SILVIA CHICHIARELLI

Silvia Chichiarelli, PhD
University of Rome “La Sapienza”
Department of Biochemical Sciences “A. Rossi Fanelli”
P.le Aldo Moro, 00185, Roma, Italy
+39 06 4991-0598 / 0871 (Room / Lab)
silvia.chichiarelli@uniroma1.it

Education and Professional EXPERIENCE
2006 to date: Assistant Professor
University of Rome “La Sapienza - Department of Biochemical Sciences “A. Rossi Fanelli” , P.le Aldo Moro, n°5 - 00185, Roma, Italy
Research Sector: Biochemistry

2005 - 2006 Post-Doc Research Fellowship in Biochemistry (Assegno di ricerca)
University of Rome “La Sapienza - Department of Biochemical Sciences “A. Rossi Fanelli”,

2004 - 2005 Fellowship (Collaborazione Coordinata e Continuativa) University of Rome “La Sapienza - Department of Biochemical Sciences “A. Rossi Fanelli”,

2002–2003 Post-Doc Research Fellowship in Biochemistry
University of Rome “La Sapienza - Department of Biochemical Sciences “A. Rossi Fanelli” - Research in Biochemistry

2001 Research Fellowship
Pasteur Institute - Cenci-Bolognetti Foundation
Research in Biochemistry

2000 Research Fellowship
Pasteur Institute - Cenci-Bolognetti Foundation
Research in Biochemistry

2001 PhD in Biochemistry
University of Rome “La Sapienza - Department of Biochemical Sciences “A. Rossi Fanelli”, - Università degli Studi di Roma "Tor Vergata" - Research in Biochemistry
2000 Research Fellowship

1997 Qualified as a Professional Biologist
(“Abilitazione alla professione di Biologo”)

1995 Degree in Biological Sciences, Molecular Biology area
Quotation of 110/110 cum laude.
Faculty of Mathematics, Physics and Natural Sciences, Università di Roma “La Sapienza”.

TEACHING EXPERIENCE
Faculty of Pharmacy and Medicine, Università di Roma “La Sapienza”.:
2022-2023 to date
Lecturer of BIOCHEMICAL BIOTECHNOLOGIES II (PHARMACEUTICAL BIOTECHNOLOGIES) into the degree course of Biochemistry

2018/2019 to date
Lecturer of MOLECULAR BIOLOGY into the degree course of Chemistry and Pharmaceutical Technologies

2013/2014 to date Lecturer of APPLIED BIOCHEMISTRY and BIOTECHNOLOGY into the degree course of Chemistry and Pharmaceutical Technologies

2012/2013 Lecturer of APPLIED BIOCHEMISTRY into the degree course of Pharmacy

2011 to 2013 Lecturer of INDUSTRIAL BIOCHEMISTRY into the degree course of Chemistry and Pharmaceutical Technologies

2007 to 2012 Lecturer of ENZYMOLOGY into the degree course of Chemistry and Pharmaceutical Technologies

PERSONAL SKILLS
Mother tongue: Italian
Other languages: English (Limited working proficiency), French (Basic)

Organisational / managerial skills ▪
Tutor of thesis in Chemistry and Pharmaceutical Technologies

Job-related skills
▪ Component of Quality Assurance Management Group of the degree in Chemistry and Pharmaceutical Technologie and Master's Degree in Biochemistry
▪ Component of the Educational Committee (Dipt. Biochemical Sciences “A Rossi Fanelli” – SAPIENZA. (involved in issues pertaining to the organization of teaching activities).
▪ Academic International Mobility Manager (RAM for the degree Course of Chemistry and Pharmaceutical Technologies) from Academic year 2020/21 to date
▪ Academic Coordinator for International Mobility - Faculty of Medicine and Pharmacy - Pharmaceutical Area - from 03/2022. to date.

ADDITIONAL INFORMATION
Memberships Member of the Italian Society of Biochemistry and Molecular Biology (SIB)
[SIB is a Member of the following International Associations: FEBS: Federation of European Biochemical Societies; IUBMB: International Union of Biochemistry and Molecular Biology]

Member of Reviewer board of the International Journal of Molecular Sciences (IJMS) to date https://www.mdpi.com/journal/ijms/submission_reviewers

Projects Research grants: I have been the recipient of some Italian grants from Sapienza University and MIUR, also I participated to projects funded by the MUR (PRIN)

LIST OF PUBLICATIONS (last 10 Years)

1. Telkoparan-Akillilar P, Chichiarelli S, Tucci P, Saso L. Integration of MicroRNAs with nanomedicine: tumor targeting and therapeutic approaches. Front Cell Dev Biol. 2025 Apr 7;13:1569101. doi: 10.3389/fcell.2025.1569101

2. Minacori M, Fiorini S, Perugini M, Iannetta A, Meschiari G, Chichiarelli S, Altieri F, Natali PG, Eufemi M. AhR and STAT3: A Dangerous Duo in Chemical Carcinogenesis. International Journal of Molecular Sciences. 2025; 26(6):2744. https://doi.org/10.3390/ijms26062744

3. Temaj G, Chichiarelli S, Saha S, Telkoparan-Akillilar P, Nuhii N, Hadziselimovic R, Saso L. Alternative Splicing: A Potential Therapeutic Target in Hematological Malignancies. Hematol Rep. 2024 Oct 29;16(4):682-697. doi: 10.3390/hematolrep16040066

4. Pinilla-González V, Rojas-Solé C, Gómez-Hevia F, González-Fernández T, Cereceda-Cornejo A, Chichiarelli S, Saso L, Rodrigo R. Tapping into Nature’s Arsenal: Harnessing the Potential of Natural Antioxidants for Human Health and Disease Prevention. Foods. 2024; 13(13):1999. https://doi.org/10.3390/foods13131999

5. Letafati A, Taghiabadi Z, Zafarian N, Tajdini R, Mondeali M, Aboofazeli A, Chichiarelli S, Saso L, Jazayeri SM. Emerging paradigms: unmasking the role of oxidative stress in HPV-induced carcinogenesis. Infect Agent Cancer. 2024 Jul 2;19(1):30. doi: 10.1186/s13027-024-00581-8.

6. Fiorini S, Rubini E, Perugini M, Altieri F, Chichiarelli S, Meschiari G, Arrighetti G, Vijgen J, Natali PG, Minacori M, et al. STAT3 Pathways Contribute to β-HCH Interference with Anticancer Tyrosine Kinase Inhibitors. International Journal of Molecular Sciences. 2024; 25(11):6181. https://doi.org/10.3390/ijms25116181

7. Rojas-Solé C, Torres-Herrera B, Gelerstein-Claro S, Medina-Pérez D, Gómez-Venegas H, Alzolay-Sepúlveda J, Chichiarelli S, Saso L, Rodrigo R. Cellular Basis of Adjuvant Role of n-3 Polyunsaturated Fatty Acids in Cancer Therapy: Molecular Insights and Therapeutic Potential against Human Melanoma. Applied Sciences. 2024; 14(11):4548. https://doi.org/10.3390/app14114548

8. Temaj G, Chichiarelli S, Telkoparan-Akillilar P, Saha S, Nuhii N, Hadziselimovic R, Saso L. P53: A key player in diverse cellular processes including nuclear stress and ribosome biogenesis, highlighting potential therapeutic compounds. Biochem Pharmacol. 2024 Jun 1:116332. doi: 10.1016/j.bcp.2024.116332

9. Temaj G, Chichiarelli S, Telkoparan-Akillilar P, Saha S, Nuhii N, Hadziselimovic R, Saso L. Advances in molecular function of UPF1 in Cancer. Arch Biochem Biophys. 2024, 13:109989. doi: 10.1016/j.abb.2024.109989

10. Pinilla-González V, Montecinos-Barrientos B, Martin-Kommer C, Chichiarelli S, Saso L, Rodrigo R. Exploring antioxidant strategies in the pathogenesis of ALS. Open Life Sci. 2024, 19(1):20220842. doi: 10.1515/biol-2022-0842

11. Briones-Valdivieso, C.; Briones, F.; Orellana-Urzúa, S.; Chichiarelli, S.; Saso, L.; Rodrigo, R. Novel Multi-Antioxidant Approach for Ischemic Stroke Therapy Targeting the Role of Oxidative Stress. Biomedicines 2024, 12, 501. doi: 10.3390/biomedicines12030501 Review

12. Temaj G, Chichiarelli S, Saha S, Telkoparan-Akillilar P, Nuhii N, Hadziselimovic R, Saso L. An intricate rewiring of cancer metabolism via alternative splicing. Biochem Pharmacol. 2023 Nov;217:115848. doi: 10.1016/j.bcp.2023.115848. Review

13. Orellana-Urzúa S, Briones-Valdivieso C, Chichiarelli S, Saso L, Rodrigo R. Potential Role of Natural Antioxidants in Countering Reperfusion Injury in Acute Myocardial Infarction and Ischemic StrokeAntioxidants (Basel). 2023 Sep 13;12(9):1760. doi: 10.3390/antiox12091760. Review.

14. Paglia G, Minacori M, Meschiari G, Fiorini S, Chichiarelli S, Eufemi M, Altieri F. Protein Disulfide Isomerase A3 (PDIA3): A Pharmacological Target in Glioblastoma? Int J Mol Sci. 2023 Aug 26;24(17):13279. doi: 10.3390/ijms241713279.

15. Temaj G, Telkoparan-Akillilar P, Nuhii N, Chichiarelli S, Saha S, Saso L. Recoding of Nonsense Mutation as a Pharmacological Strategy. Biomedicines. 2023 Feb 22;11(3):659. doi: 10.3390/biomedicines11030659

16. Méndez-Valdés G, Pérez-Carreño V, Bragato MC, Hundahl M, Chichiarelli S, Saso L, Rodrigo R. Cardioprotective Mechanisms against Reperfusion Injury in Acute Myocardial Infarction: Targeting Angiotensin II Receptors. Biomedicines. 2023; 11(1):17. doi: 10.3390/biomedicines11010017

17. Abelli J, Méndez-Valdés G, Gómez-Hevia F, Bragato MC, Chichiarelli S, Saso L, Rodrigo R. Potential Antioxidant Multitherapy against Complications Occurring in Sepsis. Biomedicines. 2022 Dec 1;10(12):3088. doi: 10.3390/biomedicines10123088.

18. Temaj G, Chichiarelli S, Eufemi M, Altieri F, Hadziselimovic R, Farooqi AA, Yaylim I, Saso L. Ribosome-Directed Therapies in Cancer. Biomedicines. 2022 Aug 26;10(9):2088. doi: 10.3390/biomedicines10092088.

19. González-Montero J, Chichiarelli S, Eufemi M, Altieri F, Saso L, Rodrigo R.
Ascorbate as a Bioactive Compound in Cancer Therapy: The Old Classic Strikes Back. Molecules. 2022 Jun 14;27(12):3818. doi: 10.3390/molecules27123818.

20. Chichiarelli S, Altieri F, Paglia G, Rubini E, Minacori M, Eufemi M.
ERp57/PDIA3: new insight. Cell Mol Biol Lett. 2022 Feb 2;27(1):12. doi: 10.1186/s11658-022-00315-x

21. Rubini E, Minacori M, Paglia G, Macone A, Chichiarelli S, Altieri F, Eufemi M.
Tomato and Olive Bioactive Compounds: A Natural Shield against the Cellular Effects Induced by β-Hexachlorocyclohexane-Activated Signaling Pathways.Molecules. 2021 Nov 25;26(23):7135. doi: 10.3390/molecules26237135

22. Rubini E, Minacori M, Paglia G, Altieri F, Chichiarelli S, Romaniello D, Eufemi M.
β-Hexachlorocyclohexane Drives Carcinogenesis in the Human Normal Bronchial Epithelium Cell Line BEAS-2B. Int J Mol Sci. 2021 May 29;22(11):5834. doi: 10.3390/ijms22115834.

23. Marrocco I, Altieri F, Rubini E, Paglia G, Chichiarelli S, Giamogante F,Macone A, Perugia G, Magliocca FM, Gurtner A, Maras B, Ragno R, Patsilinakos A,Manganaro R, Eufemi M. Shmt2: A Stat3 Signaling New Player in Prostate Cancer Energy Metabolism. Cells. 2019 Sep 6;8(9). pii: E1048. doi: 10.3390/cells8091048

24. Miele AE, Badaoui S, Maugliani L, Salza R, Boumis G, Chichiarelli S, Duclos B, Ricard-Blum S. A comparative analysis of secreted protein disulfide isomerases from the tropical co-endemic parasites Schistosoma mansoni and Leishmania major. Sci Rep. 2019 Jul 2;9(1):9568. doi: 10.1038/s41598-019-45709-8

25. Cocchiola R, Rubini E, Altieri F, Chichiarelli S, Paglia G, Romaniello D, Carissimi S, Giorgi A, Giamogante F, Macone A, Perugia G, Gurtner A, Eufemi M. STAT3 Post-Translational Modifications Drive Cellular Signaling Pathways in Prostate Cancer Cells. Int J Mol Sci. 2019 Apr 12;20(8). pii: E1815. doi: 10.3390/ijms20081815

26. Altieri F, Cairone F, Giamogante F, Carradori S, Locatelli M, Chichiarelli S, Cesa S. Influence of Ellagitannins Extracted by Pomegranate Fruit on DisulfideIsomerase PDIA3 Activity. Nutrients. 2019 Jan 17;11(1). pii: E186. doi:10.3390/nu11010186

27. Rubini E, Altieri F, Chichiarelli S, Giamogante F, Carissimi S, Paglia G,Macone A, Eufemi M. STAT3, a Hub Protein of Cellular Signaling Pathways, Is Triggered by β-Hexaclorocyclohexane. Int J Mol Sci. 2018 Jul 20;19(7). pii:E2108. doi: 10.3390/ijms19072108.

28. Giamogante F, Marrocco I, Cervoni L, Eufemi M, Chichiarelli S, Altieri F. Punicalagin, an active pomegranate component, is a new inhibitor of PDIA3 reductase activity. Biochimie. 2018 Feb 6. pii: S0300-9084(18)30034-8. doi:10.1016/j.biochi.2018.01.008.

29. Cocchiola R, Romaniello D, Grillo C, Altieri F, Liberti M, Magliocca FM, Chichiarelli S, Marrocco I, Borgoni G, Perugia G, Eufemi M. Analysis of STAT3 post-translational modifications (PTMs) in human prostate cancer with different Gleason Score. Oncotarget. 2017 Jun 27;8(26):42560-42570. doi:10.18632/oncotarget.17245

30. Gaucci E, Raimondo D, Grillo C, Cervoni L, Altieri F, Nittari G, Eufemi M, Chichiarelli S. Analysis of the interaction of calcitriol with the disulfide isomerase ERp57.
Sci Rep. 2016 Nov 29;6:37957. doi: 10.1038/srep37957

31. Giamogante F, Marrocco I, Romaniello D, Eufemi M, Chichiarelli S, Altieri F. Comparative Analysis of the Interaction between Different Flavonoids and PDIA3Oxidative Medicine and Cellular Longevity - Volume 2016 (2016), Article ID 4518281, 12 pages
http://dx.doi.org/10.1155/2016/4518281