Curriculum
EUROPASS CURRICULUM VITAE
Personal Informations
First name(s) / Surname(s) RICCARDO POFI
Address(es) VIALE VITTORIO EMANUELE 64, ANAGNI (FR), 03012, ITALY
E-mail riccardo.pofi@uniroma1.it, riccardo.pofi@ocdem.ox.ac.uk
Work Experience
• Dates (from-to) 2025 – now – Associate Professor, Sapienza University of Rome- Department of Experimental Medicine – Policlinico Umberto I, Rome
2022 – 2025 - Clinical Research Fellow, University of Oxford - Radcliffe Department of Medicine – Churchill Hospital - Oxford Centre for Diabetes, Endocrinology and Metabolism. PI: Prof. Jeremy Tomlinson. Title of research: “Dissecting the Contribution of glucocorticoid metabolism in MACS: a randomised controlled trial of the 11β-HSD1 inhibitor SPI-62 (DC-MACS)”.
2022 – 2025 – Honorary Clinician in Endocrinology, NHS trust - Radcliffe Department of Medicine – Churchill Hospital - Oxford Centre for Diabetes, Endocrinology and Metabolism.
• Name and address of employer Sapienza University of Rome- Department of Experimental Medicine – Policlinico Umberto I, Rome
• Occupation or position held Associate Professor in Endocrinology and Metabolism.
• Main activities and responsibilities Research and Clinical practice on Adrenal, Pituitary and Metabolic diseases.
EDUCATION AND TRAINING
• DateS 2022- 2025 - Clinical Research Fellow, University of Oxford - Radcliffe Department of Medicine – Churchill Hospital - Oxford Centre for Diabetes, Endocrinology and Metabolism. PI: Prof. Jeremy Tomlinson. Title of research: “Dissecting the Contribution of glucocorticoid metabolism in MACS: a randomised controlled trial of the 11β-HSD1 inhibitor SPI-62 (DC-MACS)”.
2018- 2021 – PhD degree, Endocrinological, Metabolic and Andrological Sciences, Sapienza University of Rome, cum laude and special mention of Doctor Europaeus, Supervisor Prof. Elisa Giannetta (Sapienza University of Rome) and Jeremy W. Tomlinson (Oxford University). Title of research: “Defining and predicting the adverse effects of prescribed steroids”;
2017- 2019 – Research Fellowship in Oxford at OCDEM (Oxford Center for Diabetes, Endocrinology and Metabolism). Supervisor: Prof. Jeremy W. Tomlinson;
2013 - 2018 – Specialty course in Endocrinology and Metabolic Diseases (70 cum laude/70). Supervisors: Prof. Andrea M. Isidori (“Sapienza” University of Rome) and Prof Jeremy W. Tomlinson (Oxford University). Thesis title: “The short Synacthen (corticotropin) test can be used to predict recovery of hypothalamo-pituitary-adrenal axis function.”;
(25/09/2012) - Degree course in Medicine and Surgery (110 cum laude/110). Thesis title: "Pathophysiology of diabetic cardiomyopathy in Diabetes Mellitus Type 2. Prospective longitudinal study on the progression of heart damage and identification of new markers of disease." Tutor Prof. Andrea M. Isidori
Organisation providing education and training Sapienza University of Rome
Oxford University
Principal subjects /occupational skills covered Clinical Research in Endocrinology (mainly adrenal, pituitary, metabolic and cardiovascular endocrinology), Andrology. Diagnostic ultrasound of Thyroid (including Fine Needle Aspiration) and ultrasound of Testis for clinics and research, Kidney ultrasound for the purpose of research; Statistics advanced skills.
Title of qualification awarded Medical Doctor (Physician) – Endocrine Specialist – PhD – Doctor Europaeus
Level in national or international classification Highest Educational Degree in Europe
PERSONAL SKILLS AND COMPETENCES
Mother tongue(s) ITALIAN
Other Language(s) ENGLISH – OCCUPATIONAL ENGLISH TEST (OET) CERTIFIED – C1
Social skills and competences Excellent communication skills with mentors, colleagues and patients; ability to keep for a long time collaboration in the purpose of research. Currently working both with Oxford University and Sapienza University of Rome for research purpose.
Organizational skills and competences - Leadership, former responsible for PhD students and resident students in the department of Experimental Medicine, Sapienza University of Rome.
2025 – now: Treasurer of the Italian Society of Endocrinology;
2021 – 2025: Member of the National Scientific Commission of the Young Italian Endocrinologist;
2023 – now: Coordinator of the Cardiovascular Endocrinology Club of the Italian Society of Endocrinology;
2023 – now: Associate editor for Frontiers in Endocrinology, section of Adrenal Endocrinology;
2021 – 2023: Sub-Investigator in the clinical trial “NBI-74788-CAH3003 - A Randomized, Double
Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Crinecerfont (NBI-74788) in Adult Subjects with Classic Congenital Adrenal Hyperplasia, Followed by Open-Label Treatment”
ADDITIONAL INFORMATION
Registrations and Affiliations: Full registration in Italy: Frosinone Provincial Order of Medical Doctors-Surgeons and Dentists (May 2013 – n° 3920) Full registration in UK: GMC reference n° 7989673
Qualification: Scientific National Qualification (Art. 16 of the law 30 December 2010, n.240 – abilitazione scientifica nazionale ASN) Associate professor in Endocrinology MED13 (2022)
ANNEXES AND PUBBLICATIONS Publications in international journals: Author of 86 original scientific publications in international journals. Total Citations = 2523 (Google scholar), Total Citations = 2159 (scopus); H-index = 31 (Google scholar), H-index (scopus) = 27, First Name Works = 15; Last Name Works = 7; Total IF = 542.687
RESEARCH GRANTS Funded grants
2021-2023 “Call for research proposal” awarded from “Sapienza University of Rome” with the project titled: “Effects of 5 alpha-Reductase Inhibitors on glucose metabolism in patients with BPH and Type 2 diabetes mellitus” (2000€).
2025 - 2027 Italian Ministry of Health – Fondo Italiano per la Scienza 2 – Starting grant: “Reshaping The Landscape of the 11 beta HSD System In Androgen Metabolism Kinetics (Re-ThInK)” (1.323.601 €)
LIST OF MAIN PUBLICATIONS
1. Phosphodiesterase-5 inhibition preserves renal hemodynamics and function in mice with diabetic kidney disease by modulating miR-22 and BMP7.
Pofi R, Fiore D, De Gaetano R, Panio G, Gianfrilli D, Pozza C, Barbagallo F, Xiang YK, Giannakakis K, Morano S, Lenzi A, Naro F, Isidori AM, Venneri MA. Sci Rep. 2017 Mar 15;7:44584.
doi: 10.1038/srep44584; PMID: 28294194
2. The short Synacthen (corticotropin) test can be used to predict recovery of hypothalamo-pituitary-adrenal axis function.
Pofi R, Feliciano C, Sbardella E, Argese N, Woods CP, Grossman AB, Jafar-Mohammadi B, Gleeson H, Lenzi A, Isidori AM, Tomlinson JW. JCEM. 2018 May 25, jc.2018-00529. doi:10.1210/jc.2018-00529; PMID 29846658
3. Recovery of the hypothalamo-pituitary-adrenal axis after trans-sphenoidal surgery for non-ACTH secreting macro adenomas.
Pofi R, Gunatilake S, Macgregor V, Shine B, Joseph R, Grossman AB, Isidori AM, Cudlip S, Jafar-Mohammadi B, Tomlinson JW, Pal A. J Clin Endocrinol Metab. 2019 Nov 1;104(11):5316-5324.
doi: 10.1210/jc.2019-00406. PMID: 31225871
4. Plasma renin measurements are unrelated to mineralocorticoid replacement dose in patients with primary adrenal insufficiency.
Pofi R, Prete A, Thornton-Jones V, Bryce J, Ali SR, Faisal Ahmed S, Balsamo A, Baronio F, Cannuccia A, Guven A, Guran T, Darendeliler F, Higham C, Bonfig W, de Vries L, Bachega TASS, Miranda MC, Mendonca BB, Iotova V, Korbonits M, Krone NP, Krone R, Lenzi A, Arlt W, Ross RJ, Isidori AM, Tomlinson JW.
JCEM, 2019 Oct 16. doi: 10.1210/clinem/dgz055. PMID: 31613957
5. COVID-19 infection and glucocorticoids: update from the Italian Society of Endocrinology Expert Opinion on steroid replacement in adrenal insufficiency.
Isidori AM, Arnaldi G, Boscaro M, Falorni A, Giordano C, Giordano R, Pivonello R, Pofi R, Hasenmajer V, Venneri MA, Sbardella E, Simeoli C, Scaroni C, Lenzi A. J Endocrinol Invest. 2020 Apr 25:1-7.
doi: 10.1007/s40618-020-01266-w. PMID: 32335855.
6. Diabetic Cardiomiopathy Progression is Triggered by miR122-5p and Involves Extracellular Matrix: A 5-Year Prospective Study.
Pofi R, Giannetta E, Galea N, Francone M, Campolo F, Barbagallo F, Gianfrilli D, Venneri MA, Filardi T, Cristini C, Antonini G, Badagliacca R, Frati G, Lenzi A, Carbone I, Isidori AM. JACC Cardiovasc Imaging. 2020 Nov 18:S1936-878X(20)30916-5. doi: 10.1016/j.jcmg.2020.10.009. PMID: 33221242
7 Sex-specific effects of daily tadalafil on diabetic heart kinetics in RECOGITO, a randomized, double-blind, placebo-controlled trial.
Pofi R, Giannetta E, Feola T, Galea N, Barbagallo F, Campolo F, Badagliacca R, Barbano B, Ciolina F, Defeudis G, Filardi T, Sesti F, Minnetti M, Vizza CD, Pasqualetti P, Caboni P, Carbone I, Francone M, Catalano C, Pozzilli P, Lenzi A, Venneri MA, Gianfrilli D, Isidori AM. Sci Transl Med. 2022 Jun 15;14(649):eabl8503. doi: 10.1126/scitranslmed.abl8503. PMID: 35704597.
8 Susceptibility and characteristics of infections in patients with glucocorticoid excess or insufficiency: the ICARO tool.
Minnetti M, Hasenmajer V, Sbardella E, Angelini F, Simeoli C, Di Paola N, Cozzolino A, Pivonello C, De Alcubierre D, Chiloiro S, Baldelli R, De Marinis L, Pivonello R, Pofi R*, Isidori AM*. Eur J Endocrinol. 2022 Oct 13;187(5):719-731. doi: 10.1530/EJE-22-0454. PMID: 36102827
9 Treating the Side Effects of Exogenous Glucocorticoids; Can We Separate the Good From the Bad?
Pofi R, Caratti G, Ray DW, Tomlinson JW. Endocr Rev. 2023 Nov 9;44(6):975-1011.
doi: 10.1210/endrev/bnad016. PMID: 37253115
10 Impact of Female Sex and Mild Cortisol Secretion on Coagulation Profile in Adrenal Incidentalomas.
Bonaventura I, Minnetti M, Ferrari D, Hasenmajer V, Tomaselli A, De Alcubierre D, Lenzi A, Pofi R*, Isidori AM*. J Endocr Soc. 2024 Dec 12;9(1):bvae215.
doi: 10.1210/jendso/bvae215. PMID: 39669652
11 Dose-dependent and tissue-specific adverse effects of exogenous glucocorticoids: insights for optimizing clinical practice.
Pofi R, Othonos N, Marjot T, Bonaventura I, Barrett A, White S, Miller H, Potter T, Bailey M, Eastell R, Gossiel F, Woods C, Hazlehurst JM, Hodson L, Tomlinson JW. J Endocrinol Invest. 2025 Sep;48(9):2067-2076. doi: 10.1007/s40618-025-02637-x. Epub 2025 Jul 7. PMID: 40622517
12 Venous thromboembolism in patients with pituitary adenoma: UK multicentre cohort study.
Isand K, Pofi R, Haermson O, Vergis M, Mahendran H, Ayuk J, Wass J, Yajnik P, Bradley K, Karavitaki N, Pal A. Eur J Endocrinol. 2025 Jul 31;193(2):270-277. doi: 10.1093/ejendo/lvaf139. PMID: 40608956
13 Chronotherapy with Once-Daily Osilodrostat Improves Cortisol Rhythm, Quality of Life, and Sleep in Cushing's Syndrome.
Ferrari D, Bonaventura I, Simeoli C, Tomaselli A, Vincenzi L, De Alcubierre D, Sciarra F, Rizzo F, Cerroni L, Di Paola N, Minnetti M, Sbardella E, Venneri MA, Pofi R, Pivonello R, Gianfrilli D, Hasenmajer V, Isidori AM. J Clin Endocrinol Metab. 2025 Apr 2:dgaf206. doi: 10.1210/clinem/dgaf206. PMID: 40172910
The undersigned RICCARDO POFI is aware that false declarations lead to the application of criminal sanctions
provided for by the art. 76 of the Presidential Decree 445/2000 declares that the information reported in the following curriculum vitae drawn up in European format corresponds to the truth
Date
Rome, 20/10/2025
Riccardo Pofi