M.J., Trezza V. 8th FENS Forum of Neuroscience, Barcelona, Spain, 14 – 18 July 2012.
• The indirect cannabinoid agonist URB597 modulates social behavior in rats. Manduca A., Campolongo P., Peloso A., Vanderschuren L.J.M.J., Trezza V., Cuomo V. Monothematic Conference “Cannabinoids: Present and Future”, Ferrara, Italy, 14 – 15 September 2012.
• Role of the amygdala and nucleus accumbens in endocannabinoid modulation of social play behavior in adolescent rats. Manduca A., Trezza V., Cuomo V. 16th National Meeting of PhD student and Postdoctoral scholar in Pharmacological studies, Rimini, Italy, 16 – 19 September 2012.
• Strain- and context- dependent effects of URB597 on social behavior in rats. Manduca A., Campolongo P., Palmery M., Trezza V., Cuomo V. Monothematic Conference “Cannabinoids: from Biology to the Clinic”, Cagliari, Italy, 29 – 30 September 2011.
• Effects of the indirect cannabinoid agonist URB597 in the modulation of social behavior in rats. Manduca A., Campolongo P., Bedetta M.C., Palmery M., Trezza V., Cuomo V. 35th Congress of the Italian Society of Pharmacology (SIF), Bologna, Italy, 14 – 17 September 2011.
• Effects of central administration of the indirect cannabinoid agonist URB597 in the modulation of emotional memory in rats. Ratano P., Trezza V., Morena M., Manduca A., Miele J., Campolongo P., Cuomo V. 24th ECNP Congress, Paris, France, 5 – 6 September 2011.
• The endocannabinoid transport inhibitor AM404 differentially modulates emotionality and short-term memory depending on environmental aversivness. Ratano P., Morena M., Manduca A., Miele J., Trezza V., Scattoni M.L., Palmery M., Campolongo P., Cuomo V. The Emotional Brain: from Neurobiology to new therapeutic opportunities, Rome, Italy, 5 – 6 September 2011.
• The role of mevalonate pathway in the regulation of emotionality and cognitive performance in rodents. Segatto M., Trapani L., Lecis C., Manduca A., Trezza V., Pallottini V. The Emotional Brain: from Neurobiology to new therapeutic opportunities, Rome, Italy, 5 – 6 September 2011.
• Effects of the dual FAAH-MAGL inhibitor JZL195 in the regulation of emotionality in adolescent and adult rats. Manduca A., Morena M., Campolongo P., Carrara V., Palmery M., Cuomo V., Vanderschuren L.J.M.J., Trezza V. The Emotional Brain: from Neurobiology to new therapeutic opportunities, Rome, Italy, 5 – 6 September 2011.

PUBLISHED ABSTRACT
• Ultrasonic vocalization and homing behaviour in the valproic acid rat model of autism spectrum disorders: role of the endocannabinoid system. Servadio M., Manduca A., Montebello L., Dore R., De Castro V., Trezza V. European Neuropsychopharmacology. Volume 25, Supplement 1, 2015, s30.
• Role of the endocannabinoid system in the behavioral alterations observed in the rat valproic acid model of autism. Servadio M., Melancia F., Manduca A., Trezza V. European Neuropsychopharmacology. Volume 25, Supplement 1, 2015, s297.

SUPERVISION OF GRADUATE, UNDERGRADUATE, MASTER AND PHD STUDENTS
 Research mentorship of PhD students: A. Bara, INMED, Marseille, France (2015-2017); E. Carbone (2019 – 2023), V. Buzzelli (2020 – 2024), Roma Tre University, Rome, Italy; G. Prosperi, Sapienza University of Rome, Rome, Italy (2024 – ongoing).
 Research mentorship of master students: M. Deroche, INMED, Marseille, France (2015), P. Guily, INMED, Marseille, France (2017-2018).
 Research mentorship of undergraduate students: C. Lecis, V. Buzzelli, C. Cacchione, A. Taddeo, F. Rendina, A. Feo, F. Ascone, M. Tesi, B. Vitaletti, M. Di Trapano, C. Coianiz, Faculty of Biology, Roma Tre University, Rome, Italy (2013–2023) and L. Montebello, A. Pasquale, M.C. Bedetta, C. Pecci, J. Miele, Sapienza University of Rome, Rome, Italy (2011–2014).
 Tutor of the undergraduate students: M.C. Natangelo, C. D’Angelo, S. M. Guccione, C. Fossa, Z. Cuvato, Faculty of Pharmacy and Medicine, Sapienza University of Rome, Rome, Italy (2024–to date); S. Teobaldelli, Faculty of Mathematical, Physical and Natural Sciences, Sapienza University of Rome, Rome, Italy (2024–to date).
 Tutor of two undergraduate students (V. Biddau, matricula 1897236 and S. Polizzano, matricula 1951269) enrolled in the excellence path (Percorso di eccellenza) for the master’s degree in Neurobiology, Sapienza University of Rome (2024-2025).

TEACHING ACTIVITIES
 Teaching Assistant at Faculty of Pharmacy, Sapienza University of Rome, Rome, Italy, course of “Pharmacology and Pharmacotherapy”, academic years: 2010/11, 2011/12 and 2012/13.
 Teaching Assistant at Faculty of Pharmacy, Sapienza University of Rome, Rome, Italy, course of “Toxicology” academic years: 2010/11, 2011/12 and 2012/13.
 Teaching Assistant at Faculty of Biology, Roma Tre University, Rome, Italy, course of “Pharmacology”, “Toxicology”, “Psychobiology”, “Experimental Models of Neuroscience”, academic years: 2011/12, 2012/13, 2013/14, 2019/2020, 2020/2021, 2021/2022.
 Lecture at Faculty of Biology, Roma Tre University, Rome, Italy, master of “Embryology”, 8 May 2021, 28 April 2022 and 14 April 2023.
 Lecture at Faculty of Biology, University of Naples Federico II, Naples, Italy, course of “Cellular Neurophysiology”, 9 May 2022.
 Course of “Nonhuman primate models of human behavior: psychobiological and evolutionary perspectives” (6 CFU) of the Master Course in Neurobiology, Faculty of Mathematical, Physical and Natural Sciences, Sapienza University of Rome; Teacher and President of examining committee of the course (2022-2023).
 Course of “Pharmacology” (2 CFU) of the Master Course in Medical Biotechnology, Faculty of Pharmacy and Medicine, Sapienza University of Rome; Teacher and member of examining committee of the course (2022-2023; 2023-2024; 2024-2025).
 Course of “Neuropsychopharmacology” (3 CFU) of the Master Course in Neurobiology, Faculty of Mathematical, Physical and Natural Sciences, Sapienza University of Rome; Teacher and member of examining committee of the course (2023-2024; 2024-2025; 2025-2026).
 Course of “Pharmacology” (2 CFU) of the Bachelor Course in Audiometric Techniques, Faculty of Medicine and Surgery, Sapienza University of Rome; Teacher and member of examining committee of the course (2023-2024).
 Course of “Pharmacology” (1 CFU) of the Bachelor Course in Environment and workplace prevention techniques, Faculty of Medicine and Surgery, Sapienza University of Rome; Teacher and member of examining committee of the course (2023-2024; 2024-2025).
 Course of “Pharmacology” (2 CFU) of the Bachelor Course in Science in Nursing (S. Spirito Hospital), Faculty of Medicine and Surgery, Sapienza University of Rome; Teacher and member of examining committee of the course (2023-2024).
 Course of “Pharmacology” (2 CFU) of the Bachelor Course in Science in Nursing (S. Camillo-Forlanini Hospital), Faculty of Medicine and Surgery, Sapienza University of Rome; Teacher and member of examining committee of the course (2023-2024).
 Course of “Pharmacology” (2 CFU) of the Master Course in Medicine and Surgery HT, Faculty of Medicine and Surgery, Sapienza University of Rome; Teacher and member of examining committee of the course (2023-2024; 2024-2025; 2025-2026).
 Course of “Advanced Pharmacological Technologies” (3 CFU) of the Master Course in Medicine and Surgery HT, Faculty of Medicine and Surgery, Sapienza University of Rome; Teacher and member of examining committee of the course (2024-2025; 2025-2026).
 Course of “Pharmacology” (2 CFU) of the Master Course in Medicine and Surgery “B”, Faculty of Medicine and Surgery, Sapienza University of Rome; Teacher and member of examining committee of the course (2023-2024; 2024-2025; 2025-2026).
 Course of “Pharmacology” (2 CFU) of the Master Course in Dentistry and Dental Prosthodontics, Faculty of Medicine and Surgery, Sapienza University of Rome; Teacher and member of examining committee of the course (2023-2024; 2024-2025; 2025-2026).
 Course of “Pharmacology” (3 CFU) of the Master Course in Languages English Dentistry and Dental Prosthodontics, Faculty of Medicine and Surgery, Sapienza University of Rome; Teacher and member of examining committee of the course (2024-2025; 2025-2026).

INSTITUTIONAL, COMMISIONAL AND REVIEW ACTIVITIES
2011: Scientific Secretariat Member of the International conference “The Emotional Brain: from Neurobiology to new therapeutic opportunities”, Rome, Italy (Rome, Italy, 5 – 6 September 2011).
2014: Scientific Judging Committee Member at the 24th Annual International Cannabinoid Research Society Symposium on the Cannabinoids (ICRS) (Baveno, Italy, 28 June – 3 July 2014).
2014 – 2016: Scientific Traineer of «L'arbre des connaissances. Association pour la Promotion des Sciences et de la Recherche». Marseille, France.
2017: Organizing Committee of «Atelier sur le Cannabis», Tous Chercheurs Association, Marseille, France (28 March 2017).
2017: Member of the Judging Committee of the “Vivere le Emozioni” Prize, Fondazione Valentina de Castro onlus, Morolo, Italy (06 April 2017).
2013 – to date: Reviewer at Frontiers in Behavioral Neuroscience, Plos One, Neuropharmacology, Frontiers Neurology, Behavioral Pharmacology, Brain Research Journals, Scientific Reports, Research in Autism Spectrum Disorder, Biomedicine and Pharmacology, Neurobiology of Disease, British Journal of Pharmacology, Frontiers in Neuroscience, Environmental Toxicology and Pharmacology, Psychopharmacology, Translational Psychiatry, Biological Psychiatry. Progress in Neuropsychopharmacology.
2020-2024: Grant Reviewer for the National Science Centre, Poland (NCN). Funding scheme: OPUS-18, ID: 462056; SONATA-16, ID: 497952; MAESTRO-15, ID: 565045; DAINA 3, ID: 612322.
2021: Chair and Moderator of the Symposium “Exploring the behavioral signature of abnormal brain endocannabinoid signaling”, XIX National Congress of the Italian Society of Neuroscience (SINS) (Virtual Meeting, 9 – 11 September 2021).
2021: Editor of the Research Topic “Behavioral Dysfunctions in Neuropsychiatric Diseases: Exploring New Therapeutic Targets" in Frontiers in Psychiatry – Section Molecular Psychiatry.
2022: Chair and Moderator of the Symposium “Exploring new therapeutic targets to treat neurodevelopmental diseases: from synapse to behavior”, 8th MNS Meeting (Dubrovnik, Croatia, May 29 – June 2, 2022).
2022: Chair and Moderator of the Symposium in Neuropharmacology, XXIV SIF Seminar on Pharmacology for PhD Students, Fellows, Post Doc and Specialist Trainees (Rome, Italy, 15 – 16 November 2022).
2023: Member of the PhD examination committee, Department of Biosciences and Territory, University of Molise. Candidate: M. Colardo (Pesche, Italy, 3 May 2023).
2023: Chair and Moderator of the Symposium “Maternal stressors matter: deconstructing the neurobehavioral signature of fetal insults”, XX National Congress of the Italian Society of Neuroscience (SINS) (Turin, Italy, 14 – 17 September 2023).
2023: Chair and Moderator of the Symposium “Dissecting the complexity of neurodevelopmental disorders: from pathophysiology to novel therapeutic approaches”, 8th MNS Meeting (Carthage, Tunisia, 14 – 18 October 2023).
2023 – 2025: Member of the master’s thesis examination committee, Course in Neurobiology, Faculty of Mathematical, Physical and Natural Sciences, Sapienza University of Rome, Rome, Italy (Sessions: 21 July, 20 October, 15 December 2023; 15 Decembre 2024; 17 January 2025; 17 October 2025).
2024: Member of the master’s thesis examination committee, Course in Medical Biotechnology, Faculty of Pharmacy and Medicine, Sapienza University of Rome, Rome, Italy (Sessions: 26 January, 20 November 2024, 29 October 2025).
2024: Member of the master’s thesis examination committee, Course in Pharmacy, Faculty of Pharmacy and Medicine, Sapienza University of Rome, Rome, Italy (Sessions: 17 July 2024; 13 October 2025).
2024: Lecture, PhD Programme in Biology and Applied Sciences, Department of Biosciences and Territory, University of Molise (22 and 26 February 2024). Title: Experimental models in behavioral pharmacology.
2024: Lecture, PhD Programme in Pharmacology and Toxicology, Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy (Session: 24 May 2024). Title: Behavioral phenotyping in animal models of neurodevelopmental disorders: new insights into pharmacological approaches.
2024: Elective teaching activities, Master Course in Medicine and Surgery “B”, Sapienza University of Rome, Rome, Italy (14 May 2024). Title: Clinical and pharmacological application of medical Cannabis.
2024: Member of the evaluation committee for the comparative assessment procedure for the allocation of two research grants of category B), type I, for the disciplinary sector 05/G1 - BIOS-11/A scientific field, related to the following calls: CALL AR No. 30/2023_PRIN2022_PNRR_Manduca and CALL AR No. 04/2023_PRIN2022_Manduca.
2024: Member of the Scientific Board of the PhD Program in Pharmacology and Toxicology, Sapienza University of Rome.
2024: Member of the Scientific Board of the First-Level Master’s Degree in Cosmetology and Dermatology of the Head and Neck District, Sapienza University of Rome, Director Prof. Marco Artico.
2023-2025: Member of the Scientific Board of the Second-Level Master’s Degree in Integrated Medicine in Pharmacy, Sapienza University of Rome, Director Prof. Annabella Vitalone.
2025: Member of the Examining Committee of the Second-Level Master’s Degree in Integrated Medicine in Pharmacy, Sapienza University of Rome, Director Prof. Annabella Vitalone.
2024-2025: Scientific Member of the Organismo Preposto al Benessere degli Animali (OPBA), Dept. Physiology and Pharmacology, Sapienza University of Rome.
2025: Evaluator member of the doctoral thesis, 37th Cycle of the PhD Program in Cellular and Molecular Biotechnologies, Department of Biosciences and Agro-Food and Environmental Technologies, University of Teramo.
2025: Chair and Moderator of the Symposium “Maternal stressors matter: deconstructing the neurobehavioral signature of fetal insults”, XX National Congress of the Italian Society of Neuroscience (MNS) (Chania, Crete, 7 – 11 June 2025).
2025: Selected Expert as External Reviewers within the framework of the 2020–2024 Evaluation of Research Quality (VQR).

OUTREACH ACTIVITIES
1. Newspaper article published on 25 November 2015. Title: "Une équipe «Espoirs de la Recherche 2015". La Lettre de Grand Luminy Technopôle. https://www.grandluminy.com/sites/default/files/lettre86-nov2015.pdf.
2. Newspaper article published on 1 September 2016. Title: "CONGRES MAAD". La Lettre de Grand Luminy Technopôle. https://www.grandluminy.com/sites/default/files/lettre-89-sept2016-grand....
3. Newspaper article published on 27 October 2017. Title: “L’ORÉAL- UNESCO POUR LES FEMMES ET LA SCIENCE 2017". https://fondationloreal.com/categories/publications-284/lang/fr.
4. Radio interview (10 October 2017). France Blue Provence, Marseille, France.
5. Radio interview (18 July 2018). Radio Alfa, Salerno, Italy. Program: Salernitani nel mondo. Title: “Salernitani nel mondo, a Marsiglia la ricercatrice Antonia Manduca studia gli effetti della Cannabis”. https://www.radioalfa.fm/salernitani-nel-mondo-a-marsiglia-la-ricercatri....
6. Online articles (11 September 2018). Title: “Prenatal exposure to cannabis impacts sociability of male offspring only”. https://www.sciencedaily.com/releases/2018/09/180911132101.htm. https://www.eurekalert.org/pub_releases/2018-09/e-pet091118.php; https://neurosciencenews.com/cannabis-male-sociability-9840/.
7. Press Release: INSERM. Title: Prenatal exposure to cannabis impacts sociability of male rats. https://presse.inserm.fr/en/francais-lexposition-in-utero-au-cannabis-im....
8. Press Release: Autism Speaks (9 September 2019). Title: Autism Speaks awards more than $4.7 million for autism research. https://www.autismspeaks.org/science-news/autism-speaks-awards-more-47-m....
9. Press Release: Roma Tre University (September 2019). Title: Prestigioso finanziamento della Autism Speaks al laboratorio della prof.ssa Trezza. https://www.uniroma3.it/articoli/pre-prestigioso-finanziamento-della-aut...
10. Scientific Traineer of “Adolescent brains: gender differences in vulnerability to the effects of drugs of abuse”. Terza Missione Project (Proponent: Prof. P. Campolongo) sponsored by Sapienza University of Rome in partnership with Associazione Valentina de Castro Onlus (Sessions: 25 October 2022: IC Pablo Neruda, Rome; 11 and 23 November: 2022 IC Fucini, Rome; 25 November: IC Virgili, Ronciglione).
11. WE4LEAD Women's Empowerment For LEADership and Equity in Higher Education Institutions project sponsored by European Union to increase women's access to the highest decision-making positions particularly in the Mediterranean region (Dept. Physiology and Pharmacology, Sapienza University of Rome, 24 November 2024; Dept. Psychology, Sapienza University of Rome, 22 January 2025; Dept. Statistical Sciences, Sapienza University of Rome, 7 february 2025).
12. PNRR Orientamento Next Generation Programme for the active orientation in school-university transition by supporting students in transitioning from upper secondary school to university (Liceo Classico “Aristofane”, Rome, 12 March 2024; Liceo Scientifico “Avogadro”, Rome, 14 March 2024; Liceo Classico e Scientifico Statale “Bertrand Russell”, Rome, 6 November 2024; Istituto Tecnico per il Turismo “Livia Bottardi”, 27 february 2025; Liceo Classico Linguistico e delle Scienze Umane Statale “Eugenio Montale”, Rome, 4 March 2025).
13. Co-author of the article on the online journal Forward titled «Come nascono le dipendenze: Intrappolati in un circolo vizioso» in collaboration with Dr. Maria Morena from the Department of Physiology and Pharmacology, Sapienza University of Rome, and Dr. Michela Servadio from the Department of Epidemiology, Lazio Regional Health Service, ASL Roma 1. https://forward.recentiprogressi.it/it/rivista/numero-36-abitudini/artic....
14. Scientific Traineer at “Porte Aperte alla Sapienza 2025”, Faculty of Mathematical, Physical and Natural Sciences, Sapienza University of Rome (26-28 March 2025).

INTERNATIONAL SCIENTIFIC COLLABORATIONS
- Dr. Olivier Manzoni, Institut de Neurobiologie de la Méditerranée, Marseille, France. Project : Sex differences in developmental vulnerability to neuropsychiatric disorders: focus on the endocannabinoid system.
- Dr. Martin Kuchar, Department of Chemistry of Natural Compounds, University of Prague, Czech Republic. Project : Cannabidiol effects in neurodevelopmental disorders.
- Dr. Aurore Thomazeau, Universitè Cotè D’Azur, Nice, France. Project : Synaptic physiology and its dysregulation in neurodevelopmental disorders.

NATIONAL SCIENTIFIC COLLABORATIONS
- Prof.ssa Viviana Trezza, Department of Science, Roma Tre University, Rome, Italy. Project: New therapeutic targets for autism spectrum disorders and comorbidities.
- Prof.ssa Lucia Caffino, Department of Pharmacological and Biomolecular Sciences, University of Milan, Italy. Project: Deprivation matters: exploring sex-dependent vulnerability to anorexia nervosa following social impoverishment during early adolescence.
- Prof. Nazzareno Cannella, School of Pharmaceutical Sciences and Health Products, University of Camerino, Italy. Project: Deprivation matters: exploring sex-dependent vulnerability to anorexia nervosa following social impoverishment during early adolescence

MATERNITY LEAVES
From 11/07/2016 to 25/11/2016, delivery date: 10/09/2016
From 04/09/2017 to 02/06/2018 for twins, delivery date: 02/12/2017

MEMBERSHIPS OF SCIENTIFIC SOCIETIES
Società Italiana di Farmacologia (SIF)
Società Italiana di Neuroscienze (SINS)
Mediterranean Neuroscience Society (MNS)
European Behavioural Pharmacology Society (EBPS)