patrizia lavia

Current Position:
Research Director
Institute of Molecular Biology and Pathology (IBPM), National Research Council of Italy (CNR)
c/o Dept. of Biology and Biotechnology “Charles Darwin”, University ‘La Sapienza', Rome
Via degli Apuli 4, Rome 00185.
Tel. 06-4457528 / 06-49917536,
e-mail: patrizia.lavia@uniroma1.it

Scientific career and research positions:
• 2006-present: Research Director, IBPM-CNR, Rome
• 2001- 05: Senior Research Scientist, IBPM-CNR, Rome
• 1990 -91: EU Senior Fellow, EU FP2 ‘BRIDGE' Programme, Centre for Genome Research, University of Edinburgh, UK
• 1984-87: EMB0 long-term fellow, MRC Mammalian Genome Unit, Edinburgh, UK
• 1984: Research scientist, CNR Centre of Evolutionary Genetics, Rome, Italy
• 1980: Post-doctoral fellow, Institute of Genetics, Sapienza University, Rome
• 1978: MSc in Biology, Sapienza University, Rome (Italy),

Other activities
• 2013-present: Teaching position at Sapienza University (Rome), course "Molecular Bases of the Cell Cycle"
• 2013-present: CNR Committe member for International bilateral research projects, Biology and Medical Sciences, CNR Rome
• 2009- present: co-director, Nikon microscopy reference center for Central-Southern Italy, CNR-IBPM, Rome
• 2004-present: Teaching board member, PhD School in Genetics and Molecular Biology, 'La Sapienza', University, Rome
• 2003-06: Italian Society of Biophysics and Molecular Biology (SIBBM), governing board

Areas of expertise:
Disciplines: Genetics, Molecular and Cellular Biology, Applied Biology
Research fields: Control of mitosis and cell division; The mitotic apparatus; Regulatory networks in genetic instability; Cell cycle control; Checkpoints; Innovative anti-cancer molecules and therapeutic design; Cellular imaging

Recent publications (2012-present):
1. Colicchia V, Petroni M, Guarguaglini G, Sardina F, Sahún-Roncero M, Carbonari M, Ricci B, Heil C, Capalbo C, Belardinilli F, Coppa A, Peruzzi G, Screpanti I, Lavia P, Gulino A, Giannini G. PARP inhibitors enhance replication stress and cause mitotic catastrophe in MYCN-dependent neuroblastoma. Oncogene. 2017 Apr 10. [Epub ahead of print]
2. Asteriti IA, Daidone F, Colotti G, Rinaldo S, Lavia P, Guarguaglini G, Paiardini A. Identification of small molecule inhibitors of the Aurora-A/TPX2 complex. Oncotarget. 2017;8(19):32117-32133.
3. Di Cesare E, Verrico A, Miele A, Giubettini M, Rovella P, Coluccia A, Famiglini V, La Regina G, Cundari E, Silvestri R, Lavia P. Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules. Oncotarget. 2017;8(12):19738-19759.
4. Soriani A, Borrelli C, Ricci B, Molfetta R, Zingoni A, Fionda C, Carnevale S, Abruzzese MP, Petrucci MT, Ricciardi MR, La Regina G, Di Cesare E, Lavia P, Silvestri R, Paolini R, Cippitelli M, Santoni A. p38 MAPK differentially controls NK activating ligands at transcriptional and post-transcriptional level on multiple myeloma cells. Oncoimmunology. 2016;6(1):e1264564.
5. Stelma T, Chi A, van der Watt PJ, Verrico A, Lavia P, Leaner VD. Targeting nuclear transporters in cancer: Diagnostic, prognostic and therapeutic potential. IUBMB Life. 2016;68(4):268-80.
6. Lavia P. The GTPase RAN regulates multiple steps of the centrosome life cycle. Chromosome Res. 2016;24(1):53-65. doi: 10.1007/s10577-015-9514-4.
7. Talarico C, D'Antona L, Scumaci D, Barone A, Gigliotti F, Fiumara CV, Dattilo V, Gallo E, Visca P, Ortuso F, Abbruzzese C, Botta L, Schenone S, Cuda G, Alcaro S, Bianco C, Lavia P, Paggi MG, Perrotti N, Amato R. Preclinical model in HCC: the SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapy. Oncotarget. 2015;6(35):37511-25.
8. La Regina G, Bai R, Coluccia A, Famiglini V, Pelliccia S, Passacantilli S, Mazzoccoli C, Ruggieri V, Verrico A, Miele A, Monti L, Nalli M, Alfonsi R, Di Marcotullio L, Gulino A, Ricci B, Soriani A, Santoni A, Caraglia M, Porto S, Da Pozzo E, Martini C, Brancale A, Marinelli L, Novellino E, Vultaggio S, Varasi M, Mercurio C, Bigogno C, Dondio G, Hamel E, Lavia P, Silvestri R. New indole tubulin assembly inhibitors cause stable arrest of mitotic progression, enhanced stimulation of natural killer cell cytotoxic activity, and repression of hedgehog-dependent cancer. J Med Chem. 2015;58(15):5789-807.
9. Asteriti IA, Di Cesare E, De Mattia F, Hilsenstein V, Neumann B, Cundari E, Lavia P, Guarguaglini G. The Aurora-A inhibitor MLN8237 affects multiple mitotic processes and induces dose-dependent mitotic abnormalities and aneuploidy. Oncotarget. 2014;5(15):6229-42.
10. La Regina G, Bai R, Coluccia A, Famiglini V, Pelliccia S, Passacantilli S, Mazzoccoli C, Ruggieri V, Sisinni L, Bolognesi A, Rensen WM, Miele A, Nalli M, Alfonsi R, Di Marcotullio L, Gulino A, Brancale A, Novellino E, Dondio G, Vultaggio S, Varasi M, Mercurio C, Hamel E, Lavia P, Silvestri R. New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer. J Med Chem. 2014;57(15):6531-52.
11. Guarguaglini G, de Turris V, Lavia P. Immunofluorescence methods in studies of the GTPase RAN and its effectors in interphase and in mitotic cells. Methods Mol Biol. 2014;1120:241-52.
12. La Regina G, Bai R, Rensen WM, Di Cesare E, Coluccia A, Piscitelli F, Famiglini V, Reggio A, Nalli M, Pelliccia S, Da Pozzo E, Costa B, Granata I, Porta A, Maresca B, Soriani A, Iannitto ML, Santoni A, Li J, Miranda Cona M, Chen F, Ni Y, Brancale A, Dondio G, Vultaggio S, Varasi M, Mercurio C, Martini C, Hamel E, Lavia P, Novellino E, Silvestri R. Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors. J Med Chem. 2013;56(1):123-49.
13. Amato R, Scumaci D, D'Antona L, Iuliano R, Menniti M, Di Sanzo M, Faniello MC, Colao E, Malatesta P, Zingone A, Agosti V, Costanzo FS, Mileo AM, Paggi MG, Lang F, Cuda G, Lavia P, Perrotti N. Sgk1 enhances RANBP1 transcript levels and decreases taxol sensitivity in RKO colon carcinoma cells. Oncogene. 2013;32(38):4572-8.
14. Ooi WF, Re A, Sidarovich V, Canella V, Arseni N, Adami V, Guarguaglini G, Giubettini M, Scaruffi P, Stigliani S, Lavia P, Tonini GP, Quattrone A. Segmental chromosome aberrations converge on overexpression of mitotic spindle regulatory genes in high-risk neuroblastoma. Genes Chromosomes Cancer. 2012;51(6):545-56.
15. Roscioli E, Di Francesco L, Bolognesi A, Giubettini M, Orlando S, Harel A, Schininà ME, Lavia P. Importin-β negatively regulates multiple aspects of mitosis including RANGAP1 recruitment to kinetochores. J Cell Biol. 2012;196(4):435-50.